EP2576826 - METHODS AND MEANS FOR PREDICTING OR DIAGNOSING TYPE II DIABETES OR MYOCARDIAL INFARCTION BASED ON MICRO RNA DETECTION. [Right-click to bookmark this link] | |||
Former [2013/15] | METHODS AND MEANS FOR PREDICTING OR DIAGNOSING DIABETES OR CARDIOVASCULAR DISORDERS BASED ON MICRO RNA DETECTION | ||
[2014/15] | Status | No opposition filed within time limit Status updated on 24.07.2015 Database last updated on 02.11.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states King's College London London WC2R 2LS / GB | [2013/15] | Inventor(s) | 01 /
MAYR, Manuel Cardiovascular Division The James Black Centre King's College London 125 Coldharbour Lane London SE5 9NU / GB | [2013/15] | Representative(s) | Tombling, Adrian George, et al Withers & Rogers LLP 2 London Bridge London SE1 9RA / GB | [N/P] |
Former [2013/15] | Tombling, Adrian George, et al Withers & Rogers LLP 4 More London Riverside London SE1 2AU / GB | Application number, filing date | 11725949.9 | 06.06.2011 | WO2011GB00850 | Priority number, date | GB20100009513 | 07.06.2010 Original published format: GB 201009513 | GB20110001400 | 26.01.2011 Original published format: GB 201101400 | [2013/15] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011154689 | Date: | 15.12.2011 | Language: | EN | [2011/50] | Type: | A1 Application with search report | No.: | EP2576826 | Date: | 10.04.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 15.12.2011 takes the place of the publication of the European patent application. | [2013/15] | Type: | B1 Patent specification | No.: | EP2576826 | Date: | 17.09.2014 | Language: | EN | [2014/38] | Search report(s) | International search report - published on: | EP | 15.12.2011 | Classification | IPC: | C12Q1/68 | [2013/15] | CPC: |
C12Q1/6883 (EP,US);
C12Q1/68 (US);
C12Q2600/158 (EP,US);
C12Q2600/178 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/15] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | VERFAHREN UND MITTEL FÜR DIE VORAUSSAGE DER DIAGNOSE VON TYP-2-DIABETES ODER MYOKARDINFARKT AUF BASIS EINES MICRO-RNA-NACHWEISES | [2014/15] | English: | METHODS AND MEANS FOR PREDICTING OR DIAGNOSING TYPE II DIABETES OR MYOCARDIAL INFARCTION BASED ON MICRO RNA DETECTION. | [2014/15] | French: | MÉTHODES ET MOYENS DE PRÉVISION OU DE DIAGNOSTIC DU DIABÈTE DE TYPE II OU DE L'INFARCTION DU MYOCARDE REPOSANT SUR LA DÉTECTION DE MICRO ARN | [2014/15] |
Former [2013/15] | VERFAHREN UND MITTEL FÜR DIE VORAUSSAGE DER DIAGNOSE VON DIABETES ODER KARDIOVASKULÄRER ERKRANKUNGEN AUF BASIS EINES MICRO-RNA-NACHWEISES | ||
Former [2013/15] | METHODS AND MEANS FOR PREDICTING OR DIAGNOSING DIABETES OR CARDIOVASCULAR DISORDERS BASED ON MICRO RNA DETECTION | ||
