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Extract from the Register of European Patents

EP About this file: EP2495568

EP2495568 - Method for determining sensitivity to an anticancer agent [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.06.2019
Database last updated on 17.09.2024
FormerThe patent has been granted
Status updated on  20.07.2018
FormerGrant of patent is intended
Status updated on  22.03.2018
FormerExamination is in progress
Status updated on  02.12.2016
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY, MK		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Keio University
15-45 Mita 2-chome Minato-ku
Tokyo 108-8345 / JP
For all designated states
Kabushiki Kaisha Yakult Honsha
1-19, Higashi-Shinbashi, 1-Chome
Minato-ku
Tokyo 105-8660 / JP
[2018/33]
Former [2012/36]For all designated states
Keio University
15-45 Mita 2-chome Minato-ku
Tokyo 108-8345 / JP
For all designated states
Kabushiki Kaisha Yakult Honsha
1-19, Higashi Shimbashi 1-chome Minato-ku
Tokyo 105-8660 / JP
Inventor(s)01 / Tanigawara, Yusuke
c/o School of Medicine
Keio University
35, Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
02 / Suzuki, Sayo
c/o School of Medicine
Keio University
35, Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
03 / Irie, Hidehiro
c/o School of Medicine
Keio University
35, Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
04 / Nishimuta, Akito
c/o School of Medicine
Keio University
35, Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
05 / Suzuki, Tetsuya
c/o School of Medicine
Keio University
35, Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
06 / Sugimoto, Shinji
c/o Kabushiki Kaisha Yakult Honsha
1-19, Higashi-Shinbashi, 1-Chome
Minato-ku
Tokyo 105-8660 / JP
 [2018/33]
Former [2012/36]01 / Tanigawara, Yusuke
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
02 / Suzuki, Sayo
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
03 / Irie, Hidehiro
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
04 / Nishimuta, Akito
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
05 / Suzuki, Tetsuya
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
06 / Sugimoto, Shinji
c/o Kabushiki Kaisha Yakult Honsha
1-19 Higashi Shinbashi 1-chome
Minato-ku
Tokyo 105-8660 / JP
Representative(s)Blodig, Wolfgang, et al
Wächtershäuser & Hartz
Patentanwaltspartnerschaft mbB
Weinstrasse 8
80333 München / DE
[2018/34]
Former [2012/36]Blodig, Wolfgang, et al
Wächtershäuser & Hartz
Patentanwaltspartnerschaft
Ottostrasse 4
80333 München / DE
Application number, filing date10826878.029.10.2010
[2018/34]
WO2010JP69362
Priority number, dateJP2009025025730.10.2009         Original published format: JP 2009250257
JP2010002045601.02.2010         Original published format: JP 2010020456
[2012/36]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011052748
Date:05.05.2011
Language:JA
[2011/18]
Type: A1 Application with search report 
No.:EP2495568
Date:05.09.2012
Language:EN
[2012/36]
Type: B1 Patent specification 
No.:EP2495568
Date:22.08.2018
Language:EN
[2018/34]
Search report(s)International search report - published on:JP05.05.2011
(Supplementary) European search report - dispatched on:EP12.03.2013
ClassificationIPC:A61K31/4745, A61K31/513, A61K45/06, G01N33/574
[2018/11]
CPC:
G01N33/574 (EP,US); A61K31/4745 (EP,US); A61K31/513 (EP,US);
A61K45/06 (EP,US); A61P35/00 (EP); A61P43/00 (EP);
G01N2800/52 (EP,US) (-)
C-Set:
A61K31/4745, A61K2300/00 (EP,US);
A61K31/513, A61K2300/00 (US,EP)
Former IPC [2012/36]G01N33/68, A61K31/4745, A61K31/513, A61K45/06, A61P35/00, A61P43/00, G01N27/62, G01N33/15, G01N33/50
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/36]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR BESTIMMUNG DER EMPFINDLICHKEIT FÜR EIN ANTIKREBSMITTEL[2012/36]
English:Method for determining sensitivity to an anticancer agent[2012/36]
French:Procédé de détermination de la sensibilité à un agent anticancéreux[2012/36]
Entry into regional phase24.04.2012Translation filed 
24.04.2012National basic fee paid 
24.04.2012Search fee paid 
24.04.2012Designation fee(s) paid 
24.04.2012Examination fee paid 
Examination procedure24.04.2012Examination requested  [2012/36]
01.10.2013Amendment by applicant (claims and/or description)
11.11.2013Despatch of a communication from the examining division (Time limit: M04)
11.03.2014Reply to a communication from the examining division
24.03.2014Despatch of a communication from the examining division (Time limit: M04)
24.07.2014Reply to a communication from the examining division
11.08.2015Despatch of a communication from the examining division (Time limit: M04)
10.12.2015Reply to a communication from the examining division
10.08.2016Despatch of a communication from the examining division (Time limit: M06)
