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Extract from the Register of European Patents

EP About this file: EP2453019

EP2453019 - GENE THERAPY COMPOSITIONS FOR PREVENTING AND/OR TREATING AUTOIMMUNE DISEASES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  21.03.2014
Database last updated on 19.10.2024
Most recent event   Tooltip21.03.2014Application deemed to be withdrawnpublished on 23.04.2014  [2014/17]
Applicant(s)For all designated states
Universidad Autònoma de Barcelona
Edificio Rectorado - OTRI
Bellaterra
08193 Barcelona / ES
[N/P]
Former [2012/20]For all designated states
Universidad Autònoma de Barcelona
Edificio Rectorado - OTRI Bellaterra
08193 Barcelona / ES
Inventor(s)01 / ANGUELA MARTÍNEZ, Xavier
Edificio Rectorado - OTRI
E-08193 Bellaterra - Barcelona / ES
02 / BOSCH TUBERT, María Fátima
Edificio Rectorado - OTRI
E-08193 Bellaterra - Barcelona / ES
03 / TARUFO, Sabrina
Edificio Rectorado - OTRI
E-08193 Bellaterra - Barcelona / ES
 [2012/20]
Representative(s)Illescas, Manuel
González-Bueno & Illescas
Calle de Recoletos, 13 - 5 Izq.
E-28001 Madrid / ES
[N/P]
Former [2012/20]Illescas, Manuel
González-Bueno & Illescas Calle de Recoletos, 13 - 5 Izq.
E-28001 Madrid / ES
Application number, filing date10796763.009.07.2010
WO2010ES70478
Priority number, dateES2009003044210.07.2009         Original published format: ES 200930442
[2012/20]
Filing languageES
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011004051
Date:13.01.2011
Language:ES
[2011/02]
Type: A1 Application with search report 
No.:EP2453019
Date:16.05.2012
Language:EN
[2012/20]
Search report(s)International search report - published on:ES13.01.2011
(Supplementary) European search report - dispatched on:EP20.03.2013
ClassificationIPC:A61K48/00, C07K14/65
[2013/16]
CPC:
A61K38/30 (US); A61K48/005 (EP,US); A61K48/0058 (EP,US);
A61P3/08 (EP); C07K14/65 (EP,US); C12N15/85 (EP,US);
A01K2227/105 (EP,US); C12N2800/107 (EP,US); C12N2840/007 (EP,US) (-)
Former IPC [2012/20]C12N15/16, C12N15/85, A61K48/00, A61P3/08
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/20]
TitleGerman:GENTHERAPIEZUSAMMENSETZUNGEN ZUR PRÄVENTION UND/ODER BEHANDLUNG VON AUTOIMMUNERKRANKUNGEN[2012/20]
English:GENE THERAPY COMPOSITIONS FOR PREVENTING AND/OR TREATING AUTOIMMUNE DISEASES[2012/20]
French:COMPOSITIONS DE THÉRAPIE GÉNIQUE DESTINÉES À PRÉVENIR ET/OU À TRAITER DES MALADIES AUTO-IMMUNES[2012/20]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase07.02.2012Translation filed 
07.02.2012National basic fee paid 
07.02.2012Search fee paid 
07.02.2012Designation fee(s) paid 
07.02.2012Examination fee paid 
Examination proceduredeletedCommunication of intention to grant the patent
07.02.2012Amendment by applicant (claims and/or description)
07.02.2012Examination requested  [2012/20]
19.10.2013Application deemed to be withdrawn, date of legal effect  [2014/17]
26.11.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2014/17]
Fees paidRenewal fee
16.07.2012Renewal fee patent year 03
Penalty fee
Additional fee for renewal fee
31.07.201304   M06   Not yet paid
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XI]WO2008137490  (GENZYME CORP [US], et al) [X] 1,6,7,9,10,12-14 * pages 24-29, paragraphs 16,19,21 * [I] 15;
 [E]WO2010109053  (PROYETO DE BIOMEDICINA CIMA S [ES], et al) [E] 1,6,7,9,12,13,15 * page 43 - page 44; claim 1 *;
 [XY]  - FRANZ C K ET AL, "Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS", NEUROBIOLOGY OF DISEASE, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 33, no. 3, doi:10.1016/J.NBD.2008.12.003, ISSN 0969-9961, (20090301), pages 473 - 481, (20090212), XP025941603 [X] 1-4,6-9,12,13 * pages 474,480 * * abstract * [Y] 5,11

