blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2455105

EP2455105 - Bombesin analogues [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  23.12.2016
Database last updated on 03.01.2025
Most recent event   Tooltip20.07.2018Lapse of the patent in a contracting state
New state(s): IS, MT
published on 22.08.2018  [2018/34]
Applicant(s)For all designated states
Piramal Imaging SA
Route de l'Ecole 13
1753 Matran / CH
[2012/39]
Former [2012/21]For all designated states
Bayer Pharma Aktiengesellschaft
Müllerstrasse 178
13353 Berlin / DE
Inventor(s)01 / Lehmann, Lutz
Gartenstr. 3
Haus C
10115 Berlin / DE
02 / Srinivasan, Ananth
Leibnizstr. 56
10629 Berlin / DE
03 / Brumby, Thomas
Lepsiusstr. 60
12163 Berlin / DE
04 / Suelzle, Detlev
Olafstr. 88
13467 Berlin / DE
05 / Stellfeld, Timo
Schlangenbader Str. 84
14197 Berlin / DE
06 / Karramkam, Myléne
7 lot Cassiopée
Dupuy
97122 Baie-Mahault Guadeloupe / FR
07 / Ametamey, Simon
Uetlibergstr. 308
8045 Zürich / CH
 [2012/21]
Representative(s)Kilger, Ute, et al
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[N/P]
Former [2016/07]Kilger, Ute, et al
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Patentanwälte Rechtsanwälte
Pettenkoferstrasse 20-22
80336 München / DE
Former [2012/39]Kilger, Ute, et al
Boehmert & Boehmert
Pettenkoferstrasse 20-22
80336 München / DE
Former [2012/21](deleted)
Application number, filing date11193716.507.09.2007
[2012/21]
Priority number, dateEP2006009016608.09.2006         Original published format: EP 06090166
EP2007009007923.04.2007         Original published format: EP 07090079
[2012/21]
Previously filed application, dateWO2007EP0804207.09.2007
[2012/21]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2455105
Date:23.05.2012
Language:EN
[2012/21]
Type: A3 Search report 
No.:EP2455105
Date:05.09.2012
Language:EN
[2012/36]
Type: B1 Patent specification 
No.:EP2455105
Date:17.02.2016
Language:EN
[2016/07]
Search report(s)(Supplementary) European search report - dispatched on:EP06.08.2012
ClassificationIPC:C07K7/06
[2015/17]
CPC:
C07K14/6555 (EP,US); C07D405/04 (KR); A61K51/04 (KR);
A61K51/08 (KR); A61K51/088 (EP,US); A61P35/00 (EP);
C07C255/58 (KR); C07K14/57545 (EP,US) (-)
Former IPC [2012/21]A61K49/04, A61K49/08, A61K49/10, A61K51/04, C07D249/18, C07D405/14, C07D405/04, C07D409/04, A61K31/7072, A61K38/08, C07K7/06, C07K1/13, C07K5/023, C07K5/02
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/07]
Former [2012/21]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Bombesin Analoga[2012/21]
English:Bombesin analogues[2012/21]
French:Analogues de la bombesin[2012/21]
Examination procedure05.03.2013Examination requested  [2013/15]
26.08.2013Despatch of a communication from the examining division (Time limit: M06)
24.01.2014Reply to a communication from the examining division
30.03.2015Communication of intention to grant the patent
31.07.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
16.09.2015Communication of intention to grant the patent
14.12.2015Fee for grant paid
14.12.2015Fee for publishing/printing paid
14.12.2015Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP07802326.4  / EP2063918
Divisional application(s)EP16153790.7  / EP3056509
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20070802326) is  21.12.2009
Opposition(s)18.11.2016No opposition filed within time limit [2017/04]
