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Extract from the Register of European Patents

EP About this file: EP2395095

EP2395095 - In vivo screening models for treatment of Alzheimer's disease and other QPCT-related disorders [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.04.2013
Database last updated on 24.08.2024
Most recent event   Tooltip26.04.2013Application deemed to be withdrawnpublished on 29.05.2013  [2013/22]
Applicant(s)For all designated states
Probiodrug AG
Weinbergweg 22
06120 Halle/Saale / DE
[2011/50]
Inventor(s)01 / Schilling, Stephan
Glockenweg 4
06130 Halle/Sale / DE
02 / Cynis, Holger
Steinweg 39
06110 Halle/Saale / DE
03 / Hoffmann, Torsten
Koernerstrasse 8
06114 Halle/Saale / DE
04 / Demuth, Hans-Ulrich
Am Waldrand 13a
06120 Halle/Saale / DE
05 / Wermann, Michael
Helmut-Just-Strasse 48a
06118 Halle/Saale / DE
06 / Schulz, Katrin
Rainstrasse 1
06114 Halle/Saale / DE
 [2011/50]
Representative(s)Hoffmann, Matthias, et al
Maikowski & Ninnemann
Patentanwälte
Kurfürstendamm 54-55
10707 Berlin / DE
[2012/29]
Former [2011/50]Hoffmann, Matthias
Probiodrug AG Weinbergweg 22
06120 Halle/Saale / DE
Application number, filing date11178419.518.01.2008
[2011/50]
Priority number, dateUS20070885649P19.01.2007         Original published format: US 885649 P
[2011/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2395095
Date:14.12.2011
Language:EN
[2011/50]
Search report(s)(Supplementary) European search report - dispatched on:EP16.11.2011
ClassificationIPC:C12N15/85
[2011/50]
CPC:
C12N15/8509 (EP,US); A01K67/0275 (EP,US); A61P1/04 (EP);
A61P1/14 (EP); A61P1/16 (EP); A61P11/00 (EP);
A61P13/12 (EP); A61P15/08 (EP); A61P17/06 (EP);
A61P19/02 (EP); A61P25/02 (EP); A61P25/14 (EP);
A61P25/16 (EP); A61P25/20 (EP); A61P25/28 (EP);
A61P29/00 (EP); A61P3/00 (EP); A61P35/00 (EP);
A61P37/04 (EP); A61P37/06 (EP); A61P5/00 (EP);
A61P7/00 (EP); A61P9/10 (EP); C12N9/104 (EP,US);
A01K2217/052 (EP,US); A01K2267/0312 (EP,US); A01K2267/0318 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/50]
TitleGerman:In-vivo-Screening-Modelle zur Behandlung der Alzheimer-Krankheit und anderer Erkrankungen in Zusammenhang mit dem QPCT-Gen[2011/50]
English:In vivo screening models for treatment of Alzheimer's disease and other QPCT-related disorders[2011/50]
French:Modèles de criblage in vivo pour traiter la maladie d'Alzheimer ou d'autres troubles associés à QPCT[2011/50]
Examination procedure14.06.2012Amendment by applicant (claims and/or description)
14.06.2012Examination requested  [2012/31]
01.08.2012Despatch of a communication from the examining division (Time limit: M04)
12.12.2012Application deemed to be withdrawn, date of legal effect  [2013/22]
15.01.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/22]
Parent application(s)   TooltipEP08707977.8  / EP2121944
Fees paidRenewal fee
14.09.2011Renewal fee patent year 03
14.09.2011Renewal fee patent year 04
25.01.2012Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
