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Extract from the Register of European Patents

EP About this file: EP2448952

EP2448952 - NOVEL GUANOSINE-RICH MODIFIED OLIGONUCLEOTIDES AND ANTIPROLIFERATIVE ACTIVITY THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.08.2017
Database last updated on 26.03.2026
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
Aptabio Therapeutics Inc.
118-2, Ajou University
Industry Cooperation Foundation
San 5, Woncheon-dong
Yeongtong-gu, Suwon-si
Gyeonggi-do 443-749 / KR
[2016/41]
Former [2012/19]For all designated states
Aptabio Therapeutics Inc.
118-2 Ajou Universit Industry Cooperation Foundation San 5 Woncheon-dong Ongtong-gu Suwon-si
Gyeonggi-do 443-749 / KR
Inventor(s)01 / LEE, Soo Jin
424-1702 Gunyoung 1-cha Apt.
Cheongmyeong Maeul
1047-1 Yeongtong-dong
Yeongtong-gu
Suwon-si Gyeonggi-do 443-738 / KR
02 / MOON, Sung Hwan
8706-603, Hoban Vertium Apt.
Iui-dong
Yeongtong-gu
Suwon-si, Gyeonggi-do 443-270 / KR
 [2012/21]
Former [2012/19]01 / LEE, Soo Jin
424-1702 Gunyoung 1-cha Apt.
Cheongmyeong Maeul
1047-1 Yeongtong-dong
Yeongtong-gu
Suwon-si Gyeonggi-do 443-738 / KR
02 / MOON, Sung Hwan
410-101 LG Village
520 Geumgok-dong
Gwonseon-gu
Suwon-si Gyeonggi-do 441-704 / KR
Representative(s)WSL Patentanwälte Partnerschaft mbB
Kaiser-Friedrich-Ring 98
65185 Wiesbaden / DE
[2016/41]
Former [2012/19]WSL Patentanwälte Partnerschaftsgesellschaft
Kaiser-Friedrich-Ring 98
65185 Wiesbaden / DE
Application number, filing date10794335.929.06.2010
[2016/41]
WO2010KR04202
Priority number, dateKR2009005849829.06.2009         Original published format: KR 20090058498
KR2010005120231.05.2010         Original published format: KR 20100051202
[2012/19]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011002200
Date:06.01.2011
Language:EN
[2011/01]
Type: A2 Application without search report 
No.:EP2448952
Date:09.05.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 06.01.2011 takes the place of the publication of the European patent application.
[2012/19]
Type: B1 Patent specification 
No.:EP2448952
Date:12.10.2016
Language:EN
[2016/41]
Search report(s)International search report - published on:AT29.09.2011
(Supplementary) European search report - dispatched on:EP29.05.2013
ClassificationIPC:C07H19/173, C07H21/00
[2016/21]
CPC:
C07H19/173 (EP,US); A61P35/00 (EP); C07H21/00 (EP,US)
Former IPC [2012/19]C07H19/06, C07H21/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/19]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:NEUE GUANOSINREICHE MODIFIZIERTE OLIGONUKLEOTIDE UND DEREN ANTIPROLIFERATIVE WIRKUNG[2012/19]
English:NOVEL GUANOSINE-RICH MODIFIED OLIGONUCLEOTIDES AND ANTIPROLIFERATIVE ACTIVITY THEREOF[2012/19]
French:NOUVEAUX OLIGONUCLÉOTIDES MODIFIÉS RICHES EN GUANOSINE À ACTIVITÉ ANTIPROLIFÉRATIVE[2012/19]
Entry into regional phase26.01.2012National basic fee paid 
26.01.2012Search fee paid 
26.01.2012Designation fee(s) paid 
26.01.2012Examination fee paid 
Examination procedure26.01.2012Examination requested  [2012/19]
17.12.2013Amendment by applicant (claims and/or description)
04.04.2014Despatch of a communication from the examining division (Time limit: M06)
02.10.2014Reply to a communication from the examining division
28.01.2016Despatch of a communication from the examining division (Time limit: M04)
15.04.2016Reply to a communication from the examining division
08.06.2016Communication of intention to grant the patent
16.08.2016Receipt of the translation of the claim(s)
31.08.2016Fee for grant paid
31.08.2016Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.04.2014
Opposition(s)13.07.2017No opposition filed within time limit [2017/38]
Fees paidRenewal fee
31.03.2012Renewal fee patent year 03
20.06.2013Renewal fee patent year 04
31.03.2014Renewal fee patent year 05
19.06.2015Renewal fee patent year 06
27.06.2016Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU29.06.2010
AL12.10.2016
AT12.10.2016
BE12.10.2016
CY12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
MK12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
TR12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
MT29.06.2017
CH30.06.2017
LI30.06.2017
[2020/33]
Former [2020/15]HU29.06.2010
AT12.10.2016
BE12.10.2016
CY12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
MK12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
TR12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
MT29.06.2017
CH30.06.2017
LI30.06.2017
Former [2019/52]HU29.06.2010
AT12.10.2016
BE12.10.2016
CY12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
MK12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
MT29.06.2017
CH30.06.2017
LI30.06.2017
Former [2019/46]HU29.06.2010
AT12.10.2016
BE12.10.2016
CY12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
MT29.06.2017
CH30.06.2017
LI30.06.2017
Former [2019/31]HU29.06.2010
AT12.10.2016
BE12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
MT29.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/43]AT12.10.2016
BE12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
MT29.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/23]AT12.10.2016
BE12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
IE29.06.2017
LU29.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/21]AT12.10.2016
BE12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
LU29.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/11]AT12.10.2016
BE12.10.2016
CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
HR12.10.2016
LT12.10.2016
LV12.10.2016
MC12.10.2016
NL12.10.2016
PL12.10.2016
RO12.10.2016
SE12.10.2016
SI12.10.2016
SK12.10.2016
SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
IS12.02.2017
PT13.02.2017
Former [2017/52]AT12.10.2016
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CZ12.10.2016
DK12.10.2016
EE12.10.2016
FI12.10.2016
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LT12.10.2016
LV12.10.2016
NL12.10.2016
PL12.10.2016
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SE12.10.2016
SI12.10.2016
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SM12.10.2016
BG12.01.2017
NO12.01.2017
GR13.01.2017
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PT13.02.2017
Former [2017/38]AT12.10.2016
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BG12.01.2017
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Former [2017/37]AT12.10.2016
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Former [2017/36]AT12.10.2016
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Former [2017/35]AT12.10.2016
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Former [2017/34]AT12.10.2016
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Former [2017/33]AT12.10.2016
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DK12.10.2016
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HR12.10.2016
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LV12.10.2016
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Documents cited:Search[XA] WO0168144  (DYNAVAX TECH CORP et al.) [X] 1-7,9,10 * Pages 17-18, in particular SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8. *[A] 8
 [YD] US5614505  (GMEINER WILLIAM H et al.) [YD] 1-10 * the whole document *
 [YD] US7314926  (MILLER DONALD M et al.) [YD] 1-10 * the whole document *
 [XA]   HIROSHI SUGIYAMA ET AL: "Photoinduced deoxyribose C2' oxidation in DNA. Alkali-dependent cleavage of erythrose-containing sites via a retroaldol reaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 11, 1 June 1993 (1993-06-01), pages 4443 - 4448, XP055063204, ISSN: 0002-7863, DOI: 10.1021/ja00064a004 [X] 1-7,9 * Whole document; in particular entries 2, 4, 5 and 6 in Table 1 and hexamer disclosed on page 4446, 2nd column, 3rd paragraph. *[A] 8,10

