EP2511281 - ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES AND MEDICINE USES THEREOF [Right-click to bookmark this link] | Status | The application has been withdrawn Status updated on 10.07.2015 Database last updated on 31.08.2024 | Most recent event Tooltip | 05.08.2015 | New entry: Additional fee for renewal fee: despatch of communication + time limit | Applicant(s) | For all designated states Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China No. 27 Taiping Road Haidian District, Beijing 100850 / CN | [2012/42] | Inventor(s) | 01 /
ZHONG, Bohua No. 27 Taiping Road Haidian District Beijing 100850 / CN | 02 /
HE, Xinhua No. 27 Taiping Road Haidian District Beijing 100850 / CN | 03 /
WANG, Yongguang No. 27 Taiping Road Haidian District Beijing 100850 / CN | 04 /
LIU, He No. 27 Taiping Road Haidian District Beijing 100850 / CN | [2012/42] | Representative(s) | Weickmann & Weickmann PartmbB Postfach 860 820 81635 München / DE | [N/P] |
Former [2012/42] | Böhm, Brigitte Weickmann & Weickmann Patentanwälte Postfach 86 08 20 81635 München / DE | Application number, filing date | 10835359.0 | 21.06.2010 | WO2010CN00902 | Priority number, date | CN20091252161 | 10.12.2009 Original published format: CN200910252161 | [2012/42] | Filing language | ZH | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011069322 | Date: | 16.06.2011 | Language: | ZH | [2011/24] | Type: | A1 Application with search report | No.: | EP2511281 | Date: | 17.10.2012 | Language: | EN | [2012/42] | Search report(s) | International search report - published on: | CN | 16.06.2011 | (Supplementary) European search report - dispatched on: | EP | 25.04.2013 | Classification | IPC: | C07F9/40, A61K31/675, A61P31/12, C07F9/6561 | [2013/22] | CPC: |
C07F9/65616 (EP,US);
A61P1/16 (EP);
A61P31/12 (EP);
A61P31/20 (EP)
|
Former IPC [2012/42] | C07F9/40, A61K31/675, A61P31/12 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2012/42] | Title | German: | ACYCLISCHE NUCLEOSIDPHOSPHONATDERIVATE UND IHRE MEDIZINISCHE VERWENDUNG | [2012/42] | English: | ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES AND MEDICINE USES THEREOF | [2012/42] | French: | DÉRIVÉ DE NUCLÉOSIDE PHOSPHONATE ACYCLIQUE ET SON UTILISATION MÉDICALE | [2012/42] | Entry into regional phase | 04.07.2012 | Translation filed | 04.07.2012 | National basic fee paid | 04.07.2012 | Search fee paid | 04.07.2012 | Designation fee(s) paid | 04.07.2012 | Examination fee paid | Examination procedure | 04.07.2012 | Examination requested [2012/42] | 19.11.2013 | Amendment by applicant (claims and/or description) | 30.06.2015 | Application withdrawn by applicant [2015/33] | Fees paid | Renewal fee | 04.07.2012 | Renewal fee patent year 03 | 10.06.2013 | Renewal fee patent year 04 | 12.06.2014 | Renewal fee patent year 05 | Penalty fee | Additional fee for renewal fee | 30.06.2015 | 06   M06   Not yet paid |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XDY]EP0785208 (MITSUBISHI CHEM CORP [JP]) [XD] 1-12 * page 36 - page 37; compounds 1404, 1439 * * Markush formula of :;; claim 1 * * Pharmaceutical compositions :;; claim 17 * * Use of compounds as antiviral agent and for treatment of viral infections like hepatitis;; claims 18-19 * * Process of making the compounds of Markush formula I reacting 6-Chloro-9H-purin-2-amine (formula VI) with phosphonate (formula IV), then reacting with thiophenol derivative (formula VIII) to obtain a formula I' compound, which is then transesterified via hydrolysis to a phosphonic acid I'' (page 45) to a formula XIII compound according to claim 1, see:; page 43 - page 45 * [Y] 1-12; | [Y]CN1827627 (BEIJING MEIBEITA PHARMACEUTICA [CN]) [Y] 1-12 * compound 2,2-dimethyl-propanoic acid 2,2-dimethyl-[[[2-[2-amino-6-[[4-(methylthio)phenyl]thio]-9H-purin-9-yl]ethoxy]methyl]phosphinylidene]bis(oxymethylene)-ester, with CAS registry number 909869-46-1. * * Pharmaceutical composition and use as antiviral agent:;; claim 10 *; | [Y]CN101066981 (SHANGHAI INST OF MEDICINES CAS [CN]) [Y] 1-12 * page 5; compounds 21, 22 * * Use in treatment of viral infections, notably hepatitis and HIV;; claims 6-8 * | [Y] - JIN, YONGZENG ET AL, "Preparation of purine derivatives as antiviral agents for treatment of Hepatitis B", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2006:940072, URL: STN, XP002695611 [Y] 1-12 * abstract * | International search | [X]CN1164534 (MITSUBISHI CHEM CORP [JP]); | [X]CN1827627 (BEIJING MEIBEITA PHARMACEUTICA [CN]); | [A]CN1670024 (INST PHARM & TOXICOLOGY AMMS [CN]) | by applicant | EP0785208 | - CLARK CHAN ET AL., "Clinical Pharmacokinetics of Alamifovir and Its Metabolites", ANTIVICROB AGENTS CHEMOTHER, (2005), vol. 49, no. 5, pages 1813 - 1822 | - KAMIYA N ET AL., "Antiviral activities of MCC-478, a novel and specific inhibitor of hepatitis B Virus", ANTIMICROB AGENTS CHEMOTHER, (2002), vol. 46, no. 9, doi:doi:10.1128/AAC.46.9.2872-2877.2002, page 2872, XP001153184 DOI: http://dx.doi.org/10.1128/AAC.46.9.2872-2877.2002 | - SUZANE KIOKO ONO-NITA; ONO-NITA SK ET AL., "Novel Nucleoside analogue MCC-478 (LY582563)is effective against wild-type or lamivudine-resistant hepatitis B virus", ANTIMICROB AGENTS CHEMOTHER, (2002), vol. 46, doi:doi:10.1128/AAC.46.8.2602-2605.2002, pages 2602 - 2605, XP002245846 DOI: http://dx.doi.org/10.1128/AAC.46.8.2602-2605.2002 | - CLARK CHAN ET AL., "Clinical Pharmaco-kinetics of Alamifovir and Its Metabolites", ANTIVICROB AGENTS CHEMOTHER, (2005), vol. 49, no. 5, pages 1813 - 1822 | - S. M. BERGE ET AL., "Pharmaceutical Salts", J. PHARM. SCI., (1977), vol. 66, doi:doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560 DOI: http://dx.doi.org/10.1002/jps.2600660104 | - PRESCOTT, ED., Methods in Cell Biology, ACADEMIC PRESS, (1976), vol. XIV, page 33 | - CLARK CHAN ET AL., CLINICAL PHARMACO-KINETICS OF ALAMIFOVIR AND ITS METABOLITES ANTIVICROB AGENTS CHEMOTHER, (2005), vol. 49, no. 5, pages 1813 - 1822 |