31.01.201306   M06   Not yet paid
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Documents cited:Search[YD]EP0653154  (HOECHST JAPAN [JP]) [YD] 1-22 * the whole document *;
 [A]US6066778  (GINSBURG DAVID [US], et al) [A] 1-22;
 [A]WO2005049027  (PROBIODRUG AG [DE], et al)[A] 1-22;
 [Y]  - SCHILLING S., Charakterisierung der humanen Glutaminyl-Cyclase im Vergleich mit dem analogen Enzym aus Carica papaya, ULB SACHSEN ANHALT, (20040505), XP002476967 [Y] 1-22 * figure 2.3 * * page 24, paragraph 3 - page 31 * * Inclosed manuscript "Inhibition of cyclase prevents the formation of pGlu-amyloid-beta related peptides" *
 [Y]  - M.R. SNAITH ET AL., "The use of transgenic systems in pharmaceutical research", BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, (200207), vol. 1, no. 2, pages 119 - 130, XP002476966 [Y] 1-22 * abstract * * page 120, column 1, paragraph 3 - column 2, paragraph 2 * * page 123, column 1, paragraph 2 - page 124, column 1, paragraph 2 * * page 126, column 2, paragraph 2 - page 127, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1093/bfgp/1.2.119
 [Y]  - CYNIS ET AL, "Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, ELSEVIER, (200610), vol. 1764, no. 10, ISSN 1570-9639, pages 1618 - 1625, XP005707926 [Y] 1-22 * abstract * * page 1618, column 2, paragraph 2 - page 1617, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/j.bbapap.2006.08.003
 [A]  - RUSS A ET AL, "Random mutagenesis in the mouse as a tool in drug discovery", DDT - DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, (20021201), vol. 7, no. 23, ISSN 1359-6446, pages 1175 - 1183, XP002359650 [A] 1-22

DOI:   http://dx.doi.org/10.1016/S1359-6446(02)02515-1
by applicantEP0264166
 US4873191
 US4873316
 WO9008832
 US5175384
 US5602299
 US5981830
 US6037521
 US6066778
 WO2004098625
 EP2011349
    - MESSER, M., NATURE, (1963), vol. 4874, page 1299
    - BUSBY, W. H. J. ET AL., J BIOL CHEM, (1987), vol. 262, pages 8532 - 8536
    - FISCHER, W. H., SPIESS, J., PROC NATL ACAD SCI U S A, (1987), vol. 84, pages 3628 - 3632
    - BOCKERS, T. M. ET AL., J NEUROENDOCRINOL, (1995), vol. 7, pages 445 - 453
    - EL MOUSSAOUI, A. ET AL., CELL MOL LIFE SCI, (2001), vol. 58, pages 556 - 570
    - DAHL, S. W. ET AL., PROTEIN EXPR PURIF, (2000), vol. 20, pages 27 - 36
    - POHL, T. ET AL., PROC NATL ACAD SCI U S A, (1991), vol. 88, pages 10059 - 10063
    - CONSALVO, A. P. ET AL., ANAL BIOCHEM, (1988), vol. 175, pages 131 - 138
    - GOLOLOBOV, M. Y. ET AL., BIOL CHEM HOPPE SEYLER, (1996), vol. 377, pages 395 - 398
    - ATEMAN, R. C. ET AL., BIOCHEMISTRY, (2001), vol. 40, pages 11246 - 11250
    - TERRY, R. D., KATZMAN, R., ANN NEUROL, (1983), vol. 14, pages 497 - 506
    - GLENNER, G. G., WONG, C. W., BIOCHEM BIOPHYS RES COMM, (1984), vol. 120, pages 885 - 890
    - INTAGAKI, S. ET AL., J NEUROIMMUNOL, (1989), vol. 24, pages 173 - 182
    - FUNATO, H. ET AL., AM J PATHOL, (1998), vol. 152, pages 983 - 992
