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Extract from the Register of European Patents

EP About this file: EP2369003

EP2369003 - PROCESS FOR PREPARING AN OIL-IN-WATER EMULSION CONTAINING SQUALENE FROM YEASTS [Right-click to bookmark this link]
Former [2011/39]Production of squalene from hyper-producing yeasts
[2019/25]
StatusNo opposition filed within time limit
Status updated on  21.08.2020
Database last updated on 04.11.2024
FormerThe patent has been granted
Status updated on  13.09.2019
FormerGrant of patent is intended
Status updated on  26.06.2019
FormerExamination is in progress
Status updated on  02.11.2018
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Novartis AG
Lichtstrasse 35
4056 Basel / CH
[2019/42]
Former [2011/39]For all designated states
Novartis AG
Lichtstrasse 35
4056 Basel / CH
Inventor(s)01 / Broeker, Michael
Pappelweg 30
35041 Marburg / DE
 [2011/39]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2019/42]
Former [2011/39]Marshall, Cameron John
Carpmaels & Ransford One Southampton Row London
WC1B 5HA / GB
Application number, filing date11170769.128.08.2009
[2011/39]
Priority number, dateUS20080190486P28.08.2008         Original published format: US 190486 P
[2011/39]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2369003
Date:28.09.2011
Language:EN
[2011/39]
Type: B1 Patent specification 
No.:EP2369003
Date:16.10.2019
Language:EN
[2019/42]
Search report(s)(Supplementary) European search report - dispatched on:EP22.07.2011
ClassificationIPC:C12P5/02
[2011/39]
CPC:
C12P5/02 (EP,KR,US); A61K9/113 (KR); A61P37/04 (EP);
C12N1/18 (KR); C12N15/52 (KR); C12P5/007 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2019/42]
Former [2011/39]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
Extension statesAL28.03.2012
BA28.03.2012
RS28.03.2012
TitleGerman:HERSTELLUNG EINES ÖL-IM-WASSER-EMULSIONS ENTHALTEND SQUALEN AUS HEFEN[2019/30]
English:PROCESS FOR PREPARING AN OIL-IN-WATER EMULSION CONTAINING SQUALENE FROM YEASTS[2019/30]
French:PRODUCTION D'UN EMULSION HUILE DANS EAU CONTENANT SQUALÈNE À PARTIR DE LEVURES[2019/30]
Former [2011/39]Herstellung von Squalen aus hyperproduzierenden Hefen
Former [2011/39]Production of squalene from hyper-producing yeasts
Former [2011/39]Production de squalène à partir de levures hyperproductrices
Examination procedure28.03.2012Examination requested  [2012/19]
08.05.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
16.07.2012Amendment by applicant (claims and/or description)
31.10.2018Despatch of a communication from the examining division (Time limit: M06)
10.05.2019Reply to a communication from the examining division
27.06.2019Communication of intention to grant the patent
05.09.2019Fee for grant paid
05.09.2019Fee for publishing/printing paid
05.09.2019Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP09786243.7  / EP2268823
Opposition(s)17.07.2020No opposition filed within time limit [2020/39]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
16.07.2012Request for further processing filed
16.07.2012Full payment received (date of receipt of payment)
Request granted
27.07.2012Decision despatched
Fees paidRenewal fee
21.06.2011Renewal fee patent year 03
10.08.2012Renewal fee patent year 04
19.08.2013Renewal fee patent year 05
13.08.2014Renewal fee patent year 06
10.08.2015Renewal fee patent year 07
11.08.2016Renewal fee patent year 08
14.08.2017Renewal fee patent year 09
10.08.2018Renewal fee patent year 10
15.08.2019Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.08.2009
AT16.10.2019
CY16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
MK16.10.2019
MT16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
TR16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
[2022/32]
Former [2022/27]HU28.08.2009
AT16.10.2019
CY16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
MT16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
TR16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2022/26]AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
TR16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2021/18]AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/51]AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/37]AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/36]AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/35]AT16.10.2019
CZ16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
RO16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/25]AT16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/24]AT16.10.2019
FI16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/23]AT16.10.2019
FI16.10.2019
LT16.10.2019
LV16.10.2019
PL16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
Former [2020/22]FI16.10.2019
LT16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
PT17.02.2020
Former [2020/21]NO16.01.2020
Documents cited:Search[A]WO9916886  (SCHERING AG [DE], et al) [A] 1-22 * See pages 15-20 (Examples) *;
 [Y]WO0168129  (CHIRON BEHRING GMBH & CO [DE], et al) [Y] 1-13,15-22 * See pages 1-4 *;
 [A]WO2008056263  (NOVARTIS AG [CH], et al) [A] 1-22 * See pages 1-2 *;
 [E]WO2009143490  (CIBUS INTERNATIONAL L P, et al) [E] 1,5,7* See the whole document; the priority date is before the priority date of the present Application *;
 [Y]  - SPANOVA ET AL, "Squalene storage and subcellular distribution in the yeast Saccharomyces cerevisiae", CHEMISTRY AND PHYSICS OF LIPIDS, (20080708), vol. 154S, page S35, XP022823541 [Y] 1-13,15-22 * See Abstract (from the 49th International Conference on the Bioscience of Lipids); early online publication *

