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Extract from the Register of European Patents

EP About this file: EP2412808

EP2412808 - LH-TYPE BISPECIFIC ANTIBODY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.07.2017
Database last updated on 20.12.2024
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
Tohoku University
1-1 Katahira 2-chome Aoba-ku Sendai-shi
Miyagi 980-8577 / JP
[2012/05]
Inventor(s)01 / KUMAGAI Izumi
c/o TOHOKU UNIVERSITY
1-1 Katahira 2-chome
Aoba-ku
Sendai-shi Miyagi 980-8577 / JP
02 / ASANO Ryutaro
c/o TOHOKU UNIVERSITY
1-1 Katahira 2-chome
Aoba-ku
Sendai-shi Miyagi 980-8577 / JP
03 / UMETSU Mitsuo
c/o TOHOKU UNIVERSITY
1-1 Katahira 2-chome
Aoba-ku
Sendai-shi Miyagi 980-8577 / JP
 [2012/05]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2016/36]Woods, Geoffrey Corlett
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2012/05]Woods, Geoffrey Corlett
J.A. Kemp & Co. 14 South Square Gray's Inn London
WC1R 5JJ / GB
Application number, filing date10755725.804.01.2010
[2016/36]
WO2010JP50008
Priority number, dateJP2009007505025.03.2009         Original published format: JP 2009075050
JP2009026057616.11.2009         Original published format: JP 2009260576
[2012/05]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010109924
Date:30.09.2010
Language:JA
[2010/39]
Type: A1 Application with search report 
No.:EP2412808
Date:01.02.2012
Language:EN
[2012/05]
Type: B1 Patent specification 
No.:EP2412808
Date:07.09.2016
Language:EN
[2016/36]
Search report(s)International search report - published on:JP30.09.2010
(Supplementary) European search report - dispatched on:EP20.12.2012
ClassificationIPC:C12N15/09, A61K39/395, A61P35/00, C07K16/28, C07K16/46, C12N1/21, C12P21/08
[2012/05]
CPC:
C07K16/46 (EP,US); A61P35/00 (EP); C07K16/2809 (EP,US);
C07K16/2863 (EP,US); C07K16/468 (US); C07K2317/14 (US);
C07K2317/24 (EP,US); C07K2317/31 (EP,US); C07K2317/622 (US);
C07K2317/626 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/05]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:BISPEZIFISCHER LH-ANTIKÖRPER[2012/05]
English:LH-TYPE BISPECIFIC ANTIBODY[2012/05]
French:ANTICORPS BISPÉCIFIQUE DU TYPE LH[2012/05]
Entry into regional phase07.10.2011Translation filed 
07.10.2011National basic fee paid 
07.10.2011Search fee paid 
07.10.2011Designation fee(s) paid 
07.10.2011Examination fee paid 
Examination procedure17.06.2010Request for preliminary examination filed
International Preliminary Examining Authority: JP
07.10.2011Examination requested  [2012/05]
19.06.2013Amendment by applicant (claims and/or description)
16.07.2013Despatch of a communication from the examining division (Time limit: M06)
09.12.2013Reply to a communication from the examining division
04.08.2014Despatch of a communication from the examining division (Time limit: M06)
13.02.2015Reply to a communication from the examining division
30.10.2015Despatch of a communication from the examining division (Time limit: M02)
09.12.2015Reply to a communication from the examining division
14.04.2016Communication of intention to grant the patent
26.07.2016Fee for grant paid
26.07.2016Fee for publishing/printing paid
26.07.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.07.2013
Opposition(s)08.06.2017No opposition filed within time limit [2017/33]
Fees paidRenewal fee
07.10.2011Renewal fee patent year 03
10.01.2013Renewal fee patent year 04
21.01.2014Renewal fee patent year 05
13.01.2015Renewal fee patent year 06
11.01.2016Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.01.2010
AT07.09.2016
BE07.09.2016
CY07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
MK07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
TR07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IE04.01.2017
LU04.01.2017
MT04.01.2017
IS07.01.2017
PT09.01.2017
[2020/15]
Former [2019/51]HU04.01.2010
AT07.09.2016
BE07.09.2016
CY07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
MK07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IE04.01.2017
LU04.01.2017
MT04.01.2017
IS07.01.2017
PT09.01.2017
Former [2019/46]HU04.01.2010
AT07.09.2016
BE07.09.2016
CY07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IE04.01.2017
LU04.01.2017
MT04.01.2017
IS07.01.2017
PT09.01.2017
Former [2019/31]HU04.01.2010
AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IE04.01.2017
LU04.01.2017
MT04.01.2017
IS07.01.2017
PT09.01.2017
Former [2018/43]AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IE04.01.2017
LU04.01.2017
MT04.01.2017
IS07.01.2017
PT09.01.2017
Former [2018/13]AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IE04.01.2017
LU04.01.2017
IS07.01.2017
PT09.01.2017
Former [2018/01]AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
LU04.01.2017
IS07.01.2017
PT09.01.2017
Former [2017/45]AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
MC07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IS07.01.2017
PT09.01.2017
Former [2017/37]AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SI07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IS07.01.2017
PT09.01.2017
Former [2017/34]AT07.09.2016
BE07.09.2016
CZ07.09.2016
DK07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IS07.01.2017
PT09.01.2017
Former [2017/32]AT07.09.2016
BE07.09.2016
CZ07.09.2016
EE07.09.2016
ES07.09.2016
FI07.09.2016
HR07.09.2016
IT07.09.2016
LT07.09.2016
LV07.09.2016
NL07.09.2016
PL07.09.2016
RO07.09.2016
SE07.09.2016
SK07.09.2016
SM07.09.2016
BG07.12.2016
NO07.12.2016
GR08.12.2016
IS07.01.2017
PT09.01.2017
Former [2017/13]ES07.09.2016
FI07.09.2016
HR07.09.2016
LT07.09.2016
LV07.09.2016
NL07.09.2016
SE07.09.2016
NO07.12.2016
GR08.12.2016
Former [2017/11]ES07.09.2016
FI07.09.2016
HR07.09.2016
LT07.09.2016
SE07.09.2016
NO07.12.2016
GR08.12.2016
Former [2017/10]FI07.09.2016
HR07.09.2016
LT07.09.2016
SE07.09.2016
NO07.12.2016
Former [2017/09]FI07.09.2016
LT07.09.2016
NO07.12.2016
Former [2017/07]LT07.09.2016
Documents cited:Search[I]EP2006379  (UNIV TOHOKU [JP]) [I] 1-15 * figure 1 *
International search[X]WO2007108152  (UNIV TOHOKU [JP], et al);
 [X]JP2004242638  (TOHOKU TECHNO ARCH CO LTD);
 [Y]  - TODOROVSKA A. ET AL., "Design and application of diabodies, triabodies and tetrabodies for cancer targeting", J. IMMUNOL. METHODS, (20010201), vol. 248, no. 1-2, pages 47 - 66, XP002288731

