EP2459708 - H. PYLORI LIPOPOLYSACCHARIDE OUTER CORE EPITOPE [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 28.04.2017 Database last updated on 02.09.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states National Research Council of Canada Building M-58 1200 Montreal Road Ottawa, ON K1A 0R6 / CA | [2012/23] | Inventor(s) | 01 /
ALTMAN, Eleonora Building M58 1200 Montreal Road Ottawa Ontario K1A 0R6 / CA | 02 /
HARRISON, Blair A. Building M58 1200 Montreal Road Ottawa Ontario K1A 0R6 / CA | 03 /
CHANDAN, Vandana Building M58 1200 Montreal Road Ottawa Ontario K1A 0R6 / CA | [2012/23] | Representative(s) | Jostarndt Patentanwalts-AG Metzgerstraße 61 52070 Aachen / DE | [N/P] |
Former [2016/25] | Jostarndt, Hans-Dieter Jostarndt Patentanwalts-AG Brüsseler Ring 51 52074 Aachen / DE | ||
Former [2012/23] | Jostarndt, Hans-Dieter Jostarndt Patentanwalts-AG Brüsseler Ring 51 52074 Aachen / DE | Application number, filing date | 10803776.3 | 30.07.2010 | [2016/25] | WO2010CA01173 | Priority number, date | US20090230315P | 31.07.2009 Original published format: US 230315 P | [2012/23] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011011879 | Date: | 03.02.2011 | Language: | EN | [2011/05] | Type: | A1 Application with search report | No.: | EP2459708 | Date: | 06.06.2012 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.02.2011 takes the place of the publication of the European patent application. | [2012/23] | Type: | B1 Patent specification | No.: | EP2459708 | Date: | 22.06.2016 | Language: | EN | [2016/25] | Search report(s) | International search report - published on: | CA | 03.02.2011 | (Supplementary) European search report - dispatched on: | EP | 13.02.2013 | Classification | IPC: | C12N5/16, A61K39/02, A61K39/395, A61K47/48, C07K16/12, C07K9/00, C08B37/00, C08L5/00 | [2012/23] | CPC: |
C07K16/121 (EP,US);
A61K39/105 (EP,US);
A61K47/61 (EP,US);
A61K47/6415 (EP,US);
A61K47/643 (EP,US);
A61K47/646 (EP,US);
A61P1/00 (EP);
A61P31/04 (EP);
A61P35/00 (EP);
A61P37/00 (EP);
A61P37/04 (EP);
C08B37/006 (EP,US);
C08L5/00 (EP,US);
C08L5/02 (US);
A61K2039/505 (EP,US);
A61K2039/6037 (EP,US);
A61K2039/6081 (EP,US);
C07K2317/34 (US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2012/23] | Extension states | BA | Not yet paid | ME | Not yet paid | RS | Not yet paid | Title | German: | H. PYLORI-LIPOPOLYSACCHARID-AUSSENKERN-EPITOPE | [2016/04] | English: | H. PYLORI LIPOPOLYSACCHARIDE OUTER CORE EPITOPE | [2012/23] | French: | EPITOPE DE BASE EXTERNE DE H. PYLORI LIPOPOLYSACCHARIDE | [2012/23] |
Former [2012/23] | H.PYLORI-LIPOPOLYSACCHARID-AUSSENKERN-EPITOPE | Entry into regional phase | 29.02.2012 | National basic fee paid | 29.02.2012 | Search fee paid | 29.02.2012 | Designation fee(s) paid | 29.02.2012 | Examination fee paid | Examination procedure | 29.02.2012 | Examination requested [2012/23] | 16.09.2013 | Amendment by applicant (claims and/or description) | 25.11.2013 | Despatch of a communication from the examining division (Time limit: M06) | 09.05.2014 | Reply to a communication from the examining division | 28.07.2014 | Despatch of a communication from the examining division (Time limit: M04) | 03.11.2014 | Reply to a communication from the examining division | 16.04.2015 | Despatch of a communication from the examining division (Time limit: M02) | 17.04.2015 | Reply to a communication from the examining division | 11.06.2015 | Despatch of a communication from the examining division (Time limit: M02) | 06.08.2015 | Reply to a communication from the examining division | 12.01.2016 | Communication of intention to grant the patent | 13.05.2016 | Fee for grant paid | 13.05.2016 | Fee for publishing/printing paid | 13.05.