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EP About this file: EP2488028

EP2488028 - SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF [Right-click to bookmark this link]
Former [2012/34]	SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
	[2020/13]
Status	No opposition filed within time limit Status updated on 25.06.2021 Database last updated on 09.07.2024
Former	The patent has been granted Status updated on 17.07.2020
Former	Grant of patent is intended Status updated on 27.02.2020
Former	Examination is in progress Status updated on 14.02.2020
Former	Grant of patent is intended Status updated on 06.10.2019
Former	Examination is in progress Status updated on 06.06.2018
Most recent event Tooltip	08.07.2022	Lapse of the patent in a contracting state New state(s): MK	published on 10.08.2022 [2022/32]
Applicant(s)	For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US
	[2020/34]
Former [2012/34]	For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway NJ 07065-0907 / US
Inventor(s)	01 / BOGEN, Stephane, L. 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	02 / MA, Yao 320 Bent Street Cambridge Massachusetts 02141 / US
	03 / WANG, Yaolin 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	04 / LAHUE, Brian Robert 320 Bent Street Cambridge Massachusetts 02141 / US
	05 / NAIR, Latha, G. 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	06 / SHIZUKA, Manami 320 Bent Street Cambridge Massachusetts 02141 / US
	07 / VOSS, Matthew Ernst 2000 Galloping Hill Road Kenilworth NewJersey 07033 / US
	08 / KIROVA-SNOVER, Margarita 21 Bolivar Avenue Troy New York 12180 / US
	09 / PAN, Weidong 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	10 / TIAN, Yuan 320 Bent Street Cambridge Massachusetts 02141 / US
	11 / KULKARNI, Bheemashankar, A. 132 North Street 4 Newton Massachusetts 02460 / US
	12 / GIBEAU, Craig, R. 320 Bent Street Cambridge Massachusetts 02141 / US
	13 / LIU, Yuan 320 Bent Street Cambridge Massachusetts 02141 / US
	14 / SCAPIN, Giovanna 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	15 / RINDGEN, Diane 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	16 / DOLL, Ronald, J. 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	17 / GUZI, Timothy, J. 320 Bent Street Cambridge Massachusetts 02141 / US
	18 / HICKLIN, Danny, J. 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	19 / NOMEIR, Amin 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	20 / SEIDEL-DUGAN, Cynthia 2000 Galloping Hill Road Kenilworth New Jersey 07033 / US
	21 / SHIPPS, Gerald, W., Jr. 320 Bent Street Cambridge Massachusetts 02141 / US
	22 / MACCOSS, Malcolm 48 Rose Court Freehold New Jersey 07728 / US
	[2012/34]
Representative(s)	Hussain, Deeba Merck Sharp & Dohme (UK) Limited 120 Moorgate London EC2M 6UR / GB
	[N/P]
Former [2020/34]	Hussain, Deeba Merck & Co., Inc. Patent Department Hertford Road Hoddesdon Hertfordshire EN11 9BU / GB
Former [2012/34]	Hussain, Deeba Merck & Co., Inc. Patent Department Hertford Road Hoddesdon Hertfordshire EN11 9BU / GB
Application number, filing date	10823840.3	05.10.2010
	[2020/34]
	WO2010US51403
Priority number, date	US20090251603P	14.10.2009 Original published format: US 251603 P
	US20090252468P	16.10.2009 Original published format: US 252468 P
	[2012/34]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2011046771
	Date:	21.04.2011
	Language:	EN
	[2011/16]
	Type:	A1 Application with search report
	No.:	EP2488028
	Date:	22.08.2012
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 21.04.2011 takes the place of the publication of the European patent application.
