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Extract from the Register of European Patents

EP About this file: EP2484756

EP2484756 - NOVEL PACEMAKER CELL [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.07.2018
Database last updated on 17.09.2024
FormerThe patent has been granted
Status updated on  18.08.2017
FormerGrant of patent is intended
Status updated on  11.08.2017
FormerExamination is in progress
Status updated on  02.08.2017
FormerGrant of patent is intended
Status updated on  05.04.2017
FormerExamination is in progress
Status updated on  30.12.2016
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
National University Corporation Tottori University
101 Koyamacho-Minami 4-chome Tottori-shi
Tottori 680-8550 / JP
[2012/32]
Inventor(s)01 / HISATOME, Ichiro
c/o NATIONAL UNIVERSITY CORPORATION
TOTTORI UNIVERSITY
86 Nishi-cho
Yonago-shi Tottori 683-8503 / JP
02 / SHIRAYOSHI, Yasuaki
c/o NATIONAL UNIVERSITY CORPORATION
TOTTORI UNIVERSITY
86 Nishi-cho
Yonago-shi Tottori 683-8503 / JP
03 / MIAKE, Junichiro
c/o NATIONAL UNIVERSITY CORPORATION
TOTTORI UNIVERSITY
86 Nishi-cho
Yonago-shi Tottori 683-8503 / JP
 [2012/40]
Former [2012/32]01 / HISATOME, Ichiro
c/o NATIONAL UNIVERSITY CORPORATION TOTTORI
UNIVERSITY
86 Nishi-cho
Yonago-shi Tottori 683-8503 / JP
02 / SHIRAYOSHI, Yasuaki
c/o NATIONAL UNIVERSITY CORPORATION TOTTORI
UNIVERSITY
86 Nishi-cho
Yonago-shi Tottori 683-8503 / JP
03 / MIAKE, Junichiro
c/o NATIONAL UNIVERSITY CORPORATION TOTTORI
UNIVERSITY
86 Nishi-cho
Yonago-shi Tottori 683-8503 / JP
Representative(s)Forrest, Graham Robert, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[2017/38]
Former [2012/32]Forrest, Graham Robert, et al
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Application number, filing date10820584.029.09.2010
[2017/38]
WO2010JP66952
Priority number, dateJP2009022676030.09.2009         Original published format: JP 2009226760
[2012/32]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011040469
Date:07.04.2011
Language:JA
[2011/14]
Type: A1 Application with search report 
No.:EP2484756
Date:08.08.2012
Language:EN
[2012/32]
Type: A9 Corrected patent application 
No.:EP2484756
Date:18.06.2014
[2014/25]
Type: B1 Patent specification 
No.:EP2484756
Date:20.09.2017
Language:EN
[2017/38]
Search report(s)International search report - published on:JP07.04.2011
(Supplementary) European search report - dispatched on:EP29.07.2014
ClassificationIPC:A61L27/00, C07K16/28, C07K16/18, C12N5/0735, C12N5/077, C12N5/10
[2014/34]
CPC:
C07K16/28 (EP,US); C07K16/18 (EP,US); C12N5/0606 (EP,US);
C12N5/0657 (EP,US); C12N2506/02 (EP,US); C12N2510/00 (EP,US);
C12N2533/54 (EP,US) (-)
Former IPC [2012/32]C12N5/10, A61L27/00, C07K16/28, C12N15/09
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/32]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:NEUARTIGE SCHRITTMACHERZELLE[2012/32]
English:NOVEL PACEMAKER CELL[2012/32]
French:NOUVELLE CELLULE GÉNÉRATRICE DE RYTHME[2012/32]
Entry into regional phase27.03.2012Translation filed 
27.03.2012National basic fee paid 
27.03.2012Search fee paid 
27.03.2012Designation fee(s) paid 
27.03.2012Examination fee paid 
Examination procedure08.02.2011Request for preliminary examination filed
International Preliminary Examining Authority: JP
27.03.2012Examination requested  [2012/32]
14.01.2015Amendment by applicant (claims and/or description)
04.01.2017Despatch of a communication from the examining division (Time limit: M04)
22.02.2017Reply to a communication from the examining division
06.04.2017Communication of intention to grant the patent
26.07.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
26.07.2017Fee for grant paid
26.07.2017Fee for publishing/printing paid
10.08.2017Information about intention to grant a patent
10.08.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.01.2017
Opposition(s)21.06.2018No opposition filed within time limit [2018/35]
Fees paidRenewal fee
21.09.2012Renewal fee patent year 03
20.09.2013Renewal fee patent year 04
24.09.2014Renewal fee patent year 05
