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Extract from the Register of European Patents

EP About this file: EP2493310

EP2493310 - BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 24.04.2015 Database last updated on 24.08.2024
Most recent event Tooltip	24.04.2015	Application deemed to be withdrawn	published on 27.05.2015 [2015/22]
Applicant(s)	For all designated states GlaxoSmithKline LLC One Franklin Plaza 200 North 16th Street Philadelphia, PA 19102 / US
	[N/P]
Former [2012/36]	For all designated states GlaxoSmithKline LLC One Franklin Plaza 200 North 16th Street Philadelphia, PA 19102 / US
Inventor(s)	01 / HALLMAN, Jason Five Moore Drive Cary NC 27513 / US
	02 / LAUDEMAN, Christopher Five Moore Drive Durham NC 27712 / US
	03 / LIU, Ronggang Five Moore Drive Berwyn PA 19312 / US
	04 / MILLER, Aaron Five Moore Drive Research Triangle Park NC 27709 / US
	05 / MOORE, Michael, Lee 1250 South Collegeville Road Collegeville PA 19426 / US
	06 / DOCK, Steven Five Moore Drive Research Triangle Park NC 27709 / US
	07 / MUSSO, David Five Moore Drive Raleigh NC 27615 / US
	08 / PARRISH, Cynthia 1250 South Collegeville Road Collegeville PA 19426 / US
	[2012/36]
Representative(s)	Reed, Michael Antony GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
	[N/P]
Former [2012/36]	Reed, Michael Antony GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
Application number, filing date	10828881.2	27.10.2010
	WO2010US54230
Priority number, date	US20090256096P	29.10.2009 Original published format: US 256096 P
	US20090255230P	27.10.2009 Original published format: US 255230 P
	[2012/36]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2011056635
	Date:	12.05.2011
	Language:	EN
	[2011/19]
	Type:	A1 Application with search report
	No.:	EP2493310
	Date:	05.09.2012
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 12.05.2011 takes the place of the publication of the European patent application.
	[2012/36]
Search report(s)	International search report - published on:	US	12.05.2011
	(Supplementary) European search report - dispatched on:	EP	07.02.2014
Classification	IPC:	A01N43/50, A61K31/415, C07D403/06, C07D403/14, C07D405/14, C07D413/14, C07D417/14, C07D471/04	[2014/11]
	CPC:	C07D403/14 (EP,US); A61P35/00 (EP); A61P35/02 (EP); A61P43/00 (EP); C07D403/06 (EP,US); C07D405/14 (EP,US); (+) C07D413/14 (EP,US); C07D417/14 (EP,US); C07D471/04 (EP,US) (-)
	Former IPC [2012/36]	A01N43/50, A61K31/415
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/36]
Title	German:	BENZIMIDAZOLE ALS FETTSÄURE-SYNTHASE-HEMMER	[2012/36]
	English:	BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS	[2012/36]
	French:	BENZIMIDAZOLES UTILISÉS EN TANT QU'INHIBITEURS DE L'ACIDE GRAS SYNTHASE	[2012/36]
Entry into regional phase	18.05.2012	National basic fee paid
	18.05.2012	Search fee paid
	18.05.2012	Designation fee(s) paid
	18.05.2012	Examination fee paid
Examination procedure	18.05.2012	Amendment by applicant (claims and/or description)
	18.05.2012	Examination requested [2012/36]
	09.09.2014	Application deemed to be withdrawn, date of legal effect [2015/22]
	21.11.2014	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2015/22]
Fees paid	Renewal fee
	05.10.2012	Renewal fee patent year 03
	07.10.2013	Renewal fee patent year 04
	Penalty fee
	Additional fee for renewal fee
	31.10.2014	05 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A] - HORIGUCHI A ET AL, "Pharmacological Inhibitor of Fatty Acid Synthase Suppresses Growth and Invasiveness of Renal Cancer Cells", JOURNAL OF UROLOGY, LIPPINCOTT WILLIAMS & WILKINS, BALTIMORE, MD, US, vol. 180, no. 2, doi:10.1016/J.JURO.2008.03.186, ISSN 0022-5347, (20080801), pages 729 - 736, (20080613), XP022825417 [A] 1-12 * the whole document * DOI: http://dx.doi.org/10.1016/j.juro.2008.03.186
		[A] - XUAN WANG ET AL, "The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase", BIOCHEMICAL PHARMACOLOGY, (20031101), vol. 66, no. 10, doi:10.1016/S0006-2952(03)00585-9, ISSN 0006-2952, pages 2039 - 2047, XP055099173 [A] 1-12 * the whole document * DOI: http://dx.doi.org/10.1016/S0006-2952(03)00585-9
		[A] - THUPARI ET AL, "Fatty Acid Synthase Inhibition in Human Breast Cancer Cells Leads to Malonyl-CoA-Induced Inhibition of Fatty Acid Oxidation and Cytotoxicity", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20010713), vol. 285, no. 2, doi:10.1006/BBRC.2001.5146, ISSN 0006-291X, pages 217 - 223, XP005100767 [A] 1-12 * the whole document * DOI: http://dx.doi.org/10.1006/bbrc.2001.5146
		[A] - ZHANG S Y ET AL, "Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 371, no. 4, doi:10.1016/J.BBRC.2008.04.062, ISSN 0006-291X, (20080711), pages 654 - 658, (20080422), XP022688438 [A] 1-12 * the whole document * DOI: http://dx.doi.org/10.1016/j.bbrc.2008.04.062
		[A] - YU F ET AL, "Inhibition of Coix seed extract on fatty acid synthase, a novel target for anticancer activity", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 119, no. 2, doi:10.1016/J.JEP.2008.07.015, ISSN 0378-8741, (20080926), pages 252 - 258, (20080723), XP025399344 [A] 1-12 * the whole document * DOI: http://dx.doi.org/10.1016/j.jep.2008.07.015
		[A] - WENG ET AL, "Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, (20070201), vol. 218, no. 2, doi:10.1016/J.TAAP.2006.10.021, ISSN 0041-008X, pages 107 - 118, XP005737697 [A] 1-12 * the whole document * DOI: http://dx.doi.org/10.1016/j.taap.2006.10.021
	International search	[X]US2007004713 (BARLAAM BERNARD [FR], et al);
		[Y]US2007043043 (CHEN DIZHONG [SG], et al)

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