Fees paidRenewal fee
15.12.2011Renewal fee patent year 03
15.12.2011Renewal fee patent year 04
12.06.2012Renewal fee patent year 05
12.09.2012Renewal fee patent year 06
12.09.2013Renewal fee patent year 07
01.07.2014Renewal fee patent year 08
23.09.2015Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
15.12.201105   M06   Fee paid on   12.06.2012
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.09.2007
AT17.02.2016
BE17.02.2016
CY17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IS17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
MC17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SI17.02.2016
SK17.02.2016
TR17.02.2016
BG17.05.2016
GR18.05.2016
PT17.06.2016
IE07.09.2016
LU07.09.2016
MT30.09.2016
[2018/33]
Former [2018/29]HU07.09.2007
AT17.02.2016
BE17.02.2016
CY17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
MC17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SI17.02.2016
SK17.02.2016
TR17.02.2016
BG17.05.2016
GR18.05.2016
PT17.06.2016
IE07.09.2016
LU07.09.2016
Former [2018/28]HU07.09.2007
AT17.02.2016
BE17.02.2016
CY17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
MC17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SI17.02.2016
SK17.02.2016
BG17.05.2016
GR18.05.2016
PT17.06.2016
IE07.09.2016
LU07.09.2016
Former [2017/41]AT17.02.2016
BE17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
MC17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SI17.02.2016
SK17.02.2016
BG17.05.2016
GR18.05.2016
PT17.06.2016
IE07.09.2016
LU07.09.2016
Former [2017/31]AT17.02.2016
BE17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
MC17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SI17.02.2016
SK17.02.2016
BG17.05.2016
GR18.05.2016
PT17.06.2016
Former [2017/15]AT17.02.2016
BE17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SI17.02.2016
SK17.02.2016
BG17.05.2016
GR18.05.2016
PT17.06.2016
Former [2017/03]AT17.02.2016
BE17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SK17.02.2016
GR18.05.2016
PT17.06.2016
Former [2016/50]AT17.02.2016
CZ17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
NL17.02.2016
PL17.02.2016
RO17.02.2016
SE17.02.2016
SK17.02.2016
GR18.05.2016
PT17.06.2016
Former [2016/49]AT17.02.2016
DK17.02.2016
EE17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
NL17.02.2016
PL17.02.2016
SE17.02.2016
GR18.05.2016
PT17.06.2016
Former [2016/46]AT17.02.2016
DK17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
NL17.02.2016
PL17.02.2016
SE17.02.2016
GR18.05.2016
PT17.06.2016
Former [2016/39]AT17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
LV17.02.2016
NL17.02.2016
PL17.02.2016
SE17.02.2016
GR18.05.2016
PT17.06.2016
Former [2016/38]AT17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
NL17.02.2016
PL17.02.2016
GR18.05.2016
PT17.06.2016
Former [2016/36]AT17.02.2016
ES17.02.2016
FI17.02.2016
IT17.02.2016
LT17.02.2016
NL17.02.2016
PL17.02.2016
GR18.05.2016
Former [2016/35]ES17.02.2016
FI17.02.2016
GR18.05.2016
Documents cited:Search[A]US5723578  (COY DAVID H [US], et al) [A] 1* claim 1 *
by applicantWO9933795
 WO9933815
 WO9933793
 WO9933792
 WO0109390
 WO0244144
 WO03080544
 WO2004080492
 EP1563852
 WO2006083424
 WO2007016538
    - FRITZBERG ET AL., J. NUCL. MED., (1992), vol. 33, page 394
    - BOERMAN, SEMINAR IN NUCLEAR MEDICINE, (200007), vol. 30, no. 3, pages 195 - 208
