EP2488544 - AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 22.01.2016 Database last updated on 24.08.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states Monash University Wellington Road Clayton, VIC 3168 / AU | [2012/34] | Inventor(s) | 01 /
HEARN, Milton TW 263 Union Road Balwyn, Victoria 3103 / AU | 02 /
BHAGWAT, Anjali Makarand 12 Dunns Court Wantirna South, Victoria 3152 / AU | 03 /
JACKSON, William Roy 30 Through Road Camberwell, Victoria 3124 / AU | 04 /
MOUNTFORD, Simon John 4 Hampton Court Beaconsfield, Victoria 3807 / AU | [2012/34] | Representative(s) | D Young & Co LLP 3 Noble Street London EC2V 7BQ / GB | [N/P] |
Former [2015/12] | Gallagher, Kirk James, et al D Young & Co LLP 120 Holborn London EC1N 2DY / GB | ||
Former [2012/34] | Gallagher, Kirk James, et al D Young & Co LLP 120 Holborn London EC1N 2DY / GB | Application number, filing date | 10822912.1 | 15.10.2010 | WO2010AU01368 | Priority number, date | AU20090905049 | 15.10.2009 Original published format: AU 2009905049 | [2012/34] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011044637 | Date: | 21.04.2011 | Language: | EN | [2011/16] | Type: | A1 Application with search report | No.: | EP2488544 | Date: | 22.08.2012 | Language: | EN | The application published by WIPO in one of the EPO official languages on 21.04.2011 takes the place of the publication of the European patent application. | [2012/34] | Type: | B1 Patent specification | No.: | EP2488544 | Date: | 18.03.2015 | Language: | EN | [2015/12] | Search report(s) | International search report - published on: | AU | 21.04.2011 | (Supplementary) European search report - dispatched on: | EP | 21.06.2013 | Classification | IPC: | B01J20/286, B01J20/289, C07D213/70, C07D217/22, C07D213/32, C07D215/36, B01D15/08, C07K1/22 | [2013/30] | CPC: |
B01D15/3804 (EP,US);
B01J20/286 (EP,US);
B01J20/289 (EP,US);
B01J20/3212 (EP,US);
B01J20/3219 (EP,US);
B01J20/3244 (EP,US);
B01J20/3251 (EP,US);
B01J20/3255 (EP,US);
C07D213/32 (EP,US);
C07D213/70 (EP,US);
C07D215/36 (EP,US);
C07D217/22 (EP,US);
C07K1/22 (EP,US)
(-)
|
Former IPC [2012/34] | C07K1/22, C07D213/70, C07D217/22, C07D213/32, C07D215/36, B01D15/08 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/34] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | AFFINITÄTSLIGANDEN UND VERFAHREN ZUR PROTEINREINIGUNG | [2012/34] | English: | AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION | [2012/34] | French: | LIGANDS D'AFFINITÉ ET PROCÉDÉS DE PURIFICATION DE PROTÉINE | [2012/34] | Entry into regional phase | 30.04.2012 | National basic fee paid | 30.04.2012 | Search fee paid | 30.04.2012 | Designation fee(s) paid | 30.04.2012 | Examination fee paid | Examination procedure | 30.04.2012 | Examination requested [2012/34] | 27.12.2013 | Amendment by applicant (claims and/or description) | 01.10.2014 | Communication of intention to grant the patent | 04.02.2015 | Fee for grant paid | 04.02.2015 | Fee for publishing/printing paid | 04.02.