DOI:   http://dx.doi.org/10.1021/ja00064a004
 [XA]   NGUYEN H ET AL: "Studies Towards the Design of a Modified GC Base Pair With Stability Similar to that of the AT Base Pair", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 38, no. 23, 9 June 1997 (1997-06-09), pages 4083 - 4086, XP004065032, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(97)00829-0 [X] 1-5,9 * Whole document; in particular entry 4 in table on page 4085 * [A] 6-8,10

DOI:   http://dx.doi.org/10.1016/S0040-4039(97)00829-0
 [XA]   GRUENBERGER ET AL: "Effect of Substitution of Halogen or N3-Methyl Derivatives of Uridine for Uridine in Trinucleotide Codons on their Recognition by Aminoacyl-(14C)-tRNA", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, INSTITUTE OF ORGANIC CHEMISTRY & BIOCHEMISTRY, PRAGUE; CZ, vol. 33, no. 11, 1 January 1968 (1968-01-01), pages 3858 - 3865, XP009169697, ISSN: 0010-0765 [X] 3-6 * Table I 3rd-6th lines; Table II 5th line; Table III 4th-5th lines; Table IV 6th-7th lines *[A] 1,2,7-10

DOI:   http://dx.doi.org/10.1135/cccc19683858
 [XA]   KAWAI K ET AL: "Photochemical Halogen-Exchange Reaction of 5-Iodouracil-Containing Oligonucleotides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 40, no. 31, 30 July 1999 (1999-07-30), pages 5721 - 5724, XP004171549, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(99)01082-5 [X] 1-6,9 * Whole document; in particular starting material of scheme 1 and compounds of runs 1, 2, 4, 5 and 7 in Table 2 and Scheme 1 * [A] 7,8,10

DOI:   http://dx.doi.org/10.1016/S0040-4039(99)01082-5
 [XA]   HIROSHI SUGIYAMA ET AL: "Highly sequence-selective photoreaction of 5-bromouracil-containing deoxyhexanucleotides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 18, 1 August 1990 (1990-08-01), pages 6720 - 6721, XP055063205, ISSN: 0002-7863, DOI: 10.1021/ja00174a046 [X] 3-5 * Whole document, in particular hexamers of Table 1 *[A] 1,2,6-10