Former [2013/15] | MÉTHODES ET MOYENS DE PRÉVISION OU DE DIAGNOSTIC DU DIABÈTE OU D'AFFECTIONS CARDIOVASCULAIRES REPOSANT SUR LA DÉTECTION DE MICRO ARN | Entry into regional phase | 13.12.2012 | National basic fee paid | 13.12.2012 | Designation fee(s) paid | 13.12.2012 | Examination fee paid | Examination procedure | 13.12.2012 | Examination requested [2013/15] | 10.07.2013 | Amendment by applicant (claims and/or description) | 17.10.2013 | Despatch of a communication from the examining division (Time limit: M04) | 14.02.2014 | Reply to a communication from the examining division | 10.04.2014 | Communication of intention to grant the patent | 11.08.2014 | Fee for grant paid | 11.08.2014 | Fee for publishing/printing paid | 11.08.2014 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 17.10.2013 | Opposition(s) | 18.06.2015 | No opposition filed within time limit [2015/35] | Fees paid | Renewal fee | 27.06.2013 | Renewal fee patent year 03 | 31.03.2014 | Renewal fee patent year 04 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 06.06.2011 | AL | 17.09.2014 | AT | 17.09.2014 | BE | 17.09.2014 | BG | 17.09.2014 | CY | 17.09.2014 | CZ | 17.09.2014 | DK | 17.09.2014 | EE | 17.09.2014 | ES | 17.09.2014 | FI | 17.09.2014 | HR | 17.09.2014 | IT | 17.09.2014 | LT | 17.09.2014 | LV | 17.09.2014 | MC | 17.09.2014 | MK | 17.09.2014 | MT | 17.09.2014 | NL | 17.09.2014 | PL | 17.09.2014 | RO | 17.09.2014 | RS | 17.09.2014 | SE | 17.09.2014 | SI | 17.09.2014 | SK | 17.09.2014 | SM | 17.09.2014 | TR | 17.09.2014 | NO | 17.12.2014 | GR | 18.12.2014 | IS | 17.01.2015 | PT | 19.01.2015 | IE | 06.06.2015 | LU | 06.06.2015 | [2018/46] |
Former [2018/31] | HU | 06.06.2011 | |
AT | 17.09.2014 | ||
BE | 17.09.2014 | ||
BG | 17.09.2014 | ||
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
MK | 17.09.2014 | ||
MT | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
SM | 17.09.2014 | ||
TR | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
IE | 06.06.2015 | ||
LU | 06.06.2015 | ||
Former [2017/46] | HU | 06.06.2011 | |
AT | 17.09.2014 | ||
BE | 17.09.2014 | ||
BG | 17.09.2014 | ||
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
MT | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
SM | 17.09.2014 | ||
TR | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
IE | 06.06.2015 | ||
LU | 06.06.2015 | ||
Former [2017/38] | HU | 06.06.2011 | |
AT | 17.09.2014 | ||
BG | 17.09.2014 | ||
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
MT | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
SM | 17.09.2014 | ||
TR | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
IE | 06.06.2015 | ||
LU | 06.06.2015 | ||
Former [2017/03] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
MT | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
IE | 06.06.2015 | ||
LU | 06.06.2015 | ||
Former [2016/20] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
IE | 06.06.2015 | ||
LU | 06.06.2015 | ||
Former [2016/11] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
LU | 06.06.2015 | ||
Former [2016/09] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
MC | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/50] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SI | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/37] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
IT | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/35] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
DK | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/25] | AT | 17.09.2014 | |
CY | 17.09.2014 | ||
CZ | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/24] | CY | 17.09.2014 | |