03.02.2017Reply to a communication from the examining division
13.07.2017Despatch of a communication from the examining division (Time limit: M04)
17.10.2017Reply to a communication from the examining division
22.03.2018Communication of intention to grant the patent
05.07.2018Fee for grant paid
05.07.2018Fee for publishing/printing paid
05.07.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.11.2013
Opposition(s)23.05.2019No opposition filed within time limit [2019/31]
Fees paidRenewal fee
02.10.2012Renewal fee patent year 03
21.10.2013Renewal fee patent year 04
29.10.2014Renewal fee patent year 05
31.10.2015Renewal fee patent year 06
31.10.2016Renewal fee patent year 07
31.10.2017Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU29.10.2010
AL22.08.2018
AT22.08.2018
CY22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
MK22.08.2018
NL22.08.2018
PL22.08.2018
PT22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
IE29.10.2018
LU29.10.2018
MT29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
[2020/31]
Former [2020/30]HU29.10.2010
AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
PT22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
IE29.10.2018
LU29.10.2018
MT29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2020/27]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
PT22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
IE29.10.2018
LU29.10.2018
MT29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2020/17]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
TR22.08.2018
IE29.10.2018
LU29.10.2018
MT29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2020/08]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
IE29.10.2018
LU29.10.2018
MT29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/48]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
IE29.10.2018
LU29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/40]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
LU29.10.2018
BE31.10.2018
CH31.10.2018
LI31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/38]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
LU29.10.2018
BE31.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/37]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SI22.08.2018
SK22.08.2018
SM22.08.2018
LU29.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/30]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SK22.08.2018
SM22.08.2018
LU29.10.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/28]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
MC22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/26]AL22.08.2018
AT22.08.2018
CZ22.08.2018
DK22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SK22.08.2018
SM22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/23]AL22.08.2018
AT22.08.2018
CZ22.08.2018
EE22.08.2018
ES22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
SK22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/22]AL22.08.2018
CZ22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
PL22.08.2018
RO22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/21]AL22.08.2018
FI22.08.2018
HR22.08.2018
IT22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/12]AL22.08.2018
FI22.08.2018
HR22.08.2018
LT22.08.2018
LV22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/11]FI22.08.2018
HR22.08.2018
LT22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/10]FI22.08.2018
LT22.08.2018
NL22.08.2018
RS22.08.2018
SE22.08.2018
BG22.11.2018
NO22.11.2018
GR23.11.2018
IS22.12.2018
Former [2019/09]FI22.08.2018
LT22.08.2018
NL22.08.2018
NO22.11.2018
IS22.12.2018
Former [2019/08]FI22.08.2018
LT22.08.2018
NO22.11.2018
IS22.12.2018
Former [2019/07]LT22.08.2018
Documents cited:Search[X]WO2007002069  (GONCALVES ANTHONY [US], et al) [X] 1-15 * claims 1-35 * * table 1 *;
 [X]WO2007071914  (CYCLACEL LTD [GB], et al) [X] 1-15 * claims 1-29 * * example 1 *;
 [X]  - EUN-KYOUNG YIM ET AL, "Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells.", DNA AND CELL BIOLOGY, (20041101), vol. 23, no. 11, doi:10.1089/1044549042531404, ISSN 1044-5498, pages 769 - 776, XP055055064 [X] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1089/dna.2004.23.769
 [X]  - LAJOS PUSZTAI ET AL, "Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma", CANCER, (20040501), vol. 100, no. 9, doi:10.1002/cncr.20203, ISSN 0008-543X, pages 1814 - 1822, XP055055068 [X] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1002/cncr.20203
International search[X]WO2009096196  (UNIV KEIO [JP], et al);
 [A]WO2009096189  (UNIV KEIO [JP], et al);
 [A]  - KOICHI TAKAGI ET AL., "CDK inhibitor enhances the sensitivity to 5-FU in colorectal cancer cells", 66TH ANNUAL MEETING OF THE JAPAN CANCER ASSOCIATION KOEN YOSHISHU, page 45 0-023, XP008156454
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.