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.10.2014 | Opposition(s) | 21.12.2015 | No opposition filed within time limit [2016/08] | Fees paid | Renewal fee | 02.08.2012 | Renewal fee patent year 03 | 27.01.2014 | Renewal fee patent year 04 | 28.10.2014 | Renewal fee patent year 05 | Penalty fee | Additional fee for renewal fee | 31.10.2013 | 04   M06   Fee paid on   27.01.2014 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 15.10.2010 | AL | 18.03.2015 | AT | 18.03.2015 | BE | 18.03.2015 | BG | 18.03.2015 | CY | 18.03.2015 | CZ | 18.03.2015 | DK | 18.03.2015 | EE | 18.03.2015 | ES | 18.03.2015 | FI | 18.03.2015 | HR | 18.03.2015 | IT | 18.03.2015 | LT | 18.03.2015 | LV | 18.03.2015 | MC | 18.03.2015 | MK | 18.03.2015 | MT | 18.03.2015 | NL | 18.03.2015 | PL | 18.03.2015 | RO | 18.03.2015 | RS | 18.03.2015 | SE | 18.03.2015 | SI | 18.03.2015 | SK | 18.03.2015 | SM | 18.03.2015 | TR | 18.03.2015 | NO | 18.06.2015 | GR | 19.06.2015 | IS | 18.07.2015 | PT | 20.07.2015 | IE | 15.10.2015 | LU | 15.10.2015 | CH | 31.10.2015 | LI | 31.10.2015 | [2018/46] |
Former [2018/30] | HU | 15.10.2010 | |
AT | 18.03.2015 | ||
BE | 18.03.2015 | ||
BG | 18.03.2015 | ||
CY | 18.03.2015 | ||
CZ | 18.03.2015 | ||
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GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
IE | 15.10.2015 | ||
LU | 15.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2017/38] | HU | 15.10.2010 | |
AT | 18.03.2015 | ||
BE | 18.03.2015 | ||
BG | 18.03.2015 | ||
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CZ | 18.03.2015 | ||
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SK | 18.03.2015 | ||
SM | 18.03.2015 | ||
TR | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
IE | 15.10.2015 | ||
LU | 15.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/45] | AT | 18.03.2015 | |
BE | 18.03.2015 | ||
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
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SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
IE | 15.10.2015 | ||
LU | 15.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/37] | AT | 18.03.2015 | |
BE | 18.03.2015 | ||
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
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SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 15.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/34] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
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IT | 18.03.2015 | ||
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SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 15.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/28] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
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IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
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NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 15.10.2015 | ||
Former [2016/26] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
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EE | 18.03.2015 | ||
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SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 15.10.2015 | ||
Former [2016/12] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
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SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2016/07] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
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IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
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RO | 18.03.2015 | ||
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SE | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2016/03] | AT | 18.03.2015 | |
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SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2015/51] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
