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Extract from the Register of European Patents

EP About this file: EP2512495

EP2512495 - PROCESS FOR OBTAINING A STANDARDISED EXTRACT OF QUERCETIN AN 3-O-METHYLQUERCETIN FROM FLOWERS OF MACELA (ACHYROCLINE SATUREIOIDES), AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID EXTRACT [Right-click to bookmark this link]
Former [2012/43]PROCESS FOR OBTAINING A STANDARDISED EXTRACT OF QUERCETIN AND 3-0-METHYLQUERCETIN FROM FLOWERS OF MACELA (ACHYROCLINE SATUREIOIDES), AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID EXTRACT
[2015/15]
StatusNo opposition filed within time limit
Status updated on  15.07.2016
Database last updated on 22.08.2024
Most recent event   Tooltip19.10.2018Lapse of the patent in a contracting state
New state(s): AL
published on 21.11.2018  [2018/47]
Applicant(s)For all designated states
Natura Cosméticos S.A.
Rodovia Regis Bittencourt, Km 293
06882-700 Itape Cerica da Serra SP / BR
[2015/37]
Former [2012/43]For all designated states
Natura Cosméticos S.A.
Rodovia Regis Bittencourt, Km 293
06882-700 Itape Cerica da Serra SP / BR
Inventor(s)01 / MOURA SA ROCHA, Vanessa de
Alameda Jau 1874
apto. 9-B
Jardim Paulista
01420-002 - Sao Paulo - SP / BR
02 / DELARCINA JUNIOR, Sergio
Rua Dias Vieira 326
Apto 404
Vila Sonia
05632-090 - Sao Paulo - SP / BR
03 / FIGUEREDO BEDA, Débora
Av. Diogo de Azevedo 22
Apto 131 A
05376-140 - Sao Paulo - SP / BR
04 / LORENCINI, Marcio
Av. Albino Jose Barbosa de Oliveira
2300 Casa 2
Bairro Jardim Atlfe
13084-551 - Campinas - SP / BR
05 / COSTA BEBER, Tiago
Rua Pedro Taques
117
Apto 123
Consolacao
01415-010 - Sao Paulo - SP / BR
06 / PASSERO, Alan
Rua Paulina Ortega
355 - Jd Monte Alegre
06755-240 - Taboao da Serra - SP / BR
 [2012/43]
Representative(s)Pearson, Samuel John, et al
Abel & Imray
20 Red Lion Street
London WC1R 4PQ / GB
[2014/04]
Former [2012/43]Senior, Janet, et al
Abel & Imray 20 Red Lion Street
London WC1R 4PQ / GB
Application number, filing date11710252.506.01.2011
[2015/37]
WO2011IB00015
Priority number, dateFR2009005901215.12.2009         Original published format: FR 0959012
[2012/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011073961
Date:23.06.2011
Language:EN
[2011/25]
Type: A1 Application with search report 
No.:EP2512495
Date:24.10.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 23.06.2011 takes the place of the publication of the European patent application.
[2012/43]
Type: B1 Patent specification 
No.:EP2512495
Date:09.09.2015
Language:EN
[2015/37]
Search report(s)International search report - published on:EP23.06.2011
ClassificationIPC:A61K36/28, A61P17/10, A61P29/00
[2012/43]
CPC:
A61K36/28 (EP,US); A61P17/00 (EP); A61P17/10 (EP);
A61P19/00 (EP); A61P29/00 (EP); A61P31/00 (EP);
A61K2236/331 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/43]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG EINES STANDARDISIERSTES QUERCETIN UND 3-O-METHYLQUERCETIN EXTRAKTS AUS MACELA (ACHYROCLINE SATUREIOIDES) BLÜTEN, UND KOSMETISCHE UND PHARMAZEUTISCHE ZUSAMMENZETZUNGEN, DIE DEN EXTRAKT ENTHALTEN[2015/15]
English:PROCESS FOR OBTAINING A STANDARDISED EXTRACT OF QUERCETIN AN 3-O-METHYLQUERCETIN FROM FLOWERS OF MACELA (ACHYROCLINE SATUREIOIDES), AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID EXTRACT[2015/15]
French:PROCEDE POUR OBTENIR UN EXTRAIT STANDARDISE DE QUERCETINE ET DE 3-O-METHYLQUERCETINE A PARTIR D'INFLORESCENCES DE MACELA-DO-CAMPO, ET COMPOSITION COSMETIQUE, PHARMACEUTIQUE ET VETERINAIRE LE CONTENANT[2015/15]
Former [2012/43]VERFAHREN ZUR GEWINNUNG EINES STANDARDISIERTEN EXTRAKTS AUS QUERCETIN UND 3-0-METHYLQUERCETIN AUS DER BLUMENART MACELA (ACHYROCLINE SATUREIOIDES) SOWIE KOSMETISCHE UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN MIT DIESEM EXTRAKT
