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Extract from the Register of European Patents

EP About this file: EP2514835

EP2514835 - METHOD FOR ANALYZING CERVICAL LYMPH NODE METASTASIS, AND TUMOR MARKER FOR HEAD AND NECK CANCER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  23.05.2014
Database last updated on 24.08.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
National University Corporation Ehime University
10-13, Dogohimata Matsuyama-shi
Ehime 790-8577 / JP
[2012/43]
Inventor(s)01 / NAKASHIRO, Koichi
c/o Ehime University Graduate School of Medicine
Shitsukawa
Toon-shi Ehime 791-0295 / JP
02 / HAMAKAWA, Hiroyuki
c/o Ehime University Graduate School of Medicine
Shitsukawa
Toon-shi Ehime 791-0295 / JP
03 / GODA, Hiroyuki
c/o Ehime University Hospital
Shitsukawa
Toon-shi Ehime 791-0295 / JP
 [2012/43]
Representative(s)Leathley, Anna Elisabeth, et al
Dehns St Bride's House 10 Salisbury Square London
EC4Y 8JD / GB
[2012/43]
Application number, filing date10839453.722.12.2010
WO2010JP73129
Priority number, dateJP2009029261124.12.2009         Original published format: JP 2009292611
[2012/43]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011078223
Date:30.06.2011
Language:JA
[2011/26]
Type: A1 Application with search report 
No.:EP2514835
Date:24.10.2012
Language:EN
[2012/43]
Type: B1 Patent specification 
No.:EP2514835
Date:17.07.2013
Language:EN
[2013/29]
Search report(s)International search report - published on:JP30.06.2011
(Supplementary) European search report - dispatched on:EP25.10.2012
ClassificationIPC:C12Q1/68, C12N15/09
[2012/43]
CPC:
C12Q1/6886 (EP,US); C12Q2600/112 (EP,US); C12Q2600/158 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/43]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR ANALYSE VON ZERVIKALEN LYMPHKNOTENMETASTASEN UND TUMORMARKER FÜR KOPF- UND HALSTUMOR[2012/43]
English:METHOD FOR ANALYZING CERVICAL LYMPH NODE METASTASIS, AND TUMOR MARKER FOR HEAD AND NECK CANCER[2012/43]
French:PROCÉDÉ POUR ANALYSER UNE MÉTASTASE DE GANGLION LYMPHATIQUE CERVICAL, ET MARQUEUR TUMORAL POUR LE CANCER DE LA TÊTE ET DU COU[2012/43]
Entry into regional phase20.07.2012Translation filed 
20.07.2012National basic fee paid 
20.07.2012Search fee paid 
20.07.2012Designation fee(s) paid 
20.07.2012Examination fee paid 
Examination procedure01.07.2011Request for preliminary examination filed
International Preliminary Examining Authority: JP
20.07.2012Examination requested  [2012/43]
05.12.2012Amendment by applicant (claims and/or description)
28.02.2013Communication of intention to grant the patent
05.06.2013Fee for grant paid
05.06.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.02.2013
Opposition(s)22.04.2014No opposition filed within time limit [2014/26]
Fees paidRenewal fee
19.12.2012Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.12.2010
AL17.07.2013
AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MK17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
SM17.07.2013
TR17.07.2013
NO17.10.2013
RS17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
[2018/46]
Former [2016/32]HU22.12.2010
AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MK17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
SM17.07.2013
TR17.07.2013
NO17.10.2013
RS17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2015/41]HU22.12.2010
AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MK17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
SM17.07.2013
NO17.10.2013
RS17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2015/34]HU22.12.2010
AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MK17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
SM17.07.2013
NO17.10.2013
RS17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2015/33]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
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IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MK17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
SM17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2015/25]AT17.07.2013
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CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
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IT17.07.2013
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MC17.07.2013
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PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
SM17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2015/21]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2014/48]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
IE22.12.2013
LU22.12.2013
Former [2014/38]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU22.12.2013
Former [2014/24]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/23]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/22]AT17.07.2013
BE17.07.2013
CY17.07.2013
DK17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/21]AT17.07.2013
BE17.07.2013
CY17.07.2013
DK17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/18]AT17.07.2013
BE17.07.2013
CY17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/14]AT17.07.2013
BE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
CY18.09.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/12]AT17.07.2013
BE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
CY18.09.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/11]AT17.07.2013
BE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
PL17.07.2013
SE17.07.2013
CY18.09.2013
NO17.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/10]AT17.07.2013
BE17.07.2013
HR17.07.2013
LT17.07.2013
SE17.07.2013
CY18.09.2013
NO17.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/09]AT17.07.2013
BE17.07.2013
HR17.07.2013
LT17.07.2013
SE17.07.2013
NO17.10.2013
PT18.11.2013
Former [2014/08]LT17.07.2013
NO17.10.2013
PT18.11.2013
Former [2014/07]NO17.10.2013
Documents cited:Search[AD]JP2009034071  (UNIV EHIME) [AD] 1-4 * the whole document *;
 [AD]US2006019290  (GODFREY TONY E [US], et al) [AD] 1-4 * the whole document *;
 [AD]  - HIROYUKI HAMAKAWA ET AL, "Genetic diagnosis of micrometastasis based on SCC antigen mRNA in cervical lymph nodes of head and neck cancer", CLINICAL & EXPERIMENTAL METASTASIS ; OFFICIAL JOURNAL OF THEMETASTASIS RESEARCH SOCIETY, KLUWER ACADEMIC PUBLISHERS, DO, (19990901), vol. 17, no. 7, doi:10.1023/A:1006732911057, ISSN 1573-7276, pages 593 - 599, XP019235451 [AD] 1-4 * the whole document *