DOI:   http://dx.doi.org/10.1016/j.nbd.2008.12.003
 [AP]  - SANDS MARK S, "AAV-mediated liver-directed gene therapy", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS, US, (20110101), vol. 807, doi:10.1007/978-1-61779-370-7_6, ISSN 1940-6029, pages 141 - 157, XP009167845 [AP] 1-8 * page 143 - page 145 *

DOI:   http://dx.doi.org/10.1007/978-1-61779-370-7_6
 [Y]  - LOEB J E ET AL, "ENHANCED EXPRESSION OF TRANSGENES FROM ADENO-ASSOCIATED VIRUS VECTORS WITH THE WOODCHUCK HEPATITIS VIRUS POSTTRANSCRIPTIONAL REGULATORY ELEMENT: IMPLICATION FOR GENE THERAPY", HUMAN GENE THERAPY, MARY ANN LIEBERT, NEW YORK ,NY, US, (19990920), vol. 10, doi:10.1089/10430349950016942, ISSN 1043-0342, pages 2295 - 2305, XP000985890 [Y] 5,11 * page 2303 - page 2304 *

DOI:   http://dx.doi.org/10.1089/10430349950016942
 [A]  - QIANG YOU ET AL, "Mechanism of T cell tolerance induction by murine hepatic Kupffer cells", HEPATOLOGY, (20080901), vol. 48, no. 3, doi:10.1002/hep.22395, ISSN 0270-9139, pages 978 - 990, XP055056054 [A] 1-15 * page 984 - page 989 *

DOI:   http://dx.doi.org/10.1002/hep.22395
International search[Y]WO0138535  (UNIV BARCELONA AUTONOMA [ES], et al);
 [XP]  - WANG KP ET AL., "Gene transfer of IGF1 attenuates hepatocellular apoptosis after bile duct ligation.", JOURNAL OF SURGICAL RESEARCH., (2009), URL: http:www.ncbi.nlm.nih.gov/pubmed/19926099, (20100915), XP008150674

DOI:   http://dx.doi.org/10.1016/j.jss.2009.07.051
 [X]  - HUNG K ET AL., "Gene transfer of insulin-like growth factor-I providing neuroprotection after spinal cord injury in rats.", JOURNAL OF NEUROSURGICAL SPINE., (2007), vol. 6, pages 35 - 46, XP008150675

DOI:   http://dx.doi.org/10.3171/spi.2007.6.1.35
 [Y]  - GOUGH P ET AL., "The use of human CD68 trasncriptional regulatory sequeences to direct high-levthe expression of class A scavenger receptor in macrophages in vitro and in vivo.", IMMUNOLOGY., (2001), vol. 103, pages 351 - 361, XP008150676

DOI:   http://dx.doi.org/10.1046/j.1365-2567.2001.01256.x
 [A]  - KOSUGA M ET AL., "Strong, long-term transgene expression in rat lisee using chicken beta-actin promotes associated with cytomegalovirus immediate-early inhancer (CAG promoter).", CELL TRANSPLANTATION., (2000), vol. 9, no. 5, pages 675 - 680, XP009074095
by applicantUS6342227
 US4897355
    - ALINO, S.F.; HERRERO, M.J.; NOGUERA, I.; DASI, F.; SÁNCHEZ, M., "Pig liver gene therapy by noninvasive interventionist catheterism", GENE THER, (2007), vol. 14, pages 334 - 343
    - ALLENBACH, Y. ET AL., "Role of regulatory T cells in a new mouse model of experimental autoimmune myositis", AM J PATHOL, (2009), vol. 174, pages 989 - 998
    - ATKINSON, M.A.; EISENBARTH, G.S., "Type 1 diabetes: new perspectives on disease pathogenesis and treatment", LANCET, (2001), vol. 358, doi:doi:10.1016/S0140-6736(01)05415-0, pages 221 - 229, XP005017550

