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Extract from the Register of European Patents

EP About this file: EP2435387

EP2435387 - METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  04.12.2015
Database last updated on 24.08.2024
Most recent event   Tooltip04.12.2015Application deemed to be withdrawnpublished on 06.01.2016  [2016/01]
Applicant(s)For all designated states
Duke University
2812 Erwin Road, Suite 306
Durham, NC 27705 / US
[2012/14]
Inventor(s)01 / WARNER, David, S.
Duke University
2812 Erwin Road
Suite 306
Durham, NC 27705 / US
02 / BATINIC-HABERLE, Ines
1 Cotswold Place
Durham, NC 27707 / US
03 / SHENG, Huaxin
Duke University
2812 Erwin Road
Suite 306
Durham, NC 27705 / US
04 / SPASOJEVIC, Ivan
1 Cotswold Place
Durham, NC 27707 / US
 [2012/14]
Representative(s)Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstrasse 4
80802 München / DE
[N/P]
Former [2012/14]Grünecker, Kinkeldey, Stockmair & Schwanhäusser
Anwaltssozietät
Leopoldstrasse 4
80802 München / DE
Application number, filing date10781161.426.05.2010
WO2010US36256
Priority number, dateUS20090224606P10.07.2009         Original published format: US 224606 P
US20090181273P26.05.2009         Original published format: US 181273 P
[2012/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010138633
Date:02.12.2010
Language:EN
[2010/48]
Type: A1 Application with search report 
No.:EP2435387
Date:04.04.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 02.12.2010 takes the place of the publication of the European patent application.
[2012/14]
Search report(s)International search report - published on:US02.12.2010
(Supplementary) European search report - dispatched on:EP15.02.2013
ClassificationIPC:C07B47/00, C07D487/22, A61K31/409, A61K31/4425
[2013/12]
CPC:
C07D487/22 (EP,US); A61K31/409 (EP,US); A61K31/4425 (EP,US);
A61P25/00 (EP); A61P7/04 (EP); A61P9/10 (EP)
Former IPC [2012/14]C07B47/00, C07D487/22
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/14]
TitleGerman:VERFAHREN ZUR BEREITSTELLUNG EINES NERVENSCHUTZES DURCH DIE VERWENDUNG VON PORPHYRINEN[2012/14]
English:METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS[2012/14]
French:MÉTHODE CONSISTANT À FOURNIR UNE NEUROPROTECTION AU MOYEN DE PORPHYRINES SUBSTITUÉES[2012/14]
Entry into regional phase22.12.2011National basic fee paid 
22.12.2011Search fee paid 
22.12.2011Designation fee(s) paid 
22.12.2011Examination fee paid 
Examination procedure22.12.2011Examination requested  [2012/14]
16.09.2013Amendment by applicant (claims and/or description)
20.01.2014Despatch of a communication from the examining division (Time limit: M06)
31.10.2014Reply to a communication from the examining division
17.03.2015Despatch of a communication from the examining division (Time limit: M04)
28.07.2015Application deemed to be withdrawn, date of legal effect  [2016/01]
26.08.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2016/01]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.01.2014
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
31.10.2014Request for further processing filed
31.10.2014Full payment received (date of receipt of payment)
Request granted
19.11.2014Decision despatched
Fees paidRenewal fee
25.05.2012Renewal fee patent year 03
28.05.2013Renewal fee patent year 04
27.05.2014Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
31.05.201506   M06   Not yet paid
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Documents cited:Search[Y]WO0075144  (UNIV PRINCETON [US], et al) [Y] 1-3,7-13 * See the porphyrin compounds defined in the claims and examples and in particular those having RN: 312700-30-4, 312700-31-5, 312700-37-1, 312700-34-8, 312700-35-9 and their use in the treatment of stroke, ischemia reperfusion injury, ischemic heart disease, spinal cord trauma, ischemia as result of myocardial infarction and stroke, which are mentioned in page 2, lines 12-16; page 21 lines 20-22 and page 23, lines 15-31. *;
 [Y]WO2008045358  (TRUSTEES OF PRINCETON [US], et al) [Y] 1-3,7-13 * See the porphyrin compounds having RN: 1018810-20-2 and 1018810-21-3, and their use for the treatment of stroke, ischemia - reperfusion injury, ischemic heart failure (claim 41) *;
 [Y]WO03103680  (UNIV DUKE [US], et al) [Y] 1-3,7-13 * See the compounds defined in the claims and their use for the treatment of oxidant-induced-toxicity: see in particular claims 1, 8 examples and scheme 1 *;
 [Y]WO0043395  (NAT JEWISH MED & RES CENTER [US], et al) [Y] 1-3,7-13 * See compounds defined in the claims and in pages 20, 31, 42, 45, 49, 52, 55, 61, and their use for the treatment of ischemic injuries, stroke, and other associated conditions: see page 12, lines 10-12; claims 1, 11, 17, 33. See the dosages indicated in page 16 *;
 [Y]  - MACKENSEN G B ET AL, "Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, (20010701), vol. 21, no. 13, ISSN 0270-6474, pages 4582 - 4592, XP002954859 [Y] 1-3,7-13 * See abstract, figure 1, results and discussion: porphyrin compounds administered after 3, 6, 9, 12 hours after focal ischemia, for the treatment of ischemic injury *
International search[Y]US5854210  (BURHOP KENNETH E [US], et al);
 [Y]US2007072825  (WILLIAMS WILLIAM [US]);
 [X]US2008021007  (BATINIC-HABERLE INES [US], et al);
 [Y]  - THIYAGARAJAN ET AL., "Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats.", BRITISH JOURNAL OF PHARMACOLOGY, (2004), vol. 142, pages 899 - 911, XP008148891

DOI:   http://dx.doi.org/10.1038/sj.bjp.0705811
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