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Extract from the Register of European Patents

EP About this file: EP2459708

EP2459708 - H. PYLORI LIPOPOLYSACCHARIDE OUTER CORE EPITOPE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.04.2017
Database last updated on 02.09.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
National Research Council of Canada
Building M-58 1200 Montreal Road
Ottawa, ON K1A 0R6 / CA
[2012/23]
Inventor(s)01 / ALTMAN, Eleonora
Building M58
1200 Montreal Road
Ottawa Ontario K1A 0R6 / CA
02 / HARRISON, Blair A.
Building M58
1200 Montreal Road
Ottawa Ontario K1A 0R6 / CA
03 / CHANDAN, Vandana
Building M58
1200 Montreal Road
Ottawa Ontario K1A 0R6 / CA
 [2012/23]
Representative(s)Jostarndt Patentanwalts-AG
Metzgerstraße 61
52070 Aachen / DE
[N/P]
Former [2016/25]Jostarndt, Hans-Dieter
Jostarndt Patentanwalts-AG
Brüsseler Ring 51
52074 Aachen / DE
Former [2012/23]Jostarndt, Hans-Dieter
Jostarndt Patentanwalts-AG Brüsseler Ring 51
52074 Aachen / DE
Application number, filing date10803776.330.07.2010
[2016/25]
WO2010CA01173
Priority number, dateUS20090230315P31.07.2009         Original published format: US 230315 P
[2012/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011011879
Date:03.02.2011
Language:EN
[2011/05]
Type: A1 Application with search report 
No.:EP2459708
Date:06.06.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 03.02.2011 takes the place of the publication of the European patent application.
[2012/23]
Type: B1 Patent specification 
No.:EP2459708
Date:22.06.2016
Language:EN
[2016/25]
Search report(s)International search report - published on:CA03.02.2011
(Supplementary) European search report - dispatched on:EP13.02.2013
ClassificationIPC:C12N5/16, A61K39/02, A61K39/395, A61K47/48, C07K16/12, C07K9/00, C08B37/00, C08L5/00
[2012/23]
CPC:
C07K16/121 (EP,US); A61K39/105 (EP,US); A61K47/61 (EP,US);
A61K47/6415 (EP,US); A61K47/643 (EP,US); A61K47/646 (EP,US);
A61P1/00 (EP); A61P31/04 (EP); A61P35/00 (EP);
A61P37/00 (EP); A61P37/04 (EP); C08B37/006 (EP,US);
C08L5/00 (EP,US); C08L5/02 (US); A61K2039/505 (EP,US);
A61K2039/6037 (EP,US); A61K2039/6081 (EP,US); C07K2317/34 (US);
C07K2317/75 (US); C07K2317/76 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/23]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:H. PYLORI-LIPOPOLYSACCHARID-AUSSENKERN-EPITOPE[2016/04]
English:H. PYLORI LIPOPOLYSACCHARIDE OUTER CORE EPITOPE[2012/23]
French:EPITOPE DE BASE EXTERNE DE H. PYLORI LIPOPOLYSACCHARIDE[2012/23]
Former [2012/23]H.PYLORI-LIPOPOLYSACCHARID-AUSSENKERN-EPITOPE
Entry into regional phase29.02.2012National basic fee paid 
29.02.2012Search fee paid 
29.02.2012Designation fee(s) paid 
29.02.2012Examination fee paid 
Examination procedure29.02.2012Examination requested  [2012/23]
16.09.2013Amendment by applicant (claims and/or description)
25.11.2013Despatch of a communication from the examining division (Time limit: M06)
09.05.2014Reply to a communication from the examining division
28.07.2014Despatch of a communication from the examining division (Time limit: M04)
03.11.2014Reply to a communication from the examining division
16.04.2015Despatch of a communication from the examining division (Time limit: M02)
17.04.2015Reply to a communication from the examining division
11.06.2015Despatch of a communication from the examining division (Time limit: M02)
06.08.2015Reply to a communication from the examining division
12.01.2016Communication of intention to grant the patent
13.05.2016Fee for grant paid
13.05.2016Fee for publishing/printing paid
13.05.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  25.11.2013
Opposition(s)23.03.2017No opposition filed within time limit [2017/22]
Fees paidRenewal fee