Former [2012/43]PROCESS FOR OBTAINING A STANDARDISED EXTRACT OF QUERCETIN AND 3-0-METHYLQUERCETIN FROM FLOWERS OF MACELA (ACHYROCLINE SATUREIOIDES), AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID EXTRACT
Former [2012/43]PROCÉDÉ D'OBTENTION D'UN EXTRAIT STANDARDISÉ DE QUERCÉTINE ET DE 3-O-MÉTHYLQUERCÉTINE À PARTIR DE FLEURS DE MACELA, COMPOSITIONS COSMÉTIQUE, PHARMACEUTIQUE ET VÉTÉRINAIRE CONTENANT LEDIT L'EXTRAIT
Entry into regional phase21.06.2012National basic fee paid 
21.06.2012Designation fee(s) paid 
21.06.2012Examination fee paid 
Examination procedure14.10.2011Request for preliminary examination filed
International Preliminary Examining Authority: EP
21.06.2012Examination requested  [2012/43]
21.05.2013Amendment by applicant (claims and/or description)
26.02.2014Despatch of a communication from the examining division (Time limit: M06)
08.10.2014Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
30.10.2014Reply to a communication from the examining division
27.03.2015Communication of intention to grant the patent
30.07.2015Fee for grant paid
30.07.2015Fee for publishing/printing paid
30.07.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.02.2014
Opposition(s)10.06.2016No opposition filed within time limit [2016/33]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
30.10.2014Request for further processing filed
30.10.2014Full payment received (date of receipt of payment)
Request granted
13.11.2014Decision despatched
21.05.2013Request for further processing filed
21.05.2013Full payment received (date of receipt of payment)
Request granted
05.06.2013Decision despatched
Fees paidRenewal fee
10.01.2013Renewal fee patent year 03
27.01.2014Renewal fee patent year 04
30.01.2015Renewal fee patent year 05
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Lapses during opposition  TooltipHU06.01.2011
AL09.09.2015
AT09.09.2015
BE09.09.2015
BG09.09.2015
CY09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
MK09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
SM09.09.2015
TR09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
MT31.01.2016
[2018/47]
Former [2018/38]HU06.01.2011
AT09.09.2015
BE09.09.2015
BG09.09.2015
CY09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
MK09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
SM09.09.2015
TR09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
MT31.01.2016
Former [2018/31]HU06.01.2011
AT09.09.2015
BE09.09.2015
CY09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
MK09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
SM09.09.2015
TR09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
MT31.01.2016
Former [2018/29]HU06.01.2011
AT09.09.2015
BE09.09.2015
CY09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
MK09.09.2015
MT09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
SM09.09.2015
TR09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
Former [2018/28]HU06.01.2011
AT09.09.2015
BE09.09.2015
CY09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
MK09.09.2015
MT09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
SM09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
Former [2017/47]AT09.09.2015
BE09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
MT09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
Former [2017/07]AT09.09.2015
BE09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
IE06.01.2016
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
Former [2017/03]AT09.09.2015
BE09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
LU06.01.2016
IS09.01.2016