DOI:   http://dx.doi.org/10.1021/ja00174a046
 [XA]   TAKANORI OYOSHI ET AL: "Photoreactivity of 5-Iodouracil-Containing DNA-Sso7d Complex in Solution: The Protein-Induced DNA Kink Causes Intrastrand Hydrogen Abstraction from the 5-Methyl of Thymine at the 5' Side", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 124, no. 10, 1 March 2002 (2002-03-01), pages 2086 - 2087, XP055063196, ISSN: 0002-7863, DOI: 10.1021/ja016968s [X] 3-6 * Scheme 1 * [A] 1,2,7-10

DOI:   http://dx.doi.org/10.1021/ja016968s
 [XA]   FUJIMOTO K ET AL: "Deoxyribonolactone formation in photoirradiation of 5-bromouracil-containing oligonucleotides by direct C1' hydrogen abstraction", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 43, no. 12, 18 March 2002 (2002-03-18), pages 2243 - 2245, XP027241835, ISSN: 0040-4039, [retrieved on 20020318] [X] 3-5 * Whole document, in particular oligonucleotides 2a and 2b * [A] 1,2,6-10
 [XA]   TANAKA ET AL: "Production of radical species and modification of DNA through one-electron reduction with indium metal", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 18, 5 April 2007 (2007-04-05), pages 3167 - 3169, XP022021557, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2007.03.056 [X] 3-6 * Whole document, in particular oligonucleotide described on page 3168 2nd column 4th paragraph 2nd sentence. *[A] 1,2,7-10

DOI:   http://dx.doi.org/10.1016/j.tetlet.2007.03.056
 [XA]   DUTTA ET AL: "Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 12, 1 January 1998 (1998-01-01), pages 3001 - 3005, XP002143310, ISSN: 0305-1048, DOI: 10.1093/NAR/26.12.3001 [X] 1,3-5,9 * Second oligonucleotide disclosed in the section "Materials and methods" 1 st sentence. * [A] 2,6-8,10

DOI:   http://dx.doi.org/10.1093/nar/26.12.3001
 [XPA]   JOSHUA I. FRIEDMAN ET AL: "Indirect Detection of Labile Solute Proton Spectra via the Water Signal Using Frequency-Labeled Exchange (FLEX) Transfer", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 6, 17 February 2010 (2010-02-17), pages 1813 - 1815, XP055063159, ISSN: 0002-7863, DOI: 10.1021/ja909001q [XP] 1-6,9 * Figure 3 *[A] 7,8,10

DOI:   http://dx.doi.org/10.1021/ja909001q
 [YD]   BATES P J ET AL: "Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer", EXPERIMENTAL AND MOLECULAR PATHOLOGY, ACADEMIC PRESS, US, vol. 86, no. 3, 1 June 2009 (2009-06-01), pages 151 - 164, XP026096499, ISSN: 0014-4800, [retrieved on 20090120], DOI: 10.1016/J.YEXMP.2009.01.004 [YD] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.yexmp.2009.01.004
Examination  T D SAKORE ET AL: "Mutagen-nucleic acid intercalative binding: Structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex", PROC. NATL. ACAD. SCI., vol. 74, no. 1, 1 January 1977 (1977-01-01), pages 188 - 192, XP055110699 [X] 1-7,9 * Whole document; in particular entries 2, 4, 5 and 6 in Table 1 and hexamer disclosed on page 4446, 2nd column, 3rd paragraph. *[A] 8,10

DOI:   http://dx.doi.org/10.1073/pnas.74.1.188
   CONNER B N ET AL: "Helix geometry and hydration in an A-DNA tetramer: C-C-G-G", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 174, no. 4, 25 April 1984 (1984-04-25), pages 663 - 695, XP024010344, ISSN: 0022-2836, [retrieved on 19840425], DOI: 10.1016/0022-2836(84)90089-5 [X] 1-5,9 * Whole document; in particular entry 4 in table on page 4085 *[A] 6-8,10

DOI:   http://dx.doi.org/10.1016/0022-2836(84)90089-5
   ZARLING D A ET AL: "Immunoglobulin recognition of synthetic and natural left-handed Z DNA conformations and sequences", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 176, no. 3, 5 July 1984 (1984-07-05), pages 369 - 415, XP024021554, ISSN: 0022-2836, [retrieved on 19840705], DOI: 10.1016/0022-2836(84)90495-9 [X] 3-6 * Table I 3rd-6th lines; Table II 5th line; Table III 4th-5th lines; Table IV 6th-7th lines *[A] 1,2,7-10

DOI:   http://dx.doi.org/10.1016/0022-2836(84)90495-9
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DOI:   http://dx.doi.org/10.1021/bi00414a039
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