23.07.2012Renewal fee patent year 03
22.07.2013Renewal fee patent year 04
23.07.2014Renewal fee patent year 05
23.07.2015Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.07.2010
AL22.06.2016
AT22.06.2016
BE22.06.2016
BG22.06.2016
CY22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
MK22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SI22.06.2016
SK22.06.2016
SM22.06.2016
TR22.06.2016
IE30.07.2016
LU30.07.2016
MT31.07.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
[2018/46]
Former [2018/38]HU30.07.2010
AT22.06.2016
BE22.06.2016
BG22.06.2016
CY22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
MK22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SI22.06.2016
SK22.06.2016
SM22.06.2016
TR22.06.2016
IE30.07.2016
LU30.07.2016
MT31.07.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2018/33]HU30.07.2010
AT22.06.2016
BE22.06.2016
CY22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
MK22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SI22.06.2016
SK22.06.2016
SM22.06.2016
TR22.06.2016
IE30.07.2016
LU30.07.2016
MT31.07.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2018/29]HU30.07.2010
AT22.06.2016
BE22.06.2016
CY22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
MK22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SI22.06.2016
SK22.06.2016
SM22.06.2016
TR22.06.2016
IE30.07.2016
LU30.07.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2018/28]HU30.07.2010
AT22.06.2016
BE22.06.2016
CY22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
MK22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SI22.06.2016
SK22.06.2016
SM22.06.2016
IE30.07.2016
LU30.07.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2017/38]AT22.06.2016
BE22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SI22.06.2016
SK22.06.2016
SM22.06.2016
IE30.07.2016
LU30.07.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2017/23]AT22.06.2016
BE22.06.2016
CZ22.06.2016
DK22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SK22.06.2016
SM22.06.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2017/17]AT22.06.2016
BE22.06.2016
CZ22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
MC22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SK22.06.2016
SM22.06.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2017/11]AT22.06.2016
BE22.06.2016
CZ22.06.2016
EE22.06.2016
ES22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SK22.06.2016
SM22.06.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
PT24.10.2016
Former [2017/10]BE22.06.2016
CZ22.06.2016
EE22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
NL22.06.2016
PL22.06.2016
RO22.06.2016
SE22.06.2016
SK22.06.2016
NO22.09.2016
GR23.09.2016
IS22.10.2016
Former [2017/09]CZ22.06.2016
EE22.06.2016
FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
NL22.06.2016
RO22.06.2016
SE22.06.2016
BE31.07.2016
NO22.09.2016
GR23.09.2016
Former [2017/03]FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
NL22.06.2016
SE22.06.2016
BE31.07.2016
NO22.09.2016
GR23.09.2016
Former [2016/52]FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
NL22.06.2016
SE22.06.2016
NO22.09.2016
GR23.09.2016
Former [2016/51]FI22.06.2016
HR22.06.2016
LT22.06.2016
LV22.06.2016
NO22.09.2016
GR23.09.2016
Former [2016/49]FI22.06.2016
LT22.06.2016
NO22.09.2016
Former [2016/46]LT22.06.2016
NO22.09.2016
Documents cited:Search[X]  - K. HIRATSUKA ET AL, "Identification of a D-glycero-D-manno-Heptosyltransferase Gene from Helicobacter pylori", JOURNAL OF BACTERIOLOGY, (20050720), vol. 187, no. 15, doi:10.1128/JB.187.15.5156-5165.2005, ISSN 0021-9193, pages 5156 - 5165, XP055052023 [X] 1-3,7-9,15-20 * the whole document * * In particular: Title; Abstract; Materials and methods section; Table 2; Fig. 6. *

