EP2536438 - COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.10.2014 Database last updated on 03.09.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states Ecole Nationale Supérieure de Chimie de Rennes Campus de Beaulieu Avenue du Général Leclerc, CS 50837 35708 Rennes Cedex 7 / FR | For all designated states Centre Eugène Marquis Avenue de la Bataille Flandres-Dunkerque CS 44229 35042 Rennes / FR | For all designated states Université de Rennes I 2, rue du Thabor CS 46510 35065 Rennes Cedex / FR | [2013/49] |
Former [2012/52] | For all designated states Ecole Nationale Supérieure De Chimie De Rennes Campus de Beaulieu Avenue du Général Leclerc, CS 50837 35708 Rennes Cedex 7 / FR | ||
For all designated states Centre Eugène Marquis Avenue de la Bataille Flandres-Dunkerque CS 44229 35042 Rennes / FR | |||
For all designated states Universite De Rennes I 2 Rue du Thabor CS 46510 35065 Rennes Cédex / FR | Inventor(s) | 01 /
NOIRET, Nicolas 23 rue Raoul de la Futaye F-35250 St Sulpice La Foret / FR | 02 /
GARIN, Etienne Le Fumeson F-35520 La Meziere / FR | 03 /
LEPAREUR, Nicolas 25 rue de la Touche F-35770 Vern Sur Seiche / FR | 04 /
ARDISSON, Valérie 1 allée Louis Auguste Jobbe Duval F-35000 Rennes / FR | [2012/52] | Representative(s) | Larcher, Dominique Cabinet Vidon 16 B, rue Jouanet B.P. 90333 Technopole Atalante 35703 Rennes Cedex 7 / FR | [N/P] |
Former [2012/52] | Larcher, Dominique Cabinet Vidon, 16 B, rue Jouanet, BP 90333 Technopole Atalante 35703 Rennes Cedex 7 / FR | Application number, filing date | 11705507.9 | 18.02.2011 | WO2011EP52420 | Priority number, date | FR20100000681 | 18.02.2010 Original published format: FR 1000681 | [2012/52] | Filing language | FR | Procedural language | FR | Publication | Type: | A1 Application with search report | No.: | WO2011101436 | Date: | 25.08.2011 | Language: | FR | [2011/34] | Type: | A1 Application with search report | No.: | EP2536438 | Date: | 26.12.2012 | Language: | FR | The application published by WIPO in one of the EPO official languages on 25.08.2011 takes the place of the publication of the European patent application. | [2012/52] | Type: | B1 Patent specification | No.: | EP2536438 | Date: | 04.12.2013 | Language: | FR | [2013/49] | Search report(s) | International search report - published on: | EP | 25.08.2011 | Classification | IPC: | A61K51/04, A61K103/10 | [2012/52] | CPC: |
A61K51/0404 (EP);
A61K51/04 (KR);
A61K31/10 (KR);
A61K51/0474 (EP);
A61P1/16 (EP);
A61P35/00 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/52] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | ZUSAMMENSETZUNG ZUR BEHANDLUNG VON LEBERKREBS BEI MENSCHEN AUF DER BASIS VON RHENIUM-188 UND VERFAHREN FÜR DIE ZUBEREITUNG EINER DERARTIGEN ZUSAMMENSETZUNG | [2012/52] | English: | COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION | [2012/52] | French: | COMPOSITION POUR LE TRAITEMENT DU CANCER DU FOIE CHEZ L'HOMME A BASE DE RHENIUM-188 ET PROCEDE DE PREPARATION D'UNE TELLE COMPOSITION | [2012/52] | Entry into regional phase | 13.08.2012 | National basic fee paid | 13.08.2012 | Designation fee(s) paid | 13.08.2012 | Examination fee paid | Examination procedure | 13.08.2012 | Examination requested [2012/52] | 13.03.2013 | Amendment by applicant (claims and/or description) | 01.07.2013 | Communication of intention to grant the patent | 24.10.2013 | Fee for grant paid | 24.10.2013 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.07.2013 | Opposition(s) | 05.09.2014 | No opposition filed within time limit [2014/46] | Fees paid | Renewal fee | 28.02.2013 | Renewal fee patent year 03 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 18.02.2011 | AL | 04.12.2013 | AT | 04.12.2013 | BG | 04.12.2013 | CY | 04.12.2013 | CZ | 04.12.2013 | DK | 04.12.2013 | EE | 04.12.2013 | ES | 04.12.2013 | FI | 04.12.2013 | HR | 04.12.2013 | IT | 04.12.2013 | LT | 04.12.2013 | LV | 04.12.2013 | MC | 04.12.2013 | MK | 04.12.2013 | MT | 04.12.2013 | NL | 04.12.2013 | PL | 04.12.2013 | RO | 04.12.2013 | RS | 04.12.2013 | SE | 04.12.2013 | SI | 04.12.2013 | SK | 04.12.2013 | SM | 04.12.2013 | TR | 04.12.2013 | IE | 18.02.2014 | LU | 18.02.2014 | CH | 28.02.2014 | LI | 28.02.2014 | NO | 04.03.2014 | GR | 05.03.2014 | IS | 04.04.2014 | PT | 04.04.2014 | [2018/46] |
