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Extract from the Register of European Patents

EP About this file: EP2431358

EP2431358 - Method of preparing a factor XA inhibitor [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  18.10.2013
Database last updated on 06.07.2024
Most recent event   Tooltip18.10.2013Application deemed to be withdrawnpublished on 20.11.2013  [2013/47]
Applicant(s)For all designated states
Millennium Pharmaceuticals, Inc.
40 Landsdowne Street
Cambridge, MA 02139 / US
[2012/12]
Inventor(s)01 / Grant, Craig
South Lodge
South Street
Risby
Suffolk IP28 6QU / GB
02 / Kanter, James P.
9591 Alcosta Blvd
San Ramon, CA California 94583 / US
03 / Langlands, Graeme
44 Northfield Park
Soham, Cambridgeshire CB7 5UZ / GB
 [2012/26]
Former [2012/12]01 / Grant, Craig
10 Burgley Rise
Burwell, CB5 0LW / GB
02 / Kanter, James P.
9591 Alcosta Blvd
San Ramon, CA California 94583 / US
03 / Langlands, Graeme
44 Northfield Park
Soham, Cambridgeshire CB7 5UZ / GB
Representative(s)Sexton, Jane Helen
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
[2012/12]
Application number, filing date11187927.607.11.2006
[2012/12]
Priority number, dateUS20050735224P08.11.2005         Original published format: US 735224 P
[2012/12]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2431358
Date:21.03.2012
Language:EN
[2012/12]
Search report(s)(Supplementary) European search report - dispatched on:EP21.02.2012
ClassificationIPC:C07D213/75, A61K31/44
[2012/12]
CPC:
A61K31/44 (EP,KR,US); A61K31/194 (EP,US); A61K31/616 (EP,US);
A61K9/20 (US); A61P11/00 (EP); A61P43/00 (EP);
A61P7/02 (EP); A61P9/00 (EP); A61P9/10 (EP);
C07D213/75 (EP,KR,US); Y02A50/30 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2012/12]
TitleGerman:Herstellverfahren für einem Faktor-XA-Inhibitor[2012/12]
English:Method of preparing a factor XA inhibitor[2012/12]
French:Procédé de préparation d'un inhibiteur du facteur XA[2012/12]
Examination procedure21.09.2012Amendment by applicant (claims and/or description)
21.09.2012Examination requested  [2012/44]
14.11.2012Despatch of a communication from the examining division (Time limit: M06)
26.02.2013Application deemed to be withdrawn, date of legal effect  [2013/47]
02.07.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/47]
Parent application(s)   TooltipEP06837238.2  / EP1948608
Fees paidRenewal fee
04.11.2011Renewal fee patent year 03
04.11.2011Renewal fee patent year 04
04.11.2011Renewal fee patent year 05
04.11.2011Renewal fee patent year 06
23.11.2012Renewal fee patent year 07
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Documents cited:Search[IDY]US6376515  (ZHU BING-YAN [US], et al) [ID] 1-15 * Column 331, example 206; Column 224, lines 8-10, 16-22. * [Y] 1-15;
 [IDY]US6844367  (ZHU BING-YAN [US], et al) [ID] 1-15 * Column 198, example 266; column 64, lines 22-24, 30-36. * [Y] 1-15;
 [Y]  - ZHANG ET AL., "Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs", BIOORG. MED. CHEM. LETT., (20040223), vol. 14, no. 4, doi:10.1016/J.BMCL.2003.11.079, pages 983 - 987, XP002471265 [Y] 1-15 * Page 985, scheme 4, step d. *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2003.11.079
 [Y]  - JIA ET AL., "1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. part 2: A survey of P4 motifs", BIOORG. MED. CHEM. LETT., (20040101), vol. 14, no. 5, doi:10.1016/J.BMCL.2003.12.053, pages 1221 - 1227, XP002408687 [Y] 1-15 * Page 1225, scheme 3, step g. *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2003.12.053
by applicantWO9413693
 WO9721437
 EP0798295
 US5735105
 WO9828269
 WO9910316
 US6376515
 US6835739
 US6844367
    - ERIKSSON, QUINLAN, DRUGS, (2006), vol. 11, pages 1411 - 1429
    - COUGHLIN, J., THROMBOSIS HAEMOSTASIS, (2005), vol. 3, pages 1800 - 1814
    - MANN ET AL., J. THROMBOSIS. HAEMOSTASIS, (2003), vol. 1, pages 1504 - 1514
    - MANN ET AL., BLOOD, (1990), vol. 76, no. L, pages 1 - 16
    - TURPIE ET AL., ARCHIVES INTERNAL MEDICINE, (2002), vol. 162, no. 16, pages 1833 - 1840
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.