DOI:   http://dx.doi.org/10.1128/JB.187.15.5156-5165.2005
 [A]  - E. ALTMAN ET AL, "Analysis of Helicobacter pylori isolates from Chile: occurrence of selective type 1 Lewis b antigen expression in lipopolysaccharide", JOURNAL OF MEDICAL MICROBIOLOGY, (20080501), vol. 57, no. 5, doi:10.1099/jmm.0.47783-0, ISSN 0022-2615, pages 585 - 591, XP055052024 [A] 1-11,13-21 * the whole document * * In particular: Title; Abstract; Methods section; fig. 1. *

DOI:   http://dx.doi.org/10.1099/jmm.0.47783-0
 [A]  - MORAN A P ET AL, "Role of Helicobacter pylori rfaJ genes (HP0159 and HP1416) in lipopolysaccharide synthesis", FEMS MICROBIOLOGY LETTERS, WILEY-BLACKWELL PUBLISHING LTD, GB, (20041201), vol. 241, no. 1, doi:10.1016/J.FEMSLE.2004.10.004, ISSN 0378-1097, pages 57 - 65, XP004647144 [A] 1-11,13-21 * the whole document * * In particular: Title; Abstract; Materials and methods section; Fig. 3. *

DOI:   http://dx.doi.org/10.1016/j.femsle.2004.10.004
International search[X]  - LOGAN, S. M. ET AL., "Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori", GLYCOBIOLOGY., (2005), vol. 15, pages 721 - 733, XP008148851

DOI:   http://dx.doi.org/10.1093/glycob/cwi057
 [X]  - ALTMAN, E. ET AL., "Effect of the HP0159 ORF mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori", FEMS IMMUNOL. MED.MICROBIOL., (2008), vol. 53, pages 204 - 213, XP008148856

DOI:   http://dx.doi.org/10.1111/j.1574-695X.2008.00416.x
 [X]  - LOGAN, S. M. ET AL., "Functional genomics of Helicobacter pylori: Identification of a b-1-4 galactosyltransferase and generation of mutants with altered lipopolysaccharide", MOLECULAR MICROBIOLOGY., (2000), vol. 35, pages 1156 - 1167, XP008148849

DOI:   http://dx.doi.org/10.1046/j.1365-2958.2000.01784.x
 [A]  - MONTEIRO, M. A. ET AL., "Helicobacter pylori: A wolf in sheep's clothing: the glycotype families of Helicobacter pylori lipopolysaccharides expressing histo- blood groups structure, biosynthesis and role in pathogenesis", ADVANCES IN CARBOHVDRATE CHEMISTRY AND BIOCHEMISTRY, (2001), vol. 57, pages 99 - 158, XP008148875

DOI:   http://dx.doi.org/10.1016/S0065-2318(01)57016-X
 [A]  - YOKOTA, S-I. ET AL., "Human antibody response to Helicobacter pylory lipopolysaccharide: Presence of an immunodominant epitope in the polysaccharide chain of lipopolysaccharide", INFECTION AND IMMUNITY., vol. 66, pages 3006 - 3011, XP008148852
by applicant   - HIRATSUKA ET AL., J. BACTERIOL., (2005), vol. 187, pages 5156 - 5165
    - ALTMAN ET AL., J. MED. MICROBIOL., (2000), vol. 57, pages 585 - 591
    - LOGAN ET AL., GLYCOBIOL., (2005), vol. 15, pages 721 - 733
    - ALTMAN ET AL., J. MED. MICROBIOL., (2008), vol. 57, pages 585 - 591
    - ALTMAN E; CHANDAN V; LAROCQUE S; AUBRY A; LOGAN SM; VINOGRADOV E; LI J, "Effect of the HP0159 ORF mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori", FEMS IMMUNOL MED MICROBIOL, (2008), vol. 53, doi:doi:10.1111/j.1574-695X.2008.00416.x, pages 204 - 213, XP008148856

DOI:   http://dx.doi.org/10.1111/j.1574-695X.2008.00416.x
    - ALTMAN E; FERNANDEZ H; CHANDAN V; HARRISON BA; WILSON SCHUSTER M; OTTH RADEMACHER L; TOLEDO C, "Analysis of Helicobacter pylori isolates from Chile: occurrence of a selective type 1 Lewis b antigen expression in lipopolysaccharide", J MED MICROBIOL, (2008), vol. 57, doi:doi:10.1099/jmm.0.47783-0, pages 585 - 591, XP055052024

