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Extract from the Register of European Patents

EP About this file: EP2478113

EP2478113 - COMPOSITIONS AND METHODS FOR IN VIVO EVALUATION OF BIOLUMINESCENCE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.07.2021
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  31.07.2020
FormerGrant of patent is intended
Status updated on  07.05.2020
FormerExamination is in progress
Status updated on  28.09.2018
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Caliper Life Sciences, Inc.
850 Marina Village Parkway
Alameda, CA 94501-1038 / US
[2012/30]
Inventor(s)01 / OLDFIELD, Stephen
c/o Caliper Life Sciences, Inc.
850 Marina Village Parkway
Alameda, CA 94501 / US
02 / ANSALDI, Daniel
c/o Caliper Life Sciences, Inc.
850 Marina Village Parkway
Alameda, CA 94501 / US
03 / SINGH, Rajendra
c/o Caliper Life Sciences, Inc.
850 Marina Village Parkway
Alameda, CA 94501 / US
04 / ZHANG, Ning
c/o Caliper Life Sciences, Inc.
850 Marina Village Parkway
Alameda, CA 94501 / US
 [2020/31]
Former [2012/30]01 / OLDFIELD, Stephen
c/o Caliper Life Sciences
850 Marina Village Parkway
Alameda, CA 94501 / US
02 / ANSALDI, Daniel
c/o Caliper Life Sciences
850 Marina Village Parkway
Alameda, CA 94501 / US
03 / SINGH, Rajendra
c/o Caliper Life Sciences
850 Marina Village Parkway
Alameda, CA 94501 / US
04 / ZHANG, Ning
c/o Caliper Life Sciences
850 Marina Village Parkway
Alameda, CA 94501 / US
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[2020/36]
Former [2012/30]Brasnett, Adrian Hugh, et al
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Application number, filing date10817561.316.09.2010
[2020/36]
WO2010US02526
Priority number, dateUS20090276989P18.09.2009         Original published format: US 276989 P
[2012/30]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011034590
Date:24.03.2011
Language:EN
[2011/12]
Type: A1 Application with search report 
No.:EP2478113
Date:25.07.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 24.03.2011 takes the place of the publication of the European patent application.
[2012/30]
Type: B1 Patent specification 
No.:EP2478113
Date:02.09.2020
Language:EN
[2020/36]
Search report(s)International search report - published on:US24.03.2011
(Supplementary) European search report - dispatched on:EP26.01.2015
ClassificationIPC:C12Q1/66, G01N21/76, A61K49/00, G01N33/58, // G01N21/27
[2015/09]
CPC:
A61K49/0021 (EP,US); A01K67/0275 (US); A61K49/0013 (EP,US);
A61K49/0017 (US); G01N21/763 (EP,US); G01N33/582 (EP,US);
A01K2267/03 (US); G01N21/274 (EP,US) (-)
Former IPC [2012/30]C12Q1/66, G01N21/76
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/30]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR IN-VIVO-EVALUATION EINER BIOLUMINESZENZ[2012/30]
English:COMPOSITIONS AND METHODS FOR IN VIVO EVALUATION OF BIOLUMINESCENCE[2012/30]
French:COMPOSITIONS ET PROCÉDÉS POUR L'ÉVALUATION DE BIOLUMINESCENCE IN VIVO[2012/30]
Entry into regional phase23.03.2012National basic fee paid 
23.03.2012Search fee paid 
23.03.2012Designation fee(s) paid 
23.03.2012Examination fee paid 
Examination procedure23.03.2012Examination requested  [2012/30]
14.04.2015Amendment by applicant (claims and/or description)
26.09.2018Despatch of a communication from the examining division (Time limit: M04)
29.01.2019Reply to a communication from the examining division
14.04.2020Cancellation of oral proceeding that was planned for 28.04.2020
28.04.2020Date of oral proceedings (cancelled)
08.05.2020Communication of intention to grant the patent
23.07.2020Fee for grant paid
23.07.2020Fee for publishing/printing paid
23.07.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20173931.5  / EP3715466
EP22188125.3
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.09.2018
Opposition(s)03.06.2021No opposition filed within time limit [2021/32]
Fees paidRenewal fee
25.09.2012Renewal fee patent year 03
27.09.2013Renewal fee patent year 04
29.09.2014Renewal fee patent year 05
28.09.2015Renewal fee patent year 06
27.09.2016Renewal fee patent year 07
27.09.2017Renewal fee patent year 08
27.09.2018Renewal fee patent year 09
27.09.2019Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.09.2010
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MK02.09.2020
MT02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
TR02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
GB02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
[2022/32]
Former [2022/27]HU16.09.2010
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MT02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
TR02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
GB02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2022/26]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
TR02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
GB02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2022/23]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
GB02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2022/10]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
GB02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
DE01.04.2021
Former [2021/49]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
GB02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2021/48]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2021/37]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
IE16.09.2020
LU16.09.2020
BE30.09.2020
CH30.09.2020
LI30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2021/36]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
LU16.09.2020
BE30.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2021/35]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SK02.09.2020
SM02.09.2020
LU16.09.2020
NL01.10.2020
FR02.11.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
DE01.04.2021
Former [2021/31]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SK02.09.2020
SM02.09.2020
LU16.09.2020
NL01.10.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/30]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SK02.09.2020
SM02.09.2020
LU16.09.2020
NL01.10.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/28]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SK02.09.2020
SM02.09.2020
LU16.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/27]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SM02.09.2020
LU16.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/25]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/24]AT02.09.2020
CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/23]CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/22]CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RO02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/21]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/10]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/09]FI02.09.2020
LT02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/08]FI02.09.2020
LT02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
Former [2021/07]FI02.09.2020
LT02.09.2020
NO02.12.2020
Documents cited:Search[Y]US5377676  (VARI SANDOR G [US], et al) [Y] 5,6,12,13* column 2, line 7 - line 36 *;
 [XI]EP1865073  (OLYMPUS IMAGING CORP [JP]) [X] 1,3,9 * paragraph [0212] * [I] 10;
 [XI]US2009047219  (OHMIYA YOSHIHIRO [JP], et al) [X] 1-3,9 * paragraphs [0011] , [0031] , [0046] * [I] 10;
 [XI]  - THEODOSSIOU THEODOSSIS ET AL, "Firefly luciferin-activated rose bengal: In vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20030415), vol. 63, no. 8, ISSN 0008-5472, pages 1818 - 1821, XP002421372 [X] 1-3,9 * page 1818, column l, paragraph l - column r, paragraph 1 * * page 1821, column l * [I] 10
 [XYI]  - FRANK BERGER ET AL, "Uptake kinetics and biodistribution of 14C-d-luciferin-a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER, BERLIN, DE, (20080726), vol. 35, no. 12, doi:10.1007/S00259-008-0870-6, ISSN 1619-7089, pages 2275 - 2285, XP019654464 [X] 1-3,8,9,14,15 * page 2276, column r * * page 2278 * * page 2281, column r - page 2282, column l * * page 2283, column l * * page 2284, column r, paragraph 3 - paragraph 5 * [Y] 5,6,12,13 [I] 4,7,10,11