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SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
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FI | 18.03.2015 | ||
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SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
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EE | 18.03.2015 | ||
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NO | 18.06.2015 | ||
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PT | 20.07.2015 | ||
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LV | 18.03.2015 | ||
RS | 18.03.2015 | ||
SE | 18.03.2015 | ||
NO | 18.06.2015 | ||
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Former [2015/37] | FI | 18.03.2015 | |
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
SE | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
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NO | 18.06.2015 | Documents cited: | Search | [A]WO9533557 (OSCARSSON SVEN [SE], et al) [A] 1-15 * example 1 *; | [X]DE102007012645 (BAYER HEALTHCARE AG [DE]) [X] 10-13 * compounds 43A, 45A, 46A *; | [X]US2006173022 (SCHAPER WOLFGANG [DE]) [X] 10-13 * compounds 75-78, 92, 412-415, 428 *; | [X]US2004192712 (BECKMANN MARION [DE], et al) [X] 10-13 * compounds 62-64, 100 * | [A] - SCHOLZ G H ET AL, "Salt-independent binding of antibodies from human serum to thiophilic heterocyclic ligands", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, (19980529), vol. 709, no. 2, doi:10.1016/S0378-4347(98)00109-1, ISSN 1570-0232, pages 189 - 196, XP004123630 [A] 1-15 * table 1 * DOI: http://dx.doi.org/10.1016/S0378-4347(98)00109-1 | International search | [X]EP0522606 (TAKEDA CHEMICAL INDUSTRIES LTD [JP]); | [X]WO2007142578 (GE HEALTHCARE BIO SCIENCES AB [SE], et al) | [X] - IKEDA, S. ET AL., "Solid phase peptide synthesis by the use of 3-nitro-2-pyridine-sulfenyl (Npys)-amino acids", PEPTIDE CHEMISTRY., (1986), vol. 23, pages 115 - 120, XP008155581 | [X] - AIMOTO, S. ET AL., "Development of a facile method for polypeptide synthesis. Synthesis of bovine pancreatic trypsin inhibitor (BPTI)", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, (1989), vol. 62, pages 524 - 531, XP055066604 DOI: http://dx.doi.org/10.1246/bcsj.62.524 | [X] - WANG, S.-S. ET AL., "Automated peptide synthesis under mild conditions", PEPTIDE CHEMISTRY., (1981), vol. 19, pages 37 - 40, XP008155580 | [X] - RAJAGOPALAN, S. ET AL., "Use of the 3-nitro-2-pyridine sulfenyl protecting group to introduce Nepsilon-branching at lysine during solid-phase peptide synthesis", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH., (1995), vol. 45, pages 173 - 179, XP008155296 | [X] - AIMOTO, S. ET AL., "Synthesis of phosphorylated calmodulin-binding site of Ca2+/calmodulin-dependent protein kinase II (CaM KII) by a thioester method", PEPTIDE CHEMISTRY., (1995), vol. 32, pages 197 - 200, XP008155579 | [X] - ERSHAD, S. ET AL., "A selective optical chemosensor based on a thia-containing Schiff- base iron(III) complex for thiocyanate ion", ANALYTICAL SCIENCES., (2009), vol. 25, doi:doi:10.2116/analsci.25.665, pages 665 - 668, XP008155297 DOI: http://dx.doi.org/10.2116/analsci.25.665 | [X] - CAS, (19870214), Database accession no. 106670-43-3, XP008155936 | [X] - CAS, (20090827), Database accession no. 1176537-84-0, XP008155935 | [X] - CAS, (20041226), Database accession no. 802581-82-4, XP008155934 | [X] - CAS, (19880130), Database accession no. 112598-84-2, XP008155933 | [X] - CAS, (19841116), Database accession no. 61832-51-7, XP008155927 | [X] - CAS, (19841116), Database accession no. 57667-42-2, XP008155929 | [X] - CAS, (19841116), Database accession no. 38585-75-0, XP008155930 | [X] - CAS, (20060602), Database accession no. 886585-56-4, XP008155931 | [X] - CAS, (19841116), Database accession no. 29460-40-0, XP008155932 | by applicant | EP0464509 | CA2068255 | JPH0459754B | - H. ANDERSSON; F. ALMQVIST; R. OLSSON, ORG. LETT., (2007), vol. 9, pages 1335 - 1337 | - S. LIU; L. S. LIEBESKIND, J. AM. CHEM. SOC., (2008), vol. 130, pages 6918 - 6919 | - M. MOVASSAGHI; M. D. HILL; O. K. AHMAD, J. AM. CHEM. SOC., (2007), vol. 129, pages 10096 - 10097 | - M. C. BAGLEY; J. W. DALE; J. BOWER, SYNLETT, (2001), pages 1149 - 1151 | - X. XIONG; M. C. BAGLEY; K. CHAPANERI, TETRAHEDRON LETT., (2004), vol. 45, pages 6121 - 6124 | - M. C. BAGLEY; R. LUNN; X. XIONG, TETRAHEDRON LETT., (2002), vol. 43, pages 8331 - 8334 | - M. MOVASSAGHI; M. D. HILL, JAM. CHEM. SOC., (2006), vol. 128, pages 4592 - 4593 | - K. PARTHASARARATHY; M. JEGANMOHAN; C.-H. CHENG, ORG. LETT., (2008), vol. 10, pages 325 - 328 | - K. TANAKA; N. SUZUKI; G. NISHIDA, EUR. J ORG. CHEM., (2006), pages 3917 - 3922 | - B. M. TROST; A. C. GUTIERREZ, ORG. LETT., (2007), vol. 9, pages 1473 - 1476 | - D. SUZUKI; Y. NOBE; R. TANAKA; Y. TAKAYAMA; F. SATO; H. URABE, JAM. CHEM. SOC., (2005), vol. 127, pages 7474 - 7479 | - X. FANG; Y.-C. LIU; C. LI, J ORG. CHEM., (2007), vol. 72, pages 8608 - 8610 | - N. NAKAMICHI; Y. KAWASHITA; M. HAYASHI, SYNTHESIS, (2004), pages 1015 - 1020 | - M. C. BAGLEY; M. C. LUBINU, SYNTHESIS, (2006), pages 1283 - 1288 | - J. S. YADAV; B. V. S. REDDY; A. K. BASAK; G. BAISHYA; A. V. NARSAIAH, SYNTHESIS, (2006), pages 451 - 454 | - B. C. RANU; R. JANA; S. SOWMIAH, J ORG. CHEM., (2007), vol. 72, pages 3152 - 3154 | - LI, R.; DOWD, V.; STEWART, D. J.; BURTON, S. J.; LOWE, C. R., NAT. BIOTECHNOL., (1998), vol. 16, pages 190 - 195 | - TENG, S. F.; SPROULE, K.; HUSSAIN, A.; LOWE, C. R., J. MOL. RECOGNIT., (1999), vol. 12, pages 67 - 75 | - TENG, S. F.; SPROULE, K.; HUSSAIN, A.; LOWE, C. R, J. CHROMATOGR. B, (2000), vol. 740, pages 1 - 15 | - FASSINA, G.; VERDOLIVA, A.; PALOMBO, G.; RUVO, M.; CASSANI, G., J. MOL. RECOGNIT., (1998), vol. 11, pages 128 - 33 | - PORATH, J.; MAISANO, F.; BELEW, M., FEBS LETT., (1985), vol. 185, pages 306 - 310 | - PORATH, J.; OSCARSSON, S., MAKROMOL. CHEM., MACROMOL. SYMP., (1988), vol. 17, pages 359 - 371 | - KNUDSEN, K. L.; HANSEN, M. B.; HENRIKSEN, L. R.; ANDERSEN, B. K.; LIHME, A., ANAL. BIOCHEM., (1992), vol. 201, pages 170 - 177 | - SCHWARZ, A.; KOHEN, F.; WILCHEK, M., J. CHROMATOGR. B, (1995), vol. 664, pages 83 - 88 | - SCHWARZ, A., J. MOL. RECOGNIT., (1996), vol. 9, pages 672 - 674 | - SCHOLZ, G. H.; WIPPICH, P.; LEISTNER, S.; HUSE, K., J. CHROMATOGR. B, (1998), vol. 709, pages 189 - 196 | - DRÖSSLER, K.; LEISTNER, S., IMMUNOBIOLOGY, (1993), vol. 189, page 232 | - SCHOLZ, G. H.; VIEWEG, S.; LEISTNER, S.; SEISSLER, J.; SCHERBAUM, W.A.; HUSE, K., J. IMMUNOL. METHODS, (1998), vol. 219, pages 109 - 118 | - CONSTABLE, E. C.; MORRIS, D.; CARR, S., NEW J. CHEM., (1998), vol. 22, pages 287 - 294 | - BLACKBURN, T. P.; COX, B.; GUILDFORD, A. J.; LE COUNT, D. J.; MIDDLEMISS, D. N.; PEARCE, R. J.; THORNBER, C. W., J. MED. CHEM., (1987), vol. 30, pages 2252 - 2259 | - BOSCHELLI, D. H.; CONNOR, D. T.; LESCH, M. E.; SCHRIER, D. J., BIOORG. MED. CHEM., (1996), vol. 4, pages 557 - 562 | - CHEM. ABSTR., (1992), vol. 140, page 77261 | - CHEMICAL ABSTRACTS, Database accession no. 121,35336 | - ZARAGOZA, F., TETRAHEDRON, (2001), vol. 57, pages 5451 - 5454 | - BUSCHAUER, A., ARCHIV DER PHARMAZIE, (1988), vol. 321, pages 415 - 418 | - FEL'DMAN, I. KH.; VOROPAEVA, A. V. TRUDY, LENINGRADSKOGO KHIMIKO-FARMATSEVTICHESKOGO INSTITUTA, (1962), pages 21 - 24 | - TILLEY, J. W.; LEVITAN, P.; LIND, J.; WELTON, A. F.; CROWLEY, H. J.; TOBIAS, L. D.; O'DONNELL, M., J. MED. CHEM., (1987), vol. 30, pages 185 - 193 | - CHEMICAL ABSTRACTS, Database accession no. 105, 226620 | - KAASJAGER, V. E.; PUGLISI, L.; BOUWMAN, E.; DRIESSEN, W. L.; REEDIJK, J., INORG. CHIM. ACTA, (2000), vol. 310, pages 183 - 190 | - ZHANG, C. X.; LIANG, H.-C.; KIM, E.; SHEARER, J.; HELTON, M. E.; KIM, E.; KADERLI, S.; INCARVITO, C. D.; ZUBERBUEHLER, A. D.; RHEI, J. AM. CHEM. SOC., (2003), vol. 125, pages 634 - 635 | - TOLSTIKOV, G. A.; EMILEEV, U. M.; YUR'EV, V. P.; GERSHANOV, F. B.; RAFIKOV, S. R., TETRAHEDRON LETT., (1971), pages 2807 - 2808 | - MALKOV, A. V.; HAND, J. B.; KOCOVSKY, P., CHEM. COMMUN., (2003), pages 1948 - 1949 | - SHIOTANI, S.; TANIGUCHI, K. J., HETEROCYCL. CHEM., (1997), vol. 34, pages 925 - 929 | - GROS, P.; FORT, Y., J. ORG. CHEM., (2003), vol. 68, pages 2028 - 2029 | - GILMAN, H.; EDWARD, J.T., CAN. J. BIOCHEM., (1953), vol. 31, pages 457 - 468 | - HAMANA, M.; KUMADAKI, S., YAKUGAKU ZASSHI, (1968), vol. 6, pages 672 - 677 | - CHEMICAL ABSTRACTS, Database accession no. 69, 106503 | - INHOFF, O.; RICHARDS, J.M.; BRIET, J.W.; LOWE, G.; KRAUTH-SIEGEL, R.L., J. MED. CHEM., (2002), vol. 45, pages 4524 - 4530 | - CONSTABLE, E.C; WARD, M.D., J. CHEM. SOC. DALTON TRANS., (1990), pages 1405 - 1409 | - TESTAFERRI, L. T.; TIECCO, M.; TINGOL, M.; BARTOLI, D.; MASSOLI, A., TETRAHEDRON, (1985), vol. 41, pages 1373 - 1340 | - PORATH, J.; JANSON, J. C.; LAAS, T., J. CHROMATOGR., (1971), vol. 60, pages 167 - 177 | - WIRTH, H. J.; UNGER, K. K.; HEARN, M. T. W., ANAL. BIOCHEM., (1993), vol. 208, pages 16 - 25 | - "Physiochemicalfactors in polypeptide and protein purification and analysis by High-Performance Liquid Chromatographic techniques: Current status and challenges for the future", HEARN, M. T., Handbook of Bioseparations, ACADEMIC PRESS, (2000), vol. 2, pages 72 - 237 | - ANSPACH, F. B.; JOHNSTON, A.; WIRTH, H. J.; UNGER, K. K.; HEARN, M. T., J. CHROMATOGR., (1990), vol. 499, pages 103 - 124 | - WIRTH, H. J.; UNGER, K. K.; HEARN, M. T. W., J. CHROMATOGR., (1990), vol. 550, pages 383 - 395 | - LAEMMLI, U. K., NATURE, (1970), vol. 227, pages 680 - 685 | - SWAIN, M.; ROSS, N. W., ELECTROPHORESIS, (1995), vol. 16, pages 948 - 951 | - "General methods and coupling procedures", PORATH, J., Methods in Enzymology, ELSEVIER, (1974), vol. 34, pages 13 - 30 | - "Concentration of the Extract", HARRIS, E. L. V., Protein Purifications Methods: A Practical Approach, OXFORD UNIVERSITY PRESS, (1989), pages 125 - 161 | - "Quality control of antibodies for human use", RICHTER, A.; JOSTAMELING, M.; MILLER, K.; HERRMANN, A.; PITSCHKE, M., Antibodies, Vol. 1: Production and purification, KLUWER ACADEMIC/PLENUM PUBLISHERS, (2004), pages 169 - 187 | - ARIS, J. P., "In-Gel", TRYPSIN DIGESTION PROTOCOL FOR PROTEINS IN SDS-PAGE GEL SLICES, DEPARTMENT OF ANATOMY AND CELL BIOLOGY | - "UniProt Knowledgebase", EXPASY SWISS-PROT AND TREMBL, (200310), URL: http://ca.expasy.org/sprot | - PAPPIN ET AL., CURRENT BIOLOGY, (1993), vol. 3, page 327 | US19830521308 |