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EP About this file: EP2484757

EP2484757 - METHOD FOR THE PREPARATION OF VIRUS EXPRESSING ALPHA-GALACTOSYL EPITOPES [Right-click to bookmark this link]
Former [2012/32]	VIRUS CAPABLE OF EXPRESSING -GALACTOSE EPITOPE, AND METHOD FOR PRODUCTION OF VACCINE
	[2014/45]
Status	No opposition filed within time limit Status updated on 04.03.2016 Database last updated on 09.04.2026
Most recent event Tooltip	12.10.2018	Lapse of the patent in a contracting state New state(s): AL	published on 14.11.2018 [2018/46]
Applicant(s)	For all designated states National University Corporation Obihiro University of Agriculture and Veterinary Medicine 11, Nishi 2-sen, Inada-cho Obihiro-shi, Hokkaido 080-8555 / JP
	[2014/45]
Former [2012/32]	For all designated states National University Corporation Obihiro University of Agriculture and Veterinary Medicine 11, Nishi 2-sen, Inada-cho Obihiro-shi, Hokkaido 080-8555 / JP
	For all designated states Incorporated Administrative Agency National Agriculture and Food Research Organization 3-1-1 Kannondai Tsukuba-shi Ibaraki 305-8517 / JP
Inventor(s)	01 / OGAWA, Haruko c/o Research Center for Animal Hygiene and Food Safety National University Corporation Obihiro University of Agriculture, and Veterinary Medicine, 11 Nishi 2-sen Inada-cho, Obihiro-shi Hokkaido 080-8555 / JP
	02 / IMAI, Kunitoshi c/o Research Center for Animal Hygiene and Food Safety National University Corporation Obihiro University, of Agriculture and Veterinary Medicine, 11 Nishi 2-sen Inada-cho, Obihiro-shi Hokkaido 080-8555 / JP
	03 / TAGAMI, Takahiro c/o National Institute of Livestock and Grassland Science Incorporated Administrative Agency National Agriculture and Food Research Organization, 2 Ikenodai Tsukuba-shi Ibaraki 305-0901 / JP
	[2012/42]
Former [2012/32]	01 / OGAWA, Haruko c/o Research Center for Animal Hygiene and Food Safety National University Corporation Obihiro University, of Agriculture and Veterinary Medicine, 11 Nishi 2-sen Inada-ch Obihiro-shi Hokkaido 080-8555 / JP
	02 / IMAI, Kunitoshi c/o Research Center for Animal Hygiene and Food Safety National University Corporation Obihiro University, of Agriculture and Veterinary Medicine, 11 Nishi 2-sen Inada-ch Obihiro-shi Hokkaido 080-8555 / JP
	03 / TAGAMI, Takahiro c/o National Institute of Livestock and Grassland Science Incorporated Administrative Agency National Agriculture and Food Research Organization, 2 Ikenodai Tsukuba-shi Ibaraki 305-0901 / JP
Representative(s)	Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
	[2015/18]
Former [2012/32]	Vossius & Partner Siebertstrasse 4 81675 München / DE
Application number, filing date	10820641.8	30.09.2010
	WO2010JP67082
Priority number, date	JP20090227753	30.09.2009 Original published format: JP 2009227753
	[2012/32]
Filing language	JA
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2011040526
	Date:	07.04.2011
	Language:	JA
	[2011/14]
	Type:	A1 Application with search report
	No.:	EP2484757
	Date:	08.08.2012
	Language:	EN
	[2012/32]
	Type:	A9 Corrected patent application
	No.:	EP2484757
	Date:	04.12.2013
	[2013/49]
	Type:	B1 Patent specification
	No.:	EP2484757
	Date:	29.04.2015
	Language:	EN
	[2015/18]
Search report(s)	International search report - published on:	JP	07.04.2011
	(Supplementary) European search report - dispatched on:	EP	05.06.2013
Classification	IPC:	C12N7/00, A61K39/145, A61K39/165, A61K39/17, A61K39/20, A61K39/21, A61K39/255, A61K39/285, A61P31/12, A61P31/16, C12N7/04, C12N15/09, C12N9/10	[2013/27]
	CPC:	A61K39/145 (EP,US); A61K39/12 (EP,US); A61P31/12 (EP); A61P31/16 (EP); A61P37/04 (EP); C12N7/00 (EP,US); (+) C12N9/1051 (EP,US); A61K39/00 (EP,US); C12N2760/16034 (EP,US); C12N2760/16052 (EP,US) (-)
	Former IPC [2012/32]	C12N7/00, A61K39/145, A61K39/165, A61K39/17, A61K39/20, A61K39/21, A61K39/255, A61K39/285, A61P31/12, A61P31/16, C12N7/04, C12N15/09
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2012/32]
Extension states	BA	Not yet paid
	ME	Not yet paid
	RS	Not yet paid
Title	German:	VERFAHREN ZUR HERSTELLUNG EINES VIRUSES, WELCHES ALPHA-GALAKTOSYL-EPITOPE EXPRIMIERT	[2014/45]
	English:	METHOD FOR THE PREPARATION OF VIRUS EXPRESSING ALPHA-GALACTOSYL EPITOPES	[2014/45]