24.09.2015Renewal fee patent year 06
26.09.2016Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU29.09.2010
AL20.09.2017
AT20.09.2017
CY20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
MK20.09.2017
NL20.09.2017
PL20.09.2017
PT20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
TR20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
[2020/33]
Former [2020/27]HU29.09.2010
AT20.09.2017
CY20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
MK20.09.2017
NL20.09.2017
PL20.09.2017
PT20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
TR20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2020/16]HU29.09.2010
AT20.09.2017
CY20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
MK20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
TR20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2019/52]HU29.09.2010
AT20.09.2017
CY20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
MK20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2019/46]HU29.09.2010
AT20.09.2017
CY20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2019/31]HU29.09.2010
AT20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2018/52]AT20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SI20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2018/50]AT20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
GB20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2018/43]AT20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
MT29.09.2017
BE30.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2018/36]AT20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
BE30.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2018/33]AT20.09.2017
CZ20.09.2017
DK20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
MC20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SK20.09.2017
SM20.09.2017
IE29.09.2017
LU29.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
DE04.04.2018
Former [2018/24]AT20.09.2017
CZ20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
IT20.09.2017
LT20.09.2017
LV20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SK20.09.2017
SM20.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
Former [2018/23]AT20.09.2017
CZ20.09.2017
EE20.09.2017
ES20.09.2017
FI20.09.2017
HR20.09.2017
LT20.09.2017
LV20.09.2017
NL20.09.2017
PL20.09.2017
RO20.09.2017
SE20.09.2017
SK20.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
IS20.01.2018
Former [2018/21]CZ20.09.2017
FI20.09.2017
HR20.09.2017
LT20.09.2017
LV20.09.2017
NL20.09.2017
SE20.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
Former [2018/15]FI20.09.2017
HR20.09.2017
LT20.09.2017
LV20.09.2017
NL20.09.2017
SE20.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
Former [2018/12]FI20.09.2017
HR20.09.2017
LT20.09.2017
LV20.09.2017
SE20.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
Former [2018/11]FI20.09.2017
HR20.09.2017
LT20.09.2017
SE20.09.2017
BG20.12.2017
NO20.12.2017
GR21.12.2017
Former [2018/09]FI20.09.2017
LT20.09.2017
SE20.09.2017
NO20.12.2017
Former [2018/08]FI20.09.2017
LT20.09.2017
NO20.12.2017
Former [2018/07]LT20.09.2017
NO20.12.2017
Documents cited:Search[XYI]  - D CAPILUPO ET AL, "Acta Physiologica Congress", THE 60TH NATIONAL CONGRESS OF THE ITALIAN PHYSIOLOGICAL SOCIETY, (20090901), vol. 197, XP055099679 [X] 1-6,10-12 * abstract * [Y] 7-9 [I] 14
 [XP]  - MORIKAWA KUMI ET AL, "Identification, isolation and characterization of HCN4-positive pacemaking cells derived from murine embryonic stem cells during cardiac differentiation.", PACING AND CLINICAL ELECTROPHYSIOLOGY : PACE MAR 2010, (201003), vol. 33, no. 3, ISSN 1540-8159, pages 290 - 303, XP055099647 [XP] 1-12,14 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1540-8159.2009.02614.x
 [Y]  - OU DONG-BO ET AL, "Using embryonic stem cells to form a biological pacemaker via tissue engineering technology.", BIOESSAYS : NEWS AND REVIEWS IN MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY FEB 2009, (200902), vol. 31, no. 2, ISSN 1521-1878, pages 246 - 252, XP055099695 [Y] 7-9 * the whole document *