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 25.11.2013 | Opposition(s) | 23.03.2017 | No opposition filed within time limit [2017/22] | Fees paid | Renewal fee | 23.07.2012 | Renewal fee patent year 03 | 22.07.2013 | Renewal fee patent year 04 | 23.07.2014 | Renewal fee patent year 05 | 23.07.2015 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 30.07.2010 | AL | 22.06.2016 | AT | 22.06.2016 | BE | 22.06.2016 | BG | 22.06.2016 | CY | 22.06.2016 | CZ | 22.06.2016 | DK | 22.06.2016 | EE | 22.06.2016 | ES | 22.06.2016 | FI | 22.06.2016 | HR | 22.06.2016 | LT | 22.06.2016 | LV | 22.06.2016 | MC | 22.06.2016 | MK | 22.06.2016 | NL | 22.06.2016 | PL | 22.06.2016 | RO | 22.06.2016 | SE | 22.06.2016 | SI | 22.06.2016 | SK | 22.06.2016 | SM | 22.06.2016 | TR | 22.06.2016 | IE | 30.07.2016 | LU | 30.07.2016 | MT | 31.07.2016 | NO | 22.09.2016 | GR | 23.09.2016 | IS | 22.10.2016 | PT | 24.10.2016 | [2018/46] |
Former [2018/38] | HU | 30.07.2010 | |
AT | 22.06.2016 | ||
BE | 22.06.2016 | ||
BG | 22.06.2016 | ||
CY | 22.06.2016 | ||
CZ | 22.06.2016 | ||
DK | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
MK | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SI | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
TR | 22.06.2016 | ||
IE | 30.07.2016 | ||
LU | 30.07.2016 | ||
MT | 31.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2018/33] | HU | 30.07.2010 | |
AT | 22.06.2016 | ||
BE | 22.06.2016 | ||
CY | 22.06.2016 | ||
CZ | 22.06.2016 | ||
DK | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
MK | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SI | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
TR | 22.06.2016 | ||
IE | 30.07.2016 | ||
LU | 30.07.2016 | ||
MT | 31.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2018/29] | HU | 30.07.2010 | |
AT | 22.06.2016 | ||
BE | 22.06.2016 | ||
CY | 22.06.2016 | ||
CZ | 22.06.2016 | ||
DK | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
MK | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SI | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
TR | 22.06.2016 | ||
IE | 30.07.2016 | ||
LU | 30.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2018/28] | HU | 30.07.2010 | |
AT | 22.06.2016 | ||
BE | 22.06.2016 | ||
CY | 22.06.2016 | ||
CZ | 22.06.2016 | ||
DK | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
MK | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SI | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
IE | 30.07.2016 | ||
LU | 30.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2017/38] | AT | 22.06.2016 | |
BE | 22.06.2016 | ||
CZ | 22.06.2016 | ||
DK | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SI | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
IE | 30.07.2016 | ||
LU | 30.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2017/23] | AT | 22.06.2016 | |
BE | 22.06.2016 | ||
CZ | 22.06.2016 | ||
DK | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2017/17] | AT | 22.06.2016 | |
BE | 22.06.2016 | ||
CZ | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
MC | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2017/11] | AT | 22.06.2016 | |
BE | 22.06.2016 | ||
CZ | 22.06.2016 | ||
EE | 22.06.2016 | ||
ES | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SK | 22.06.2016 | ||
SM | 22.06.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
PT | 24.10.2016 | ||
Former [2017/10] | BE | 22.06.2016 | |
CZ | 22.06.2016 | ||
EE | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