	French:	PROCEDE DE PREPARATION DE VIRUS EXPRIMANT DES EPITOPES D'ALPHA-GALACTOSYLE	[2014/45]
	Former [2012/32]	VIRUS ZUR EXPRESSION VON ALPHA-GALAKTOSE-EPITOPEN SOWIE VERFAHREN ZUR HERSTELLUNG EINES IMPFSTOFFS
	Former [2012/32]	VIRUS CAPABLE OF EXPRESSING -GALACTOSE EPITOPE, AND METHOD FOR PRODUCTION OF VACCINE
	Former [2012/32]	VIRUS CAPABLE D'EXPRIMER UN ÉPITOPE DE -GALACTOSE, ET PROCÉDÉ DE PRODUCTION DE VACCIN
Entry into regional phase	27.04.2012	Translation filed
	27.04.2012	National basic fee paid
	27.04.2012	Search fee paid
	27.04.2012	Designation fee(s) paid
	27.04.2012	Examination fee paid
Examination procedure	30.06.2011	Request for preliminary examination filed International Preliminary Examining Authority: JP
	27.04.2012	Examination requested [2012/32]
	22.10.2013	Amendment by applicant (claims and/or description)
	19.11.2013	Despatch of a communication from the examining division (Time limit: M01)
	30.12.2013	Reply to a communication from the examining division
	08.10.2014	Communication of intention to grant the patent
	16.02.2015	Fee for grant paid
	16.02.2015	Fee for publishing/printing paid
	16.02.2015	Receipt of the translation of the claim(s)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 19.11.2013
Opposition(s)	01.02.2016	No opposition filed within time limit [2016/14]
Fees paid	Renewal fee
	12.09.2012	Renewal fee patent year 03
	12.09.2013	Renewal fee patent year 04
	12.09.2014	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	30.09.2010
	AL	29.04.2015
	AT	29.04.2015
	BE	29.04.2015
	BG	29.04.2015
	CY	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	MK	29.04.2015
	MT	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SE	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	SM	29.04.2015
	TR	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	CH	30.09.2015
	IE	30.09.2015
	LI	30.09.2015
	LU	30.09.2015
	[2018/46]
Former [2018/30]	HU	30.09.2010
	AT	29.04.2015
	BE	29.04.2015
	BG	29.04.2015
	CY	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	MK	29.04.2015
	MT	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SE	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	SM	29.04.2015
	TR	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	CH	30.09.2015
	IE	30.09.2015
	LI	30.09.2015
	LU	30.09.2015
Former [2017/38]	HU	30.09.2010
	AT	29.04.2015
	BE	29.04.2015
	BG	29.04.2015
	CY	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	MT	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SE	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	SM	29.04.2015
	TR	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	CH	30.09.2015
	IE	30.09.2015
	LI	30.09.2015
	LU	30.09.2015
Former [2017/22]	AT	29.04.2015
	BE	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	MT	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	CH	30.09.2015
	IE	30.09.2015
	LI	30.09.2015
	LU	30.09.2015
Former [2016/37]	AT	29.04.2015
	BE	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	CH	30.09.2015
	IE	30.09.2015
	LI	30.09.2015
	LU	30.09.2015
Former [2016/33]	AT	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	CH	30.09.2015
	IE	30.09.2015
	LI	30.09.2015
	LU	30.09.2015
Former [2016/24]	AT	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SI	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	LU	30.09.2015
Former [2016/23]	AT	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	MC	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	LU	30.09.2015
Former [2016/21]	AT	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	IT	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
	LU	30.09.2015
Former [2016/10]	AT	29.04.2015
	CZ	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	PL	29.04.2015
	RO	29.04.2015
	SK	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
Former [2016/09]	AT	29.04.2015
	DK	29.04.2015
	EE	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
Former [2016/07]	AT	29.04.2015
	DK	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
Former [2015/51]	AT	29.04.2015
	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
Former [2015/50]	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	IS	29.08.2015
	PT	31.08.2015
Former [2015/49]	ES	29.04.2015
	FI	29.04.2015
	HR	29.04.2015
	LT	29.04.2015
	LV	29.04.2015
	NL	29.04.2015
	NO	29.07.2015