PT11.01.2016
CH31.01.2016
LI31.01.2016
Former [2016/46]AT09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
LU06.01.2016
IS09.01.2016
PT11.01.2016
BE31.01.2016
CH31.01.2016
LI31.01.2016
Former [2016/42]AT09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
MC09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
LU06.01.2016
IS09.01.2016
PT11.01.2016
BE31.01.2016
Former [2016/39]AT09.09.2015
CZ09.09.2015
DK09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
LU06.01.2016
IS09.01.2016
PT11.01.2016
BE31.01.2016
Former [2016/36]AT09.09.2015
CZ09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SI09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
IS09.01.2016
PT11.01.2016
BE31.01.2016
Former [2016/24]AT09.09.2015
CZ09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
NL09.09.2015
PL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
IS09.01.2016
PT11.01.2016
BE31.01.2016
Former [2016/23]CZ09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
NL09.09.2015
RO09.09.2015
RS09.09.2015
SE09.09.2015
SK09.09.2015
NO09.12.2015
GR10.12.2015
IS09.01.2016
Former [2016/22]CZ09.09.2015
EE09.09.2015
FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
NL09.09.2015
RS09.09.2015
SE09.09.2015
NO09.12.2015
GR10.12.2015
IS09.01.2016
Former [2016/14]FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
NL09.09.2015
RS09.09.2015
SE09.09.2015
NO09.12.2015
GR10.12.2015
Former [2016/11]FI09.09.2015
HR09.09.2015
LT09.09.2015
LV09.09.2015
RS09.09.2015
SE09.09.2015
NO09.12.2015
GR10.12.2015
Former [2016/09]FI09.09.2015
LT09.09.2015
LV09.09.2015
NO09.12.2015
GR10.12.2015
Former [2016/08]LT09.09.2015
NO09.12.2015
Former [2016/07]LT09.09.2015
Cited inInternational search[Y]JPS5944313  ;
 [YD]BR0103468  (UNIV FED DO RIO GRANDE DO SUL [BR]) [YD] 6-10 * see claims 1-10, page 4 and table 3 *;
 [XY]EP1475097  (DAJAS MENDEZ JOSE FEDERICO [UY], et al) [X] 6-10 * see claims1-16 *[Y] 1-10;
 [Y]US2008070875  (MAJEWSKI GEORGE P [US], et al) [Y] 9,10 * see claim 1, paragraphs [0013], [0025] *;
 [XY]  - DIAZ CLAUDIA ET AL, "Variations in the flavonoid profile and free quercetin content in different extracts of Achyrocline satureoides", ACTA FARMACEUTICA BONAERENSE, COLEGIO DE FARMACEUTICOS DE LA PROVINCIA DE BUENOS AIRES, AR, (20061001), vol. 25, no. 4, ISSN 0326-2383, pages 574 - 577, XP009135059 [X] 6-8 * the whole document * [Y] 1-10
 [Y]  - DATABASE WPI, 0, Derwent World Patents Index, vol. 1984, no. 16, Database accession no. 1984-098314, XP002590550 & JPS5944313 A 19840312 (YAKULT HONSHA KK) [Y] 9,10 * abstract *
 [Y]  - SIMOES C M O ET AL, "ANTIINFLAMMATORY ACTION OF ACHYROCLINE SATUREIOIDES EXTRACTS APPLIED TOPICALLY", FITOTERAPIA, IDB HOLDING, MILAN, IT, (19880101), vol. 59, no. 5, ISSN 0367-326X, pages 419 - 421, XP009033958 [Y] 6-10 * see abstract, page 419, table 1 *
 [YD]  - MORQUIO A. ET AL., "Photoprotection by topical application of Achyrocline satureioides ("Marcela")", PHYTOTHER. RES., (2005), vol. 19, pages 486 - 490, XP002590551 [YD] 9,10 * seec abstract and page 487 *

DOI:   http://dx.doi.org/10.1002/PTR.1665
by applicantJPS5944313B
 JPH10226619
 BR0103468
 US2004170581
 US2004220119
 US7192611
 US2008070875
    - CARNEY, J.R. ET AL., "Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides", J. NAT. PROD., (2002), vol. 65, no. 2, doi:doi:10.1021/NP010374L, pages 203 - 205, XP002591817

DOI:   http://dx.doi.org/10.1021/NP010374L
    - CHAN AL, HUANG HL, CHIEN HC, CHEN CM, LIN CN, KO WC, "Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [(3) H]-rolipram binding in guinea pig tissues", INVEST NEW DRUGS., (200810), vol. 26, no. 5, pages 417 - 24, XP019602926