    - C.J. SMITH, "Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: an in vitro l in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 human prostate cancer cells.", NUCL. MED. BIO., (2003), vol. 30, no. 2, doi:doi:10.1016/S0969-8051(02)00391-8, pages 101 - 9, XP004413110

DOI:   http://dx.doi.org/10.1016/S0969-8051(02)00391-8
    - E.GARCIA GARAYOA ET AL., "Chemical and biological characterization of new Re(CO)3/[99mTc](CO)3 bombesin Analogues.", NUCL. MED. BIOL., (2007), doi:doi:10.1016/j.nucmedbio.2006.10.004, pages 17 - 28, XP005823963

DOI:   http://dx.doi.org/10.1016/j.nucmedbio.2006.10.004
    - OKARVI ET AL., "Recent progress in fluorine-18 labeled peptide radiopharmaceuticals.", EUR. J. NUCL. MED., (200107), vol. 28, no. 7, doi:doi:10.1007/s002590100508, pages 929 - 38, XP001189313

DOI:   http://dx.doi.org/10.1007/s002590100508
    - XIANZHONG ZHANG ET AL., "18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer.", J. NUCL. MED., (2006), vol. 47, no. 3, pages 492 - 501, XP055009865
    - THORSTEN POETHKO ET AL., "Two-step methodology for high-yield routine radiohalogenation of peptides: 18F-labeled RGD and octreotide analogs.", J. NUCL. MED., (200405), vol. 45, no. 5, pages 892 - 902, XP002520745
    - THORSTEN POETHKO ET AL., "First 18F-labeled tracer suitable for routine clinical imaging of somatostatin receptor-expressing tumors using positron emission tomography.", CLIN. CANCER RES., (20040601), vol. 10, no. 11, pages 3593 - 606
    - IRIE ET AL., FLUORINE CHEM., (1982), vol. 27, pages 117 - 191
    - OYA ET AL., J. MED. CHEM., (2002), vol. 45, no. 21, pages 4716 - 4723
    - LI ET AL., BIOCONJUGATE CHEMISTRY, (2003), vol. 14, no. 2, pages 287 - 294
    - ENAS ET AL., J. FLUORINE CHEM., (1993), vol. 63, no. 3, pages 233 - 41
    - SEIMBILLE ET AL., J. LABELED COMPD. RADIOPHARM., (2005), vol. 48, no. 11, pages 829 - 843
    - LANGER, BIOORG. MED. CHEM., (2001), vol. 3, pages 677 - 694
    - LANG ET AL., J. MED. CHEM., (1999), vol. 42, no. 9, pages 1576 - 1586
    - AMOKHTARI ET AL., J. LABELED COMPD. RADIOPHARM., (1999), vol. S42, no. 1, pages S622 - S623
    - LEMAIRE ET AL., J. LABELED COMPD. RADIOPHARM., (2001), vol. 44, pages 3857 - S859
    - VANBROCKLIN, J. LABELED COMPD. RADIOPHARM., (2001), vol. 44, pages S880 - S882
    - D.A.SUTTON ET AL., "Evaluation of 1-fluoro-2-nitro-4-trimethylammoniobenzene iodide, a protein-solubilizing agent", BIOCHEM. J., (1972), vol. 130, pages 589 - 595, XP002417690
    - C.LEMAIRE ET AL., "Highly enantioselective synthesis of no-carrier added 6-[18F]fluoro-L-dopa by chiral phase-transfer alkylation", EUR. J. ORG. CHEM., (2004), doi:doi:10.1002/EJOC.200400059, pages 2899 - 2904, XP002509250

DOI:   http://dx.doi.org/10.1002/EJOC.200400059
    - L.LANG ET AL., "Development of fluorine-18-labeled 5-HTIA antagonists", J. MED. CHEM., (1999), vol. 42, no. 9, pages 1576 - 1586
    - S.OYA ET AL., "New PET imaging agent for the serotonin transporter [18F]ACF (2-[(amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine", J. MED. CHEM., (2002), vol. 45, pages 4716 - 4723, XP002693644
    - M.J.AI-DARWICH ET AL., "Enantioselective synthesis of non-carrier-added (n.c.a.) (S)-4-chloro-2-[18eF]fluorophenylalanine and (S)-(a-methyl)-4-chloro-2-[18F]fluorophenylalanine", J. FLUORINE CHEM., (1996), vol. 80, pages 117 - 124