DOI:   http://dx.doi.org/10.1099/jmm.0.47783-0
    - ALTMAN E; HARRISON BA; HIRAMA T; CHANDAN V; TO R; MACKENZIE R, "Characterization of murine monoclonal antibodies against Helicobacter pylori lipopolysaccharide specific for Lex and Ley blood group antigens", BIOCHEM CELL BIOL, (2005), vol. 83, pages 589 - 596
    - ALTMAN E; SMIRNOVA N; LI J; AUBRY A; LOGAN SM, "Occurrence of a nontypable Helicobacter pylori strain lacking Lewis blood group O antigens and DD-heptoglycan: evidence for the role of the core alpha1,6-glucan in colonization", GLYCOBIOLOGY, (2003), vol. 13, doi:doi:10.1093/glycob/cwg106, pages 777 - 783, XP055052159

DOI:   http://dx.doi.org/10.1093/glycob/cwg106
    - ANDERSON PW; PICHICHERO ME; INSEL RA; BETTS R; EBY R; SMITH DH, "Vaccines consisting of periodate-cleaved oligosaccharides from the capsule of Haemophilus influenzae type b coupled to a protein carrier: structural and temporal requirements for priming in the human infant", J IMMUNOL, (1986), vol. 137, pages 1181 - 1186, XP055007229
    - ANGELAKOPOULOS H; HOHMANN EL, "Pilot study of phoP/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers", INFECT IMMUN, (2000), vol. 68, pages 2135 - 2141
    - APPELMELK BJ; SIMMONS-SMIT L; NEGRINI R; MORAN AP; ASPINALL GO; FORTE JG ET AL., "Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity", INFECT IMMUN, (1996), vol. 64, pages 2031 - 2040
    - BRISSON J-R; CRAWFORD E; UHRIN D; KHIEU NH; PERRY MB; SEVERN WB; RICHARDS JC, "The core oligosaccharide component from Mannheimia (Pasteurella) haemolytica serotype A1 lipopolysaccharide contains L-glycero-D-manno- and D-glycero-D-manno-heptoses: Analysis of the structure and conformation by high-resolution NMR spectroscopy", CAN J CHEM, (2002), vol. 80, doi:doi:10.1139/v02-114, pages 949 - 963, XP008076881

DOI:   http://dx.doi.org/10.1139/v02-114
    - CASTILLO-ROJAS G; MAZARI-HIRIART M; LOPEZ-VIDAL Y, "Helicobacter pylori: focus on CagA and VacA major virulence factors", SALUD P6BLICA DE MEXICO, (2004), vol. 46, pages 538 - 548
    - CHANDAN V; LOGAN SM; HARRISON BA; VINOGRADOV E; AUBRY A; STUPAK J; LI J; ALTMAN, E., "Characterization of a waaF mutant of Helicobacter pylori strains 26695 provides evidence that an extended lipopolysaccharide structure has a limited role in the invasion of gastric cancer cells", BIOCHEM CELL BIOL, (2007), vol. 85, pages 582 - 590
    - CHU C; LIU B; WATSON D; SZU S; BRYLA D; SHILOACH J; SCHNEERSON R; ROBBINS JB, "Preparation, characterization, and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 (Shiga's bacillus) bound to tetanus toxoid", INFECT IMMUN, (1991), vol. 59, pages 4450 - 4458
    - CIUCANU , KEREK F., "A simple and rapid method for the permethylation of carbohydrates", CARBOHYDR RES, (2004), vol. 131, pages 209 - 217
    - CIUCANU , KEREK, F., "A simple and rapid method for the permethylation of carbohydrates", CARBOHYDR RES, (2004), vol. 131, pages 209 - 217
    - COX AD; ZOU W; GIDNEY MAJ; LACELLE S; PLESTED JS; MAKEPEACE K; WRIGHT JC; COULL PA; MOXON ER; RICHARDS JC, "Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: Developmental chemistry and investigation of immunological responses following immunization of mice and rabbits", VACCINE, (2005), vol. 23, doi:doi:10.1016/j.vaccine.2005.06.011, pages 5045 - 5054, XP005081369

DOI:   http://dx.doi.org/10.1016/j.vaccine.2005.06.011
    - DUBOIS M; GILLES KA; HAMILTON JK; REBERS PA; SMITH, F, "Colorimetric method for determination of sugars and related substances", ANAL CHEM, (1956), vol. 28, doi:doi:10.1021/ac60111a017, pages 350 - 356, XP000918426

