blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2441769

EP2441769 - Design, synthesis and assembly of synthetic nucleic acids [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.03.2015
Database last updated on 25.09.2024
Most recent event   Tooltip13.10.2017Lapse of the patent in a contracting state
New state(s): HU, TR		published on 15.11.2017  [2017/46]
Applicant(s)For all designated states
REPLIGEN CORPORATION
41 Seyon Street Building 1 Suite 100
Waltham, MA 02453 / US
[2012/16]
Inventor(s)01 / Govindarajan, Sridhar
530 Osprey Drive
Redwood City, CA 94065 / US
02 / Kulikov, Nicolay V.
1270 Connecticut Drive
Redwood City, CA 94061 / US
03 / Minshull, Jeremy S.
679 Los Ninos Way
Los Altos, CA 94022 / US
04 / Ness, Jon E.
710 Bair Island Road, Nr. 405
Redwood City, CA 94063 / US
 [2012/16]
Representative(s)Peterreins, Frank
Fish & Richardson P.C.
Highlight Business Towers
Mies-van-der-Rohe-Strasse 8
80807 München / DE
[2012/16]
Application number, filing date11161698.304.05.2005
[2012/16]
Priority number, dateUS20040567460P04.05.2004         Original published format: US 567460 P
US20050666909P31.03.2005         Original published format: US 666909 P
[2012/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2441769
Date:18.04.2012
Language:EN
[2012/16]
Type: B1 Patent specification 
No.:EP2441769
Date:07.05.2014
Language:EN
[2014/19]
Search report(s)(Supplementary) European search report - dispatched on:EP21.03.2012
ClassificationIPC:C07H21/00, B01J19/00
[2012/16]
CPC:
C07H21/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2012/16]
Extension statesAL08.04.2011
BA08.04.2011
HR08.04.2011
LV08.04.2011
MK08.04.2011
YU08.04.2011
TitleGerman:Design, Synthese und Anordnung von synthetischen Nukleinsäuren[2012/16]
English:Design, synthesis and assembly of synthetic nucleic acids[2012/16]
French:Conception, synthèse et assemblage d'acides nucléiques synthétiques[2012/16]
Examination procedure08.04.2011Examination requested  [2012/16]
18.10.2012Amendment by applicant (claims and/or description)
26.02.2013Despatch of a communication from the examining division (Time limit: M04)
08.07.2013Reply to a communication from the examining division
26.11.2013Communication of intention to grant the patent
21.03.2014Fee for grant paid
21.03.2014Fee for publishing/printing paid
Parent application(s)   TooltipEP05780055.9  / EP1771579
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050780055) is  24.08.2011
Opposition(s)10.02.2015No opposition filed within time limit [2015/16]
Fees paidRenewal fee
08.04.2011Renewal fee patent year 03
08.04.2011Renewal fee patent year 04
08.04.2011Renewal fee patent year 05
08.04.2011Renewal fee patent year 06
08.04.2011Renewal fee patent year 07
28.03.2012Renewal fee patent year 08
28.05.2013Renewal fee patent year 09
26.03.2014Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.05.2005
AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
IT07.05.2014
LT07.05.2014
MC07.05.2014
PL07.05.2014
RO07.05.2014
SI07.05.2014
SK07.05.2014
TR07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
[2017/39]
Former [2016/06]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
IT07.05.2014
LT07.05.2014
MC07.05.2014
PL07.05.2014
RO07.05.2014
SI07.05.2014
SK07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/36]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
IT07.05.2014
LT07.05.2014
PL07.05.2014
RO07.05.2014
SI07.05.2014