CZ | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
PL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/23] | CY | 17.09.2014 | |
CZ | 17.09.2014 | ||
EE | 17.09.2014 | ||
ES | 17.09.2014 | ||
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
SK | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
IS | 17.01.2015 | ||
PT | 19.01.2015 | ||
Former [2015/22] | CY | 17.09.2014 | |
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
RO | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
PT | 19.01.2015 | ||
Former [2015/16] | CY | 17.09.2014 | |
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
NL | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
Former [2015/12] | CY | 17.09.2014 | |
FI | 17.09.2014 | ||
HR | 17.09.2014 | ||
LT | 17.09.2014 | ||
LV | 17.09.2014 | ||
RS | 17.09.2014 | ||
SE | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
Former [2015/11] | CY | 17.09.2014 | |
FI | 17.09.2014 | ||
LT | 17.09.2014 | ||
SE | 17.09.2014 | ||
NO | 17.12.2014 | ||
GR | 18.12.2014 | ||
Former [2015/10] | FI | 17.09.2014 | |
LT | 17.09.2014 | ||
SE | 17.09.2014 | ||
NO | 17.12.2014 | ||
Former [2015/09] | FI | 17.09.2014 | |
LT | 17.09.2014 | ||
SE | 17.09.2014 | ||
Former [2015/08] | LT | 17.09.2014 | Cited in | International search | [Y]US2008305474 (CHEN YUAN-TSONG [TW], et al) [Y] 23 * the whole document * * paragraph [0033] - paragraph [0038] *; | [A]US2009005336 (WANG ZHIGUO [CA]) [A] 1-23 * the whole document *; | [X]WO2009143379 (HUTCHINSON FRED CANCER RES [US], et al) [X] 14-22 * the whole document * * page 35, paragraph 1 * * page 36, paragraph 4 * * page 40, paragraph 2 * * page 42, paragraph 4 *; | [YA]WO2010019574 (UNIV TEXAS [US], et al) [Y] 23 * the whole document * * example 2 * [A] 1-22; | [X] - CHEN L ET AL, "The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma", JOURNAL OF HEPATOLOGY, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 50, no. 2, doi:DOI:10.1016/J.JHEP.2008.09.015, ISSN 0168-8278, (20090201), pages 358 - 369, (20081121), XP025949528 [X] 18-22 * the whole document * * page 359, paragraph 2.3 * DOI: http://dx.doi.org/10.1016/j.jhep.2008.09.015 | [X] - P. MESTDAGH ET AL, "High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA", NUCLEIC ACIDS RESEARCH, (20081021), vol. 36, no. 21, doi:10.1093/nar/gkn725, ISSN 0305-1048, pages E143 - E143, XP055003045 [X] 18-22 * the whole document * * page 2, paragraph 4 * DOI: http://dx.doi.org/10.1093/nar/gkn725 | [X] - KELLER ANDREAS ET AL, "miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experiments", BMC CANCER, BIOMED CENTRAL, LONDON, GB, (20091006), vol. 9, no. 1, doi:DOI:10.1186/1471-2407-9-353, ISSN 1471-2407, page 353, XP021062692 [X] 14-17 * the whole document * * page 3, column l * DOI: http://dx.doi.org/10.1186/1471-2407-9-353 | [X] - WANG GUO-KUN ET AL, "Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans", EUROPEAN HEART JOURNAL (ONLINE), OXFORD UNIVERSITY PRESS, GB, US, NL, (20100301), vol. 31, no. 6, doi:DOI:10.1093/EURHEART/EHQ013, ISSN 1522-9645, pages 659 - 666, XP002586116 [X] 18-22 * the whole document * * page 660, column r, paragraph 2 * DOI: http://dx.doi.org/10.1093/EURHEART/EHQ013 | [A] - HOEKSTRA MENNO ET AL, "The peripheral blood mononuclear cell microRNA signature of coronary artery disease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20100401), vol. 394, no. 3, doi:DOI:10.1016/J.BBRC.2010.03.075, ISSN 0006-291X, pages 792 - 797, XP002586117 [A] 1-23 * the whole document * DOI: http://dx.doi.org/10.1016/J.BBRC.2010.03.075 | [A] - FASANARO P ET AL, "microRNA: Emerging therapeutic targets in acute ischemic diseases", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 125, no. 1, ISSN 0163-7258, (20100101), pages 92 - 104, (20091106), XP026812449 [A] 1-23 * the whole document * * page 98, paragraph 4.1 * * page 99, paragraph 5.1 * | [YDA] - JASON E. FISH ET AL, "miR-126 Regulates Angiogenic Signaling and Vascular Integrity", DEVELOPMENTAL CELL, (20080812), vol. 15, no. 2, doi:10.1016/j.devcel.2008.07.008, ISSN 1534-5807, pages 272 - 284, XP055002871 [YD] 23 * the whole document * [A] 1-22 DOI: http://dx.doi.org/10.1016/j.devcel.2008.07.008 | [A] - XI CHEN ET AL, "Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases", CELL RESEARCH CHINA,, vol. 18, no. 10, doi:DOI:10.1038/CR.2008.282, ISSN 1748-7838, (20081001), pages 997 - 1006, (20080902), XP002634302 [A] 1-23 * the whole document * * page 1001, column r - page 1003, column l * DOI: http://dx.doi.org/10.1038/cr.2008.282 | [AP] - SUN L L ET AL, "MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression", DIABETES RESEARCH AND CLINICAL PRACTICE, AMSTERDAM, NL, vol. 91, no. 1, ISSN 0168-8227, (20110101), pages 94 - 100, (20101224), XP027574330 [AP] 1-23 * the whole document * | [A] - H. LU ET AL, "MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism", CARDIOVASCULAR RESEARCH, (20100601), vol. 86, no. 3, doi:10.1093/cvr/cvq010, ISSN 0008-6363, pages 410 - 420, XP055003032 [A] 1-23 * the whole document * DOI: http://dx.doi.org/10.1093/cvr/cvq010 | [A] - A. HE ET AL, "Overexpression of Micro Ribonucleic Acid 29, Highly Up-Regulated in Diabetic Rats, Leads to Insulin Resistance in 3T3-L1 Adipocytes", MOLECULAR ENDOCRINOLOGY, (20071101), vol. 21, no. 11, doi:10.1210/me.2007-0167, ISSN 0888-8809, pages 2785 - 2794, XP055003191 [A] 1-23 * the whole document * DOI: http://dx.doi.org/10.1210/me.2007-0167 | [XP] - ZAMPETAKI ANNA ET AL, "Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes.", CIRCULATION RESEARCH 17 SEP 2010 LNKD- PUBMED:20651284, (20100917), vol. 107, no. 6, ISSN 1524-4571, pages 810 - 817, XP008139609 [XP] 5-22 * the whole document * DOI: http://dx.doi.org/10.1161/CIRCRESAHA.110.226357 | by applicant | - ACH ET AL., BMC BIOTECHNOLOGY, (2008), vol. 8, page 69 | - GOEMAN J.J., "L penalized estimation in the Cox proportional hazards model.", BIOM. J., (2010), vol. 52, no. 1, pages 70 - 84 | - BARTEL DP., CELL., (20090123), vol. 136, no. 2, pages 215 - 233 | - PILLAI RS, BHATTACHARYYA SN, FILIPOWICZ W., TRENDS CELL BIOL., (200703), vol. 17, no. 3, pages 118 - 26 | - KLOOSTERMAN WP, PLASTERK RH., DEV CELL, (200610), vol. 11, no. 4, pages 441 - 50 | - STEFANI G, SLACK FJ., NAT REV MOL CELL BIOL., (200803), vol. 9, no. 3, pages 219 - 30 | - LATRONICO MV, CATALUCCI D, CONDORELLI G., CIRC RES., (20071207), vol. 101, no. 