NL | 22.06.2016 | ||
PL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
SK | 22.06.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
IS | 22.10.2016 | ||
Former [2017/09] | CZ | 22.06.2016 | |
EE | 22.06.2016 | ||
FI | 22.06.2016 | ||
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
NL | 22.06.2016 | ||
RO | 22.06.2016 | ||
SE | 22.06.2016 | ||
BE | 31.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
Former [2017/03] | FI | 22.06.2016 | |
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
NL | 22.06.2016 | ||
SE | 22.06.2016 | ||
BE | 31.07.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
Former [2016/52] | FI | 22.06.2016 | |
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
NL | 22.06.2016 | ||
SE | 22.06.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
Former [2016/51] | FI | 22.06.2016 | |
HR | 22.06.2016 | ||
LT | 22.06.2016 | ||
LV | 22.06.2016 | ||
NO | 22.09.2016 | ||
GR | 23.09.2016 | ||
Former [2016/49] | FI | 22.06.2016 | |
LT | 22.06.2016 | ||
NO | 22.09.2016 | ||
Former [2016/46] | LT | 22.06.2016 | |
NO | 22.09.2016 | Documents cited: | Search | [X] - K. HIRATSUKA ET AL, "Identification of a D-glycero-D-manno-Heptosyltransferase Gene from Helicobacter pylori", JOURNAL OF BACTERIOLOGY, (20050720), vol. 187, no. 15, doi:10.1128/JB.187.15.5156-5165.2005, ISSN 0021-9193, pages 5156 - 5165, XP055052023 [X] 1-3,7-9,15-20 * the whole document * * In particular: Title; Abstract; Materials and methods section; Table 2; Fig. 6. * DOI: http://dx.doi.org/10.1128/JB.187.15.5156-5165.2005 | [A] - E. ALTMAN ET AL, "Analysis of Helicobacter pylori isolates from Chile: occurrence of selective type 1 Lewis b antigen expression in lipopolysaccharide", JOURNAL OF MEDICAL MICROBIOLOGY, (20080501), vol. 57, no. 5, doi:10.1099/jmm.0.47783-0, ISSN 0022-2615, pages 585 - 591, XP055052024 [A] 1-11,13-21 * the whole document * * In particular: Title; Abstract; Methods section; fig. 1. * DOI: http://dx.doi.org/10.1099/jmm.0.47783-0 | [A] - MORAN A P ET AL, "Role of Helicobacter pylori rfaJ genes (HP0159 and HP1416) in lipopolysaccharide synthesis", FEMS MICROBIOLOGY LETTERS, WILEY-BLACKWELL PUBLISHING LTD, GB, (20041201), vol. 241, no. 1, doi:10.1016/J.FEMSLE.2004.10.004, ISSN 0378-1097, pages 57 - 65, XP004647144 [A] 1-11,13-21 * the whole document * * In particular: Title; Abstract; Materials and methods section; Fig. 3. * DOI: http://dx.doi.org/10.1016/j.femsle.2004.10.004 | International search | [X] - LOGAN, S. M. ET AL., "Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori", GLYCOBIOLOGY., (2005), vol. 15, pages 721 - 733, XP008148851 DOI: http://dx.doi.org/10.1093/glycob/cwi057 | [X] - ALTMAN, E. ET AL., "Effect of the HP0159 ORF mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori", FEMS IMMUNOL. MED.MICROBIOL., (2008), vol. 53, pages 204 - 213, XP008148856 DOI: http://dx.doi.org/10.1111/j.1574-695X.2008.00416.x | [X] - LOGAN, S. M. ET AL., "Functional genomics of Helicobacter pylori: Identification of a b-1-4 galactosyltransferase and generation of mutants with altered lipopolysaccharide", MOLECULAR MICROBIOLOGY., (2000), vol. 35, pages 1156 - 1167, XP008148849 DOI: http://dx.doi.org/10.1046/j.1365-2958.2000.01784.x | [A] - MONTEIRO, M. A. ET AL., "Helicobacter pylori: A wolf in sheep's clothing: the glycotype families of Helicobacter pylori lipopolysaccharides expressing histo- blood groups structure, biosynthesis and role in pathogenesis", ADVANCES IN CARBOHVDRATE CHEMISTRY AND BIOCHEMISTRY, (2001), vol. 57, pages 99 - 158, XP008148875 DOI: http://dx.doi.org/10.1016/S0065-2318(01)57016-X | [A] - YOKOTA, S-I. ET AL., "Human antibody response to Helicobacter pylory lipopolysaccharide: Presence of an immunodominant epitope in the polysaccharide chain of lipopolysaccharide", INFECTION AND IMMUNITY., vol. 66, pages 3006 - 3011, XP008148852 | by applicant | - HIRATSUKA ET AL., J. BACTERIOL., (2005), vol. 187, pages 5156 - 5165 | - ALTMAN ET AL., J. MED. MICROBIOL., (2000), vol. 57, pages 585 - 591 | - LOGAN ET AL., GLYCOBIOL., (2005), vol. 15, pages 721 - 733 | - ALTMAN ET AL., J. MED. MICROBIOL., (2008), vol. 57, pages 585 - 591 | - ALTMAN E; CHANDAN V; LAROCQUE S; AUBRY A; LOGAN SM; VINOGRADOV E; LI J, "Effect of the HP0159 ORF mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori", FEMS IMMUNOL MED MICROBIOL, (2008), vol. 53, doi:doi:10.1111/j.1574-695X.2008.00416.x, pages 204 - 213, XP008148856 DOI: http://dx.doi.org/10.1111/j.1574-695X.2008.00416.x | - ALTMAN E; FERNANDEZ H; CHANDAN V; HARRISON BA; WILSON SCHUSTER M; OTTH RADEMACHER L; TOLEDO C, "Analysis of Helicobacter pylori isolates from Chile: occurrence of a selective type 1 Lewis b antigen expression in lipopolysaccharide", J MED MICROBIOL, (2008), vol. 57, doi:doi:10.1099/jmm.0.47783-0, pages 585 - 591, XP055052024 DOI: http://dx.doi.org/10.1099/jmm.0.47783-0 | - ALTMAN E; HARRISON BA; HIRAMA T; CHANDAN V; TO R; MACKENZIE R, "Characterization of murine monoclonal antibodies against Helicobacter pylori lipopolysaccharide specific for Lex and Ley blood group antigens", BIOCHEM CELL BIOL, (2005), vol. 83, pages 589 - 596 | - ALTMAN E; SMIRNOVA N; LI J; AUBRY A; LOGAN SM, "Occurrence of a nontypable Helicobacter pylori strain lacking Lewis blood group O antigens and DD-heptoglycan: evidence for the role of the core alpha1,6-glucan in colonization", GLYCOBIOLOGY, (2003), vol. 13, doi:doi:10.1093/glycob/cwg106, pages 777 - 783, XP055052159 DOI: http://dx.doi.org/10.1093/glycob/cwg106 | - ANDERSON PW; PICHICHERO ME; INSEL RA; BETTS R; EBY R; SMITH DH, "Vaccines consisting of periodate-cleaved oligosaccharides from the capsule of Haemophilus influenzae type b coupled to a protein carrier: structural and temporal requirements for priming in the human infant", J IMMUNOL, (1986), vol. 137, pages 1181 - 1186, XP055007229 | - ANGELAKOPOULOS H; HOHMANN EL, "Pilot study of phoP/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers", INFECT IMMUN, (2000), vol. 68, pages 2135 - 2141 | - APPELMELK BJ; SIMMONS-SMIT L; NEGRINI R; MORAN AP; ASPINALL GO; FORTE JG ET AL., "Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity", INFECT IMMUN, (1996), vol. 64, pages 2031 - 2040 | - BRISSON J-R; CRAWFORD E; UHRIN D; KHIEU NH; PERRY MB; SEVERN WB; RICHARDS JC, "The core oligosaccharide component from Mannheimia (Pasteurella) haemolytica serotype A1 lipopolysaccharide contains L-glycero-D-manno- and D-glycero-D-manno-heptoses: Analysis of the structure and conformation by high-resolution NMR spectroscopy", CAN J CHEM, (2002), vol. 80, doi:doi:10.1139/v02-114, pages 949 - 963, XP008076881 DOI: http://dx.doi.org/10.1139/v02-114 | - CASTILLO-ROJAS G; MAZARI-HIRIART M; LOPEZ-VIDAL Y, "Helicobacter pylori: focus on CagA and VacA major virulence factors", SALUD P6BLICA DE MEXICO, (2004), vol. 46, pages 538 - 548 | - CHANDAN V; LOGAN SM; HARRISON BA; VINOGRADOV E; AUBRY A; STUPAK J; LI J; ALTMAN, E., "Characterization of a waaF mutant of Helicobacter pylori strains 26695 provides evidence that an extended lipopolysaccharide structure has a limited role in the invasion of gastric cancer cells", BIOCHEM CELL BIOL, (2007), vol. 85, pages 582 - 590 | - CHU C; LIU B; WATSON D; SZU S; BRYLA D; SHILOACH