DOI:   http://dx.doi.org/10.1007/s00259-008-0870-6
 [XYI]  - K.-H Lee ET AL, "Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging", doi:10.1097/01.mnm.0000090431.24184.49, (20030101), URL: http://web.stanford.edu/group/mips/luc_lee.pdf, (20150108), XP055160758 [X] 1-3,8,9,14,15 * abstract * * page 2004, column r, paragraph 2 - paragraph 3 * * page 1007, column l, paragraph l - page 1008, column l, paragraph 1 * [Y] 5,6,12,13 [I] 4,7,10,11

DOI:   http://dx.doi.org/10.1097/00006231-200309000-00009
 [A]  - COLLACO ANNE M ET AL, "Monitoring immediate-early gene expression through firefly luciferase imaging of HRS/J hairless mice", BMC PHYSIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, (20030819), vol. 3, no. 1, doi:10.1186/1472-6793-3-8, ISSN 1472-6793, page 8, XP021006105 [A] 1-15 * abstract * * figures 1,2 * * page 2, column r, paragraph 1 * * page 9, column r, paragraph 1 *

DOI:   http://dx.doi.org/10.1186/1472-6793-3-8
International search[X]US2004166553  (NGUYEN QUAN [US], et al);
 [A]US2008293795  (DONAWHO CHERRIE K [US], et al);
 [A]US2009060843  (BERGGREN PER-OLOF [SE], et al);
 [A]  - REYNOLDS ET AL., "Imaging of spontaneous canine mammary tumors using fluorescent contrast agents.", PHOTOCHEMISTRY AND PHOTOBIOLOGY, (1999), vol. 70, no. 1, pages 87 - 94, XP008153869

DOI:   http://dx.doi.org/10.1111/j.1751-1097.1999.tb01953.x
 [A]  - WEISSLEDER ET AL., "Shedding light onto live molecular targets.", NATURE MEDICINE, (2003), vol. 9, no. 1, pages 123 - 128, XP008153874

DOI:   http://dx.doi.org/10.1038/nm0103-123
ExaminationUS5128069
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.