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Extract from the Register of European Patents

EP About this file: EP2531032

EP2531032 - MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.02.2020
Database last updated on 19.03.2026
FormerThe patent has been granted
Status updated on  08.03.2019
FormerGrant of patent is intended
Status updated on  10.01.2019
FormerExamination is in progress
Status updated on  12.12.2018
FormerGrant of patent is intended
Status updated on  01.10.2018
FormerExamination is in progress
Status updated on  12.05.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Indiana University Research and Technology Corporation
518 Indiana Avenue
Indianapolis, IN 46202 / US
[2017/25]
Former [2012/50]For all designated states
Indiana University Research and Technology Corporation
351 West 10th Street
Indianapolis, IN 46202 / US
Inventor(s)01 / TURCHI, John, J.
5445 North Pennsylvania Street
Indianapolis, IN 46220 / US
02 / SHUCK, Sarah
22298 Redwood Pointe
Lake Forest, CA 92630 / US
 [2019/03]
Former [2012/50]01 / TURCHI, John, J.
5445 North Pennsylvania Street
Indianapolis, IN 46220 / US
02 / SHUCK, Sarah
5530 Knob Road
Nashville, TN 37209 / US
Representative(s)HGF
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
[N/P]
Former [2019/15]HGF Limited
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Former [2014/07]Armstrong, Iain Cheshire, et al
Harrison Goddard Foote LLP
4th Floor, Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Former [2012/50]Harrison Goddard Foote
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Application number, filing date11740474.905.02.2011
[2019/15]
WO2011US23838
Priority number, dateUS20100301778P05.02.2010         Original published format: US 301778 P
[2012/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011097545
Date:11.08.2011
Language:EN
[2011/32]
Type: A1 Application with search report 
No.:EP2531032
Date:12.12.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 11.08.2011 takes the place of the publication of the European patent application.
[2012/50]
Type: B1 Patent specification 
No.:EP2531032
Date:10.04.2019
Language:EN
[2019/15]
Search report(s)International search report - published on:US11.08.2011
(Supplementary) European search report - dispatched on:EP05.08.2013
ClassificationIPC:A61K31/415, A61K31/4709, A61K31/5377, A61K33/24, A61P35/00, C07D401/04
[2018/43]
CPC:
A61K31/5377 (EP,US); A61K31/415 (EP,US); A61K31/4709 (EP,US);
A61K33/243 (EP,US); A61K45/06 (EP,US); A61K47/26 (US);
A61K47/38 (US); A61K9/0053 (US); A61P31/00 (EP);
A61P35/00 (EP); A61P43/00 (EP); C07D401/04 (EP,US);
Y02A50/30 (EP) (-)
C-Set:
A61K31/415, A61K2300/00 (EP,US);
A61K31/4709, A61K2300/00 (US,EP);
A61K31/5377, A61K2300/00 (US,EP);
A61K33/24, A61K2300/00 (US,EP)
Former IPC [2013/34]A61K31/415, A61K31/4709, A61K31/5377, A61P35/00
Former IPC [2012/50]A01N43/56
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/50]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MATERIALIEN UND VERFAHREN ZUR HEMMUNG DES REPLIKATIONSPROTEINS A UND ANWENDUNGEN DAVON[2012/50]
English:MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF[2012/50]
French:MATIÈRES ET PROCÉDÉ POUR INHIBER LA PROTÉINE DE RÉPLICATION A ET LEURS UTILISATIONS[2012/50]
Entry into regional phase23.08.2012National basic fee paid 
23.08.2012Search fee paid 
23.08.2012Designation fee(s) paid 
23.08.2012Examination fee paid 
Examination procedure23.08.2012Examination requested  [2012/50]
28.02.2014Amendment by applicant (claims and/or description)
02.05.2014Despatch of a communication from the examining division (Time limit: M06)
12.11.2014Reply to a communication from the examining division
13.01.2016Despatch of a communication from the examining division (Time limit: M06)
23.05.2016Reply to a communication from the examining division
04.05.2017Despatch of a communication from the examining division (Time limit: M06)
13.11.2017Reply to a communication from the examining division
02.10.2018Communication of intention to grant the patent
11.12.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
11.12.2018Fee for grant paid
11.12.2018Fee for publishing/printing paid
09.01.2019Information about intention to grant a patent
09.01.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.05.2014
Opposition(s)13.01.2020No opposition filed within time limit [2020/12]
Fees paidRenewal fee
27.02.2013Renewal fee patent year 03
27.02.2014Renewal fee patent year 04
26.02.2015Renewal fee patent year 05
26.02.2016Renewal fee patent year 06
27.02.2017Renewal fee patent year 07
27.02.2018Renewal fee patent year 08
27.02.2019Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.02.2011
AL10.04.2019
AT10.04.2019
CY10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
MC10.04.2019
MK10.04.2019
MT10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
RS10.04.2019
SE10.04.2019
SI10.04.2019
SK10.04.2019
SM10.04.2019
TR10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
[2022/32]
Former [2022/27]HU05.02.2011
AL10.04.2019
AT10.04.2019
CY10.04.2019
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EE10.04.2019
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BG10.07.2019
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Documents cited:Search[XY] WO2008045663  (KALYPSYS INC et al.) [X] 1-9,15,18 * examples 5, 17-20, 22, 27, 70-72, 97-99 * * page 18, lines 19-27 * * page 27, lines 3-8 * * the whole document *[Y] 1-18
 [XY] WO2009145829  (UNIV MASSACHUSETTS et al.) [X] 1,2,4-7,15,18 * the whole document * * claim 2, point d * * claim 31 * * page 49, paragraph l *[Y] 1-18
 [XY] WO2007120842  (CORNELL RES FOUNDATION INC et al.) [X] 1-9,15-18 * the whole document * * figure 4 * * page 24/43;; figure 15 * * page 3 - page 4, paragraph 2 * * pages 47,69-70 *[Y] 1-18
 [XY]   VIDAL ET AL: "Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 8, 23 July 2007 (2007-07-23), EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, pages 1102 - 1108, XP022165144, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2007.01.017 [X] 1-3,7,8,15 * the whole document * * compound 4 *[Y] 1-18

