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Extract from the Register of European Patents

EP About this file: EP2502993

EP2502993 - HUMAN ARTIFICIAL CHROMOSOME VECTOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.06.2018
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  23.06.2017
FormerGrant of patent is intended
Status updated on  13.02.2017
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
SAB, LLC
2301 E 60th Street North
Sioux Falls, SD 57104 / US
[2017/44]
Former [2013/24]For all designated states
Sanford Applied Biosciences L.L.C.
2301 E 60th Street North
Sioux Falls SD 57104 / US
Former [2012/39]For all designated states
Kyowa Hakko Kirin Co., Ltd.
1-6-1, Ohtemachi Chiyoda-ku
Tokyo 100-8185 / JP
Inventor(s)01 / KUROIWA Yoshimi
c/o Hematech Inc.
4401 South Technology Drive
Sioux Falls, SD 57106 / US
02 / MATSUSHITA Hiroaki
c/o Hematech Inc.
4401 South Technology Drive
Sioux Falls, SD 57106 / US
03 / SANO Akiko
c/o Biologics Research Laboratories
Kyowa Hakko Kirin Co., Ltd.
6-6, Asahi-machi 3-chome
Machida-shi Tokyo 194-8533 / JP
 [2012/39]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2017/30]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2012/39]Woods, Geoffrey Corlett
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date10831601.917.11.2010
[2017/30]
WO2010JP70514
Priority number, dateUS20090261935P17.11.2009         Original published format: US 261935 P
[2012/39]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011062207
Date:26.05.2011
Language:JA
[2011/21]
Type: A1 Application with search report 
No.:EP2502993
Date:26.09.2012
Language:EN
[2012/39]
Type: B1 Patent specification 
No.:EP2502993
Date:26.07.2017
Language:EN
[2017/30]
Search report(s)International search report - published on:JP26.05.2011
(Supplementary) European search report - dispatched on:EP15.05.2013
ClassificationIPC:C12N15/09, A01K67/027, C07K16/00, // C07K16/12, C12N15/85
[2013/24]
CPC:
C07K16/00 (EP,US); A01K67/0278 (US); C07K16/1278 (EP,US);
C12N15/85 (EP,US); C12N15/8509 (EP,US); A01K2207/15 (EP,US);
A01K2217/052 (US); A01K2217/072 (EP,US); A01K2227/101 (EP,US);
A01K2267/01 (EP,US); C12N2800/208 (EP,US) (-)
Former IPC [2012/39]C12N15/09, A01K67/027, C07K16/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/39]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HAC-VEKTOR (HUMAN ARTIFICIAL CHROMOSOME - KÜNSTLICHES MENSCHLICHES CHROMOSOM)[2012/39]
English:HUMAN ARTIFICIAL CHROMOSOME VECTOR[2012/39]
French:VECTEUR DE CHROMOSOME HUMAIN ARTIFICIEL[2012/39]
Entry into regional phase16.05.2012Translation filed 
16.05.2012National basic fee paid 
16.05.2012Search fee paid 
16.05.2012Designation fee(s) paid 
16.05.2012Examination fee paid 
Examination procedure16.05.2012Examination requested  [2012/39]
02.12.2013Amendment by applicant (claims and/or description)
19.05.2015Despatch of a communication from the examining division (Time limit: M04)
21.09.2015Reply to a communication from the examining division
03.01.2017Cancellation of oral proceeding that was planned for 31.01.2017
31.01.2017Date of oral proceedings (cancelled)
14.02.2017Communication of intention to grant the patent
13.06.2017Fee for grant paid
13.06.2017Fee for publishing/printing paid
13.06.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.05.2015
Opposition(s)30.04.2018No opposition filed within time limit [2018/27]
Fees paidRenewal fee
13.11.2012Renewal fee patent year 03
27.11.2013Renewal fee patent year 04
26.11.2014Renewal fee patent year 05
30.11.2015Renewal fee patent year 06
28.11.2016Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU17.11.2010
AL26.07.2017
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
[2020/33]
Former [2020/27]HU17.11.2010
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
Former [2020/15]HU17.11.2010
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
Former [2019/52]HU17.11.2010
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
Former [2019/46]HU17.11.2010
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
Former [2019/31]HU17.11.2010
AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
Former [2018/50]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
BE30.11.2017
CH30.11.2017
LI30.11.2017
Former [2018/45]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IE17.11.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
CH30.11.2017
LI30.11.2017
Former [2018/43]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
LU17.11.2017
MT17.11.2017
IS26.11.2017
CH30.11.2017
LI30.11.2017
Former [2018/39]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
LU17.11.2017
IS26.11.2017
CH30.11.2017
LI30.11.2017
Former [2018/33]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
CH30.11.2017
LI30.11.2017
Former [2018/24]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/23]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SK26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/21]AT26.07.2017
CZ26.07.2017
DK26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/12]AT26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/11]AT26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/10]AT26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
NL26.07.2017
RS26.07.2017
SE26.07.2017
NO26.10.2017
Former [2018/09]FI26.07.2017
LT26.07.2017
NL26.07.2017
SE26.07.2017
NO26.10.2017
Former [2018/08]FI26.07.2017
LT26.07.2017
NL26.07.2017
NO26.10.2017
Former [2018/07]LT26.07.2017
NO26.10.2017
Documents cited:Search[A]  - YOSHIMI KUROIWA ET AL, "Antigen-specific human polyclonal antibodies from hyperimmunized cattle", NATURE BIOTECHNOLOGY, (20090201), vol. 27, no. 2, doi:10.1038/nbt.1521, ISSN 1087-0156, pages 173 - 181, XP055012629 [A] 1-7 * page 173, paragraph last - page 174, paragraph first; figure 1 * * page 178, column left, paragraph 2nd - paragraph 3rd *