SK07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/22]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
IT07.05.2014
LT07.05.2014
PL07.05.2014
RO07.05.2014
SK07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/11]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
LT07.05.2014
PL07.05.2014
RO07.05.2014
SK07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/10]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
LT07.05.2014
PL07.05.2014
SK07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/08]AT07.05.2014
BE07.05.2014
CY07.05.2014
DK07.05.2014
ES07.05.2014
FI07.05.2014
LT07.05.2014
PL07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/02]AT07.05.2014
CY07.05.2014
ES07.05.2014
FI07.05.2014
LT07.05.2014
PL07.05.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2014/51]AT07.05.2014
CY07.05.2014
ES07.05.2014
FI07.05.2014
LT07.05.2014
PL07.05.2014
GR08.08.2014
IS07.09.2014
Former [2014/50]CY07.05.2014
ES07.05.2014
FI07.05.2014
LT07.05.2014
PL07.05.2014
GR08.08.2014
IS07.09.2014
Former [2014/49]CY07.05.2014
FI07.05.2014
LT07.05.2014
IS07.09.2014
Former [2014/48]CY07.05.2014
LT07.05.2014
Former [2014/47]CY07.05.2014
Documents cited:Search[A]US2004029781  (HERNAN RONALD A [US], et al) [A] 1-9 * claim 21; sequence 4 *;
 [A]  - UHLEN M ET AL, "Complete sequence of the staphylococcal gene encoding protein A. A gene evolved through multiple duplications", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC, US, (19840101), vol. 259, no. 3, ISSN 0021-9258, pages 1695 - 1702, XP008092291 [A] 1-9 * abstract *
 [A]  - SHUTTLEWORTH H L ET AL, "Nucleotide sequence analysis of the gene for protein A from Staphylococcus aureus Cowan 1 (NCTC8530) and its enhanced expression in Escherichia coli", GENE, ELSEVIER, AMSTERDAM, NL, vol. 58, no. 2-3, doi:10.1016/0378-1119(87)90383-0, ISSN 0378-1119, (19870101), pages 283 - 295, (19870101), XP023544339 [A] 1-9 * abstract * * page 293, column r - page 294, column left, paragraph 2; table 1 *

DOI:   http://dx.doi.org/10.1016/0378-1119(87)90383-0
 [A]  - JING G ET AL, "High-level expression of staphylococcal nuclease R gene in Escherichia coli", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 22, no. 3, doi:10.1016/0168-1656(92)90145-Y, ISSN 0168-1656, (19920201), pages 271 - 282, (19920201), XP023705250 [A] 1-9 * abstract * * page 275, line 11 - line 35; figures 1-3; table 2 *

DOI:   http://dx.doi.org/10.1016/0168-1656(92)90145-Y
 [T]  - WELCH MARK ET AL, "Design Parameters to Control Synthetic Gene Expression in Escherichia coli", PLOS ONE, (200909), vol. 4, no. 9, ISSN 1932-6203, XP002670364 [T] * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.pone.0007002
by applicantUS5681702
 US5780610
 US4598049
    - HAYDEN ET AL., DNA, (1988), vol. 7, pages 571 - 7
    - CICCARELLI ET AL., NUCLEIC ACIDS RES, (1991), vol. 19, pages 6007 - 13
    - JAYARAMAN ET AL., PROC NATL ACAD SCI U S A, (1991), vol. 88, pages 4084 - 8
    - JAYARAMAN ET AL., BIOTECHNIQUES, (1992), vol. 12, pages 392 - 8
    - GRAHAM ET AL., NUCLEIC ACIDS RES, (1993), vol. 21, pages 4923 - 8
    - KOBAYASHI ET AL., BIOTECHNIQUES, (1997), vol. 23, pages 500 - 3
    - AU ET AL., BIOCHEM BIOPHYS RES COMMUN., (1998), vol. 248, pages 200 - 203
    - HOOVER ET AL., NUCLEIC ACIDS RES, (2002), vol. 30, page E43
    - GAIT, PRACTICAL APPROACH SERIES, (1984), vol. XIII, page 217
    - MATTEUCCI, CARUTHERS, J AM CHEM SOC., (1981), vol. 103, pages 3185 - 3191
