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Extract from the Register of European Patents

EP About this file: EP2536827

EP2536827 - METHODS OF MANUFACTURE OF THERAPEUTIC PRODUCTS COMPRISING VITALIZED PLACENTAL DISPERSIONS [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 16.11.2018 Database last updated on 28.03.2026
Former	The patent has been granted Status updated on 08.12.2017
Former	Grant of patent is intended Status updated on 05.11.2017
Former	Examination is in progress Status updated on 09.10.2017
Former	Grant of patent is intended Status updated on 21.05.2017
Most recent event Tooltip	26.06.2020	Lapse of the patent in a contracting state New state(s): MK	published on 29.07.2020 [2020/31]
Applicant(s)	For all designated states Osiris Therapeutics, Inc. 7015 Albert Einstein Drive Columbia, MD 21046 / US
	[2012/52]
Inventor(s)	01 / JANSEN, Timothy 93 High Street, Apt. 3 Portsmouth, NH 03801 / US
	02 / TOM, Samson 72 Liberty Ridge Road Basking Ridge, NJ 07920 / US
	03 / DANILKOVITCH, Alla 9489 Good Lion Road Columbia Maryland 21045 / US
	04 / YOO, Dana 6749 Darrells Grant Place Falls Church, VA 22043 / US
	05 / ZERHUSEN, Jaime 5045 Hesperus Drive Columbia, MD 21044 / US
	[2013/05]
Former [2013/03]	01 / JANSEN, Timothy 93 High Street Apt. 3 Portsmouth, NH 03801 / US
	02 / TOM, Samson 72 Liberty Ridge Road Basking Ridge, NJ 07920 / US
	03 / DANILKOVITCH, Alla 9489 Good Lion Road Columbia Maryland 21045 / US
	04 / YOO, Dana 6749 Darrells Grant Place Falls Church, VA 22043 / US
	05 / ZERHUSEN, Jaime 5045 Hesperus Drive Columbia, MD 21044 / US
Former [2012/52]	01 / JANSEN, Timothy 1420 Light Street, Apt. 1 Baltimore Maryland 21230 / US
	02 / TOM, Samson 5200 Leavers Court Baltimore Maryland 21237 / US
	03 / DANILKOVITCH, Alla 9489 Good Lion Road Columbia Maryland 21045 / US
	04 / YOO, Dana 7154 Harlan Lane Sykesville Maryland 21784 / US
	05 / ZERHUSEN, Jaime 4 Little Patuxent Pkwy. Apt. 102 Columbia Maryland 21044 / US
Representative(s)	Schnappauf, Georg, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
	[2018/02]
Former [2012/52]	Schnappauf, Georg, et al Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6 81679 München / DE
Application number, filing date	11745361.3	18.02.2011
	[2018/02]
	WO2011US25493
Priority number, date	US20100369562P	30.07.2010 Original published format: US 369562 P
	US20100338489P	18.02.2010 Original published format: US 338489 P
	US20100338464P	18.02.2010 Original published format: US 338464 P
	[2012/52]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2011103472
	Date:	25.08.2011
	Language:	EN
	[2011/34]
	Type:	A1 Application with search report
	No.:	EP2536827
	Date:	26.12.2012
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 25.08.2011 takes the place of the publication of the European patent application.