J; SCHNEERSON R; ROBBINS JB, "Preparation, characterization, and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 (Shiga's bacillus) bound to tetanus toxoid", INFECT IMMUN, (1991), vol. 59, pages 4450 - 4458 | - CIUCANU , KEREK F., "A simple and rapid method for the permethylation of carbohydrates", CARBOHYDR RES, (2004), vol. 131, pages 209 - 217 | - CIUCANU , KEREK, F., "A simple and rapid method for the permethylation of carbohydrates", CARBOHYDR RES, (2004), vol. 131, pages 209 - 217 | - COX AD; ZOU W; GIDNEY MAJ; LACELLE S; PLESTED JS; MAKEPEACE K; WRIGHT JC; COULL PA; MOXON ER; RICHARDS JC, "Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: Developmental chemistry and investigation of immunological responses following immunization of mice and rabbits", VACCINE, (2005), vol. 23, doi:doi:10.1016/j.vaccine.2005.06.011, pages 5045 - 5054, XP005081369 DOI: http://dx.doi.org/10.1016/j.vaccine.2005.06.011 | - DUBOIS M; GILLES KA; HAMILTON JK; REBERS PA; SMITH, F, "Colorimetric method for determination of sugars and related substances", ANAL CHEM, (1956), vol. 28, doi:doi:10.1021/ac60111a017, pages 350 - 356, XP000918426 DOI: http://dx.doi.org/10.1021/ac60111a017 | - DUNN BE; COHEN H; BLASER MJ, "Helicobacterpylori", CLIN MICROBIOL REV, (1997), vol. 10, pages 720 - 741 | - ELLMAN GL, "Tissue sulfhydryl groups", ARCH BIOCHEM BIOPHYS, (1959), vol. 82, doi:doi:10.1016/0003-9861(59)90090-6, pages 70 - 77, XP024815603 DOI: http://dx.doi.org/10.1016/0003-9861(59)90090-6 | - FERNANDEZ-SANTANA V; GONZAIEZ-LIO R; SARRACENT-PÉREZ J; VEREZ-BENCOMO V, "Conjugation of 5-azido-3-oxapentyl glycosides with thiolated proteins through the use of thiophilic derivatives", GLYCOCONJUGATE J, (1998), vol. 15, doi:doi:10.1023/A:1006903524007, pages 549 - 553, XP002344695 DOI: http://dx.doi.org/10.1023/A:1006903524007 | - GU X-X; TSAI C-M; UEYAMA T; BARENKAMP SJ; ROBBINS JB; LIM DJ, "Synthesis, characterization, and immunological properties of detoxified lipooligosaccharide from nontypable Haemophilus influenzae conjugated to proteins", INFECT IMMUN, (1996), vol. 64, pages 4047 - 4053 | - HIRATSUKA K; LOGAN SM; CONLAN JW; CHANDAN V; AUBRY A; SMIRNOVA N; ULRICHSEN H; CHAN KHN; GRIFFITH DW; HARRISON BA, "Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori", J BACTERIOL, (2005), vol. 187, doi:doi:10.1128/JB.187.15.5156-5165.2005, pages 5156 - 5165, XP055052023 DOI: http://dx.doi.org/10.1128/JB.187.15.5156-5165.2005 | - HOLST O; BRADE L; KOSMA P; BRADE, H, "Structure, serological specificity, and synthesis of artificial glycoconjugates representing the genus-specific lipopolysaccharide epitope of Chlamidia spp", J BACTERIOL, (1991), vol. 173, pages 1862 - 1866 | - "Molecular Biology of Anti-a-(l - 6)dextrans. Antibody responses to a Single-Site-Filling Antigenic Determinant", KABAT EA, Carbohydrate Antigens, AMERICAN CHEMICAL SOCIETY, (1993), vol. 159, pages 146 - 58 | - KOHLER G; MILSTEIN C., "Continuous cultures of fused cells secreting antibody of predefined specificity", NATURE, (1975), vol. 256, pages 495 - 497, XP002024548 | - LOGAN SM; ALTMAN E; MYKYTCZUK O; BRISSON J-R; CHANDAN V; ST MICHAEL F; MASSON A; LECLERC S; HIRATSUKA K; SMIRNOVA N, "Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori", GLYCOBIOLOGY, (2005), vol. 15, doi:doi:10.1093/glycob/cwi057, pages 721 - 733, XP008148851 DOI: http://dx.doi.org/10.1093/glycob/cwi057 | - LOGAN SM; CONLAN JW; MONTEIRO MA; WAKARCHUK WW; ALTMAN E, "Functional genomics of Helicobacter pylori: identification of a (3-1,4 galactosyltransferase and generation of mutants with altered lipopolysaccharide", MOL