DOI:   http://dx.doi.org/10.1002/bies.200800179
 [T]  - CHUNG YOUNG ET AL, "Human embryonic stem cell lines generated without embryo destruction", CELL STEM CELL, (200802), vol. 2, no. 2, ISSN 1934-5909, pages 113 - 117, XP002719579 [T] * the whole document *

DOI:   http://dx.doi.org/10.1016/j.stem.2007.12.013
International search[Y]WO2007014134  (UNIV COLUMBIA [US], et al);
 [Y]WO2009017254  (ASUBIO PHARMA CO LTD [JP], et al);
 [A]WO2007047522  (UNIV JOHNS HOPKINS [US], et al)
 [X]  - YASUAKI SHIRAYOSHI ET AL., "Ion Channel o Kashika Senbetsu Marker to shita ES Saibo Yurai Seibutsugakuteki Pacemaker Saibo no Juritsu to sono Tokusei no Kento", SHINDENZU, (2008), vol. 28, no. 5, page 466, XP008157434
 [X]  - YANO, S. ET AL., "Changes of HCN gene expression and If currents in Nkx2.5-positive cardiomyocytes derived from murine embryonic stem cells during differentiation", BIOMED RES, (2008), vol. 29, no. 4, pages 195 - 203, XP008154655

DOI:   http://dx.doi.org/10.2220/biomedres.29.195
 [X]  - KENTOKU YANAGI ET AL., "ES Saibo Yurai Shinkin Pacemaker Saibo no Jidono Iji ni Okeru Ion Channel HCN1, 4 Oyobi Cav3.1 no Igi", FOLIA ENDOCRINOLOGICA JAPONICA, (2006), vol. 82, no. 2, page 512, XP008154720
 [X]  - BARBUTI, A. ET AL., "Molecular composition and Functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (200903), vol. 46, no. 3, pages 343 - 351, XP008154569

DOI:   http://dx.doi.org/10.1016/j.yjmcc.2008.12.001
 [X]  - YANAGI, K. ET AL., "Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes", STEM CELLS, DAYTON, OHIO, (2007), vol. 25, no. 11, pages 2712 - 2719, XP008154663

DOI:   http://dx.doi.org/10.1634/stemcells.2006-0388
 [Y]  - YANG X.J. ET AL., "Mesenchymal stem cells as a gene delivery system to create biological pacemaker cells in vitro", THE JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, (2008), vol. 36, no. 5, pages 1049 - 1055, XP008154681

DOI:   http://dx.doi.org/10.1177/147323000803600523
 [Y]  - BOINK, G.J. ET AL., "Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer", THE JOURNAL OF GENE MEDICINE, (2008), vol. 10, no. 5, pages 487 - 497, XP008154664

DOI:   http://dx.doi.org/10.1002/jgm.1172
 [XP]  - SHIRAYOSHI, Y. ET AL., "Identification, Isolation and Characterization of HCN4- positive Cardiac Pacemaking Cells Derived from Murine EGFP Knock-in Embryonic Stem Cells at HCN4 Locus", CIRC J, (20100301), vol. 74, no. 1, page 400, XP008155157
 [XP]  - SHIN'ICHI ITO ET AL., "ES Saibo Yurai Shinzo Pacemaker Saibo no Bunshu to Tokusei Kaiseki", SAISEI IRYO, (20100205), vol. 9, page 216, XP008158415
by applicantJP2009226760
    - YANO S; MIAKE J; MIZUTA E; MANABE K; BAHRUDIN U; MORIKAWA K; ARAKAWA K ET AL., "Changes of HCN gene expression and I(f) currents in Nkx2.5-positive cardiomyocytes derived from murine embryonic stem cells during differentiation", BIOMED RES, (2008), vol. 29, doi:doi:10.2220/biomedres.29.195, pages 195 - 203, XP008154655

DOI:   http://dx.doi.org/10.2220/biomedres.29.195
    - KURATA Y; MATSUDA H; HISATOME I; SHIBAMOTO T., "Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineering", AM J PHYSIOL HEART CIRC PHYSIOL., (200701), vol. 292, no. 1, pages H701 - 18
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.