EP2547369 - A NANOPARTICLE COMPRISING A MICELLE FORMED BY AN AMPHIPHILIC BLOCK-COPOLYMER AND ENCAPSULATING A GADOLINIUM COMPLEX [Right-click to bookmark this link] | |||
Former [2013/04] | A NANOPARTICLE COMPRISING A MICELLE FORMED BY AN AMPHIPHILIC BLOCK- COPOLYMER AND ENCAPSULATING A GADOLINIUM COMPLEX | ||
[2016/44] | Status | No opposition filed within time limit Status updated on 23.02.2018 Database last updated on 02.11.2024 | |
Former | The patent has been granted Status updated on 17.03.2017 | ||
Former | Grant of patent is intended Status updated on 24.02.2017 | Most recent event Tooltip | 10.07.2020 | Lapse of the patent in a contracting state New state(s): AL | published on 12.08.2020 [2020/33] | Applicant(s) | For all designated states King Saud University Box 2454 Riyadh 11451 / SA | For all designated states Universidade do Algarve Campus de Gambelas 8005-139 Faro / PT | [2013/04] | Inventor(s) | 01 /
MOUFFOUK, Fouzi King Saud University King Abdulla Institute for Nanotechnology P.O. Box 2454 Riyadh 11451 / SA | 02 /
RODRIGUES DOS SANTOS, Nuno Faculty of Sciences and Technology (Building 8) University of Algarve Campus de Gambelas P-8005-139 Faro / PT | 03 /
ALROKAYAN, Salman, A., H. King Saud University P.O. Box 2454 Riyadh 11451 / SA | 04 /
DA COSTA, Ana M. Rosa IBB/CBME, CIQA and DQF, Faculdade de Ciencias e Tecnologia University of Algarve Campus de Gambelas P-8005-139 Faro / PT | 05 /
ABUSALAH, Khalid Mustafa c/o King Saudi University King Abdulllah Institute for Nanotechnology P.O. Box 2454 11451 Riyadh / SA | [2016/01] |
Former [2013/04] | 01 /
MOUFFOUK, Fouzi King Saud University King Abdulla Institute for Nanotechnology P.O. Box 2454 Riyadh 11451 / SA | ||
02 /
RODRIGUES DOS SANTOS, Nuno Faculty of Sciences and Technology (Building 8) University of Algarve Campus de Gambelas P-8005-139 Faro / PT | |||
03 /
ALROKAYAN, Salman, A., H. King Saud University P.O. Box 2454 Riyadh 11451 / SA | |||
04 /
DA COSTA, Ana M. Rosa IBB/CBME, CIQA and DQF, Faculdade de Ciencias e Tecnologia University of Algarve Campus de Gambelas P-8005-139 Faro / PT | Representative(s) | Engelhard, Markus Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22 80336 München / DE | [N/P] |
Former [2017/16] | Engelhard, Markus Boehmert & Boehmert Anwaltspartnerschaft mbB Patentanwälte Rechtsanwälte Pettenkoferstrasse 20-22 80336 München / DE | ||
Former [2013/04] | Engelhard, Markus Boehmert & Boehmert Pettenkoferstrasse 20-22 80336 München / DE | Application number, filing date | 11709651.1 | 21.03.2011 | [2017/16] | WO2011EP01392 | Priority number, date | PT20100105017 | 19.03.2010 Original published format: PT 10501710 | [2013/04] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011113616 | Date: | 22.09.2011 | Language: | EN | [2011/38] | Type: | A1 Application with search report | No.: | EP2547369 | Date: | 23.01.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.09.2011 takes the place of the publication of the European patent application. | [2013/04] | Type: | B1 Patent specification | No.: | EP2547369 | Date: | 19.04.2017 | Language: | EN | [2017/16] | Search report(s) | International search report - published on: | EP | 22.09.2011 | Classification | IPC: | A61K49/18, A61K9/107, A61P35/00, B82Y5/00 | [2013/04] | CPC: |
A61K49/103 (EP);
A61K49/1806 (EP);
A61K9/1075 (EP);
A61K9/5146 (EP);