DOI:   http://dx.doi.org/10.1016/S0140-6736(01)05415-0
    - BANICA, L.; BESLIU, A.; PISTOL, G.; STAVARU, C.; LONESCU, R.; FORSEA, A.M.; TANASEANU, C.; DUMITRACHE, S.; OTELEA, D.; TAMSULEA, I, "Quantification and molecular characterization of regulatory T cells in connective tissue diseases", AUTOIMMUNITY, (2009), vol. 42, pages 41 - 49
    - BERGEROT, I.; FABIEN, N.; MAGUER, V.; THIVOLET, C., "Insulin-like growth factor-1 (IGF-I) protects NOD mice from insulitis and diabetes", CLIN EXP IMMUNOL, (1995), vol. 102, pages 335 - 340
    - BOYER, 0.; SAADOUN, D.; ABRIOL, J.; DODILLE, M.; PIETTE, J.C.; CACOUB, P.; KLATZMANN, D., "CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis", BLOOD, (2004), vol. 103, pages 3428 - 3430
    - BRADSHAW, G.; GUTIERREZ, A.; MIYAKE, J.H.; DAVIS, K.R.; LI, A.C.; GLASS, C.K.; CURTISS, L.K.; DAVIS, R.A., "Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice", PROC NATL ACAD SCI USA, (2005), vol. 102, no. 31, pages 11029 - 11034
    - CAO, D.; MALMSTROM, V.; BAECHER-ALLAN, C.; HAFLER, D.; KLARESKOG, L.; TROLLMO, C., "Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis", EUR J IMMUNOL, (2003), vol. 33, doi:doi:10.1002/immu.200390024, pages 215 - 223, XP002549910

DOI:   http://dx.doi.org/10.1002/immu.200390024
    - CASELLAS, A.; SALAVERT, A.; AGUDO, J.; AYUSO, E.; JIMENEZ, V.; MOYA, M.; MUNOZ, S.; FRANCKHAUSER, S.; BOSCH, F., "Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes", DIABETES, (2006), vol. 55, doi:doi:10.2337/db06-0328, pages 3246 - 3255, XP055053051

DOI:   http://dx.doi.org/10.2337/db06-0328
    - COHEN, J.L.; BOYER, O., "The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease", CURR OPIN IMMUNOL, (2006), vol. 18, doi:doi:10.1016/j.coi.2006.07.007, pages 580 - 585, XP025079060

DOI:   http://dx.doi.org/10.1016/j.coi.2006.07.007
    - COUPER, J.J.; HUDSON, I.; WERTHER, G.A.; WARNE, G.L.; COURT, J.M.; HARRISON, L.C., "Factors predicting residual beta-cell function in the first year after diagnosis of childhood type 1 diabetes", DIABETES RES CLIN PRACT, (1991), vol. 11, doi:doi:10.1016/0168-8227(91)90135-Z, pages 9 - 16, XP023119369

DOI:   http://dx.doi.org/10.1016/0168-8227(91)90135-Z
    - CHEN, L.; YANG, P.; ZHOU, H.; HE, H.; REN, X.; CHI, W.; WANG, L.; KIJLSTRA, A., "Diminished frequency and function of CD4+CD25high regulatory T cells associated with active uveitis in Vogt-Koyanagi-Harada syndrome", INVEST OPHTHALMOL VIS SCI, (2008), vol. 49, pages 3475 - 3482
    - CHEN, Z.; HERMAN, A.E.; MATOS, M.; MATHIS, D.; BENOIST, C., "Where CD4+CD25+ T reg cells impinge on autoimmune diabetes", J EXP MED, (2005), vol. 202, pages 1387 - 1397
    - DENNING, T.L.; KIM, G.; KRONENBERG, M., "Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis", J LMMUNO, (2005), vol. 174, pages 7487 - 7491
    - EIZIRIK, D.L.; COLLI, M.L.; ORTIS, F., "The role of inflammation in insulitis and beta-cell loss in type 1 diabetes", NAT REV ENDOCRINOL, (2009), vol. 5, pages 219 - 226
    - FORGER, F.; VILLIGER, P.M.; OSTENSEN, M., "Pregnancy in patients with ankylosing spondylitis: do regulatory T cells play a role?", ARTHRITIS RHEUM, (2009), vol. 61, pages 279 - 283
    - GEORGE, M.; AYUSO, E.; CASELLAS, A.; COSTA, C.; DEVEDJIAN, J.C.; BOSCH, F., "Beta cell expression of IGF-I leads to recovery from type 1 diabetes", J CLIN INVEST, (2002), vol. 109, doi:doi:10.1172/JCI200212969, pages 1153 - 1163, XP055247324