DOI:   http://dx.doi.org/10.1021/ac60111a017
    - DUNN BE; COHEN H; BLASER MJ, "Helicobacterpylori", CLIN MICROBIOL REV, (1997), vol. 10, pages 720 - 741
    - ELLMAN GL, "Tissue sulfhydryl groups", ARCH BIOCHEM BIOPHYS, (1959), vol. 82, doi:doi:10.1016/0003-9861(59)90090-6, pages 70 - 77, XP024815603

DOI:   http://dx.doi.org/10.1016/0003-9861(59)90090-6
    - FERNANDEZ-SANTANA V; GONZAIEZ-LIO R; SARRACENT-PÉREZ J; VEREZ-BENCOMO V, "Conjugation of 5-azido-3-oxapentyl glycosides with thiolated proteins through the use of thiophilic derivatives", GLYCOCONJUGATE J, (1998), vol. 15, doi:doi:10.1023/A:1006903524007, pages 549 - 553, XP002344695

DOI:   http://dx.doi.org/10.1023/A:1006903524007
    - GU X-X; TSAI C-M; UEYAMA T; BARENKAMP SJ; ROBBINS JB; LIM DJ, "Synthesis, characterization, and immunological properties of detoxified lipooligosaccharide from nontypable Haemophilus influenzae conjugated to proteins", INFECT IMMUN, (1996), vol. 64, pages 4047 - 4053
    - HIRATSUKA K; LOGAN SM; CONLAN JW; CHANDAN V; AUBRY A; SMIRNOVA N; ULRICHSEN H; CHAN KHN; GRIFFITH DW; HARRISON BA, "Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori", J BACTERIOL, (2005), vol. 187, doi:doi:10.1128/JB.187.15.5156-5165.2005, pages 5156 - 5165, XP055052023

DOI:   http://dx.doi.org/10.1128/JB.187.15.5156-5165.2005
    - HOLST O; BRADE L; KOSMA P; BRADE, H, "Structure, serological specificity, and synthesis of artificial glycoconjugates representing the genus-specific lipopolysaccharide epitope of Chlamidia spp", J BACTERIOL, (1991), vol. 173, pages 1862 - 1866
    - "Molecular Biology of Anti-a-(l - 6)dextrans. Antibody responses to a Single-Site-Filling Antigenic Determinant", KABAT EA, Carbohydrate Antigens, AMERICAN CHEMICAL SOCIETY, (1993), vol. 159, pages 146 - 58
    - KOHLER G; MILSTEIN C., "Continuous cultures of fused cells secreting antibody of predefined specificity", NATURE, (1975), vol. 256, pages 495 - 497, XP002024548
    - LOGAN SM; ALTMAN E; MYKYTCZUK O; BRISSON J-R; CHANDAN V; ST MICHAEL F; MASSON A; LECLERC S; HIRATSUKA K; SMIRNOVA N, "Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori", GLYCOBIOLOGY, (2005), vol. 15, doi:doi:10.1093/glycob/cwi057, pages 721 - 733, XP008148851

DOI:   http://dx.doi.org/10.1093/glycob/cwi057
    - LOGAN SM; CONLAN JW; MONTEIRO MA; WAKARCHUK WW; ALTMAN E, "Functional genomics of Helicobacter pylori: identification of a (3-1,4 galactosyltransferase and generation of mutants with altered lipopolysaccharide", MOL MICROBIOL, (2000), vol. 35, doi:doi:10.1046/j.1365-2958.2000.01784.x, pages 1156 - 1167, XP008148849

DOI:   http://dx.doi.org/10.1046/j.1365-2958.2000.01784.x
    - MIESZALA M; KOGAN G; JENNINGS HJ, "Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their epitopes and results in conjugate vaccines having improved immunological properties", CARBOHYDR RES, (2003), vol. 338, doi:doi:10.1016/S0008-6215(02)00395-6, pages 167 - 175, XP004401753