    - Y.SEIMBILLE, "Fluorine-18 labeling of 6, 7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: synthesis of 18F-Iressa and related molecular probes", J. LABELED COMPD. RADIOPHARRN., (2005), vol. 48, doi:doi:10.1002/jlcr.998, pages 829 - 843, XP008072762

DOI:   http://dx.doi.org/10.1002/jlcr.998
    - EUR. J. NUCL. MED., (2001), vol. 28, pages 929 - 938
    - J. NUCL. MED., (2004), vol. 45, no. 5, pages 892 - 902
    - BIOCONJUGATE CHEM., (1991), vol. 2, pages 44 - 49
    - J. NUCL. MED., (1987), vol. 28, pages 462 - 470
    - J. LABELED COMPD. RADIOPHARM., (1989), vol. 26, pages 287 - 289
    - BIOCONJUGATE CHEM., (2003), vol. 14, pages 1253 - 1259
    - BIOCONJUGATE CHEM., (2000), vol. 11, pages 627 - 636
    - J. ORG. CHEM., (1995), vol. 60, pages 6680 - 6681
    - HATU; DIPEA, EUR. J. NUCL. MED. MOL. IMAGING., (2002), vol. 29, pages 754 - 759
    - NUCL. MED. BIO/., (1996), vol. 23, page 365
    - "Biotransformation of Drugs", GOODMAN; GILMAN, The Pharmaco- logical Basis of Therapeutics, MCGRAW-HIM, (1992), pages 13 - 15
    - P.E. NIELSEN, ACE. CHEM. RES., vol. 32, pages 624 - 30
    - J.H. JONES, J. PEPTIDE SCI., (2003), vol. 9, pages 1 - 8
    - J. NUCL. MED., (20060404), vol. 7, no. 4, pages 668 - 78
    - "Aptamers as Tools in Molecular Biology and Immunology", M FAMULOK; G MAYER, Combinatorial Chemistry in Biology, Current Topics in Microbiology and Immunology, SPRINGER VERLAG, (1999), vol. 243, pages 123 - 136
    - CHEM. REV., (1991), vol. 91, pages 165 - 195
    - CHEM. REV., (1991), vol. 91, page 165
    - "Fluorine-18 Labeling Methods: Features and Possibilities of Basic Reactions", COENEN, PET-Chemistry - The Driving Force in Molecular Imaging, SPRINGER, (2006), pages 15 - 50
    - P.L.JAGER; M.A.KORTE; M.N.LUB-DE HOOGE; A. VAN WAARDE; K.P.KOOPMANS; P.J.PERIK; E.G.E. DE VRIES, CANCER IMAGING, (2005), vol. 5, pages 27 - 32
    - W.D.HEISS; K.HERHOLZ, J. NUCL. MED., (2006), vol. 47, no. 2, pages 302 - 312
    - M.SCHWAIGER, CURR. CARDIOL. REP., (2006), vol. 8, no. 2, pages 131 - 138
    - CHEM REV., (1999), vol. 42, no. 9, pages 165 - 195
    - Remington's Practice of Pharmacy
    - J. OF. PHARMACEUTICAL SCIENCE & TECHNOLOGY, vol. 52, no. 5, pages 238 - 311
    - J. FLUORINE CHEM., (1985), vol. 27, pages 117 - 191
    - J. AM. CHEM. SOC., (2005), vol. 127, no. 48, pages 16912 - 16920
    - HELV. CHIM. ACTA, (2005), vol. 88, no. 7, pages 1630 - 1657
    - BIOORG. MED. CHEM. LETT., (2000), vol. 10, no. 23
    - BIOORG. MED. CHEM., (2003), vol. 11, pages 4189 - 4206
    - NUCLEIC ACIDS RESEARCH, (2004), vol. 32, no. 19, pages 5757 - 5765
    - J.W.CARPENTER ET AL., METH. MOL. BIOL., (2002), vol. 190, pages 31 - 49
    - J. FLUORINE CHEM., (1993), vol. 63, no. 1-2, pages 25 - 30
    - J. MED. CHEM., (1992), vol. 35, no. 24, pages 4613 - 4627
    - J. MED. CHEM., (1997), vol. 40, no. 13, pages 2017 - 2034
    - BIOORG. MED. CHEM., (1998), vol. 6, no. 8, pages 1185 - 1208
    - J. FLUORINE CHEM., (1995), vol. 74, no. 1, pages 113 - 122
    - J. PHARM. SCI., (1993), vol. 82, no. 9, pages 927 - 933
    - PHARM.CHEM.J.(ENGL.TRANSL., (1975), vol. 9, no. 3, page 158
    - J. MED. CHEM, (2004), vol. 47, page 1413
    - J. MED. CHEM., (2004), vol. 47, pages 1413 - 1422
    - TETRAHEDRON, (2004), pages 8729 - 8738
    - TETRAHEDRON, (2004), vol. 60, pages 8729 - 8738
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.