DOI:   http://dx.doi.org/10.1172/JCI200212969
    - GEORGE, J., "Mechanisms of disease: the evolving role of regulatory T cells in atherosclerosis", NAT CLIN PRACT CARDIOVASC MED, (2008), vol. 5, pages 531 - 540
    - GIANNOUKAKIS, N.; MI, Z.; RUDERT, W.A.; GAMBOTTO, A.; TRUCCO, M.; ROBBINS, P., "Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor", GENE THER, (2000), vol. 7, pages 2015 - 2022
    - HAAS, J.; HUG, A.; VIEHOVER, A.; FRITZSCHING, B.; FALK, C.S.; FILSER, A.; VETTER, T.; MILKOVA, L.; KORPORAL, M.; FRITZ, B. ET AL., "Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis", EUR J IMMUNOL, (2005), vol. 35, doi:doi:10.1002/eji.200526065, pages 3343 - 3352, XP055085663

DOI:   http://dx.doi.org/10.1002/eji.200526065
    - HOLMEN, N.; LUNDGREN, A.; LUNDIN, S.; BERGIN, A.M.; RUDIN, A.; SJOVALL, H.; OHMAN, L., "Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity", INFLAMM BOWEL DIS, (2006), vol. 12, pages 447 - 456
    - KAINO, Y.; HIRAI, H.; ITO, T.; KIDA, K., "Insulin-like growth factor I (IGF-I) delays the onset of diabetes in nonobese diabetic (NOD) mice", DIABETES RES CLIN PRACT, (1996), vol. 34, pages 7 - 11
    - KLEIN, I.; CORNEJO, J.C.; POLAKOS, N.K.; JOHN, B.; WUENSCH, S.A.; TOPHAM, D.J.; PIERCE, R.H.; CRISPE, I.N., "Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages", BLOOD, (2007), vol. 110, pages 4077 - 4085
    - KRIEGEL, M.A.; LOHMANN, T.; GABLER, C.; BLANK, N.; KALDEN, J.R.; LORENZ, H.M., "Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type", J EXP MED, (2004), vol. 199, pages 1285 - 1291
    - KUHN, A.; BEISSERT, S.; KRAMMER, P.H., "CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus", ARCH DERMATOL RES, (2009), vol. 301, pages 71 - 81, XP019657202
    - KUKREJA, A.; COST, G.; MARKER, J.; ZHANG, C.; SUN, Z.; LIN-SU, K.; TEN, S.; SANZ, M.; EXLEY, M.; WILSON, B. ET AL., "Multiple immuno-regulatory defects in type-1 diabetes", J CLIN INVEST, (2002), vol. 109, doi:doi:10.1172/JCI200213605, pages 131 - 140, XP002549911

DOI:   http://dx.doi.org/10.1172/JCI200213605
    - LAN, R.Y.; CHENG, C.; LIAN, Z.X.; TSUNEYAMA, K.; YANG, G.X.; MORITOKI, Y.; CHUANG, Y.H.; NAKAMURA, T.; SAITO, S.; SHIMODA, S. ET A, "Liver- targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis", HEPATOLOGY, (2006), vol. 43, pages 729 - 737
    - LINDLEY, S.; DAYAN, C.M.; BISHOP, A.; ROEP, B.O.; PEAKMAN, M.; TREE, T.I., "Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes", DIABETES, (2005), vol. 54, pages 92 - 99
    - LIU, F.; SONG, Y.; LIU, D., "Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA", GENE THER, (1999), vol. 6, doi:doi:10.1038/sj.gt.3300947, pages 1258 - 1266, XP009036645

