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Extract from the Register of European Patents

EP About this file: EP2600863

EP2600863 - USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.02.2019
Database last updated on 13.09.2024
FormerThe patent has been granted
Status updated on  23.02.2018
FormerGrant of patent is intended
Status updated on  14.02.2018
FormerExamination is in progress
Status updated on  02.02.2018
FormerGrant of patent is intended
Status updated on  03.10.2017
FormerExamination is in progress
Status updated on  17.01.2017
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): IS		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
ESTEVE PHARMACEUTICALS, S.A.
Passeig de la Zona Franca, 109, 4ª Planta
08038 Barcelona / ES
[2018/37]
Former [2017/44]For all designated states
Laboratorios del Dr. Esteve, S.A.
Avda. Mare de Déu de Montserrat, 221
08041 Barcelona / ES
Former [2013/24]For all designated states
Laboratorios del. Dr. Esteve, S.A.
Avda Mare de Deu de Montserrat 221
08041 Barcelona / ES
Inventor(s)01 / VELA HERNÁNDEZ, José Miguel
Rambla Badal nº 153, 8º 3ª
08028 Barcelona / ES
02 / ZAMANILLO-CASTANEDO, Daniel
Avda. Mare de Déu de Montserrat 252, 5º 2ª
08041 Barcelona / ES
03 / PUIG RIERA de CONIAS, Margarita
C/ Roger de Lluria 8, 3º 1ª
08010 Barcelona / ES
 [2018/13]
Former [2013/24]01 / VELA HERNÁNDEZ, José Miguel
Rambla Badal nº 153, 8º, 3ª
E- 08028 Barcelona / ES
02 / ZAMANILLO-CASTANEDO, Daniel
Avda. Mare de Dèu de Montserrat 252, 5º- 2ª
E-08041 Barcelona / ES
03 / PUIG RIERA de CONIAS, Margarita
C/ Roger de Lluria 8 3º1
E - 08010 Barcelona / ES
Representative(s)ABG Intellectual Property Law, S.L.
Avenida de Burgos, 16D
Edificio Euromor
28036 Madrid / ES
[N/P]
Former [2013/24]ABG Patentes, S.L.
Avenida de Burgos, 16D
Edificio Euromor
28036 Madrid / ES
Application number, filing date11738245.702.08.2011
[2018/13]
WO2011EP63286
Priority number, dateEP2010038221503.08.2010         Original published format: EP 10382215
[2013/24]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2012016980
Date:09.02.2012
Language:EN
[2012/06]
Type: A2 Application without search report 
No.:EP2600863
Date:12.06.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 09.02.2012 takes the place of the publication of the European patent application.
[2013/24]
Type: B1 Patent specification 
No.:EP2600863
Date:28.03.2018
Language:EN
[2018/13]
Search report(s)International search report - published on:EP29.03.2012
ClassificationIPC:A61K31/415, A61K31/4155, A61K31/5377, A61P23/00, A61P29/00
[2013/24]
CPC:
A61K31/5377 (EP,KR,US); A61K31/415 (EP,KR,US); C07D231/22 (CN);
A61K31/4155 (EP,KR,US); A61K45/06 (CN); A61P23/00 (EP);
A61P25/04 (EP); A61P29/00 (EP); A61P37/08 (EP);
A61P39/00 (EP); A61P43/00 (EP); C07D207/36 (CN);
C07D401/12 (CN); C07D401/14 (CN); C07D403/12 (CN) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/24]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERWENDUNG VON SIGMA LIGANDEN IN OPIOID-INDUZIERTER HYPERALGÄSIE[2017/40]
English:USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA[2013/24]
French:UTILISATION DE LIGANDS SIGMA DANS L'HYPERALGÉSIE INDUITE PAR LES OPIOIDES[2017/40]
Former [2013/24]VERWENDUNG VON SIGMALIGANDEN BEI OPIOIDINDUZIERTER HYPERALGESIE
Former [2013/24]UTILISATION DE LIGANDS SIGMA DANS UNE HYPERALGIE INDUITE PAR DES OPIOÏDES
Entry into regional phase20.02.2013National basic fee paid 
20.02.2013Designation fee(s) paid 
20.02.2013Examination fee paid 
Examination procedure20.02.2013Amendment by applicant (claims and/or description)
20.02.2013Examination requested  [2013/24]
28.04.2015Despatch of a communication from the examining division (Time limit: M04)
30.07.2015Reply to a communication from the examining division
23.08.2016Despatch of a communication from the examining division (Time limit: M04)
23.12.2016Reply to a communication from the examining division
04.10.2017Communication of intention to grant the patent
30.01.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
30.01.2018Fee for grant paid
30.01.2018Fee for publishing/printing paid
13.02.2018Information about intention to grant a patent
13.02.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.04.2015
Opposition(s)03.01.2019No opposition filed within time limit [2019/10]
Fees paidRenewal fee
23.07.2013Renewal fee patent year 03
24.06.2014Renewal fee patent year 04
08.07.2015Renewal fee patent year 05
09.08.2016Renewal fee patent year 06
10.07.2017Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU02.08.2011
AL28.03.2018
CY28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
MK28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SI28.03.2018
SK28.03.2018
SM28.03.2018
TR28.03.2018
BG28.06.2018
NO28.06.2018
IS28.07.2018
MT02.08.2018
[2020/32]
Former [2020/31]HU02.08.2011
AL28.03.2018
CY28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
MK28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SI28.03.2018
SK28.03.2018
SM28.03.2018
TR28.03.2018
BG28.06.2018
NO28.06.2018
MT02.08.2018
Former [2020/28]HU02.08.2011
AL28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SI28.03.2018
SK28.03.2018
SM28.03.2018
TR28.03.2018
BG28.06.2018
NO28.06.2018
MT02.08.2018
Former [2020/16]AL28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SI28.03.2018
SK28.03.2018
SM28.03.2018
TR28.03.2018
BG28.06.2018
NO28.06.2018
MT02.08.2018
Former [2020/08]AL28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SI28.03.2018
SK28.03.2018
SM28.03.2018
BG28.06.2018
NO28.06.2018
MT02.08.2018
Former [2019/26]AL28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SI28.03.2018
SK28.03.2018
SM28.03.2018
BG28.06.2018
NO28.06.2018
Former [2019/15]AL28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
MC28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SK28.03.2018
SM28.03.2018
BG28.06.2018
NO28.06.2018
Former [2019/08]AL28.03.2018
CZ28.03.2018
DK28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SK28.03.2018
SM28.03.2018
BG28.06.2018
NO28.06.2018
Former [2018/52]AL28.03.2018
CZ28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SK28.03.2018
SM28.03.2018
BG28.06.2018
NO28.06.2018
Former [2018/50]AL28.03.2018
CZ28.03.2018
EE28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
PL28.03.2018
RO28.03.2018
RS28.03.2018
SE28.03.2018
SK28.03.2018
BG28.06.2018
NO28.06.2018
Former [2018/46]AL28.03.2018
FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
RS28.03.2018
SE28.03.2018
BG28.06.2018
NO28.06.2018
Former [2018/41]FI28.03.2018
HR28.03.2018
LT28.03.2018
LV28.03.2018
RS28.03.2018
SE28.03.2018
BG28.06.2018
NO28.06.2018
Former [2018/35]FI28.03.2018
HR28.03.2018
LT28.03.2018
NO28.06.2018
Cited inInternational search[X]EP2116539  (ESTEVE LABOR DR [ES]) [X] 1-12 * paragraph [0001] - paragraph [0009] * * paragraph [0032] - paragraph [0035] * * claims 9,10 *;
 [Y]WO2007098953  (ESTEVE LABOR DR [ES], et al) [Y] 1-12 * page 25, line 21 - page 26, line 7 *;
 [Y]WO2006021462  (ESTEVE LABOR DR [ES], et al) [Y] 1-12 * page 59, line 6 - page 60, line 5 *;
 [Y]EP2113501  (ESTEVE LABOR DR [ES]) [Y] 1-12 * paragraph [0083] - paragraph [0085]; claims 11-14 *;
 [Y]  - Anonymous, "Opioid-induced hyperalgesia", (2007), URL: http://web.archive.org/web/20080712205531/http://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia, (20101001), XP002603149 [Y] 1-12 * the whole document *
 [Y]  - CHIH-CHENG CHIEN ET AL, "Sigma antagonists potentiate opioid analgesia in rats", NEUROSCIENCE LETTERS, LIMERICK, IE, (19950101), vol. 190, no. 2, doi:10.1016/0304-3940(95)11504-P, ISSN 0304-3940, pages 137 - 139, XP002498085 [Y] 1-12 * abstract *