    - PON ET AL., TETRAHEDRON LETT., (1985), vol. 26, pages 2525 - 2528
    - ADAMS ET AL., J AM CHEM SOC, (1983), vol. 105, pages 661 - 663
    - MCBRIDE ET AL., J AM CHEM SOC, (1986), vol. 108, pages 2040 - 2048
    - LETSINGER ET AL., TETRAHEDRON, (1984), vol. 40, pages 137 - 143
    - HAYAKAWA ET AL., J AM CHEM SOC, (1990), vol. 112, pages 1691 - 1696
    - HAYAKAWA, KATAOKA., J AM CHEM SOC, (1998), vol. 120, pages 12395 - 12401
    - PON, NUCLEIC ACIDS RES, (1987), vol. 15, page 7203
    - HAYAKAWA ET AL., TETRAHEDRON LETT, (1986), vol. 27, pages 4191 - 4194
    - PADIYA, SALUNKHE, J CHEM RESEARCH, (1998), page 804
    - EADIE, DAVIDSON, NUCLEIC ACIDS RES, (1987), vol. 15, pages 8333 - 49
    - BOAL ET AL., NUCLEIC ACIDS RES, (1996), vol. 24, page 3115
    - KWIATKOWSKI ET AL., NUCLEIC ACIDS RES, (1996), vol. 24, pages 4632 - 4638
    - SWITZER ET AL., BIOCHEMISTRY, (1993), vol. 32, pages 10489 - 10496
    - TOR ET AL., J. AM. CHEM. SOC., (1993), vol. 115, pages 4461 - 4467
    - MANTSCH ET AL., BIOCHEM., (1993), vol. 14, pages 5593 - 5601
    - PICCIRILLI ET AL., NATURE, (1990), vol. 343, pages 33 - 37
    - LEACH ET AL., J. AM. CHEM. SOC., (1992), vol. 114, pages 3675 - 3683
    - GAIT, Gait's practical handbook, (1984), vol. XIII, page 217
    - BEAUCAGE, RADHAKRISHNAN, TETRAHEDRON, (1992), vol. 48, pages 2223 - 2311
    - URDEA, HORN, TETRAHEDRON LETT, (1986), vol. 27, pages 2933 - 2936
    - BOLLEN ET AL., CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, (2000), vol. 35, pages 393 - 432
    - MATTEUCCI, CARUTHERS, J AM CHEM SOC, (1981), vol. 103, pages 3185 - 3191
    - CHAIX ET AL., TETRAHEDRON LETT, (1989), vol. 30, pages 71 - 74
    - YU ET AL., TETRAHEDRON LETT, (1994), vol. 34, pages 8565 - 8568
    - PON ET AL., NUCLEIC ACIDS RES, (1985), vol. 13, pages 6447 - 65
    - PON ET AL., NUCLEIC ACIDS RES, (1986), vol. 14, pages 6453 - 70
    - LETSINGER ET AL., J AM CHEM SOC, (1975), pages 3278 - 3279
    - PETRI ET AL., LANGMUIR, (1999), vol. 15, pages 4520 - 4523
    - ALLENMARK, ELLIS HORWOOD SERIES IN ANALYTICAL CHEMISTRY, (1988), page 224
    - BOAL ET AL., NUCLEIC ACIDS RES, (1996), vol. 24, pages 3115 - 7
    - CHU ET AL., ELECTROPHORESIS, (1992), vol. 13, pages 105 - 14
    - ITO ET AL., NUCLEIC ACIDS RES, (1982), vol. 10, page 1755
    - EADIE, DAVIDSON, 1987, NUCLEIC ACIDS RES, vol. 15, pages 8333 - 49
    - SEPTAK, NUCLEIC ACIDS RES, (1996), vol. 24, pages 3053 - 3058
    - PAUL, ROYAPPA, NUCLEIC ACIDS RES, (1996), vol. 24, pages 3048 - 3052
    - BABON ET AL., MOL BIOTECHNOL, (2003), vol. 23, pages 73 - 81
    - THOMAS ET AL., BIOLOGICAL CHEMISTRY, (2002), vol. 383, pages 1459 - 1462
    - SMITH, MODRICH, PROC NATL ACAD SCI, (1997), vol. 94, pages 6847 - 6850
    - COTTON ET AL., PROC NATL ACAD SCI, (1998), vol. 85, pages 4397 - 4401
    - ROBERTS ET AL., NUCL ACIDS RES, (1997), vol. 25, pages 3377 - 3378
    - BUI ET AL., BMC CHEMICAL BIOLOGY, (2003), page 3, URL: http://www.biomedcentral.com/content/pdf/1472-6769-3-I
    - JUNICKE ET AL., PROC NATL ACAD SCI, (2003), vol. 100, pages 3737 - 3742
    - HORTON ET AL., GENE, (1989), vol. 77, pages 61 - 8
    - HAYAKAWA, KATAOKA, J AM CHEM SOC, (1998), vol. 120, pages 12395 - 12401
    - SELIGER ET AL., J CHROMATOGR, (1989), vol. 476, pages 49 - 57
    - LEPROUST ET AL., NUCLEIC ACIDS RES, (2001), vol. 29, pages 2171 - 80
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.