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Extract from the Register of European Patents

EP About this file: EP2336114

EP2336114 - PROCESS FOR THE SYNTHESIS OF L-3,4 DIHYDROXY-6-[18F]FLUORO-PHENYLALANINE AND 2-[18F]FLUOR-L-TYROSINE AND THEIR ALPHA-METHYLATED DERIVATIVES STARTING FROM A PRECURSOR [Right-click to bookmark this link]
Former [2011/25]Process for the synthesis of L-3,4 dihydroxy-6-[18F]fluoro-phenylalanine and 2-[18F]Fluor-L-tyrosine and their alpha-methylated derivatives starting from a precursor
[2012/49]
StatusNo opposition filed within time limit
Status updated on  21.02.2014
Database last updated on 06.07.2024
Most recent event   Tooltip04.09.2015Lapse of the patent in a contracting state
New state(s): MT		published on 07.10.2015  [2015/41]
Applicant(s)For all designated states
Forschungszentrum Jülich GmbH
52425 Jülich / DE
[N/P]
Former [2011/25]For all designated states
Forschungszentrum Jülich GmbH
52425 Jülich / DE
Inventor(s)01 / Wagner, Franziska
Feldkirchener Strasse 1
85599 Hergolding / DE
02 / Ermert, Johannes
Iserlohner Strasse 5
51109 Köln / DE
03 / Coenen, Heinrich Hubert
Mauristrasse 14a
41516 Grevenbroich / DE
 [2011/25]
Application number, filing date11001114.521.11.2008
[2011/25]
Priority number, dateDE2007105931307.12.2007         Original published format: DE102007059313
[2011/25]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report 
No.:EP2336114
Date:22.06.2011
Language:DE
[2011/25]
Type: B1 Patent specification 
No.:EP2336114
Date:17.04.2013
Language:DE
[2013/16]
Search report(s)(Supplementary) European search report - dispatched on:EP13.05.2011
ClassificationIPC:C07D233/32, C07C229/00
[2011/25]
CPC:
C07D233/32 (EP,US); C07C227/32 (EP,US); C07C229/36 (EP,US);
C07B2200/05 (EP,US); C07B2200/07 (EP,US)
C-Set:
C07C227/32, C07C229/36 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/25]
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON L-3,4 DIHYDROXY-6-[18F]FLUOR-PHENYLALANIN UND 2-[18F]FLUOR-L-TYROSIN UND DEREN ALPHA-METHYLIERTEN DERIVATEN AUS EINEM VORLÄUFER[2012/49]
English:PROCESS FOR THE SYNTHESIS OF L-3,4 DIHYDROXY-6-[18F]FLUORO-PHENYLALANINE AND 2-[18F]FLUOR-L-TYROSINE AND THEIR ALPHA-METHYLATED DERIVATIVES STARTING FROM A PRECURSOR[2012/49]
French:PROCÉDÉ DE PRODUCTION DE L-3, 4 DIHYDROXY-6-[18F] FLUORO-PHÉNYLALANINE ET 2 - [18F] FLUOR-L-TYROSINE ET LEURS DÉRIVÉS ALPHA-MÉTHYLÉS PARTIR D'UN PRÉCURSEUR[2012/49]
Former [2011/25]Verfahren zur Herstellung von L-3,4 Dihydroxy-6-[18F]fluor-phenylalanin und 2-[18F]Fluor-L-tyrosin und deren alpha-methylierten Derivaten aus einem Vorläufer
Former [2011/25]Process for the synthesis of L-3,4 dihydroxy-6-[18F]fluoro-phenylalanine and 2-[18F]Fluor-L-tyrosine and their alpha-methylated derivatives starting from a precursor
Former [2011/25]Procédé de production de L-3, 4 dihydroxy-6-[18F] fluoro-phénylalanine et 2 - [18F] fluor-L-tyrosine et leurs dérivés alpha-méthylés partir d'un précurseur
Examination procedure15.10.2011Amendment by applicant (claims and/or description)
20.10.2011Examination requested  [2011/48]
01.02.2012Despatch of a communication from the examining division (Time limit: M04)
09.03.2012Reply to a communication from the examining division
29.08.2012Despatch of a communication from the examining division (Time limit: M04)
12.09.2012Reply to a communication from the examining division
09.11.2012Communication of intention to grant the patent
07.02.2013Fee for grant paid
07.02.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP08857332.4  / EP2220049
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20080857332) is  22.10.2010
Opposition(s)20.01.2014No opposition filed within time limit [2014/13]
Fees paidRenewal fee
16.03.2011Renewal fee patent year 03