DOI:   http://dx.doi.org/10.1038/nbt.1521
 [T]  - LONBERG NILS, "Human antibodies from transgenic animals", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20050901), vol. 23, no. 9, doi:10.1038/NBT1135, ISSN 1087-0156, pages 1117 - 1125, XP002442149 [T] * page 1122 - page 1123; figure 3 *

DOI:   http://dx.doi.org/10.1038/nbt1135
 [T]  - PENICHET M L ET AL, "Design and engineering human forms of monoclonal antibodies", DRUG DEVELOPMENT RESEARCH, NEW YORK, NY, US, (20040301), vol. 61, no. 3, doi:10.1002/DDR.10347, ISSN 0272-4391, pages 121 - 136, XP002397470 [T] * page 126 - page 127, column left; figure 5 *

DOI:   http://dx.doi.org/10.1002/ddr.10347
International search[A]WO9707671  (KIRIN BREWERY [JP], et al);
 [A]WO02092812  (KIRIN BREWERY [JP], et al);
 [A]WO2005104835  (HEMATECH LLC [US], et al);
 [A]WO2008118970  (SEA LANE BIOTECHNOLOGIES LLC [US], et al);
 [A]  - TOMIZUKA K. ET AL., "Functional expression and germline transmission of a human chromosome fragment in chimaeric mice", NAT. GENET., (199706), vol. 16, no. 2, pages 133 - 143, XP008156351

DOI:   http://dx.doi.org/10.1038/ng0697-133
 [A]  - TOMIZUKA K. ET AL., "Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and K loci and expression of fully human antibodies", PROC. NATL. ACAD. SCI. USA., (20000118), vol. 97, no. 2, pages 722 - 727, XP008156360

DOI:   http://dx.doi.org/10.1073/pnas.97.2.722
Examination   - AKIKO SANO ET AL, "Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle", PLOS ONE, (20131024), vol. 8, no. 10, doi:10.1371/journal.pone.0078119, page e78119, XP055188762

DOI:   http://dx.doi.org/10.1371/journal.pone.0078119
    - L. M. Zimmerman ET AL, "Understanding the vertebrate immune system: insights from the reptilian perspective", JOURNAL OF EXPERIMENTAL BIOLOGY., GB, (20100212), vol. 213, no. 5, doi:10.1242/jeb.038315, ISSN 0022-0949, pages 661 - 671, XP055294962

DOI:   http://dx.doi.org/10.1242/jeb.038315
by applicantWO9707671
 WO9837757
 WO0010383
 WO02051997
 WO02070648
 WO02092812
 WO03097812
 WO2005104835
 WO2008013067
 WO2009111086
    - TOMIZUKA ET AL., NATURE GENETICS, (1997), vol. 16, pages 133 - 143
    - KUROIWA ET AL., NATURE BIOTECHNOLOGY, (2000), vol. 18, pages 1086 - 1090
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    - KUROIWA ET AL., NATURE GENETICS, (2004), vol. 36, pages 775 - 780
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    - KUROIWA, NATURE BIOTECHNOLOGY, (2009), vol. 27, pages 173 - 181
    - KUROIWA ET AL., NATURE BIOTECHNOLOGY, vol. 20, pages 889 - 894
    - THE PROSTATE, (2007), vol. 67, page 1163
    - KUROIWA ET AL., NAT BIOTECHNOL., (2000), vol. 18, pages 1086 - 1090
    - KUROIWA ET AL., NAT BIOTECHNOL., (2002), vol. 20, pages 889 - 894
    - KUROIWA ET AL., NAT BIOTECHNOL., (2009), vol. 27, pages 173 - 181
    - KUROIWA ET AL., NAT. BIOTECHNOL., (2009), vol. 27, pages 173 - 181
    - KUROIWA ET AL., NUCLEIC ACIDS RES, (1998), vol. 26, pages 3447 - 3448
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    - KATOH ET AL., CELL STRUCTURE AND FUNCTION, (1987), vol. 12, pages 575 - 580
    - OSHIMURA ET AL., ENVIRONMENTAL HEALTH PERSPECTIVES, (1991), vol. 93, pages 57 - 58
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.