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Extract from the Register of European Patents

EP About this file: EP2536438

EP2536438 - COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.10.2014
Database last updated on 03.09.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Ecole Nationale Supérieure de Chimie de Rennes
Campus de Beaulieu
Avenue du Général Leclerc, CS 50837
35708 Rennes Cedex 7 / FR
For all designated states
Centre Eugène Marquis
Avenue de la Bataille Flandres-Dunkerque
CS 44229
35042 Rennes / FR
For all designated states
Université de Rennes I
2, rue du Thabor
CS 46510
35065 Rennes Cedex / FR
[2013/49]
Former [2012/52]For all designated states
Ecole Nationale Supérieure De Chimie De Rennes
Campus de Beaulieu
Avenue du Général Leclerc, CS 50837
35708 Rennes Cedex 7 / FR
For all designated states
Centre Eugène Marquis
Avenue de la Bataille Flandres-Dunkerque
CS 44229
35042 Rennes / FR
For all designated states
Universite De Rennes I
2 Rue du Thabor CS 46510
35065 Rennes Cédex / FR
Inventor(s)01 / NOIRET, Nicolas
23 rue Raoul de la Futaye
F-35250 St Sulpice La Foret / FR
02 / GARIN, Etienne
Le Fumeson
F-35520 La Meziere / FR
03 / LEPAREUR, Nicolas
25 rue de la Touche
F-35770 Vern Sur Seiche / FR
04 / ARDISSON, Valérie
1 allée Louis Auguste Jobbe Duval
F-35000 Rennes / FR
 [2012/52]
Representative(s)Larcher, Dominique
Cabinet Vidon
16 B, rue Jouanet
B.P. 90333
Technopole Atalante
35703 Rennes Cedex 7 / FR
[N/P]
Former [2012/52]Larcher, Dominique
Cabinet Vidon, 16 B, rue Jouanet, BP 90333 Technopole Atalante
35703 Rennes Cedex 7 / FR
Application number, filing date11705507.918.02.2011
WO2011EP52420
Priority number, dateFR2010000068118.02.2010         Original published format: FR 1000681
[2012/52]
Filing languageFR
Procedural languageFR
PublicationType: A1 Application with search report
No.:WO2011101436
Date:25.08.2011
Language:FR
[2011/34]
Type: A1 Application with search report 
No.:EP2536438
Date:26.12.2012
Language:FR
The application published by WIPO in one of the EPO official languages on 25.08.2011 takes the place of the publication of the European patent application.
[2012/52]
Type: B1 Patent specification 
No.:EP2536438
Date:04.12.2013
Language:FR
[2013/49]
Search report(s)International search report - published on:EP25.08.2011
ClassificationIPC:A61K51/04, A61K103/10
[2012/52]
CPC:
A61K51/0404 (EP); A61K51/04 (KR); A61K31/10 (KR);
A61K51/0474 (EP); A61P1/16 (EP); A61P35/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/52]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZUSAMMENSETZUNG ZUR BEHANDLUNG VON LEBERKREBS BEI MENSCHEN AUF DER BASIS VON RHENIUM-188 UND VERFAHREN FÜR DIE ZUBEREITUNG EINER DERARTIGEN ZUSAMMENSETZUNG[2012/52]
English:COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION[2012/52]
French:COMPOSITION POUR LE TRAITEMENT DU CANCER DU FOIE CHEZ L'HOMME A BASE DE RHENIUM-188 ET PROCEDE DE PREPARATION D'UNE TELLE COMPOSITION[2012/52]
Entry into regional phase13.08.2012National basic fee paid 
13.08.2012Designation fee(s) paid 
13.08.2012Examination fee paid 
Examination procedure13.08.2012Examination requested  [2012/52]
13.03.2013Amendment by applicant (claims and/or description)
01.07.2013Communication of intention to grant the patent
24.10.2013Fee for grant paid
24.10.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.07.2013
Opposition(s)05.09.2014No opposition filed within time limit [2014/46]
Fees paidRenewal fee
28.02.2013Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.02.2011
AL04.12.2013
AT04.12.2013
BG04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MK04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
SM04.12.2013
TR04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
GR05.03.2014
IS04.04.2014
PT04.04.2014
[2018/46]
Former [2018/31]HU18.02.2011
AT04.12.2013
BG04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MK04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
SM04.12.2013
TR04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
GR05.03.2014
IS04.04.2014
PT04.04.2014
Former [2016/33]HU18.02.2011
AT04.12.2013
BG04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
SM04.12.2013
TR04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
GR05.03.2014
IS04.04.2014
PT04.04.2014
Former [2016/32]HU18.02.2011
AT04.12.2013
BG04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
SM04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
GR05.03.2014
IS04.04.2014
PT04.04.2014
Former [2016/28]AT04.12.2013
BG04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
SM04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
GR05.03.2014
IS04.04.2014
PT04.04.2014
Former [2016/22]AT04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
SM04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2016/12]AT04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
MT04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2015/18]AT04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
IT04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2015/14]AT04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SI04.12.2013
SK04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2015/07]AT04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SK04.12.2013
IE18.02.2014
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2014/48]AT04.12.2013
CY04.12.2013
CZ04.12.2013
DK04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SK04.12.2013
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2014/46]AT04.12.2013
CY04.12.2013
CZ04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SK04.12.2013
LU18.02.2014
CH28.02.2014
LI28.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2014/44]AT04.12.2013
CY04.12.2013
CZ04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
MC04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SK04.12.2013
LU18.02.2014
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2014/37]AT04.12.2013
CY04.12.2013
CZ04.12.2013
EE04.12.2013
ES04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
NL04.12.2013
PL04.12.2013
RO04.12.2013
RS04.12.2013
SE04.12.2013
SK04.12.2013
NO04.03.2014
IS04.04.2014
PT04.04.2014
Former [2014/36]AT04.12.2013
CY04.12.2013
EE04.12.2013
FI04.12.2013
HR04.12.2013
LT04.12.2013
LV04.12.2013
NL04.12.2013
RS04.12.2013
SE04.12.2013
NO04.03.2014
IS04.04.2014
Former [2014/26]AT04.12.2013
CY04.12.2013
FI04.12.2013
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LT04.12.2013
LV04.12.2013
NL04.12.2013
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SE04.12.2013
NO04.03.2014
Former [2014/25]AT04.12.2013
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LV04.12.2013
NL04.12.2013
RS04.12.2013
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HR04.12.2013
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Cited inInternational search[AD]WO0190114  (CIS BIO INT [FR]) [AD] 1-10 * page 3, line 27 - page 4, line 14 * * page 10, lignes 9,27 *;
 [A]  - GARIN E ET AL, "Effect of a <188>Re-SSS lipiodol/<131>I-lipiodol mixture, <188>Re-SSS lipiodol alone or <131>I-lipiodol alone on the survival of rats with hepatocellular carcinoma", NUCLEAR MEDICINE COMMUNICATIONS 200604 GB LNKD- DOI:10.1097/00006231-200604000-00008, (200604), vol. 27, no. 4, ISSN 0143-3636, pages 363 - 369, XP008126387 [A] 1-17 * abstract * * page 364, column right, paragraph 1 * * page 365, column left, paragraph 4 * * page 367, column left, paragraph 3 * * page 368, column left, paragraph 3 * * page 368, column right, paragraph 3 *