	GR	30.07.2015
	PT	31.08.2015
Former [2015/42]	NL	29.04.2015
Documents cited:	Search	[Y] WO2008118487 (UNIV MASSACHUSETTS MEDICAL et al.) [Y] 1-9 * the whole document *
		[Y] US2009123494 (STAPLIN WILLIAM et al.) [Y] 1-9 * the whole document *
		[Y] TAKEUCHI Y ET AL: "SENSITIZATION OF CELLS AND RETROVIRUSES TO HUMAN SERUM BY (ALPHA1-3) GALACTOSYLTRANSFERASE", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 379, no. 6560, 4 January 1996 (1996-01-04), pages 85 - 88, XP000569530, ISSN: 0028-0836, DOI: 10.1038/379085A0 [Y] 1-9 * the whole document * DOI: http://dx.doi.org/10.1038/379085a0
		[Y] HITOSHI N ET AL: "Efficient selection for high-expression transfectants with a novel eukaryotic vector", GENE, ELSEVIER, AMSTERDAM, NL, vol. 108, no. 2, 15 December 1991 (1991-12-15), pages 193 - 199, XP023541480, ISSN: 0378-1119, [retrieved on 19911215], DOI: 10.1016/0378-1119(91)90434-D [Y] 1-9 * the whole document * DOI: http://dx.doi.org/10.1016/0378-1119(91)90434-D
		[Y] IKEMATSU SHINYA ET AL: "Transgenic mouse lines with ectopic expression of alpha-1,3-galactosyltransferase: Production and characteristics", GLYCOBIOLOGY, OXFORD UNIVERSITY PRESS, US, vol. 3, no. 6, 1 January 1993 (1993-01-01), pages 575 - 580, XP002697680, ISSN: 0959-6658 [Y] 1-9 * the whole document * DOI: http://dx.doi.org/10.1093/glycob/3.6.575
		[AD] ABDEL-MOTAL USSAMA ET AL: "Increased immunogenicity of human immunodeficiency virus gp120 engineered to express Gal alpha 1-3Ga1 beta 1-4GlcNAc-R epitopes", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 80, no. 14, 1 July 2006 (2006-07-01), pages 6943 - 6951, XP002543575, ISSN: 0022-538X, DOI: 10.1128/JVI.00310-06 [AD] 1-9 * the whole document * DOI: http://dx.doi.org/10.1128/JVI.00310-06
		[AD] ABDEL-MOTAL USSAMA M ET AL: "Immunogenicity of influenza virus vaccine is increased by anti-Gal-mediated targeting to airitigen-presenting cells", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 81, no. 17, 1 September 2007 (2007-09-01), pages 9131 - 9141, XP002543576, ISSN: 0022-538X, DOI: 10.1128/JVI.00647-07 [AD] 1-9 * the whole document * DOI: http://dx.doi.org/10.1128/JVI.00647-07
	International search	[X] PREECE, AF. ET AL.: "Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement.", BLOOD, vol. 99, 2002, pages 2477 - 2482, XP008155431 DOI: http://dx.doi.org/10.1182/blood.V99.7.2477
		[Y] ABDEL-MOTAL, UM. ET AL.: "Immunogenicity of influenza virus vaccine is increased by anti-gal-mediated targeting to antigen- presenting cells.", J VIROL., vol. 81, 2007, pages 9131 - 9141, XP008155433 DOI: http://dx.doi.org/10.1128/JVI.00647-07
	by applicant	GALILI U; AVILA JL.: "a-Gal and Anti-Gal.", 1999, KLUWER ACADEMIC / PLENUM PUBLISHERS
		DERIY L; OGAWA H; GAO GP; GALILI U.: "In vivo targeting of vaccinating tumor cells to antigen-presenting cells by a gene therapy method with adenovirus containing the a-l,3galactosyltransferase gene", CANCER GENE THER., vol. 12, 2005, pages 528 - 539
		ABDEL-MOTAL UM; GUAY HM; WIGGLESWORTH K; WELSH RM; GALILI U.: "Immunogenicity of influenza virus vaccine is increased by anti-gal-mediated targeting to antigen-presenting cells", J VIROL., vol. 81, 2007, pages 9131 - 9141, XP008155433, DOI: doi:10.1128/JVI.00647-07 DOI: http://dx.doi.org/10.1128/JVI.00647-07
		ABDEL-MOTAL U; WANG S; LU S; WIGGLESWORTH K; GALILI U.: "Increased immunogenicity of human immunodeficiency virus gp 120 engineered to express Ga al-3Galpl-4GIcNAc-R epitopes", J VIROL., vol. 80, 2006, pages 6943 - 6951, XP002543575, DOI: doi:10.1128/JVI.00310-06 DOI: http://dx.doi.org/10.1128/JVI.00310-06
		ETO M; MASE M.: "Isolation of the Newcastle disease virus and the H9N2 influenza A virus from chicken imported from China", J. JPN. VET. MED. ASSOC., vol. 56, 2003, pages 333 - 339
		"WHO Manual on Animal Influenza Diagnosis and Surveillance", 2002, WHO
		KILLINGTON RA; STOKES A; HIERHOLZER JC.: "Virology Methods Manual", 1996, ACADEMIC PRESS LIMITED, article "Virus purification", pages: 71 - 89
		"Gene sequence information is available from GenBank (murine: GenBank accession number M85153", J. BIOL. CHEM., vol. 267, 1992, pages 5534 - 5541
		J. BIOL. CHEM., vol. 264, 1989, pages 14290 - 14297

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