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Extract from the Register of European Patents

EP About this file: EP2465922

EP2465922 - MESENCHYMAL STEM CELLS EXPRESSING TNF-ALPHA RECEPTOR [Right-click to bookmark this link]
Former [2012/25]Mesenchymal stem cells expressing TNF-alpha receptor
[2018/13]
StatusNo opposition filed within time limit
Status updated on  07.06.2019
Database last updated on 11.04.2026
FormerThe patent has been granted
Status updated on  29.06.2018
FormerGrant of patent is intended
Status updated on  04.03.2018
FormerExamination is in progress
Status updated on  01.09.2017
Most recent event   Tooltip09.07.2021Lapse of the patent in a contracting state
New state(s): HU		published on 11.08.2021  [2021/32]
Applicant(s)For all designated states
Mesoblast International Sàrl
Route de Pre-Bois 20
1217 Meyrin / CH
[2015/35]
Former [2013/16]For all designated states
Osiris Therapeutics, Inc.
7015 Albert Einstein Drive
Columbia, MD 21046 / US
Former [2012/25]For all designated states
Osiris Therapeutics, Inc.
2001 Aliceanna Street
Baltimore, MD 21231 / US
Inventor(s)01 / Danilkovitch, Alla
9489 Good Lion Road
Columbia MD 21045 / US
02 / Carter, Diane
1920 Covered Trail Lane
Huntington MD 20639 / US
03 / Tyrell, Alicia
6 Bishops Lane
Catonsville MD 21228 / US
04 / Bubnic, Simon
466 Scarborough Golf Club Road
Toronto Ontario M1G 1H1 / CA
05 / Marcelino, Michelle
3693 Ridgeview Road
Ijamsville MD 21754 / US
06 / Monroy, Rodney
1911 Park Beach Drive
Aberdeen MD 21001 / US
 [2018/31]
Former [2012/27]01 / Danilkovitch, Alla
9489 Good Lion Road
Columbia MD 21045 / US
02 / Carter, Diane
1920 Covered Trail Lane
Huntington MD 20639 / US
03 / Tyrell, Alicia
6 Bishops Lane
Catonsville MD 21228 / US
04 / Bubnic, Simon
466 Scarborough Golf Club Road
Toronto M1G 1H1, Ontario / CA
05 / Marcelino, Michelle
3693 Ridgeview Road
Ijamsville MD 21754 / US
06 / Monroy, Rodney
1911 Park Beach Drive
Aberdeen MD 21001 / US
Representative(s)Schnappauf, Georg, et al
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[2018/31]
Former [2012/25]Schnappauf, Georg, et al
Dr. Volker Vossius
Patent- und Rechtsanwaltskanzlei
Geibelstrasse 6
81679 München / DE
Application number, filing date11010296.905.01.2007
[2012/25]
Priority number, dateUS20060759157P13.01.2006         Original published format: US 759157 P
[2012/32]
Former [2012/25]US200675915706P13.01.2006
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2465922
Date:20.06.2012
Language:EN
[2012/25]
Type: A3 Search report 
No.:EP2465922
Date:05.12.2012
Language:EN
[2012/49]
Type: B1 Patent specification 
No.:EP2465922
Date:01.08.2018
Language:EN
[2018/31]
Search report(s)(Supplementary) European search report - dispatched on:EP07.11.2012
ClassificationIPC:C12N5/0775
[2012/25]
CPC:
C12N5/0663 (EP,US); C12N5/0662 (US); A61K35/28 (US);
A61P29/00 (EP); A61P35/00 (EP); A61K2035/122 (EP,US);
C12N2501/25 (EP,US); G01N2333/525 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/31]
Former [2012/25]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Mesenchymale Stammzellen zur TNF-Rezeptor-Expression[2012/25]
English:MESENCHYMAL STEM CELLS EXPRESSING TNF-ALPHA RECEPTOR[2018/13]
French:Cellules souches mésenchymateuses exprimant un récepteur TNF-a[2012/25]
Former [2012/25]Mesenchymal stem cells expressing TNF-alpha receptor
Examination procedure05.06.2013Amendment by applicant (claims and/or description)
05.06.2013Examination requested  [2013/29]
28.07.2015Despatch of a communication from the examining division (Time limit: M04)
01.12.2015Reply to a communication from the examining division
18.07.2017Cancellation of oral proceeding that was planned for 19.07.2017
19.07.2017Date of oral proceedings (cancelled)
22.08.2017Despatch of a communication from the examining division (Time limit: M04)
