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Extract from the Register of European Patents

EP About this file: EP2542560

EP2542560 - ARYLFLUOROPHOSPHATE INHIBITORS OF INTESTINAL APICAL MEMBRANE SODIUM/PHOSPHATE CO-TRANSPORT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.09.2016
Database last updated on 06.07.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Duophos
301 Briarmeadow Avenue
Friendswood, TX 77546 / US
[N/P]
Former [2013/02]For all designated states
Duophos
301 Briarmeadow Avenue
Firendswood, TX 77546 / US
Inventor(s)01 / PEERCE, Brian
301 Briarmeadow Avenue
Friendswood, TX 77546 / US
02 / SLOMOWITZ, Larry
1865 Alberni Street
Vancouver, BC V6H 3H9 / CA
 [2013/02]
Representative(s)Williams, Andrea, et al
Marks & Clerk LLP
62-68 Hills Road
Cambridge CB2 1LA / GB
[2015/46]
Former [2013/02]Spring, Lauren Elizabeth
Marks & Clerk LLP
62-68 Hills Road
Cambridge
CB2 1LA / GB
Application number, filing date11751437.204.03.2011
[2015/46]
WO2011US27232
Priority number, dateUS20100310902P05.03.2010         Original published format: US 310902 P
[2013/02]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011109731
Date:09.09.2011
Language:EN
[2011/36]
Type: A2 Application without search report 
No.:EP2542560
Date:09.01.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 09.09.2011 takes the place of the publication of the European patent application.
[2013/02]
Type: B1 Patent specification 
No.:EP2542560
Date:11.11.2015
Language:EN
[2015/46]
Type: B8 Corrected title page of specification 
No.:EP2542560
Date:30.12.2015
[2015/53]
Search report(s)International search report - published on:KR01.03.2012
(Supplementary) European search report - dispatched on:EP17.09.2014
ClassificationIPC:C07F9/14, C07F9/20, C07F9/26, A61K31/683, A61P9/12
[2013/02]
CPC:
C07F9/1406 (EP,US); C07F9/146 (US); A61P13/12 (EP);
A61P43/00 (EP); A61P7/00 (EP); A61P9/12 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/02]
Extension statesBA28.09.2012
ME28.09.2012
TitleGerman:ARYLFLUORPHOSPHATHEMMER EINES NATRIUM-/PHOSPHAT-TRANSPORTS DURCH APIKALMEMBRANEN IM DARM[2013/02]
English:ARYLFLUOROPHOSPHATE INHIBITORS OF INTESTINAL APICAL MEMBRANE SODIUM/PHOSPHATE CO-TRANSPORT[2013/02]
French:INHIBITEURS DU COTRANSPORT SODIUM/PHOSPHATE DANS LA MEMBRANE APICALE INTESTINALE À BASE DE FLUOROPHOSPHATES D'ARYLE[2013/02]
Entry into regional phase28.09.2012National basic fee paid 
28.09.2012Search fee paid 
28.09.2012Designation fee(s) paid 
28.09.2012Examination fee paid 
Examination procedure28.09.2012Examination requested  [2013/02]
13.04.2015Amendment by applicant (claims and/or description)
29.05.2015Communication of intention to grant the patent
29.09.2015Fee for grant paid
29.09.2015Fee for publishing/printing paid
29.09.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.05.2015
Opposition(s)12.08.2016No opposition filed within time limit [2016/42]
Fees paidRenewal fee
11.03.2013Renewal fee patent year 03
12.03.2014Renewal fee patent year 04
27.03.2015Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.03.2011
AL11.11.2015
AT11.11.2015
BE11.11.2015
BG11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
MT31.03.2016
[2018/46]
Former [2018/38]HU04.03.2011
AT11.11.2015
BE11.11.2015
BG11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
MT31.03.2016
Former [2018/31]HU04.03.2011
AT11.11.2015
BE11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
MT31.03.2016
Former [2018/29]HU04.03.2011
AT11.11.2015
BE11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
Former [2018/28]HU04.03.2011
AT11.11.2015
BE11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
Former [2017/47]AT11.11.2015
BE11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MT11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
Former [2017/03]AT11.11.2015
BE11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
Former [2016/49]AT11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
BE31.03.2016
Former [2016/47]AT11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU04.03.2016
IS11.03.2016
PT11.03.2016
BE31.03.2016
Former [2016/39]AT11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
BE31.03.2016
Former [2016/38]AT11.11.2015
CZ11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
BE31.03.2016
Former [2016/36]AT11.11.2015
CZ11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
BE31.03.2016
Former [2016/34]AT11.11.2015
CZ11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
PL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/25]AT11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
PL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/24]AT11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
PL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/23]HR11.11.2015
LT11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
IS11.03.2016
Former [2016/22]LT11.11.2015
NO11.02.2016
IS11.03.2016
Former [2016/21]LT11.11.2015
NO11.02.2016
Former [2016/20]LT11.11.2015
Documents cited:Search[A]WO0043402  (UNIV TEXAS [US], et al) [A] 1-15* the whole document *
International search[A]  - PEERCE, B. E. ET AL., "A Phosphorylated Phloretin Derivative. Synthesis and Effect on Intestinal Na+-dependant Phosphate Absorption.", AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL., (2002), vol. 283, pages G848 - G855, XP055096590

DOI:   http://dx.doi.org/10.1152/ajpgi.00308.2001
 [A]  - DABKOWSKI, W. ET AL., "Synthesis of Phosphorofluoridates and Phosphofluoridot hioates via the Phosphoramidite Approach.", ORG. BIOMOL. CHEM., (2005), vol. 3, pages 866 - 874, XP055096591

DOI:   http://dx.doi.org/10.1039/b413552k
 [A]  - PEERCE, B. E., "Effect of Substrates and pH on the Intestinal Na+/Phosphate Cotransporter: Evidence for an Intervesicular Divalent Phosphate Allosteric Regulatory Site.", BIOCHIMICA ET BIOPHYSICA ACTA, (1995), vol. 1239, no. 1, pages 1 - 10, XP055096617

DOI:   http://dx.doi.org/10.1016/0005-2736(95)00115-J
 [A]  - ROMANENKO, V. D. ET AL., "Fluorinated Organophosphates for Biomedical Targets.", TETRAHEDRON, (2008), vol. 64, pages 6153 - 6190, XP022695588

DOI:   http://dx.doi.org/10.1016/j.tet.2008.04.064
 [A]  - ALKHERRAZ, A. ET AL., "Phosphate Ester Analogues as Probes for Understanding Enzyme Catalysed Phosphoryl Transfer.", FARADAY DISCUSS., (20091029), vol. 145, pages 281 - 299, XP055096606

DOI:   http://dx.doi.org/10.1039/B908398G
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