DOI:   http://dx.doi.org/10.1023/A:1006732911057
 [T]  - OKA R ET AL., "Abstract 720: Identification of novel molecular markers for detecting lymph node metastasis of oral squamous cell carcinoma", CANCER RESEARCH, (20120415), vol. 72, no. 8 Sup 1, page 720, XP002684881 [T] * abstract *

DOI:   http://dx.doi.org/10.1158/1538-7445.AM2012-720
International search[Y]JP2007000052  (UNIV EHIME);
 [Y]WO2008044504  (UNIV NIIGATA [JP], et al);
 [Y]JP2008505644  (UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIO)
 [Y]  - HIROYUKI HAMAKAWA, "Carcinoma of oral cavity. New diagnosis and treatment", RINSHO TO KENKYU, (200507), vol. 82, no. 7, pages 1201 - 1205
 [Y]  - HIROYUKI HAMAKAWA ET AL., "Genetic Diagnosis of Oral Cancer", J. HARD TISSUE BIOLOGY, (2005), vol. 14, no. 2, pages 163 - 165
 [Y]  - HIROYUKI HAMAKAWA ET AL., "Genetic Diagnosis for Micrometastasis of Oral Cancer", JOURNAL OF THE JAPANESE STOMATOLOGICAL SOCIETY, (200105), vol. 50, no. 3, pages 145 - 154
 [Y]  - HIROYUKI GODA ET AL., "Kokugan Sentinel Lymph- setsu Seiken eno OSNA-ho no Oyo to Mondaiten, OS036-5", DAI 45 KAI JAPAN SOCIETY OF CLINICAL ONCOLOGY SOKAI SHOROKUGO, (20070920), vol. 42, no. 2, page 436
 [Y]  - ROBERT L. FERRIS ET AL., "Molecular Staging of Cervical Lymph Nodes in Squamous Cell Carcinoma of the Head and Neck", CANCER RES, (2005), vol. 65, no. 6, doi:doi:10.1158/0008-5472.CAN-04-3717, pages 2147 - 2156, XP002477565

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-04-3717
by applicantJP2007000052
 JP2009034071
    - SATOH K; HIRAYAMA H ET AL., "Sentinel lymph node biopsy using technetium 99m labeled tin colloids in breast cancer", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, (2000), vol. 192, pages 147 - 150
    - MATSUZUKA T; KANO M ET AL., "A suggested method for lymphatic mapping in squamous cell carcinoma of the head and neck", HEAD AND NECK CANCER, (2001), vol. 27, pages 192 - 197
    - KIHARA K; KONO N ET AL., "Study of sentinel lymph node biopsy in NO oral cancer", HEAD AND NECK CANCER, vol. 28, pages 108 - 113
    - MORTON D; WEN DR ET AL., "Technical details of intraoperative lymphatic mapping for early stage melanoma", ARCH SURG, (1992), vol. 127, pages 392 - 399, XP000610674
    - HAMAKAWA H; FUKUZUMI M ET AL., "Genetic detection of micrometastases based on SCC antigen mRNA in cervical lymph nodes of head and neck cancer", CLIN EXP METASTASIS, (1999), vol. 17, pages 593 - 599
    - HAMAKAWA H; TAKEMURA K ET AL., "Histological study on pN upgrading of oral cancer", VIRCHOWSARCH, (2000), vol. 437, pages 116 - 121
    - OHNISHI A, "Genetic diagnosis of micrometastasis of oral cancer to cervical lymph node by use of realtime quantitative PCR method", EHIME MEDICAL JOURNAL, (2002), vol. 21, pages 183 - 191
    - NAKASHIRO K; SHINTANI S; OHNISHIA; TERAKADO N; HAMAKAWA H, "Intraoperative rapid detection of micrometastasis in sentinel lymph nodes of oral malignant tumors", HEAD AND NECK CANCER, (2003), vol. 29, pages 64 - 69
    - FERRIS L. ROBERT ET AL., CANCER RES., (2005), vol. 65, no. 6, pages 2147 - 2156
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