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Extract from the Register of European Patents

EP About this file: EP2507630

EP2507630 - BIOMARKERS FOR DETERMINING AN ALLOGRAFT TOLERANT PHENOTYPE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.12.2017
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  23.12.2016
FormerGrant of patent is intended
Status updated on  11.11.2016
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
The Board of Trustees of the Leland Stanford Junior University
Office of the General Counsel
Building 170, 3rd Floor, Main Quad
P.O.Box 20386
Stanford, California 94305-2038 / US
[2017/13]
Former [2017/04]For all designated states
The Board of Trustees of the Leland Stanford Junior University
1705 El Camino Real
Palo Alto, CA 94306-1106 / US
Former [2012/41]For all designated states
The Board of Trustees of the Leland Stanford Junior University
1705 El Camino Real
Palo Alto, CA 94306-1106 / US
Inventor(s)01 / SARWAL, Minnie M.
305 Willowbrook Drive
Portola Valley, CA 94028 / US
02 / LI, Li
5321 Shattuck Avenue
Fremont, CA 94305 / US
 [2017/07]
Former [2012/41]01 / SARWAL, Minnie M.
305 Willowbrook Drive
Portola Valley, CA 94028 / US
02 / LI, Li
5321 Shattuck Avenue
Fremont, CA 94305 / US
03 / STROBER, Samuel
269 Campus Drive 215
Mail Code: 5166
Stanford, CA 94305 / US
Representative(s)Campbell, Joanne Marie
Stevens, Hewlett & Perkins
1 St. Augustine's Place
Bristol BS1 4UD / GB
[N/P]
Former [2017/04]Heaton, Joanne Marie
Stevens, Hewlett & Perkins
1 St. Augustine's Place
Bristol BS1 4UD / GB
Former [2012/41]Heaton, Joanne Marie
Stevens, Hewlett & Perkins 1 St. Augustine's Place
Bristol BS1 4UD / GB
Application number, filing date10835023.201.12.2010
[2017/04]
WO2010US58496
Priority number, dateUS20090283393P02.12.2009         Original published format: US 283393 P
[2012/41]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011068829
Date:09.06.2011
Language:EN
[2011/23]
Type: A1 Application with search report 
No.:EP2507630
Date:10.10.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 09.06.2011 takes the place of the publication of the European patent application.
[2012/41]
Type: B1 Patent specification 
No.:EP2507630
Date:25.01.2017
Language:EN
[2017/04]
Search report(s)International search report - published on:US09.06.2011
(Supplementary) European search report - dispatched on:EP06.06.2013
ClassificationIPC:G01N33/53, C12Q1/68
[2012/41]
CPC:
C12Q1/6883 (EP,US); C12Q1/6888 (EP,US); G01N33/6893 (US);
C12Q2600/106 (US); C12Q2600/158 (EP,US); G01N2800/245 (US);
G01N2800/52 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/41]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:BIOMARKER ZUR BESTIMMUNG EINES ALLOTRANSPLANTATTOLERANTEN PHÄNOTYPS[2012/41]
English:BIOMARKERS FOR DETERMINING AN ALLOGRAFT TOLERANT PHENOTYPE[2012/41]
French:BIOMARQUEURS POUR DÉTERMINER UN XÉNOTYPE TOLÉRANT À L'ALLOGREFFE[2012/41]
Entry into regional phase21.06.2012National basic fee paid 
21.06.2012Search fee paid 
21.06.2012Designation fee(s) paid 
21.06.2012Examination fee paid 
Examination procedure21.06.2012Examination requested  [2012/41]
31.12.2013Amendment by applicant (claims and/or description)
19.08.2014Despatch of a communication from the examining division (Time limit: M06)
18.02.2015Reply to a communication from the examining division
16.07.2015Despatch of a communication from the examining division (Time limit: M04)
19.11.2015Reply to a communication from the examining division
06.07.2016Communication of intention to grant the patent
07.11.2016Fee for grant paid
07.11.2016Fee for publishing/printing paid
07.11.2016Receipt of the translation of the claim(s)
Divisional application(s)EP17151969.7  / EP3185013
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.08.2014
Opposition(s)26.10.2017No opposition filed within time limit [2018/01]
Fees paidRenewal fee
11.12.2012Renewal fee patent year 03
12.12.2013Renewal fee patent year 04
11.12.2014Renewal fee patent year 05
10.12.2015Renewal fee patent year 06
13.12.2016Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.12.2010
AL25.01.2017
AT25.01.2017
CY25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
MC25.01.2017
MK25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
TR25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
[2020/33]
Former [2020/15]HU01.12.2010
AT25.01.2017
CY25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
MC25.01.2017
MK25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