	[2012/34]
	Type:	B1 Patent specification
	No.:	EP2488028
	Date:	19.08.2020
	Language:	EN
	[2020/34]
Search report(s)	International search report - published on:	US	21.04.2011
	(Supplementary) European search report - dispatched on:	EP	04.04.2013
Classification	IPC:	C07D401/14, C07D409/14	[2013/18]
	CPC:	C07D401/14 (EP,CN,KR,US); C07D409/14 (EP,CN,KR,US); A61K31/4436 (KR); A61P1/04 (EP); A61P13/12 (EP); A61P17/06 (EP); (+) A61P19/02 (EP); A61P31/04 (EP); A61P31/10 (EP); A61P35/00 (EP); A61P35/02 (EP); A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP); A61P43/00 (EP); A61P9/00 (EP); A61P9/10 (EP) (-)
	Former IPC [2012/34]	A01N43/40, A61K31/445
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/34]
Extension states	BA	14.05.2012
	ME	14.05.2012
Title	German:	SUBSTITUIERTE PIPERIDINE ZUR ERHÖHUNG DER P53-AKTIVITÄT UND IHRE VERWENDUNG	[2012/34]
	English:	SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF	[2020/13]
	French:	PIPÉRIDINES SUBSTITUÉES QUI ACCROISSENT L'ACTIVITÉ DE P53 ET UTILISATIONS DE CES COMPOSÉS	[2020/13]
	Former [2012/34]	SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
	Former [2012/34]	PIPÉRIDINES SUBSTITUÉES QUI ACCROISSENT L'ACTIVITÉ DE P53, ET UTILISATIONS DE CES COMPOSÉS
Entry into regional phase	14.05.2012	National basic fee paid
	14.05.2012	Search fee paid
	14.05.2012	Designation fee(s) paid
	14.05.2012	Examination fee paid
Examination procedure	14.05.2012	Examination requested [2012/34]
	01.11.2013	Amendment by applicant (claims and/or description)
	29.04.2015	Despatch of a communication from the examining division (Time limit: M06)
	06.11.2015	Reply to a communication from the examining division
	28.05.2018	Despatch of a communication from the examining division (Time limit: M06)
	05.12.2018	Reply to a communication from the examining division
	18.04.2019	Despatch of a communication from the examining division (Time limit: M04)
	15.08.2019	Reply to a communication from the examining division
	07.10.2019	Communication of intention to grant the patent
	06.02.2020	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
	28.02.2020	Communication of intention to grant the patent
	07.07.2020	Receipt of the translation of the claim(s)
	09.07.2020	Fee for grant paid
	09.07.2020	Fee for publishing/printing paid
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 29.04.2015
Opposition(s)	20.05.2021	No opposition filed within time limit [2021/30]
Fees paid	Renewal fee
	05.10.2012	Renewal fee patent year 03
	07.10.2013	Renewal fee patent year 04
	07.10.2014	Renewal fee patent year 05
	07.10.2015	Renewal fee patent year 06
	07.10.2016	Renewal fee patent year 07
	10.10.2017	Renewal fee patent year 08
	08.10.2018	Renewal fee patent year 09
	08.10.2019	Renewal fee patent year 10
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	05.10.2010
	AL	19.08.2020
	AT	19.08.2020
	CY	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	MK	19.08.2020
	MT	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SI	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	TR	19.08.2020
	IE	05.10.2020
	LU	05.10.2020
	BE	31.10.2020
	CH	31.10.2020
	LI	31.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
	[2022/32]
Former [2022/27]	HU	05.10.2010
	AL	19.08.2020
	AT	19.08.2020
	CY	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	MT	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SI	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	TR	19.08.2020
	IE	05.10.2020
	LU	05.10.2020
	BE	31.10.2020
	CH	31.10.2020
	LI	31.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2022/26]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SI	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	TR	19.08.2020
	IE	05.10.2020
	LU	05.10.2020
	BE	31.10.2020
	CH	31.10.2020
	LI	31.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/46]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SI	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	IE	05.10.2020
	LU	05.10.2020
	BE	31.10.2020
	CH	31.10.2020
	LI	31.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/37]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SI	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	LU	05.10.2020
	BE	31.10.2020
	CH	31.10.2020
	LI	31.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/36]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SI	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	LU	05.10.2020
	BE	31.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/34]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	IT	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	LU	05.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/31]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	MC	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	LU	05.10.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/28]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SK	19.08.2020
	SM	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/25]	AL	19.08.2020
	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	ES	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SM	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/24]	AT	19.08.2020
	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SM	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/23]	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	SM	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/22]	CZ	19.08.2020
	DK	19.08.2020
	EE	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RO	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/21]	DK	19.08.2020
	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/12]	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	NL	19.08.2020
	PL	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/10]	FI	19.08.2020
	HR	19.08.2020
	LT	19.08.2020
	LV	19.08.2020
	PL	19.08.2020
	RS	19.08.2020
	SE	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	IS	19.12.2020
	PT	21.12.2020
Former [2021/09]	FI	19.08.2020
	LT	19.08.2020
	SE	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	GR	20.11.2020
	PT	21.12.2020
Former [2021/08]	FI	19.08.2020
	LT	19.08.2020
	SE	19.08.2020
	BG	19.11.2020
	NO	19.11.2020
	PT	21.12.2020
Former [2021/07]	FI	19.08.2020
	LT	19.08.2020
	NO	19.11.2020
Documents cited:	Search	[ ] - No further relevant documents disclosed
	International search	[X]US2008004287 (MA YAO [US], et al);
		[AE]US7807672 (DENG YONGQI [US], et al)
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