	[2012/52]
	Type:	B1 Patent specification
	No.:	EP2536827
	Date:	10.01.2018
	Language:	EN
	[2018/02]
Search report(s)	International search report - published on:	US	25.08.2011
	(Supplementary) European search report - dispatched on:	EP	09.05.2014
Classification	IPC:	C12N5/073, A61K38/39, A61K38/57, A61K35/50, A01N1/02, A61K38/18	[2014/23]
	CPC:	A01N1/125 (EP,US); A61K35/28 (US); A61K35/50 (EP,US); A61K38/1825 (EP,US); A61K38/1841 (EP,US); A61K38/39 (EP,US); (+) A61K38/57 (EP,US); A61P17/00 (EP); A61P17/02 (EP); A61P43/00 (EP); C12N5/0605 (EP,US); C12N2500/02 (EP,US); C12N2501/115 (US); C12N2502/025 (EP,US) (-)
	Former IPC [2012/52]	C12N5/073
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/52]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	VERFAHREN ZUR HERSTELLUNG THERAPEUTISCHER PRODUKTE MIT VITALISIERTER PLAZENTA-DISPERSION	[2012/52]
	English:	METHODS OF MANUFACTURE OF THERAPEUTIC PRODUCTS COMPRISING VITALIZED PLACENTAL DISPERSIONS	[2012/52]
	French:	PROCÉDÉS DE FABRICATION DE PRODUITS THÉRAPEUTIQUES COMPRENANT DES DISPERSIONS PLACENTAIRES VITALISÉES	[2012/52]
Entry into regional phase	24.08.2012	National basic fee paid
	24.08.2012	Search fee paid
	24.08.2012	Designation fee(s) paid
	24.08.2012	Examination fee paid
Examination procedure	24.08.2012	Examination requested [2012/52]
	03.12.2014	Amendment by applicant (claims and/or description)
	27.02.2015	Despatch of a communication from the examining division (Time limit: M06)
	09.09.2015	Reply to a communication from the examining division
	24.05.2016	Despatch of a communication from the examining division (Time limit: M04)
	23.09.2016	Reply to a communication from the examining division
	22.05.2017	Communication of intention to grant the patent
	29.09.2017	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
	29.09.2017	Fee for grant paid
	29.09.2017	Fee for publishing/printing paid
	06.11.2017	Communication of intention to grant the patent
	23.11.2017	Receipt of the translation of the claim(s)
Divisional application(s)	EP17211013.2 / EP3351624
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 27.02.2015
Opposition(s)	11.10.2018	No opposition filed within time limit [2018/51]
Fees paid	Renewal fee
	21.02.2013	Renewal fee patent year 03
	20.02.2014	Renewal fee patent year 04
	23.02.2015	Renewal fee patent year 05
	26.02.2016	Renewal fee patent year 06
	28.02.2017	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	18.02.2011
	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	MK	10.01.2018
	PL	10.01.2018
	PT	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SI	10.01.2018
	SK	10.01.2018
	SM	10.01.2018
	TR	10.01.2018
	LU	18.02.2018
	MT	18.02.2018
	BE	28.02.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
	[2020/31]
Former [2020/27]	HU	18.02.2011
	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	PT	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SI	10.01.2018
	SK	10.01.2018
	SM	10.01.2018
	TR	10.01.2018
	LU	18.02.2018
	MT	18.02.2018
	BE	28.02.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2020/16]	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SI	10.01.2018
	SK	10.01.2018
	SM	10.01.2018
	TR	10.01.2018
	LU	18.02.2018
	MT	18.02.2018
	BE	28.02.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2020/08]	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SI	10.01.2018
	SK	10.01.2018
	SM	10.01.2018
	LU	18.02.2018
	MT	18.02.2018
	BE	28.02.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2019/12]	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SI	10.01.2018
	SK	10.01.2018
	SM	10.01.2018
	LU	18.02.2018
	BE	28.02.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/52]	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SK	10.01.2018
	SM	10.01.2018
	LU	18.02.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/51]	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	DK	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SK	10.01.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/50]	AL	10.01.2018
	CY	10.01.2018
	CZ	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	SK	10.01.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/49]	AL	10.01.2018
	CY	10.01.2018
	EE	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	MC	10.01.2018
	PL	10.01.2018
	RO	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/46]	AL	10.01.2018