MICROBIOL, (2000), vol. 35, doi:doi:10.1046/j.1365-2958.2000.01784.x, pages 1156 - 1167, XP008148849 DOI: http://dx.doi.org/10.1046/j.1365-2958.2000.01784.x | - MIESZALA M; KOGAN G; JENNINGS HJ, "Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their epitopes and results in conjugate vaccines having improved immunological properties", CARBOHYDR RES, (2003), vol. 338, doi:doi:10.1016/S0008-6215(02)00395-6, pages 167 - 175, XP004401753 DOI: http://dx.doi.org/10.1016/S0008-6215(02)00395-6 | - MONTEIRO MA, "Helicobacter pylori: a wolf in sheep's clothing: the glycotype families of Helicobacter pylori lipopolysaccharides expressing histo-blood groups: structure, biosynthesis, and role in pathogenesis", ADV CARBOHYDR CHEM BIOCHEM, (2001), vol. 57, doi:doi:10.1016/S0065-2318(01)57016-X, pages 99 - 158, XP008148875 DOI: http://dx.doi.org/10.1016/S0065-2318(01)57016-X | - PASSWELL JH; ASHKENAZI S; HARLEV E; MIRON D; RAMON R; FARZAM N; LERNER-GEVA L; LEVI Y; CHU C; SHILOACH J, "Safety and immunogenicity of Shigella sonnei-CRM9 and Shigella flexneri type 2a-rEPAsucc conjugate vaccines in one- to four-year old children", PEDIATR INFECT DIS J, (2003), vol. 22, pages 701 - 706, XP009112374 | - PASSWELL JH; HARLEV E; ASHKENAZI S; CHU C; MIRON D; RAMON R; FARZAN N; SHILOACH J; BRYLA DA; MAJADLY F, "Safety and immunogenicity of improved Shigella O-specific polysaccharide-protein conjugate vaccines in adults in Israel", INFECT IMMUN, (2000), vol. 69, doi:doi:10.1128/IAI.69.3.1351-1357.2001, pages 1351 - 1357, XP002305349 DOI: http://dx.doi.org/10.1128/IAI.69.3.1351-1357.2001 | - PON RA; LUSSIER M; YANG Q-L; JENNINGS HJ, "N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis", J EXP MED, (1997), vol. 185, pages 1929 - 1938 | - ROSSI G; RUGGIERO P; PEPPOLONI S; PANCOTTO L; FORTUNA D; LAURETTI L; VOLPINI G; MANCIANTI S; CORAZZA M; TACCINI E, "Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy", INFECT IMMUN, (2004), vol. 72, pages 3252 - 3259 | - ROY, R.; KATZENELLENBOGEN, E.; JENNINGS, H.J., "Improved procedures for the conjugation of oligosaccharides to protein by reductive amination", CAN J. BIOCHEM. CELL BIOL., (1984), vol. 62, pages 270 - 275, XP002913707 DOI: http://dx.doi.org/10.1139/o84-037 | - RUGGIERO P; PEPPOLONI S; RAPPUOLI R; DEL GIUDICE G, "The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?", MICROBES INFECT, (2003), vol. 5, doi:doi:10.1016/S1286-4579(03)00125-4, pages 749 - 756, XP002463618 DOI: http://dx.doi.org/10.1016/S1286-4579(03)00125-4 | - SAWARDEKER JH; SLONEKER JH; JEANNES A, "Quantitative determination of monosaccharides as their alditol acetates by gas liquid chromatography", ANAL CHEM, (1967), vol. 39, pages 1602 - 1604 | - WESTPHAL, O; JANN K., "Bacterial polysaccharides. Extraction with phenol-water and further applications of the procedure", METH CARBOHYDR CHEM, (1965), vol. 5, pages 83 - 91 | - WIRTH HP; YANG M; KARITA M; BLASER MJ, "Expression of the human cell surface glycoconjugates Lewis X and Lewis Y by Helicobacter pylori isolates is related to cagA status", INFECT IMMUN, (1996), vol. 64, pages 4598 - 4605, XP002910666 | - YOKOTA, S.; AMANO, K.; FUJII, N.; YOKOCHI, T., "Comparison of serum antibody titers to Helicobacter pylori lipopolysaccharides, CagA, VacA and partially purified cellular extracts in a Japanese population", FEMS MICROBIOL LETT, (2000), vol. 185, pages 193 - 198 | - YU S; GU X-X, "Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis", INFECT IMMUN, (2007), vol. 75, doi:doi:10.1128/IAI.01915-06, pages 2974 - 2980, XP055010194 DOI: http://dx.doi.org/10.1128/IAI.01915-06 |