    - D'AVILA, M.C., Dissertação, FACUL- DADE LIVRE DE MEDICINA E FARMACIA DE PORTO ALEGRE, (1910), page 155
    - HNATYSZYN, O. ET AL., "Flavonoids from Achyrocline satureioides with relaxant effects on the smooth muscle of Guinea pig corpus cavernosum", PHYTOMEDICINE, (2004), vol. 11, no. 4, doi:doi:10.1078/0944711041495182, pages 366 - 369, XP004957010

DOI:   http://dx.doi.org/10.1078/0944711041495182
    - IKUTA, A.R.Y., Dissertation, FEDERAL UNIVERSITY OF RIO GRANDE DO SUL, (1993), page 205
    - JIANG, J.-S. ET AL., "Potent suppressive effects of 3-O-methylquercetin 5,7,3',4'-O-tetraacetate on ovalbumin-induced airway hyperresponsiveness", PLANTA MEDICA, (2007), vol. 73, no. 11, pages 156 - 1162
    - KADARIAN, C. ET AL., "Hepatoprotective activity of Achyrocline satureioides (Lam) D. C.", PHARMACOL. RES., (2002), vol. 45, no. 1, pages 57 - 61
    - KO WC, WANG HL, LEI CB, SHIH CH, CHUNG MI, LIN CN, "Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea", PLANTA MED., (200201), vol. 68, no. 1, pages 30 - 5
    - LEMOS, G.C.S., "Bacterial activity of macela (Achyrocline satureioides) against strains of Staphylococcus aureus isolated from subclinical bovine mastitis", REV. BRAS. PI. MED., (2000), vol. 3, no. 1, pages 67 - 72
    - LINES, T.C., "ONO, M. FRS 1000, an extract of red onion peel, strongly inhi bits phosphodiesterase 5a (pde 5a)", PHYTOMEDICINE, (2006), vol. 13, no. 4, pages 236 - 239
    - MARQUES, F.C., BARROS, I.B.I., "Crescimento inicial de marcela (Achyrocline satureioides) em ambiente protegido (Initial growth of marcela (Achyrocline satureioides) in a protected environment)", RURAL SCIENCE, (2001), vol. 31, no. 1, pages 517 - 518
    - MARQUES, F.C., BARROS, I.B.I., "Qualidade de sementes de marcela (Achyrocline satureioides) provenientes de duas populações do Rio Grande do Sul (Quality of seeds of marcela (Achyrocline satureioides) from two populations of Rio Grande do Sul)", RURAL SCIENCE, (2000), vol. 30, no. 2, pages 241 - 247
    - "Análise da qualidade de sementes de marcela", MARQUES, F.C., Analysis of the quality of seeds of marcela, Achyrocline, RIO GRANDE DO SUL
    - Dissertation (Master's Degree in Plant Science) - Master's Course in Plant Science, FEDERAL UNIVERSITY OF RIO GRANDE DO SUL, (1995), page 143
    - "Flora medicinal dos sitiantes da Reserva Particular do Patrimônio Natural das Pedras, Mangaratiba, Rio de Janeiro, Brasil:taxonomia e aspectos etnobotânicos", MEDEIROS, M. F.T., REGINA HELENA P. ET AL., Medicinal flora of the farms of the Private Reserve of Natural Heritage, Rio das Pedras, Mangaratiba, Rio de Janeiro, Brazil: Taxonomy and ethnobotanic aspects., PUBL. A-VUL. MUS. NAC., (200503), pages 3 - 24
    - OLIVEIRA ET AL., "Achyrocline satureioides, Asteraceae, comparative evaluation of the plant ingredient and preliminary studies of the optimization of extraction", PHARMACY NOTEBOOK, (2001), vol. 17, no. 1, pages 33 - 38
    - "Estaquia de marcela Achyrocline satureioides (Lam.) D.C. sob diferentes periodos de enraizamento e doses de acido indolbutirico (Staking of marcela Achyrocline satureioides (Lam.) D.C. under different", PARDO, V.A, Dissertation (Master's Degree in Plant Science) - Master's Course in Plant Science, FEDERAL UNIVERSITY OF RIO GRANDE DO SUL, (1995), page 78
    - RITTER, "Plantas usadas como medicinais no municipio de Ipê. (Plants used as medicines in the municipality of Ipê)", RS. REV. BRAS. FARMACOGN., (2002), vol. 12, no. 2, pages 51 - 62
    - SIMOES, C.M.O., "Antiinflammatory action of Achyrocline satureioides extracts applied topically", FITOTERAPIA, (1988), vol. 59, no. 5, pages 419 - 421, XP009033958
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.