DOI:   http://dx.doi.org/10.1016/S0022-1759(00)00342-2
 [Y]  - LU D. ET AL., "The effect of variable domain orientation and arrangement on the antigen- binding activity of a recombinant human bispecific diabody", BIOCHEM. BIOPHYS. RES. COMMUN., (20040528), vol. 318, no. 2, pages 507 - 513, XP004505410

DOI:   http://dx.doi.org/10.1016/j.bbrc.2004.04.060
by applicantJP3803790B
 WO2007108152
 EP0239400
 EP0451216
 WO9222653
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    - J MOL BIOL, (2003), vol. 330, no. 1, pages 99 - 111
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    - HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - ALT M, "Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin gammal Fc or CH3 region", FEBS LETT., (1999), vol. 454, pages 90 - 4
    - LU D, "A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity", J BIOL CHEM., (2005), vol. 280, pages 19665 - 72
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    - KREBBER, A. ET AL., "Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system", J IMMUNOL METHODS, (1997), vol. 201, pages 35 - 55
    - JONES ET AL., NATURE, (1986), vol. 321, pages 522 - 525
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    - R. SAIKI ET AL., SCIENCE, (1985), vol. 230, page 1350
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    - "DNA Cloning", The Practical Approach Series, OXFORD UNIVERSITY PRESS, (1995), vol. 1
    - M.A. FROHMAN, PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 8998 - 9002
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.