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Extract from the Register of European Patents

EP About this file: EP2488256

EP2488256 - NA-K PUMP MODULATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.06.2019
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  06.07.2018
FormerGrant of patent is intended
Status updated on  05.03.2018
FormerExamination is in progress
Status updated on  04.07.2017
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY, MK		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Rasmussen, Helge H.
29 Mosman Street
Mosman, NSW 2088 / AU
[2012/34]
Inventor(s)01 / see applicant
...
 [2012/34]
Representative(s)Zwicker, Jörk, et al
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[2018/32]
Former [2012/34]Zwicker, Jörk, et al
Dr. Volker Vossius
Patent- und Rechtsanwaltskanzlei
Geibelstrasse 6
81679 München / DE
Application number, filing date10822911.315.10.2010
[2018/32]
WO2010AU01367
Priority number, dateAU2009090505515.10.2009         Original published format: AU 2009905055
[2012/34]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011044636
Date:21.04.2011
Language:EN
[2011/16]
Type: A1 Application with search report 
No.:EP2488256
Date:22.08.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 21.04.2011 takes the place of the publication of the European patent application.
[2012/34]
Type: B1 Patent specification 
No.:EP2488256
Date:08.08.2018
Language:EN
[2018/32]
Search report(s)International search report - published on:AU21.04.2011
(Supplementary) European search report - dispatched on:EP28.10.2013
ClassificationIPC:C07K14/47, // A61K38/00
[2018/12]
CPC:
C07K14/4702 (EP,US); A61P35/00 (EP); A61P39/06 (EP);
A61P9/10 (EP); A61K38/00 (EP,US)
Former IPC [2012/34]A61P9/10, A61K38/17, A61P35/00, C07K14/435
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/34]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:NA/K-PUMPEN-MODULATION[2012/34]
English:NA-K PUMP MODULATION[2012/34]
French:MODULATION DE POMPE NA-K[2012/34]
Entry into regional phase07.05.2012National basic fee paid 
07.05.2012Search fee paid 
07.05.2012Designation fee(s) paid 
07.05.2012Examination fee paid 
Examination procedure15.08.2011Request for preliminary examination filed
International Preliminary Examining Authority: AU
07.05.2012Examination requested  [2012/34]
14.05.2014Amendment by applicant (claims and/or description)
18.08.2014Despatch of a communication from the examining division (Time limit: M04)
19.12.2014Reply to a communication from the examining division
04.12.2015Despatch of a communication from the examining division (Time limit: M06)
03.06.2016Reply to a communication from the examining division
22.02.2017Cancellation of oral proceeding that was planned for 23.06.2017
14.06.2017Cancellation of oral proceeding that was planned for 06.07.2017
23.06.2017Despatch of a communication from the examining division (Time limit: M02)
23.06.2017Date of oral proceedings (cancelled)
06.07.2017Date of oral proceedings (cancelled)
21.08.2017Reply to a communication from the examining division
06.03.2018Communication of intention to grant the patent
27.06.2018Fee for grant paid
27.06.2018Fee for publishing/printing paid
27.06.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.08.2014
Opposition(s)09.05.2019No opposition filed within time limit [2019/29]
Fees paidRenewal fee
11.10.2012Renewal fee patent year 03
14.10.2013Renewal fee patent year 04
29.10.2014Renewal fee patent year 05
12.10.2015Renewal fee patent year 06
11.10.2016Renewal fee patent year 07
13.11.2017Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
31.10.201708   M06   Fee paid on   13.11.2017
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU15.10.2010
AL08.08.2018
AT08.08.2018
CY08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
MK08.08.2018
NL08.08.2018
PL08.08.2018
PT08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
TR08.08.2018
IE15.10.2018
LU15.10.2018
MT15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
[2020/31]
Former [2020/30]HU15.10.2010
AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
PT08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
TR08.08.2018
IE15.10.2018
LU15.10.2018
MT15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2020/27]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
PT08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
TR08.08.2018
IE15.10.2018
LU15.10.2018
MT15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2020/16]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
TR08.08.2018
IE15.10.2018
LU15.10.2018
MT15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2020/08]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
IE15.10.2018
LU15.10.2018
MT15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/48]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
IE15.10.2018
LU15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/40]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
LU15.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/38]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
LU15.10.2018
BE31.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/37]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
SM08.08.2018
LU15.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/30]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SK08.08.2018
SM08.08.2018
LU15.10.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/28]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SK08.08.2018
SM08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/26]AL08.08.2018
AT08.08.2018
CZ08.08.2018
DK08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SK08.08.2018
SM08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/24]AL08.08.2018
AT08.08.2018
CZ08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/22]AL08.08.2018
AT08.08.2018
CZ08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
RS08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/12]AL08.08.2018
AT08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RS08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/11]AT08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
NL08.08.2018
PL08.08.2018
RS08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/10]AT08.08.2018
FI08.08.2018
LT08.08.2018
NL08.08.2018
PL08.08.2018
RS08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/09]FI08.08.2018
LT08.08.2018
NL08.08.2018
NO08.11.2018
IS08.12.2018
Former [2019/08]FI08.08.2018
LT08.08.2018
NO08.11.2018
IS08.12.2018
Former [2019/07]LT08.08.2018
Documents cited:Search[XY]  - Anonymous, "Protecting the heart from Ischemia-reperfusion injury: a new role for FXYD proteins?", (20090331), The University of Sydney, URL: http://sydney.edu.au/research/opportunities/opportunities/1424, (20130904), XP002713129 [X] 1-3,10-13 * the whole document * [Y] 4-9
 [Y]  - KAYED H ET AL, "FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth", INTERNATIONAL JOURNAL OF CANCER, UNION INTERNATIONALE CENTRE LE CANCER, vol. 118, no. 1, doi:10.1002/IJC.21257, ISSN 0020-7136, (20060101), pages 43 - 54, (20050707), XP002585528 [Y] 4-9 * page 53, column 2 *