A61P35/00 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/04] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | NANOPARTIKEL MIT EINER ANHAND EINES AMPHIPHILEN BLOCKCOPOLYMERS GEBILDETEN MIZELLE ZUR VERKAPSELUNG EINES GADOLINIUMKOMPLEXES | [2013/04] | English: | A NANOPARTICLE COMPRISING A MICELLE FORMED BY AN AMPHIPHILIC BLOCK-COPOLYMER AND ENCAPSULATING A GADOLINIUM COMPLEX | [2016/44] | French: | NANOPARTICULE COMPRENANT UNE MICELLE FORMÉE PAR UN COPOLYMÈRE SÉQUENCÉ AMPHIPHILE ET ENCAPSULANT UN COMPLEXE DE GADOLINIUM | [2013/04] |
Former [2013/04] | A NANOPARTICLE COMPRISING A MICELLE FORMED BY AN AMPHIPHILIC BLOCK- COPOLYMER AND ENCAPSULATING A GADOLINIUM COMPLEX | Entry into regional phase | 12.09.2012 | National basic fee paid | 12.09.2012 | Designation fee(s) paid | 12.09.2012 | Examination fee paid | Examination procedure | 12.09.2012 | Examination requested [2013/04] | 24.04.2013 | Amendment by applicant (claims and/or description) | 02.03.2015 | Despatch of a communication from the examining division (Time limit: M04) | 28.04.2015 | Reply to a communication from the examining division | 19.09.2016 | Cancellation of oral proceeding that was planned for 25.10.2016 | 21.10.2016 | Communication of intention to grant the patent | 25.10.2016 | Date of oral proceedings (cancelled) | 21.02.2017 | Fee for grant paid | 21.02.2017 | Fee for publishing/printing paid | 21.02.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 02.03.2015 | Opposition(s) | 22.01.2018 | No opposition filed within time limit [2018/13] | Fees paid | Renewal fee | 11.03.2013 | Renewal fee patent year 03 | 12.03.2014 | Renewal fee patent year 04 | 10.03.2015 | Renewal fee patent year 05 | 10.03.2016 | Renewal fee patent year 06 | 10.03.2017 | Renewal fee patent year 07 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 21.03.2011 | AL | 19.04.2017 | AT | 19.04.2017 | CY | 19.04.2017 | CZ | 19.04.2017 | DK | 19.04.2017 | EE | 19.04.2017 | ES | 19.04.2017 | FI | 19.04.2017 | HR | 19.04.2017 | IT | 19.04.2017 | LT | 19.04.2017 | LV | 19.04.2017 | MC | 19.04.2017 | MK | 19.04.2017 | NL | 19.04.2017 | PL | 19.04.2017 | PT | 19.04.2017 | RO | 19.04.2017 | RS | 19.04.2017 | SE | 19.04.2017 | SI | 19.04.2017 | SK | 19.04.2017 | SM | 19.04.2017 | TR | 19.04.2017 | BG | 19.07.2017 | NO | 19.07.2017 | GR | 20.07.2017 | IS | 19.08.2017 | [2020/33] |
Former [2020/31] | HU | 21.03.2011 | |
AT | 19.04.2017 | ||
CY | 19.04.2017 | ||
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
IT | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
MC | 19.04.2017 | ||
MK | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
PT | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SI | 19.04.2017 | ||
SK | 19.04.2017 | ||
SM | 19.04.2017 | ||
TR | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2020/27] | HU | 21.03.2011 | |
AT | 19.04.2017 | ||
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
IT | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
MC | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
PT | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SI | 19.04.2017 | ||
SK | 19.04.2017 | ||
SM | 19.04.2017 | ||
TR | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2020/15] | AT | 19.04.2017 | |
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
IT | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
MC | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SI | 19.04.2017 | ||
SK | 19.04.2017 | ||
SM | 19.04.2017 | ||
TR | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2018/52] | AT | 19.04.2017 | |
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
IT | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