15.10.2011Renewal fee patent year 04
20.10.2012Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU21.11.2008
CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
IT17.04.2013
LT17.04.2013
LV17.04.2013
MC17.04.2013
MT17.04.2013
PL17.04.2013
RO17.04.2013
SI17.04.2013
SK17.04.2013
TR17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
IE21.11.2013
LU21.11.2013
[2015/41]
Former [2015/34]HU21.11.2008
CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
IT17.04.2013
LT17.04.2013
LV17.04.2013
MC17.04.2013
PL17.04.2013
RO17.04.2013
SI17.04.2013
SK17.04.2013
TR17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
IE21.11.2013
LU21.11.2013
Former [2015/32]CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
IT17.04.2013
LT17.04.2013
LV17.04.2013
MC17.04.2013
PL17.04.2013
RO17.04.2013
SI17.04.2013
SK17.04.2013
TR17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
IE21.11.2013
Former [2014/48]CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
IT17.04.2013
LT17.04.2013
LV17.04.2013
MC17.04.2013
PL17.04.2013
RO17.04.2013
SI17.04.2013
SK17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
IE21.11.2013
Former [2014/33]CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
IT17.04.2013
LT17.04.2013
LV17.04.2013
MC17.04.2013
PL17.04.2013
RO17.04.2013
SI17.04.2013
SK17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2014/11]CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
IT17.04.2013
LT17.04.2013
LV17.04.2013
PL17.04.2013
RO17.04.2013
SI17.04.2013
SK17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2014/10]CY17.04.2013
CZ17.04.2013
EE17.04.2013
FI17.04.2013
HR17.04.2013
LT17.04.2013
LV17.04.2013
PL17.04.2013
SI17.04.2013
SK17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2013/52]CY17.04.2013
FI17.04.2013
HR17.04.2013
LT17.04.2013
LV17.04.2013
PL17.04.2013
SI17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2013/51]FI17.04.2013
HR17.04.2013
LT17.04.2013
LV17.04.2013
PL17.04.2013
SI17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2013/50]FI17.04.2013
LT17.04.2013
LV17.04.2013
PL17.04.2013
SI17.04.2013
BG17.07.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2013/49]FI17.04.2013
LT17.04.2013
SI17.04.2013
NO17.07.2013
GR18.07.2013
IS17.08.2013
PT19.08.2013
Former [2013/48]LT17.04.2013
NO17.07.2013
IS17.08.2013
PT19.08.2013
Former [2013/47]LT17.04.2013
NO17.07.2013
PT19.08.2013
Documents cited:Search[IY]  - KURODA C ET AL, "Synthesis of a chiral precursor for no-carrier-added (NCA) PET tracer 6- [<18>F]fluoro-L-dopa based on regio- and enantioselective alkylation of 2,4- bis(chloromethyl)-5-iodoanisole", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 200002 JP LNKD- DOI:10.1246/BCSJ.73.417, (200002), vol. 73, no. 2, ISSN 0009-2673, pages 417 - 422, XP002634866 [I] 1-5,7,8 * Seite 420, Schema 8 und rechte Spalte, erster Absatz * [Y] 2,3,5,6

DOI:   http://dx.doi.org/10.1246/BCSJ.73.417
 [Y]  - SHEN ET AL, "Decarbonylation of multi-substituted [<18>F]benzaldehydes for modelling syntheses of <18>F-labelled aromatic amino acids", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB, (20071017), vol. 65, no. 11, ISSN 0969-8043, pages 1227 - 1231, XP022302102 [Y] 2,3,5,6 * Seite 1228, Absatz 2.3 *

DOI:   http://dx.doi.org/10.1016/j.apradiso.2007.06.002
by applicant   - THIERRY PAGES, "Fluorination of aromatic compounds from 1-aryl-3,3-dimethyltriazenes and fluoride anions in acidic medium 2. Synthesis of (S)- [18F]-3-fluoro-a-methyl- phenylalanine", JOURNAL OF FLUORINE CHEMISTRY, (2001), vol. 107, pages 329 - 335
    - NUC. MED. BIOL., (2007), vol. 34, pages 345 - 351
    - CHEN X; PARK R; SHAHINIAN AH ET AL., "18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis", NUC. MED. BIOL., (2004), vol. 31, pages 179 - 189
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.