DOI:   http://dx.doi.org/10.1002/IJC.21257
 [Y]  - WONG J C ET AL, "W1877 Changes in FXYD3 and NPM1 Expressions Are Early Markers of Adenomas in the Colon", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 136, no. 5, doi:10.1016/S0016-5085(09)63436-3, ISSN 0016-5085, (20090501), pages A - 745, (20090501), XP026113983 [Y] 4-9 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0016-5085(09)63436-3
 [Y]  - NAKANISHI YUKIHIRO ET AL, "Prognostic significance of dysadherin expression in tongue cancer: Immunohistochemical analysis of 91 cases", APPLIED IMMUNOHISTOCHEMSITRY AND MOLECULAR MORPHOLOGY, LIPPINCOTT WILLIAMS & WILKINS, US, (20041201), vol. 12, no. 4, ISSN 1541-2016, pages 323 - 328, XP009172612 [Y] 4-9 * page 327, paragraph L *

DOI:   http://dx.doi.org/10.1097/00129039-200412000-00006
 [Y]  - LIU J-G ET AL, "Expression of FXYD6 in pancreatic adenocarcinoma and its clinical significance", SHIJIE HUAREN XIAOHUA ZAZHI - WORLD CHINESE JOURNAL OF DIGESTOLOGY, SHIJIE WEI-CHANGBINGXUE ZAZHISHE, TAIYUAN, CN, (20080301), vol. 16, no. 5, ISSN 1009-3079, pages 540 - 543, XP009172301 [Y] 4-9 * abstract *
 [Y]  - ARIMOCHI JUNKO ET AL, "Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells", BIOLOGICAL & PHARMACEUTICAL BULLETIN, (200704), vol. 30, no. 4, ISSN 0918-6158, pages 648 - 654, XP002713130 [Y] 4-9 * page 648, column 1 * * page 654, paragraph 2 *

DOI:   http://dx.doi.org/10.1248/bpb.30.648
 [YP]  - OKUDELA KOJI ET AL, "Down-Regulation of FXYD3 Expression in Human Lung Cancers Its Mechanism and Potential Role in Carcinogenesis", AMERICAN JOURNAL OF PATHOLOGY, (200912), vol. 175, no. 6, pages 2646 - 2656, XP002713134 [YP] 4-9 * the whole document *