DOI:   http://dx.doi.org/10.1097/01.mnm.0000202863.52046.7f
 [IA]  - GARIN ETIENNE ET AL, "188Re-SSS lipiodol: radiolabelling and biodistribution following injection into the hepatic artery of rats bearing hepatoma", NUCLEAR MEDICINE COMMUNICATIONS, (200410), vol. 25, no. 10, ISSN 0143-3636, pages 1007 - 1013, XP008126388 [I] 12,14-17 * page 1008, section "materials and methods: radiochemistry" * * page 1009, column left, paragraph 2 * * page 1011, column right, paragraph 1 * * page 1012, column left, paragraph last - column right, line 2 * [A] 1-11,13

DOI:   http://dx.doi.org/10.1097/00006231-200410000-00004
 [A]  - GARIN E ET AL, "Effect of Stabilized Iodized Oil Emulsion on Experimentally Induced Hepatocellular Carcinoma in Rats", JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, VA, vol. 16, no. 6, ISSN 1051-0443, (20050601), pages 841 - 848, (20050601), XP025345500 [A] 1-17 * abstract * * page 843, 3ème colonne, section "Injection of 99mTc-SSS LUF", 5ème ligne *
 [A]  - SANDRINE BALLOT ET AL, "99mTc/188Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER, BERLIN, DE LNKD- DOI:10.1007/S00259-005-0007-0, (20060201), vol. 33, no. 5, ISSN 1619-7089, pages 602 - 607, XP019422341 [A] 1-17 * abstract * * page 602, column right, paragraph last - page 603, column right * * page 604, column left, paragraph 2 *

DOI:   http://dx.doi.org/10.1007/s00259-005-0007-0
 [L]  - ANONYMOUS, "Tadeo. Automated Module for Synthesis of Theraupetic Radiopharmaceuticals", pages 1 - 10, COMECER, URL: http://www.emnovation.nl/PDF/Radiochemistry_Target_SynthesisR.pdf, (20100916), XP002600909 [L] 12-17 * pages 1-2 *
 [A]  - JOURNAL D'INFORMATION DU CENTRE EUGÈNE MARQUIS, no. 20, (200707), URL: http://www.centre-eugene-marquis.fr/uploads/fichiers/journal%20CEM%2007-2007%20intranet.pdf, (20100916), XP002600908 [A] 12-17 * page 3 *
 [AD]  - OH S J ET AL, "Automated preparation of <188>Re-labeled radiopharmaceuticals for endovascular radiation therapy", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB LNKD- DOI:10.1016/S0969-8043(03)00170-2, (20031001), vol. 59, no. 4, ISSN 0969-8043, pages 225 - 230, XP004458714 [AD] 12-17 * abstract *

DOI:   http://dx.doi.org/10.1016/S0969-8043(03)00170-2
 [AP]  - ANONYMOUS, "188RE-SSS Lipiodol to Treat HepatoCellular Carcinomas", (20100518), Clinical Trials Feeds, URL: http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01126463, (20100917), XP002600910 [AP] 1-17 * the whole document *
 [T]  - LEPAREUR N ET AL, "Automation of labelling of Lipiodol with high-activity generator-produced <188>Re", APPLIED RADIATION AND ISOTOPES 2011 ELSEVIER LTD GBR LNKD- DOI:10.1016/J.APRADISO.2010.11.001, (201102), vol. 69, no. 2, ISSN 0969-8043, pages 426 - 430, XP002630129 [T] 12,14-17 * publié en ligne le 12.11.2010 * * page 428, colonne de droite, section 4 "Discussion" 2ème alinéa *

DOI:   http://dx.doi.org/10.1016/j.apradiso.2010.11.001
by applicantWO0190114
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