Former [2018/31] | HU | 18.02.2011 | |
AT | 04.12.2013 | ||
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IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
GR | 05.03.2014 | ||
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PT | 04.04.2014 | ||
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TR | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
GR | 05.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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AT | 04.12.2013 | ||
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CY | 04.12.2013 | ||
CZ | 04.12.2013 | ||
DK | 04.12.2013 | ||
EE | 04.12.2013 | ||
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FI | 04.12.2013 | ||
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IT | 04.12.2013 | ||
LT | 04.12.2013 | ||
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RS | 04.12.2013 | ||
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SI | 04.12.2013 | ||
SK | 04.12.2013 | ||
SM | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
GR | 05.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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BG | 04.12.2013 | ||
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CZ | 04.12.2013 | ||
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RS | 04.12.2013 | ||
SE | 04.12.2013 | ||
SI | 04.12.2013 | ||
SK | 04.12.2013 | ||
SM | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
GR | 05.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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CY | 04.12.2013 | ||
CZ | 04.12.2013 | ||
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EE | 04.12.2013 | ||
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PL | 04.12.2013 | ||
RO | 04.12.2013 | ||
RS | 04.12.2013 | ||
SE | 04.12.2013 | ||
SI | 04.12.2013 | ||
SK | 04.12.2013 | ||
SM | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
Former [2016/12] | AT | 04.12.2013 | |
CY | 04.12.2013 | ||
CZ | 04.12.2013 | ||
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SI | 04.12.2013 | ||
SK | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
Former [2015/18] | AT | 04.12.2013 | |
CY | 04.12.2013 | ||
CZ | 04.12.2013 | ||
DK | 04.12.2013 | ||
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LT | 04.12.2013 | ||
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PL | 04.12.2013 | ||
RO | 04.12.2013 | ||
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SI | 04.12.2013 | ||
SK | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
Former [2015/14] | AT | 04.12.2013 | |
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RO | 04.12.2013 | ||
RS | 04.12.2013 | ||
SE | 04.12.2013 | ||
SI | 04.12.2013 | ||
SK | 04.12.2013 | ||
IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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PL | 04.12.2013 | ||
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IE | 18.02.2014 | ||
LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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LU | 18.02.2014 | ||
CH | 28.02.2014 | ||
LI | 28.02.2014 | ||
NO | 04.03.2014 | ||
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PT | 04.04.2014 | ||
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IS | 04.04.2014 | ||
PT | 04.04.2014 | ||
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NO | 04.03.2014 | Cited in | International search | [AD]WO0190114 (CIS BIO INT [FR]) [AD] 1-10 * page 3, line 27 - page 4, line 14 * * page 10, lignes 9,27 *; | [A] - GARIN E ET AL, "Effect of a <188>Re-SSS lipiodol/<131>I-lipiodol mixture, <188>Re-SSS lipiodol alone or <131>I-lipiodol alone on the survival of rats with hepatocellular carcinoma", NUCLEAR MEDICINE COMMUNICATIONS 200604 GB LNKD- DOI:10.1097/00006231-200604000-00008, (200604), vol. 27, no. 4, ISSN 0143-3636, pages 363 - 369, XP008126387 [A] 1-17 * abstract * * page 364, column right, paragraph 1 * * page 365, column left, paragraph 4 * * page 367, column left, paragraph 3 * * page 368, column left, paragraph 3 * * page 368, column right, paragraph 3 * DOI: http://dx.doi.org/10.1097/01.mnm.0000202863.52046.7f | [IA] - GARIN ETIENNE ET AL, "188Re-SSS lipiodol: radiolabelling and biodistribution following injection into the hepatic artery of rats bearing hepatoma", NUCLEAR MEDICINE COMMUNICATIONS, (200410), vol. 25, no. 10, ISSN 0143-3636, pages 1007 - 1013, XP008126388 [I] 12,14-17 * page 1008, section "materials and methods: radiochemistry" * * page 1009, column left, paragraph 2 * * page 1011, column right, paragraph 1 * * page 1012, column left, paragraph last - column right, line 2 * [A] 1-11,13 DOI: http://dx.doi.org/10.1097/00006231-200410000-00004 | [A] - GARIN E ET AL, "Effect of Stabilized Iodized Oil Emulsion on Experimentally Induced Hepatocellular Carcinoma in Rats", JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, VA, vol. 16, no. 6, ISSN 1051-0443, (20050601), pages 841 - 848, (20050601), XP025345500 [A] 1-17 * abstract * * page 843, 3ème colonne, section "Injection of 99mTc-SSS LUF", 5ème ligne * | [A] - SANDRINE BALLOT ET AL, "99mTc/188Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER, BERLIN, DE LNKD- DOI:10.1007/S00259-005-0007-0, (20060201), vol. 33, no. 5, ISSN 1619-7089, pages 602 - 607, XP019422341 [A] 1-17 * abstract * * page 602, column right, paragraph last - page 603, column right * * page 604, column left, paragraph 2 * DOI: http://dx.doi.org/10.1007/s00259-005-0007-0 | [L] - ANONYMOUS, "Tadeo. Automated Module for Synthesis of Theraupetic Radiopharmaceuticals", pages 1 - 10, COMECER, URL: http://www.emnovation.nl/PDF/Radiochemistry_Target_SynthesisR.pdf, (20100916), XP002600909 [L] 12-17 * pages 1-2 * | [A] - JOURNAL D'INFORMATION DU CENTRE EUGÈNE MARQUIS, no. 20, (200707), URL: http://www.centre-eugene-marquis.fr/uploads/fichiers/journal%20CEM%2007-2007%20intranet.pdf, (20100916), XP002600908 [A] 12-17 * page 3 * | [AD] - OH S J ET AL, "Automated preparation of <188>Re-labeled radiopharmaceuticals for endovascular radiation therapy", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB LNKD- DOI:10.1016/S0969-8043(03)00170-2, (20031001), vol. 59, no. 4, ISSN 0969-8043, pages 225 - 230, XP004458714 [AD] 12-17 * abstract * DOI: http://dx.doi.org/10.1016/S0969-8043(03)00170-2 | [AP] - ANONYMOUS, "188RE-SSS Lipiodol to Treat HepatoCellular Carcinomas", (20100518), Clinical Trials Feeds, URL: http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01126463, (20100917), XP002600910 [AP] 1-17 * the whole document * | [T] - LEPAREUR N ET AL, "Automation of labelling of Lipiodol with high-activity generator-produced <188>Re", APPLIED RADIATION AND ISOTOPES 2011 ELSEVIER LTD GBR LNKD- DOI:10.1016/J.APRADISO.2010.11.001, (201102), vol. 69, no. 2, ISSN 0969-8043, pages 426 - 430, XP002630129 [T] 12,14-17 * publié en ligne le 12.11.2010 * * page 428, colonne de droite, section 4 "Discussion" 2ème alinéa * DOI: http://dx.doi.org/10.1016/j.apradiso.2010.11.001 | by applicant | WO0190114 | - E. GARIN; P. BOURGUET, Nuclear Medicine in Clinical Diagnosis and Treatment, CHURCHILL-LIVINGSTONE, (2004), pages 473 - 483 | - B. LAMBERT, J.NUCL.MED., (2005), vol. 46, pages 60 - 66 | - S.J. WANG ET AL., J. NUCL. MED., (1996), vol. 37, pages 332 - 335 | - S.J. WANG ET AL., APPL. RADIAT. ISOT., (1996), vol. 47, pages 267 - 271 | - B. LAMBERT ET AL., J. NUCL. MED., (2005), vol. 46, pages 60 - 66 | - B. LAMBERT ET AL., EUR. J. NUCL. MED., (2006), vol. 33, pages 344 - 352 | - A. BOSCHI ET AL., NUCL. MED. COMMUN., (2004), vol. 25, pages 691 - 699 | - F. MéVELLEC ET AL., INORG. CHEM. COMM., (1999), vol. 2, pages 230 - 233 | - N. LEPAREUR ET AL., J. LABEL. COMPD. RADIOPHARM., (2004), vol. 47, pages 857 - 867 | - E. GARIN ET AL., EUR. J. NUCL. MED. MOL. IMAGING, (2004), vol. 31, pages 542 - 546 | - S.J. OH ET AL., APPL. RADIAT. ISOT., (2001), vol. 54, pages 419 - 427 | - S.J. OH ET AL., APPL. RADIAT. ISOT., (2003), vol. 59, pages 225 - 230 | - B. LAMBERT ET AL., J.NUCL. MED., (2005), vol. 46, pages 60 - 66 |