DOI:   http://dx.doi.org/10.2353/AJPATH.2009.080571
 [A]  - FIGTREE GEMMA A ET AL, "Reversible Oxidative Modification A Key Mechanism of Na+-K+ Pump Regulation", CIRCULATION RESEARCH, (200907), vol. 105, no. 2, doi:10.1161/CIRCRESAHA.109.199547, ISSN 0009-7330, XP002713132 [A] 1-13 * Pages 185-193, Online Supplement: pages 1 -17 * * page 191, paragraph Discussion *

DOI:   http://dx.doi.org/10.1161/CIRCRESAHA.109.199547
 [T]  - BIBERT STEPHANIE ET AL, "FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta(1) Subunit", JOURNAL OF BIOLOGICAL CHEMISTRY, (201105), vol. 286, no. 21, ISSN 0021-9258, pages 18562 - 18572, XP002713133 [T] * page 18571, column 1, paragraph 3 *

DOI:   http://dx.doi.org/10.1074/jbc.M110.184101
International search[X]  - GARTY, H. ET AL., "Role of FXYD Proteins in Ion Transport", ANNUAL REVIEW OF PHYSIOLOGY, (2006), vol. 68, pages 431 - 459, XP008156195

DOI:   http://dx.doi.org/10.1146/annurev.physiol.68.040104.131852
 [X]  - GEERING, K., "FXYD Proteins: New Regulators of Na-K-ATPase", AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, (2006), vol. 290, no. 2, pages F241 - F250, XP008156196

DOI:   http://dx.doi.org/10.1152/ajprenal.00126.2005
 [X]  - WETZEL, R. K. ET AL., "Stress-Induced Expression of the Gamma Subunit (FXYD2) Modulates Na,K-ATPase Activity and Cell Growth", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2004), vol. 279, no. 40, pages 41750 - 41757, XP008156202

DOI:   http://dx.doi.org/10.1074/jbc.M405622200
 [X]  - SHATTOCK, M. J. ET AL., "Phospholemman: Its Role in Normal Cardiac Physiology and Potential as a Drugable Target in Disease", CURRENT OPINION IN PHARMACOLOGY., (200904), vol. 9, no. 2, pages 160 - 166, XP008156199

DOI:   http://dx.doi.org/10.1016/j.coph.2008.12.015
 [Y]  - PIERRE, S. V. ET AL., "Ouabain Triggers Preconditioning Through Activation of the Na+,K+-ATPase Signaling Cascade in Rat Hearts", CARDIOVASCULAR RESEARCH., (2007), vol. 73, no. 3, pages 488 - 496, XP008156200

DOI:   http://dx.doi.org/10.1016/j.cardiores.2006.11.003
 [Y]  - WANG, J. K. T. ET AL., "Cardiac glycosides Provide Neuroprotection Against Ischemic Stroke: Discovery by a Brain Slice-Based Compound Screening Platform", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA., (2006), vol. 103, no. 27, pages 10461 - 10466, XP008156205

DOI:   http://dx.doi.org/10.1073/pnas.0600930103
 [Y]  - MIJATOVIC, T. ET AL., "Na+/K+-ATPase Alpha Subunits as New Targets in Anticancer Therapy", EXPERT OPINION ON THERAPEUTIC TARGETS., (2008), vol. 12, no. 11, pages 1403 - 1417, XP008156203

DOI:   http://dx.doi.org/10.1517114728220802482056
Examination   - GRZMIL M ET AL, "UP-REGULATED EXPRESSION OF THE MAT-8 GENE IN PROSTATE CANCER AND ITS SIRNA-MEDIATED INHIBITION OF EXPRESSION INDUCES A DECREASE IN PROLIFERATION OF HUMAN PROSTATE CARCINOMA CELLS", INTERNATIONAL JOURNAL OF ONCOLOGY, (2004), vol. 24, pages 97 - 105
    - LOFTAS P ET AL, "EXPRESSION OF FXYD-3 IS AN INDEPENDENT PROGNOSTIC FACTOR IN RECTAL CANCER PATIENTS WITH PREOPERATIVE RADIOTHERAPY", INT J RADIATION ONCOLOGY BIOL PHYS, (2009), vol. 75, no. 1, pages 137 - 142
by applicant   - Methods in Enzymology, Academic Press, Inc.
    - Current Protocols in Molecular Biology
    - Methods in Cell Biology, Academic Press, (19760000), vol. XIV, page 33
    - ARIMOCHI, J.; OHASHI-KOBAYASHI, A.; MAEDA, M., "Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells", Biol Pharm Bull, (20070000), vol. 30, doi:doi:10.1248/bpb.30.648, pages 648 - 654, XP002713130