TR25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2019/52]HU01.12.2010
AT25.01.2017
CY25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
MC25.01.2017
MK25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2019/46]HU01.12.2010
AT25.01.2017
CY25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
MC25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2019/31]HU01.12.2010
AT25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
MC25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2019/30]AT25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
MC25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2018/14]AT25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SI25.01.2017
SK25.01.2017
SM25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2017/51]AT25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SK25.01.2017
SM25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2017/50]AT25.01.2017
CZ25.01.2017
DK25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SK25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2017/49]AT25.01.2017
CZ25.01.2017
EE25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
NL25.01.2017
PL25.01.2017
RO25.01.2017
RS25.01.2017
SE25.01.2017
SK25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2017/48]AT25.01.2017
CZ25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
NL25.01.2017
PL25.01.2017
RS25.01.2017
SE25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Former [2017/40]AT25.01.2017
ES25.01.2017
FI25.01.2017
HR25.01.2017
LT25.01.2017
LV25.01.2017
NL25.01.2017
PL25.01.2017
RS25.01.2017
SE25.01.2017
BG25.04.2017
NO25.04.2017
GR26.04.2017
IS25.05.2017
PT25.05.2017
Documents cited:Search[A]EP1731620  (INST NAT SANTE RECH MED [FR]) [A] 1-15 * paragraph [0011] - paragraph [0012] * * paragraph [0019]; table 1 * * examples 1-2 * * claims 1-23 *;
 [X]  - "Agilent whole human genome microarray 4x44K", GEO-NCBI, NCBI, (20080211), Database accession no. GPL6480, URL: NCBI, XP002594592 [X] 10-15 * the whole document *
 [A]  - CHRISTOPHE BRAUD ET AL, "Immunosuppressive drug-free operational immune tolerance in human kidney transplant recipients: Part I. blood gene expression statistical analysis", JOURNAL OF CELLULAR BIOCHEMISTRY, (20080415), vol. 103, no. 6, doi:10.1002/jcb.21574, ISSN 0730-2312, pages 1681 - 1692, XP055063802 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1002/jcb.21574
 [A]  - BROUARD S ET AL, "Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 104, no. 39, doi:10.1073/PNAS.0705834104, ISSN 0027-8424, (20070925), pages 15448 - 15453, (20070914), XP002594926 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1073/PNAS.0705834104
 [A]  - FLECHNER S M ET AL, "Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes", AMERICAN JOURNAL OF TRANSPLANTATION, BLACKWELL MUNKSGAARD, DK, vol. 4, no. 9, doi:10.1111/J.1600-6143.2004.00526.X, ISSN 1600-6135, (20040901), pages 1475 - 1489, (20040607), XP008103279 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1111/J.1600-6143.2004.00526.X
 [A]  - SARWAL M ET AL, "MOLECULAR HETEROGENEITY IN ACUTE RENAL ALLOGRAFT REJECTION IDENTIFIED BY DNA MICROARRAY PROFILING", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, (20030710), vol. 349, no. 2, doi:10.1056/NEJMOA035588, ISSN 1533-4406, pages 125 - 138, XP009045203 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1056/NEJMoa035588
 [A]  - PIERRE SAINT-MEZARD ET AL, "Analysis of independent microarray datasets of renal biopsies identifies a robust transcript signature of acute allograft rejection", TRANSPLANT INTERNATIONAL, (20090301), vol. 22, no. 3, doi:10.1111/j.1432-2277.2008.00790.x, ISSN 0934-0874, pages 293 - 302, XP055063955 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1111/j.1432-2277.2008.00790.x
International search[Y]US2006088876  (BAUER A R [US]);
 [Y]  - MARTINEZ-LLORDELLA ET AL, "Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients.", J CLINICAL INVESTIGATION, (2008), vol. 118, doi:doi:10.1172/JCI35342, pages 2845 - 2857, XP002600788

DOI:   http://dx.doi.org/10.1172/JCI35342
by applicantEP0373203
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 US5288644
 US5324633
 US5432049
 WO9521265
 US5470710
 US5492806
 US5503980
 US5510270
 US5525464
 US5547839
 WO9631622
 US5580732
 WO9710365
 EP0785280
 WO9727317
 US5661028
 US5800992
 US5994076
    - GOMES ET AL., BLOOD, (20010701), vol. 98, no. 1, pages 93 - 99
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.