	CY	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	PL	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/40]	CY	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	PL	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	BG	10.04.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/39]	CY	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	LV	10.01.2018
	PL	10.01.2018
	RS	10.01.2018
	SE	10.01.2018
	NO	10.04.2018
	GR	11.04.2018
	IS	10.05.2018
Former [2018/37]	CY	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	PL	10.01.2018
	NO	10.04.2018
	GR	11.04.2018
Former [2018/36]	CY	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	PL	10.01.2018
	NO	10.04.2018
Former [2018/35]	CY	10.01.2018
	FI	10.01.2018
	HR	10.01.2018
	LT	10.01.2018
	NO	10.04.2018
Documents cited:	Search	[XI] WO2007079184 (ANTHROGENESIS CORP et al.) [X] 1,17-19 * claims 23-26 * * paragraph [0040] * * page 56 *[I] 2-16,20
		[X] BABALOLA G O ET AL: "Aggregation of dispersed human cytotrophoblastic cells: Lessons relevant to the morphogenesis of the placenta", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 137, no. 1, 1 January 1990 (1990-01-01), pages 100 - 108, XP024788428, ISSN: 0012-1606, [retrieved on 19900101], DOI: 10.1016/0012-1606(90)90011-7 [X] 17-19 * abstract * DOI: http://dx.doi.org/10.1016/0012-1606(90)90011-7
		[A] PAROLINI ORNELLA ET AL: "Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells", STEM CELLS, ALPHAMED PRESS, INC, UNITED STATES, vol. 26, no. 2, 1 February 2008 (2008-02-01), pages 300 - 311, XP002513690, ISSN: 1549-4918, DOI: 10.1634/STEMCELLS .2007-0594 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1634/STEMCELLS .2007-0594
		[A] E. DIMITRIADIS: "Cytokines, chemokines and growth factors in endometrium related to implantation", HUMAN REPRODUCTION UPDATE, vol. 11, no. 6, 25 August 2005 (2005-08-25), pages 613 - 630, XP055109724, ISSN: 1355-4786, DOI: 10.1093/humupd/dmi023 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1093/humupd/dmi023
		[A] MASATO KUBO ET AL: "Immunogenicity of Human Amniotic Membrane in Experimental Xenotransplantation", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1 June 2001 (2001-06-01), United States, pages 1539, XP055109089, Retrieved from the Internet [retrieved on 20140320] [A] 17-19 * page 1540, paragraph 1 - paragraph 2 * * page 1541, paragraph 1 * * discussion; page 1543 - page 1544 *
		[A] KRUSE F E ET AL: "CRYOPRESERVED HUMAN AMNIOTIC MEMBRANE FOR OCULAR SURFACE RECONSTRUCTION", GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, SPRINGER VERLAG, DE, vol. 238, no. 1, 1 January 2000 (2000-01-01), pages 68 - 75, XP000923120, ISSN: 0721-832X, DOI: 10.1007/S004170050012 [A] 17-19 * abstract * DOI: http://dx.doi.org/10.1007/s004170050012
	International search	[X] US2008175824 (HEIDARAN MOHAMMAD et al.)
		[Y] US2009104164 (ZHANG XIAOKUI et al.)
		[Y] US2008299087 (TSENG SCHEFFER et al.)
		[A] WO2005001076 (ETHICON INC et al.)
	by applicant	WO2009132186
		US2010098743
		PORTMANN-LANZ ET AL.: "Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 194, 2006, pages 664 - 73, XP005315891, DOI: doi:10.1016/j.ajog.2006.01.101 DOI: http://dx.doi.org/10.1016/j.ajog.2006.01.101
		"Isolation and characterization of mesenchymal cells from human fetal membranes", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 1, 2007, pages 296 - 305
		CHEN ET AL.: "Enveloping the tendon graft with periosteum to enhance tendon-bone healing in a bone tunnel: A biomechanical and histologic study in rabbits", ARTHROSCOPY, vol. 19, no. 3, March 2003 (2003-03-01), pages 290 - 6
		CHEN ET AL.: "Enveloping of periosteum on the hamstring tendon graft in anterior cruciate ligament reconstruction", ARTHROSCOPY, vol. 18, no. 5, May 2002 (2002-05-01), pages 27E, XP022381045, DOI: doi:10.1016/S0749-8063(07)60066-8 DOI: http://dx.doi.org/10.1016/S0749-8063(07)60066-8
		CHANG ET AL.: "Rotator cuff repair with periosteum for enhancing tendon-bone healing: a biomechanical and histological study in rabbits", KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY, vol. 17, no. 12, pages 1447 - 1453, XP019755755, DOI: doi:10.1007/s00167-009-0809-x DOI: http://dx.doi.org/10.1007/s00167-009-0809-x
		KWAN ET AL., HAND CLIN., vol. 25, 2009, pages 511
		TREDGET ET AL., SURG. CLIN. NORTH AM., vol. 77, 1997, pages 701
		NEDELEC ET AL., J. LAB. CLIN. MED., vol. 126, 1995, pages 474
		OCCLESTON ET AL., J. BIOMATER. SCI. POLYM. ED., vol. 19, 2008, pages 1047
		ALLORI ET AL., TISSUE ENGINEERING: PART B, vol. 8, 2008, pages 275
		MAJORS ET AL., J. ORTHOPAEDIC RES., vol. 15, 1997, pages 546

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