DOI:   http://dx.doi.org/10.1248/bpb.30.648
    - ATTALI, B.; LATTER, H.; RACHAMIM, N.; GARTY, H., "A corticosteroid-induced gene expressing an ''IsK-like'' K+ channel activity in Xenopus oocytes", Proc Natl Acad Sci USA, (19950000), vol. 92, doi:doi:10.1073/pnas.92.13.6092, pages 6092 - 6096, XP002052595

DOI:   http://dx.doi.org/10.1073/pnas.92.13.6092
    - BEGUIN, P.; CRAMBERT, G.; MONNET-TSCHUDI, F.; ULDRY, M.; HORISBERGER, J.-D.; GARTY, H.; GEERING, K., "FXYD7 is a brain-specific regulator of Na,K-ATPase {alpha} 1-{beta} isozymes", EMBO J, (20020000), vol. 21, pages 3264 - 3273
    - CHOW, D.C.; BROWNING, C.M.; FORTE, J.G., "Gastric H+-K+-ATPase activity is inhibited by reduction of disulfide bonds in beta-subunit", Am J Physiol, (19920000), vol. 263, pages C39 - 46
    - CORNELIUS, F.; MAHMMOUD, Y.A., "Functional modulation of the sodium pump: the regulatory proteins ''Fixit", News Physiol Sci, (20030000), vol. 18, pages 119 - 124
    - CROWELL, K.J.; FRANZIN, C.M.; KOLTAY, A.; LEE, S.; LUCCHESE, A.M.; SNYDER, B.C.; MARASSI, F.M., "Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers", Biochim Biophys Acta, (20030000), vol. 1645, doi:doi:10.1016/S1570-9639(02)00473-9, pages 15 - 21, XP004401454

DOI:   http://dx.doi.org/10.1016/S1570-9639(02)00473-9
    - DENG, V.; MATAGNE, V.; BANINE, F.; FRERKING, M.; OHLIGER, P.; BUDDEN, S.; PEVSNER, J.; DISSEN, G.A.; SHERMAN, L.S.; OJEDA, S.R., "FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice", Hum Mol Genet, (20070000), vol. 16, pages 640 - 650
    - FIGTREE, G.A.; LIU, C.C.; BIBERT, S.; HAMILTON, E.J.; GARCIA, A.; WHITE, C.N.; CHIA, K.K.M.; CORNELIUS, F.; GEERING, K.; RASMUSSEN, "Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation", Circ Res, (20090000), vol. 105, doi:doi:10.1161/CIRCRESAHA.109.199547, pages 185 - 193, XP002713132

DOI:   http://dx.doi.org/10.1161/CIRCRESAHA.109.199547
    - FU, X.; KAMPS, M., "E2a-Pbxl induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts", Mol Cell Biol, (19970000), vol. 17, pages 1503 - 1512
    - GEERING, K., "The functional role of the beta-subunit in the maturation and intracellular transport of Na,K-ATPase", FEBS Lett, (19910000), vol. 285, pages 189 - 193
    - GEERING, K., "FXYD proteins: new regulators of Na-K-ATPase", Am J Physiol Renal Physiol, (20060000), vol. 290, pages F241 - 250
    - GHEZZI, P., "Regulation of protein function by glutathionylation", Free Radic Res, (20050000), vol. 39, pages 573 - 580
    - KAYED, H.; KLEEFF, J.; KOLB, A.; KETTERER, K.; KELEG, S.; FELIX, K.; GIESE, T.; PENZEL, R.; ZENTGRAF, H.; BUCHLER, M.W. et al., "FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth", Int J Cancer, (20060000), vol. 118, doi:doi:10.1002/IJC.21257, pages 43 - 54, XP002585528