    - SELKOE, D. J., PHYSIOL REV, (2001), vol. 81, pages 741 - 766
    - BORCHELT, D. R. ET AL., NEURON, (1996), vol. 17, pages 1005 - 1013
    - LEMERE, C. A. ET AL., NAT MED, (1996), vol. 2, pages 1146 - 1150
    - MANN, D. M., IWATSUBO, T., NEURODEGENERATION, (1996), vol. 5, pages 115 - 120
    - CITRON, M. ET AL., NAT MED, (1997), vol. 3, pages 67 - 72
    - KANG, J. ET AL., NATURE, (1987), vol. 325, pages 733 - 736
    - SELKOE, D. J., TRENDS CELL BIOL, (1998), vol. 8, pages 447 - 453
    - HAASS, C., SELKOE, D. J., CELL, (1993), vol. 75, pages 1039 - 1042
    - SIMONS, M. ET AL., J NEUROSCI, (1996), vol. 16, pages 899 - 908
    - PIKE, C. J. ET AL., J BIOL CHEM, (1995), vol. 270, pages 23895 - 23898
    - SAIDO, T. C. ET AL., NEURON, (1995), vol. 14, pages 457 - 466
    - RUSSO, C ET AL., NATURE, (2000), vol. 405, pages 531 - 532
    - RUSSO, C. ET AL., FEBS LETT, (1997), vol. 409, pages 411 - 416
    - RUSSO, C. ET AL., NEUROBIOL DIS, (2001), vol. 8, pages 173 - 180
    - TEKIRIAN, T. L. ET AL., J NEUROPATHOL EXP NEUROL, (1998), vol. 57, pages 76 - 94
    - GUNTERT, A. ET AL., NEUROSCIENCE, (2006), vol. 143, pages 461 - 475
    - MORI, H. ET AL., J BIOL CHEM, (1992), vol. 267, pages 17082 - 17086
    - GEDDES, J. W. ET AL., NEUROBIOL AGING, (1999), vol. 20, pages 75 - 79
    - HARIGAYA, Y. ET AL., BIOCHEM BIOPHYS RES COMMUN, (2000), vol. 276, pages 422 - 427
    - LALOWSKI, M. ET AL., J BIOL CHEM, (1996), vol. 271, pages 33623 - 33631
    - TEKIRIAN, T. L. ET AL., J NEUROCHEM, (1999), vol. 73, pages 1584 - 1589
    - HE, W., BARROW, C. J., BIOCHEMISTRY, (1999), vol. 38, pages 10871 - 10877
    - SHIROTANI, K. ET AL., NEUROSCI LETT, (2002), vol. 327, pages 25 - 28
    - RUSSO, C. ET AL., J NEUROCHEM, (2002), vol. 82, pages 1480 - 1489
    - GHISO, J. ET AL., AMYLOID, (2001), vol. 8, pages 277 - 284
    - GOSSEN, BIZARD, PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 5547 - 5551
    - GOSSEN ET AL., SCIENCE, (1995), vol. 268, page 17664769
    - NO ET AL., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, pages 3346 - 3351
    - YAO ET AL., NATURE, (1993), vol. 366, pages 476 - 479
    - LEE ET AL., NATURE, (1981), vol. 294, pages 228 - 232
    - FORSS-PETTER ET AL., NEURON, (1990), vol. 5, pages 197 - 197
    - RAY ET AL., GENES AND DEVELOPMENT, (1991), vol. 5, pages 2265 - 2273
    - SASAHARA ET AL., CELL, (1991), vol. 64, pages 217 - 227
    - MAUE ET AL., NEURON, (1990), vol. 4, pages 223 - 231
    - CEBALLOS-PICOT ET AL., BRAIN RES., (1991), vol. 552, pages 198 - 214
    - NATURE, (1989), vol. 340, pages 35 - 42
    - VAN DER PUTTEN ET AL., PROC. NATL. ACAD. SCI. USA, (1985), vol. 82, pages 6148 - 6152
    - THOMPSON ET AL., CELL, (1989), vol. 56, pages 313 - 321
    - LO, MOL CELL. BIOL., (1983), vol. 3, pages 1803 - 1814
    - LAVITRANO ET AL., CELL, (1989), vol. 57, pages 717 - 723
    - JAENISCH, SCIENCE, (1988), vol. 240, pages 1468 - 1474
    - JANENICH, PROC. NATI. ACAD. SCI. USA, (1976), vol. 73, pages 1260 - 1264