DOI:   http://dx.doi.org/10.1016/S0008-6215(02)00395-6
    - MONTEIRO MA, "Helicobacter pylori: a wolf in sheep's clothing: the glycotype families of Helicobacter pylori lipopolysaccharides expressing histo-blood groups: structure, biosynthesis, and role in pathogenesis", ADV CARBOHYDR CHEM BIOCHEM, (2001), vol. 57, doi:doi:10.1016/S0065-2318(01)57016-X, pages 99 - 158, XP008148875

DOI:   http://dx.doi.org/10.1016/S0065-2318(01)57016-X
    - PASSWELL JH; ASHKENAZI S; HARLEV E; MIRON D; RAMON R; FARZAM N; LERNER-GEVA L; LEVI Y; CHU C; SHILOACH J, "Safety and immunogenicity of Shigella sonnei-CRM9 and Shigella flexneri type 2a-rEPAsucc conjugate vaccines in one- to four-year old children", PEDIATR INFECT DIS J, (2003), vol. 22, pages 701 - 706, XP009112374
    - PASSWELL JH; HARLEV E; ASHKENAZI S; CHU C; MIRON D; RAMON R; FARZAN N; SHILOACH J; BRYLA DA; MAJADLY F, "Safety and immunogenicity of improved Shigella O-specific polysaccharide-protein conjugate vaccines in adults in Israel", INFECT IMMUN, (2000), vol. 69, doi:doi:10.1128/IAI.69.3.1351-1357.2001, pages 1351 - 1357, XP002305349

DOI:   http://dx.doi.org/10.1128/IAI.69.3.1351-1357.2001
    - PON RA; LUSSIER M; YANG Q-L; JENNINGS HJ, "N-Propionylated group B meningococcal polysaccharide mimics a unique bactericidal capsular epitope in group B Neisseria meningitidis", J EXP MED, (1997), vol. 185, pages 1929 - 1938
    - ROSSI G; RUGGIERO P; PEPPOLONI S; PANCOTTO L; FORTUNA D; LAURETTI L; VOLPINI G; MANCIANTI S; CORAZZA M; TACCINI E, "Therapeutic vaccination against Helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy", INFECT IMMUN, (2004), vol. 72, pages 3252 - 3259
    - ROY, R.; KATZENELLENBOGEN, E.; JENNINGS, H.J., "Improved procedures for the conjugation of oligosaccharides to protein by reductive amination", CAN J. BIOCHEM. CELL BIOL., (1984), vol. 62, pages 270 - 275, XP002913707

DOI:   http://dx.doi.org/10.1139/o84-037
    - RUGGIERO P; PEPPOLONI S; RAPPUOLI R; DEL GIUDICE G, "The quest for a vaccine against Helicobacter pylori: how to move from mouse to man?", MICROBES INFECT, (2003), vol. 5, doi:doi:10.1016/S1286-4579(03)00125-4, pages 749 - 756, XP002463618

DOI:   http://dx.doi.org/10.1016/S1286-4579(03)00125-4
    - SAWARDEKER JH; SLONEKER JH; JEANNES A, "Quantitative determination of monosaccharides as their alditol acetates by gas liquid chromatography", ANAL CHEM, (1967), vol. 39, pages 1602 - 1604
    - WESTPHAL, O; JANN K., "Bacterial polysaccharides. Extraction with phenol-water and further applications of the procedure", METH CARBOHYDR CHEM, (1965), vol. 5, pages 83 - 91
    - WIRTH HP; YANG M; KARITA M; BLASER MJ, "Expression of the human cell surface glycoconjugates Lewis X and Lewis Y by Helicobacter pylori isolates is related to cagA status", INFECT IMMUN, (1996), vol. 64, pages 4598 - 4605, XP002910666
    - YOKOTA, S.; AMANO, K.; FUJII, N.; YOKOCHI, T., "Comparison of serum antibody titers to Helicobacter pylori lipopolysaccharides, CagA, VacA and partially purified cellular extracts in a Japanese population", FEMS MICROBIOL LETT, (2000), vol. 185, pages 193 - 198
    - YU S; GU X-X, "Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis", INFECT IMMUN, (2007), vol. 75, doi:doi:10.1128/IAI.01915-06, pages 2974 - 2980, XP055010194

DOI:   http://dx.doi.org/10.1128/IAI.01915-06
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