DOI:   http://dx.doi.org/10.1002/IJC.21257
    - MEIJ, I.C.; KOENDERINK, J.B.; VAN BOKHOVEN, H.; ASSINK, K.F.; GROENESTEGE, W.T.; DE PONT, J.J.; BINDELS, R.J.; MONNENS, L.A.; VAN, "Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit", Nat Genet, (20000000), vol. 26, pages 265 - 266
    - MERCER, R.W.; BIEMESDERFER, D.; BLISS, D.P.; COLLINS, J.H.; FORBUSH, B., "Molecular cloning and immunological characterization of the gamma-polypeptide, a small protein associated with the Na,K-ATPase", J Cell Biol, (19930000), vol. 121, doi:doi:10.1083/jcb.121.3.579, pages 579 - 586, XP002052594

DOI:   http://dx.doi.org/10.1083/jcb.121.3.579
    - MIJATOVIC T.; VAN QUAQUEBEKE E.; DELEST B.; DEBEIR O.; DARRO F.; KISS R., "Cardiotonic steroids on the road to anti-cancer therapy", Biochimica et Biophysica Acta, (20070000), vol. 1776, no. 1, doi:doi:10.1016/j.bbcan.2007.06.002, pages 32 - 57, XP022219017

DOI:   http://dx.doi.org/10.1016/j.bbcan.2007.06.002
    - MORRISON, B.W.; MOORMAN, J.R.; KOWDLEY, G.C.; KOBAYASHI, Y.M.; JONES, L.R.; LEDER, P., "Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes", J Biol Chem, (19950000), vol. 270, pages 2176 - 2182
    - MORTH, J.P.; PEDERSEN, B.P.; TOUSTRUP-JENSEN, M.S.; SORENSEN, T.L.; PETERSEN, J.; ANDERSEN, J.P; VILSEN, B.; NISSEN, P., "Crystal structure of the sodium-potassium pump", Nature, (20070000), vol. 450, doi:doi:10.1038/NATURE06419, pages 1043 - 1049, XP002518840

DOI:   http://dx.doi.org/10.1038/NATURE06419
    - PALMER, C.J.; SCOTT, B.T.; JONES, L.R., "Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium", J Biol Chem, (19910000), vol. 266, pages 11126 - 11130, XP002052593
    - PRESTI, C.F.; JONES, L.R.; LINDEMANN, J.P., "Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium", J Biol Chem, (19850000), vol. 260, pages 3860 - 3867
    - SHINODA, T.; OGAWA, H.; CORNELIUS, F.; TOYOSHIMA, C., "Crystal structure of the sodium-potassium pump at 2.4 A resolution", Nature, (20090000), vol. 459, pages 446 - 450
    - SWEADNER, K.J.; RAEL, E., "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression", Genomics, (20000000), vol. 68, doi:doi:10.1006/geno.2000.6274, pages 41 - 56, XP004437859

DOI:   http://dx.doi.org/10.1006/geno.2000.6274
    - WHITE, C.N.; FIGTREE, G.A.; LIU, C.C.; GARCIA, A.; HAMILTON, E.J.; CHIA, K.K.; RASMUSSEN, H.H., "Angiotensin II inhibits the Na+-K+ pump via PKC dependent activation of NADPH oxidase", Am J Physiol Cell Physiol, (20090000), vol. 296, pages C693 - 700
    - WHITE CN.; LIU CC; GARCIA A; HAMILTON EJ; CHIA KK; FIGTREE GA; RASMUSSEN HH, "Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity", J Biol Chem, (20100000), vol. 285, pages 13712 - 20
    - YAMAGUCHI, F.; YAMAGUCHI, K.; TAI, Y.; SUGIMOTO, K.; TOKUDA, M., "Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus", Brain Res Mol Brain Res, (20010000), vol. 86, pages 189 - 192
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