DOI:   http://dx.doi.org/10.1016/0304-3940(95)11504-P
Examination   - SILVERMAN, "Opioid induced hyperalgesia...", PAIN PHYSICIAN, (2009), vol. 12, pages 679 - 684
    - LEE, "A comprehensive review of opioid induced", PAIN PHYSICIAN, (201101), vol. 14, pages 145 - 161
by applicantWO2009130310
 WO2006021462
    - SANDFORD,M. ET AL., PAIN PHYSICIAN, (2009), vol. 12, pages 679 - 684
    - MAO,J., PAIN, (2002), vol. 100, pages 213 - 217
    - GUIGNARD,B. ET AL., ANESTHESIOLOGY, (2000), vol. 93, pages 409 - 417
    - ANGST, M.S. ET AL., ANESTHESIOLOGY, (2006), vol. 104, pages 570 - 587
    - E. CELERIER ET AL., J. NEUROSCI., (2001), vol. 21, pages 4074 - 4080
    - TRESCOT,A.M. ET AL., PAIN PHYSICIAN, (2008), vol. 11, pages S12 - S16
    - SMITH,M.T., ACUTE PAIN, (2008), vol. 10, pages 199 - 200
    - MEI J, PASTERNAK GW, "Sigma 1 receptor modulation of opioid analgesia in the mouse", J PHARMACOL EXP THER., (2002), vol. 300, no. 3, doi:doi:10.1124/jpet.300.3.1070, pages 1070 - 1074, XP055362826

DOI:   http://dx.doi.org/10.1124/jpet.300.3.1070
    - CHIEN CC, PASTERNAK GW, "Sigma antagonists potentiate opioid analgesia in rats", NEUROSCI LETT, (1995), vol. 190, no. 2, doi:doi:10.1016/0304-3940(95)11504-P, pages 137 - 139, XP002498085

DOI:   http://dx.doi.org/10.1016/0304-3940(95)11504-P
    - G. RONSISVALLE ET AL., PURE APPL. CHEM., (2001), vol. 73, pages 1499 - 1509
    - R. QUIRON ET AL., TRENDS PHARMACOL. SCI., (1992), vol. 13, pages 85 - 86
    - M.L.LEITNER, EUR. J. PHARMACOL., (1994), vol. 259, pages 65 - 69
    - S.B. HELLEWELL, W.D. BOWEN, BRAIN RES, (1990), vol. 527, pages 244 - 253
    - PRASAD, P.D. ET AL., J. NEUROCHEM., (1998), vol. 70, no. 2, pages 443 - 451
    - IASP, Classification of chronic pain, IASP PRESS, (2002), page 211
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.