07.12.2017Reply to a communication from the examining division
05.03.2018Communication of intention to grant the patent
25.06.2018Fee for grant paid
25.06.2018Fee for publishing/printing paid
25.06.2018Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP07716359.0  / EP1971679
Divisional application(s)EP17181392.6  / EP3287520
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20070716359) is  05.01.2010
Opposition(s)03.05.2019No opposition filed within time limit [2019/28]
Fees paidRenewal fee
30.12.2011Renewal fee patent year 03
30.12.2011Renewal fee patent year 04
30.12.2011Renewal fee patent year 05
30.12.2011Renewal fee patent year 06
28.01.2013Renewal fee patent year 07
21.01.2014Renewal fee patent year 08
13.01.2015Renewal fee patent year 09
11.01.2016Renewal fee patent year 10
11.01.2017Renewal fee patent year 11
15.01.2018Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.01.2007
AT01.08.2018
CY01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
PT01.12.2018
LU05.01.2019
BE31.01.2019
[2021/32]
Former [2021/26]AT01.08.2018
CY01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
PT01.12.2018
LU05.01.2019
BE31.01.2019
Former [2020/29]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
PT01.12.2018
LU05.01.2019
BE31.01.2019
Former [2020/16]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
LU05.01.2019
BE31.01.2019
Former [2019/51]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
LU05.01.2019
BE31.01.2019
Former [2019/44]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
LU05.01.2019
Former [2019/40]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/37]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/26]AT01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SK01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/24]AT01.08.2018
CZ01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
SK01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/22]AT01.08.2018
CZ01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
RO01.08.2018
SE01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/13]AT01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/10]AT01.08.2018
FI01.08.2018
LT01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
BG01.11.2018
GR02.11.2018
IS01.12.2018
Former [2019/09]FI01.08.2018
LT01.08.2018
NL01.08.2018
IS01.12.2018
Former [2019/08]FI01.08.2018
LT01.08.2018
IS01.12.2018
Former [2019/07]LT01.08.2018
Documents cited:Search[X] WO2005093044  (OSIRIS THERAPEUTICS INC et al.)
 [XD]   AGGARWAL S ET AL: "Human mesenchymal stem cells modulate allogeneic immune cell responses", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 105, no. 4, 15 February 2005 (2005-02-15), pages 1815 - 1822, XP002515730, ISSN: 0006-4971

DOI:   http://dx.doi.org/10.1182/blood-2004-04-1559
 [XD]   LE BLANC K ET AL: "Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 363, no. 9419, 1 May 2004 (2004-05-01), pages 1439 - 1441, XP002515729, ISSN: 0140-6736

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)16104-7
 [X]   BILIC GROZDANA ET AL: "In vitro lesion repair by human amnion epithelial and mesenchymal cells.", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 190, no. 1, January 2004 (2004-01-01), pages 87 - 92, XP009164009, ISSN: 0002-9378

DOI:   http://dx.doi.org/10.1016/j.ajog.2003.07.011
 [X]   TARTE KARIN ET AL: "IFN-GAMMA, UNLIKE TNF-ALPHA, LPS, OR CD40 SIGNAL, IS REQUIRED AND SUFFICIENT TO INDUCE INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY IN MESENCHYMAL STEM CELLS", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 106, no. 11, 13 December 2005 (2005-12-13), pages 650A, XP008080026, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2004-08-3344

DOI:   http://dx.doi.org/10.1182/blood-2004-08-3344
ExaminationWO2012048093
by applicantUS5486359
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.