DOI:   http://dx.doi.org/10.1016/j.chemphyslip.2008.05.096
 [Y]  - CHANG ET AL, "The isolation and characterization of Pseudozyma sp. JCC 207, a novel producer of squalene", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (20080226), vol. 78, pages 963 - 972, XP019586370 [Y] 1-13,15-22 * See pages 963-964 (Introduction); early online publication *
 [YD]  - BHATTACHARJEE ET AL, "Extraction of squalene from yeast by supercritical carbon dioxide", WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, (2003), vol. 19, pages 605 - 608, XP002567589 [YD] 1-13,15-22 * See pages 605-606 (Introduction) *
 [A]  - CHEMLER ET AL, "Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae", MICROBIAL CELL FACTORIES, (2006), vol. 5, pages 1 - 9, XP021017781 [A] 1-22 * See page 4 (Sterols / squalene and reference 37) *

DOI:   http://dx.doi.org/10.1186/1475-2859-5-20
 [A]  - N.N., "Using yeast fermentation to produce cost-effective and biodegradable lubricants", DOW AGROSCIENCES LLC / STATUS REPORT, (2006), pages 1 - 4, URL: statusreports.atp.nist.gov/reports/95-01-0148PDF.pdf, XP002567590 [A] 1-22 * See pages 1-2 *
 [YP]  - MANTZOURIDOU ET AL, "Squalene versus ergosterol formation using Saccharomyces cerevisiae: Combined effect of oxygen supply, inoculum size, and fermentation time on yield and selectivity of the bioprocess", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (20090619), vol. 57, pages 6189 - 6198, XP002567645 [YP] 1-13,15-22 * See pages 6189-6190 (Introduction) *

DOI:   http://dx.doi.org/10.1021/JF900673N
 [Y]  - DONALD ET AL, "Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (1997), vol. 63, pages 3341 - 3344, XP002566428 [Y] 1-13,15-22 * See page 3341 (Introduction) *
 [Y]  - KAMIMURA ET AL, "Construction of squalene-accumulating Saccharomyces cerevisiae mutants by gene disruption through homologous recombination", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (1994), vol. 42, pages 353 - 357, XP002648042 [Y] 1-13,15-22 * See page 353 (Introduction) *
 [YD]  - NISHIKAWA ET AL, "Thiamine-induced alteration in sterol composition of Saccharomyces carlsbergensis 4228", BIOCHIMICA ET BIOPHYSICA ACTA, (1978), vol. 531, pages 86 - 95, XP008139303 [YD] 11,12 * See page 86 (Summary: thiamine -> significant amounts of squalene) *
 [YD]  - KUCHTA ET AL, "Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole", FEMS MICROBIOLOGY LETTERS, (1997), vol. 150, pages 43 - 47, XP002648500 [YD] 11,12 * See page 46 (Table 2) *
by applicantWO9014837
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 US5460949
 US2007014805
 US2007191314
 WO2008043774
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