MC | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SI | 19.04.2017 | ||
SK | 19.04.2017 | ||
SM | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2018/25] | AT | 19.04.2017 | |
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
IT | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SI | 19.04.2017 | ||
SK | 19.04.2017 | ||
SM | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2018/11] | AT | 19.04.2017 | |
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
IT | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SK | 19.04.2017 | ||
SM | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2018/10] | AT | 19.04.2017 | |
CZ | 19.04.2017 | ||
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RO | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
SK | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2018/09] | AT | 19.04.2017 | |
DK | 19.04.2017 | ||
EE | 19.04.2017 | ||
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2017/50] | AT | 19.04.2017 | |
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
LT | 19.04.2017 | ||
LV | 19.04.2017 | ||
NL | 19.04.2017 | ||
PL | 19.04.2017 | ||
RS | 19.04.2017 | ||
SE | 19.04.2017 | ||
BG | 19.07.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2017/49] | AT | 19.04.2017 | |
ES | 19.04.2017 | ||
FI | 19.04.2017 | ||
HR | 19.04.2017 | ||
LT | 19.04.2017 | ||
NL | 19.04.2017 | ||
NO | 19.07.2017 | ||
GR | 20.07.2017 | ||
IS | 19.08.2017 | ||
Former [2017/48] | NL | 19.04.2017 | Cited in | International search | [I]WO0187227 (LABOPHARM INC [CA]) [I] 1-12 * page 5, line 33 - page 6, line 5 * * page 6, line 29 - page 7, line 3 * * page 7, lines 13-24 * * page 8, lines 3-5 * * page 12, line 23 - page 13, line 5 * * page 13, lines 18-23 * * page 14, lines 32-36 * * page 15, line 21 *; | [I]US2008241073 (YOKOYAMA MASAYUKI [JP], et al) [I] 1-12 * paragraphs [0018] , [0022] , [0023] * * figures 1,2 *; | [I]JP2008222804 (KANAGAWA KAGAKU GIJUTSU AKAD) [I] 1-12 * abstract * * paragraph [0038] *; | [IP]KR20100030955 (UNIV SUNGKYUNKWAN FOUND [KR]) [IP] 1-12 * abstract * * paragraph [0011] * * figure 4 *; | [IP] - GAO GUANG HUI ET AL, "Magnetite-nanoparticle-encapsulated pH-responsive polymeric micelle as an MRI probe for detecting acidic pathologic areas.", SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY) 6 JUN 2010 LNKD- PUBMED:20449849, (20100606), vol. 6, no. 11, ISSN 1613-6829, pages 1201 - 1204, XP002645298 [IP] 1-12 * page 1201, column left, paragraph 1 * * scheme 1 * DOI: http://dx.doi.org/10.1002/smll.200902317 | Examination | - SETHURAMAN V A ET AL, "A biodegradable pH-sensitive micelle system for targeting acidic solid tumors", PHARMACEUTICAL RESEARCH 200803 US, (200803), vol. 25, no. 3, ISSN 0724-8741, pages 657 - 666, XP019579493 | - KYUNG TAEK OH ET AL, "Cancer-associated pH-responsive tetracopolymeric micelles composed of poly(ethylene glycol)-b-poly(L-histidine)-b-poly(L-lactic acid)-b-poly(ethylene glycol)", POLYMERS FOR ADVANCED TECHNOLOGIES JOHN WILEY & SONS LTD. UK, (200812), vol. 19, no. 12, doi:doi:10.1002/pat.1228, ISSN 1042-7147, pages 1907 - 1913, XP055170525 DOI: http://dx.doi.org/10.1002/pat.1228 | - ZHAO H ET AL, "Folate-conjugated polymer micelles with pH-triggered drug release properties", MACROMOLECULAR RAPID COMMUNICATIONS - SYNTHETIC BIOMACROMOLECULES FOR DELIVERY OF THERAPEUTICS, TISSUE ENGINEERING, AND IMAGING 20100701 WILEY-VCH VERLAG DEU, (20100701), vol. 31, no. 13, doi:10.1002/MARC.200900876, pages 1163 - 1169, XP055170557 DOI: http://dx.doi.org/10.1002/marc.200900876 | - LEE ET AL, "Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine)", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (20070925), vol. 123, no. 1, doi:10.1016/J.JCONREL.2007.08.006, ISSN 0168-3659, pages 19 - 26, XP022265747 DOI: http://dx.doi.org/10.1016/j.jconrel.2007.08.006 | by applicant | - WEISSLEDER, R.; MAHMOOD, U., "Molecular imaging", RADIOLOGY, (2001), vol. 219, pages 316 - 333, XP002943544 | - MASSOUD, T. F.; GAMBHIR, S. S., "Molecular imaging in living subjects: seeing fundamental biological processes in a new light", GENE DEV., (2003), vol. 17, doi:doi:10.1101/gad.1047403, pages 545 - 580, XP007905304 DOI: http://dx.doi.org/10.1101/gad.1047403 | - WEISSLEDER, R.; LEE, A. S.; FISCHMAN, A. J.; REIMER, P.; SHEN, T.; WILKINSON, R.; CALLAHAN, R.; BRADY, T. J., "Polyclonal human immunoglobulin G labeled with polymeric iron oxide antibody MR imaging", RADIOLOGY, (1991), vol. 181, pages 245 - 249, XP000514000 | - KRIEG, F. M.; ANDRES, R. Y.; WINTERHALTER,K. H., "Superparamagnetically labeled a. neutrophils as potential abscess-specific contrast agent for MRI", MAGN. RESON. IMAGING, (1995), vol. 13, pages 393 - 400 | - KANG, H. W.; JOSEPHSON, L.; PETROVSKY, A.; WEISSLEDER, R.; BOGDANOV, JR., A., "Magnetic resonance imaging of inducible e-selectin expression in human endothelial cell culture", BIOCONJ. CHEM, (2002), vol. 13, pages 122 - 127 | - ZHAO, M.; BEAUREGARD, D. A.; LOIZOU, L.; DAVLETOV, B.; BRINDLE, K. M., "Noninvasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent", NAT. MED., (2001), vol. 7, doi:doi:10.1038/nm1101-1241, pages 1241 - 1244, XP001161288 DOI: http://dx.doi.org/10.1038/nm1101-1241 | - HO"GEMANN, D.; JOSEPHSON, L.; WEISSLEDER, R.; BASILION, J. P., "Improvement of MRI probes to allow efficient detection of gene expression", BIOCONJ. CHEM., (2000), vol. 11, pages 941 - 946 | - WADGHIRI, Y. Z.; SIGURDSSON, E. M.; SADOWSKI, M.; ELLIOTT, J. I.; LI, Y.; SCHOLTZOVA, H.; TANG, C. Y.; AGUINALDO, G.; PAPPOLLA, M., "Detection of Alzheimers amyloid in transgenic mice using magnetic resonance microimaging", MAGN. RESON. MED., (2003), vol. 50, pages 293 - 302 | - JUN, Y.-W.; HUH, Y.-M.; CHOI, J.-S.; LEE, J.-H.; SONG, H.-T.; KIM, S. J.; YOON, S.; KIM, K.-S.; SHIN, J.-S.; SUH, J.-S., "Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging", J. AM. CHEM. SOC., (2005), vol. 127, doi:doi:10.1021/ja0422155, pages 5732 - 5733, XP008129911 DOI: http://dx.doi.org/10.1021/ja0422155 | - GERWECK LE; SEETHARAMAN K, CANCER RES, (1996), vol. 56, page 1194 | - ZHANG S,WU K; SHERRY AD, ANGEW CHEM INT ED, (1999), vol. 38, page 3192 | - MOATS RA; FRASER SE; MEADE TJ, ANGEW CHEM INT ED, (1997), vol. 36, page 726 | - LI W; FRASER SE; MEADE TJ, J AM CHEM SOC, (1999), vol. 121, page 1413 | - GRYNKIEWICZ G; POENIE M; TSIEN RY, J BIOL CHEM, (1985), vol. 260, page 3440 | - W. HAMLEY, "Nanoshells and nanotubes from block copolymers", SOFT MATTE, (2005), vol. 1, pages 36 - 43 | - MICHAEL A.; R. MEIER; SEBASTIANUS N.; H. AERTS; BASTIAAN B.; P. STAAL; MIRCEA RASA, ULRICH; S. SCHUBERT, MACROMOLECULAR RAPID COMMUNICATIONS, (2002), vol. 24, pages 1918 - 1924 | - E RIZZARDO; S H TANG; G MOAD ET AL., MACROMOLECULES, (1998), vol. 31, page 5559 | - "bipyridine macrocycles incorporating a triethylenetraminetetraacetic acid core as ligand for lanthanide ions", TETRAHEDRON LETTERS, (2009), vol. 50, pages 6522 - 6525 | - MOUFFOUK, F.; CHEN, L., "Bioassay based on polymer micelles with femtomolar sensitivity", ANAL. BIOCHEM., (2008), vol. 372, pages 140 - 147 |