2, pages 1225 - 36 | - VAN ROOIJ E, MARSHALL WS, OLSON EN., CIRC RES., (20081024), vol. 103, no. 9, pages 919 - 28 | - KUEHBACHER A, URBICH C, ZEIHER AM, DIMMELER S., CIRC RES., (20070706), vol. 101, no. 1, pages 59 - 68 | - MITCHELL PS ET AL., PROC NATL ACAD SCI U S A., (20080729), vol. 105, no. 30, pages 10513 - 8 | - TANAKA M ET AL., PLOS ONE., (2009), vol. 4, no. 5, page E5532 | - LATERZA OF ET AL., CLIN CHEM., (200911), vol. 55, no. 11, pages 1977 - 83 | - WANG K ET AL., PROC NATL ACAD SCI USA., (20090317), vol. 106, no. 11, pages 4402 - 7 | - WANG GK ET AL., EUR HEART J., (201003), vol. 31, no. 6, pages 659 - 66 | - JI X, TAKAHASHI R, HIURA Y, HIROKAWA G, FUKUSHIMA Y, IWAI N., CLIN CHEM., (200911), vol. 55, no. 11, pages 1944 - 9 | - TIJSEN AJ ET AL., CIRC RES., (20100402), vol. 106, no. 6, pages 1035 - 9 | - NATHAN DM., "Long-term complications of diabetes mellitus", N ENGL J MED., (19930610), vol. 328, no. 23, pages 1676 - 85 | - FRANKEL DS ET AL., CIRCULATION., (20081209), vol. 118, no. 24, pages 2533 - 9 | - KIECHL S, N ENGL J MED., (20020718), vol. 347, no. 3, pages 185 - 92 | - BONORA E ET AL., DIABETES., (200407), vol. 53, no. 7, pages 1782 - 9 | - KIECHL S ET AL., CIRCULATION., (20070724), vol. 116, no. 4, pages 385 - 91 | - FAITH JJ, PLOS BIOL., (200701), vol. 5, no. 1, page E8 | - CHUANG HY, LEE E, LIU YT, LEE D, IDEKER T., MOL SYST BIOL., (2007), vol. 3, page 140 | - FISH JE ET AL., DEV CELL., (200808), vol. 15, no. 2, pages 272 - 84 | - WANG S ET AL., DEV CELL., (200808), vol. 15, no. 2, pages 261 - 71 | - VANWIJK MJ, VANBAVEL E, STURK A, NIEUWLAND R., CARDIOVASC RES., (20030801), vol. 59, no. 2, pages 277 - 87 | - VOLINIA S ET AL., GENOME RES., (201005), vol. 20, no. 5, pages 589 - 99 | - JEONG H ET AL., NATURE., (20010503), vol. 411, no. 6833, pages 41 - 2 | - ZERNECKE A ET AL., SCI SIGNAL., (20091208), vol. 2, no. 100, page RA81 | - PROKOPI M ET AL., BLOOD., (20090706), vol. 114, no. 3, pages 723 - 32 | - WALTENBERGER J, LANGE J, KRANZ A, CIRCULATION., (20000711), vol. 102, no. 2, pages 185 - 90 | - KIECHL S ET AL., ARTERIOSCLER THROMB VASC BIOL., (200708), vol. 27, no. 8, pages 1788 - 95 | - TSIMIKAS S ET AL., EUR HEART J., (200901), vol. 30, no. 1, pages 107 - 15 | - BACCKE JA ET AL., AM J CLIN NUTR., (198211), vol. 36, no. 5, pages 936 - 42 | - RAMAKERS C ET AL., NEUROSCI LETT., (20030313), vol. 339, no. 1, pages 62 - 6 | - ROULSTON M., PHYSICA D., (1997), vol. 110, pages 62 - 6 | - SLONIM N ET AL., PROC NATL ACAD SCI USA., (20051220), vol. 102, no. 51, pages 18297 - 302 | - BANSAL ET AL., MOL SYST BIOL., (2007), vol. 3, page 78 | - BARABASI AL., SCIENCE, (20090724), vol. 325, no. 5939, pages 412 - 3 | - ENRIGHT AJ, NUCLEIC ACIDS RES., (20020401), vol. 30, no. 7, pages 1575 - 84 | - DIEBOLD I, THROMB HAEMOST., (200812), vol. 100, no. 6, pages 984 - 91 | - SMITH A ET AL., THE CAERPHILLY STUDY, CIRCULATION., (20051115), vol. 112, no. 20, pages 3080 - 7 | - KOHLER HP ET AL., N. ENGL. J. MED., (20000615), vol. 342, no. 24, pages 1792 - 801 | - THOGERSEN AM ET AL., CIRCULATION., (19981124), vol. 98, no. 21, pages 2241 - 7 | - HAMSTEN A ET AL., LANCET., (19870704), vol. 2, no. 8549, pages 3 - 9 |