    - JAHNER ET AL., PROC. NATL. ACAD SCI. USA, (1985), vol. 82, pages 6927 - 6931
    - VAN DER PUTTEN ET AL., PROC. NATL. ACAD SCI. USA, (1985), vol. 82, pages 6148 - 6152
    - STEWART ET AL., EMBO J., (1987), vol. 6, pages 383 - 388
    - JAHNER D. ET AL., NATURE, (1982), vol. 298, pages 623 - 628
    - HASKELL, BOWEN, MAL. REPROD. DEV., (1995), vol. 40, page 386
    - CASAS ET AL., AM J PATHOL, (2004), vol. 165, pages 1289 - 1300
    - PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277
    - CALAME, EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275
    - WINOTO, BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733
    - BANERJI ET AL., CELL, (1983), vol. 33, pages 729 - 740
    - QUEEN, BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748
    - STURCHLER-PIERRAT ET AL., PROC. NATL. ACAD SCI. USA, (1997), vol. 94, pages 13287 - 13292
    - BYRNE, RUDDLE, PNAS, (1989), vol. 86, pages 5473 - 5477
    - EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916
    - SUBRAMANIAM, A, JONES WK, GULICK J, WERT S, NEUMANN J, ROBBINS J., "Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice", J BIOL CHEM, (1991), vol. 266, pages 24613 - 24620, XP002945482
    - DARNELL, J., LODISH, H., BALTIMORE, D., Molecular Cell Biology,2"d Edition, SCIENTIFIC AMERICAN BOOKS, (1990), page 63
    - MORRIS, LEARN MOTIVAT, (1981), vol. 12, pages 239 - 260
    - SAIDO T.C., MEDICAL HYPOTHESES, (2000), vol. 54, no. 3, pages 427 - 429
    - HUSE J.T. ET AL., BIOL. CHEM., (2002), vol. 277, no. 18, pages 16278 - 16284
    - GARDEN, R. W., MOROZ, T. P., GLEESON, J. M., FLOYD, P. D., LI, L. J., RUBAKHIN, S. S., SWEEDLER, J. V., J NEUROCHEM, (1999), vol. 72, pages 676 - 681
    - HOSODA R. ET AL., J NEUROPATHOL EXP NEUROL., (1998), vol. 57, pages 1089 - 1095
    - IWATSUBO, T., SAIDO, T. C., MANN, D. M., LEE, V. M., TROJANOWSKI, J. Q., AM J PATHOL, (1996), vol. 149, pages 1823 - 1830
    - PROKAL, L., PROKAI-TATRAI, K., OUYANG, X., KIM, H. S., WU, W. M., ZHARIKOVA, A., BODOR, N., J MED CHEM, (1999), vol. 42, pages 4563 - 4571
    - BINDER, E. B. ET AL., BIOL PSYCHIATRY, (2001), vol. 50, pages 856 - 872
    - FRASER, L.R., ADEOYA-OSIGUWA, S. A., VITAM HORM, (2001), vol. 63, pages 1 - 28
    - SAIDO, T.C., MED HYPOTHESES, (200003), vol. 54, no. 3, pages 427 - 9
    - BATEMAN, R.C.J. ET AL., BIOCHEMISTRY, (2001), vol. 40, pages 11246 - 11250
    - BOOTH, R.E. ET AL., BMC BIOLOGY, (2004), page 2
    - BRADFORD, M. M., ANAL BIOCHEM, (1976), vol. 72, pages 248 - 254
    - GILL, S.C., VON HIPPEL, P.H., ANAL BIOCHEM, (1989), vol. 182, pages 319 - 326
    - ZERHOUNI, S. ET AL., BIOCHIM BIOPHYS ACTA, (1989), vol. 138, pages 275 - 290
    - BATEMAN, R. C. J., J NEUROSCI METHODS, (1989), vol. 30, pages 23 - 28
    - SCHILLING S. ET AL., BIOCHEMISTRY, vol. 44, no. 40, pages 13415 - 13424
    - SCHILLING ET AL., ANAL. BIOCHEM., (2002), vol. 303, pages 49 - 56
 US20060846244
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