DOI:   http://dx.doi.org/10.1016/j.ejmech.2007.01.017
 [XP]   SHUCK SARAH C ET AL: "Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.", CANCER RESEARCH, vol. 70, no. 8, 15 April 2010 (2010-04-15), pages 3189 - 3198, XP002701292, ISSN: 1538-7445 [XP] 1-9,15-18 * the whole document *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-09-3422
 [XP]   ANCIANO GRANADILLO VICTOR J ET AL: "Targeting the OB-Folds of Replication Protein A with Small Molecules.", JOURNAL OF NUCLEIC ACIDS, vol. 2010, 304035, 2010, pages 11PP, XP002701293, ISSN: 2090-021X [XP] 1-9,15-18 * the whole document *

DOI:   http://dx.doi.org/10.4061/2010/304035
International search[Y]   DATABASE PUBCHEM [online] 10 August 2005 (2005-08-10), "4-(3,5-diphenyl-3,4-dihydropyrazol-2-yl)-4-oxobutanoic acid 4-(3,5-Diphenyl-4,5-dihydro-pyrazol-1-yl)-4-oxo-butyric acid", XP008162094, Database accession no. 3153480 [Y]
 [Y]   SHARP S.Y. ET AL: "In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors", CANCER RES., vol. 67, 2007, pages 2206 - 2216, XP008161647, Retrieved from the Internet [Y]

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-06-3473
 [Y]   ANDREWS ET AL: "Development of a high-throughput screen for inhibitors of replication protein A and its role in nucteotide excision repair", MOL CANCER THER, vol. 3, 2004, pages 385 - 391, XP008161648, Retrieved from the Internet [Y]
 [Y]   DENG ET AL: "Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation", J MOL BIOL, vol. 374, 2007, pages 865 - 876, XP022338251, Retrieved from the Internet [Y]

DOI:   http://dx.doi.org/10.1016/j.jmb.2007.09.074
 [AP]   SHUCK S.C.: "Identification of Novel Small Molecule Inhibitors of Proteins Required for Genomic Maintenance and Stability", DOCTORAL THESIS, INDIANA UNIVERSITY, June 2010 (2010-06-01), pages 1 - 131, XP008161649, Retrieved from the Internet [AP]
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.