DOI:   http://dx.doi.org/10.1038/sj.gt.3300947
    - LUTH, S.; HUBER, S.; SCHRAMM, C.; BUCH, T.; ZANDER, S.; STADELMANN, C.; BRUCK, W.; WRAITH, D.C.; HERKEL, J.; LOHSE, A.W., "Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs", J CLIN INVEST, (2008), vol. 118, pages 3403 - 3410
    - MATTA, B.; JHA, P.; BORA, P.S.; BORA, N.S., "Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells", AM J PATHOL, (2008), vol. 173, pages 1440 - 1454
    - MCHUGH, R.S., "Autoimmune gastritis is a well-defined autoimmune disease model for the study of CD4+CD25+ T cell-mediated suppression", CURR TOP MICROBIOL LMMUNOL, (2005), vol. 293, pages 153 - 177
    - MERIGGIOLI, M.N.; SHENG, J.R.; LI, L.; PRABHAKAR, B.S., "Strategies for treating autoimmunity: novel insights from experimental myasthenia gravis", ANN N Y ACAD SCI, (2008), vol. 1132, pages 276 - 282
    - PELEGRIN, M.; DEVEDJIAN, J.C.; COSTA, C.; VISA, J.; SOLANES, G.; PUJOL, A.; ASINS, G.; VALERA, A.; BOSCH, F., "Evidence from transgenic mice that interferon-beta may be involved in the onset of diabetes mellitus", J BIOL CHEM, (1998), vol. 273, pages 12332 - 12340
    - RICCIARDELLI, I.; LINDLEY, K.J.; LONDEI, M.; QUARATINO, S., "Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease", IMMUNOLOGY, (2008), vol. 125, pages 178 - 183
    - SENECHAL, B.; ELAIN, G.; JEZIORSKI, E.; GRONDIN, V.; PATEY-MARIAUD DE SERRE, N.; JAUBERT, F.; BELDJORD, K.; LELLOUCH, A.; GLORION,, "Expansion of regulatory T cells in patients with Langerhans cell histiocytosis", PLOS MED, (2007), vol. 4, page E253
    - SHENG, J.R.; LI, L.C.; GANESH, B.B.; PRABHAKAR, B.S.; MERIGGIOLI, M.N., "Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis", CLIN IMMUNOL, (2008), vol. 128, doi:doi:10.1016/j.clim.2008.03.509, pages 172 - 180, XP022849916

DOI:   http://dx.doi.org/10.1016/j.clim.2008.03.509
    - SUGIYAMA, H.; GYULAI, R.; TOICHI, E.; GARACZI, E.; SHIMADA, S.; STEVENS, S.R.; MCCORMICK, T.S.; COOPER, K.D., "Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation", J IMMUNOL, (2005), vol. 174, pages 164 - 173
    - UESUGI, T.; FROH, M.; ARTEEL, G.E.; BRADFORD, B.U.; GABELE, E.; WHEELER, M.D.; THURMAN, R.G., "Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats", HEPATOLOGY, (2001), vol. 34, no. 6, pages 1149 - 1157
    - VALENCIA, X.; YARBORO, C.; ILLEI, G.; LIPSKY, P.E., "Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus", J IMMUNOL, (2007), vol. 178, pages 2579 - 2588
    - VAN TIL, N.P.; MARKUSIC, D.M.; VAN DER RIJT, R.; KUNNE, C.; HIRALALL, J.K.; VREELING, H.; FREDERIKS, W.M.; OUDE-ELFERINK, RP.; SEP, "Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes", MOL THER, (2005), vol. 11, no. 1, doi:doi:10.1016/j.ymthe.2004.09.012, pages 26 - 34, XP004672524

DOI:   http://dx.doi.org/10.1016/j.ymthe.2004.09.012
    - VERGANI, D.; MIELI-VERGANI, G., "Aetiopathogenesis of autoimmune hepatitis", WORLD J GASTROENTEROL, (2008), vol. 14, pages 3306 - 3312
    - VIGLIETTA, V.; BAECHER-ALLAN, C.; WEINER, H.L.; HAFLER, D.A., "Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis", J EXP MED, (2004), vol. 199, doi:doi:10.1084/jem.20031579, pages 971 - 979, XP003009665

DOI:   http://dx.doi.org/10.1084/jem.20031579
    - YU, Q.; QUE, L.G.; ROCKEY, D.C., "Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver", AM J PHYSIOL GASTROINTEST LIVER PHYSIOL, (2002), vol. 282, no. 3, pages G565 - G572
 WO1995US17038
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