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Extract from the Register of European Patents

EP About this file: EP2550365

EP2550365 - PREDICTING HUMAN DEVELOPMENTAL TOXICITY OF PHARMACEUTICALS USING HUMAN STEM-LIKE CELLS AND METABOLOMICS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.05.2019
Database last updated on 15.07.2024
FormerThe patent has been granted
Status updated on  01.06.2018
FormerGrant of patent is intended
Status updated on  17.01.2018
FormerExamination is in progress
Status updated on  04.12.2017
FormerGrant of patent is intended
Status updated on  18.07.2017
FormerExamination is in progress
Status updated on  21.02.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Stemina Biomarker Discovery, Inc.
504 S. Rosa Road Suite 150
Madison, WI 53719 / US
[2013/05]
Inventor(s)01 / WEST, Paul, R.
7540 US Highway 14
Arena, WI 53503 / US
02 / WEIR, April, M.
6405 Woodington Way
Madison, WI 53711 / US
03 / SMITH, Alan, M.
1146 Erin Street
Madison, WI 53715 / US
04 / DONLEY, Elizabeth, L.R.
9201 Bear Claw Way
Madison, WI 53717 / US
05 / CEZAR, Gabriela, G.
110 Vaughn Court
Madison, WI 53705 / US
 [2013/05]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2018/27]
Former [2013/05]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date11760090.822.03.2011
[2018/27]
WO2011US29471
Priority number, dateUS20100316165P22.03.2010         Original published format: US 316165 P
US20100394426P19.10.2010         Original published format: US 394426 P
[2013/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011119637
Date:29.09.2011
Language:EN
[2011/39]
Type: A1 Application with search report 
No.:EP2550365
Date:30.01.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 29.09.2011 takes the place of the publication of the European patent application.
[2013/05]
Type: B1 Patent specification 
No.:EP2550365
Date:04.07.2018
Language:EN
[2018/27]
Search report(s)International search report - published on:US29.09.2011
(Supplementary) European search report - dispatched on:EP06.08.2013
ClassificationIPC:C12Q1/00
[2013/05]
CPC:
G01N33/5073 (EP,US); G01N33/5014 (US); G01N33/6848 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/05]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VORHERSAGE DER ENTWICKLUNG DER TOXIZITÄT VON PHARMAZEUTIKA FÜR MENSCHEN MITHILFE MENSCHLICHER STAMMZELLEN UND METABOLOME[2013/05]
English:PREDICTING HUMAN DEVELOPMENTAL TOXICITY OF PHARMACEUTICALS USING HUMAN STEM-LIKE CELLS AND METABOLOMICS[2013/05]
French:PRÉDICTION DE LA TOXICITÉ SUR LE DÉVELOPPEMENT HUMAIN D'AGENTS PHARMACEUTIQUES AU MOYEN DE CELLULES DE TYPE CELLULES SOUCHES HUMAINES ET DE LA MÉTABOLOMIQUE[2013/05]
Entry into regional phase22.10.2012National basic fee paid 
22.10.2012Search fee paid 
22.10.2012Designation fee(s) paid 
22.10.2012Examination fee paid 
Examination procedure22.10.2012Examination requested  [2013/05]
06.06.2014Amendment by applicant (claims and/or description)
13.11.2015Despatch of a communication from the examining division (Time limit: M06)
17.06.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
27.06.2016Reply to a communication from the examining division
20.07.2016Despatch of a communication from the examining division (Time limit: M02)
06.09.2016Reply to a communication from the examining division
10.02.2017Despatch of a communication from the examining division (Time limit: M04)
31.05.2017Reply to a communication from the examining division
19.07.2017Communication of intention to grant the patent
28.11.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
18.01.2018Communication of intention to grant the patent
24.05.2018Fee for grant paid
24.05.2018Fee for publishing/printing paid
24.05.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  13.11.2015
Opposition(s)05.04.2019No opposition filed within time limit [2019/24]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
27.06.2016Request for further processing filed
27.06.2016Full payment received (date of receipt of payment)
Request granted
13.07.2016Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
06.06.2014Request for further processing filed
06.06.2014Full payment received (date of receipt of payment)
Request granted
20.06.2014Decision despatched
Fees paidRenewal fee
27.03.2013Renewal fee patent year 03
27.03.2014Renewal fee patent year 04
27.03.2015Renewal fee patent year 05
31.03.2016Renewal fee patent year 06
27.03.2017Renewal fee patent year 07
27.03.2018Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL04.07.2018
AT04.07.2018
CY04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
MK04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
LU22.03.2019
MT22.03.2019
[2022/31]
Former [2021/26]AL04.07.2018
AT04.07.2018
CY04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
LU22.03.2019
MT22.03.2019
Former [2020/29]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
PT05.11.2018
LU22.03.2019
MT22.03.2019
Former [2020/16]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
TR04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
LU22.03.2019
Former [2020/01]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
LU22.03.2019
Former [2019/46]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
MC04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/37]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SI04.07.2018
SK04.07.2018
SM04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/26]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SK04.07.2018
SM04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/24]AL04.07.2018
AT04.07.2018
CZ04.07.2018
EE04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
SK04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/22]AL04.07.2018
AT04.07.2018
CZ04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RO04.07.2018
RS04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/21]AL04.07.2018
AT04.07.2018
CZ04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
IT04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RS04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/12]AL04.07.2018
AT04.07.2018
CZ04.07.2018
ES04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
LV04.07.2018
PL04.07.2018
RS04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/11]AT04.07.2018
CZ04.07.2018
FI04.07.2018
HR04.07.2018
LT04.07.2018
PL04.07.2018
RS04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/10]AT04.07.2018
CZ04.07.2018
FI04.07.2018
LT04.07.2018
PL04.07.2018
RS04.07.2018
BG04.10.2018
NO04.10.2018
GR05.10.2018
IS04.11.2018
Former [2019/08]FI04.07.2018
LT04.07.2018
NO04.10.2018
IS04.11.2018
Former [2019/07]LT04.07.2018
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 [XI]US2007248947  (CEZAR GABRIELA G [US]) [X] 16-18 * claims 17, 31,-33 45, para's 0046, 0053, 0060 ff,0075,0078,0079 * [I] 1-15,20-25;
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DOI:   http://dx.doi.org/10.1002/bdrb.20100
 [IP]  - WEST P R ET AL, "Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 247, no. 1, ISSN 0041-008X, (20100815), pages 18 - 27, (20100521), XP027142153 [IP] 1-25 * abstract *
 [T]  - WEST P R ET AL, "A High Throughput Metabolite-Based Biomarker Approach to Predict Developmental Toxicity Using Human Embryonic Stem Cells", INTERNATIONAL JOURNAL OF TOXICOLOGY, & 33RD ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-TOXICOLOGY; , FL, USA; NOVEMBER 04 -07, 2012, (201301), vol. 32, no. 1, page 70, XP009171379 [T] * the whole document *
 [T]  - KLEINSTREUER N C ET AL, "Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 257, no. 1, doi:10.1016/J.TAAP.2011.08.025, ISSN 0041-008X, (20110828), pages 111 - 121, (20110903), XP028112545 [T] * the whole document *

DOI:   http://dx.doi.org/10.1016/j.taap.2011.08.025
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 [X]US2007248947  (CEZAR GABRIELA G [US])
 [Y]  - CEZAR ET AL., "Identification of Small Molecules from Human Embryonic Stem Cells Using Metabolomics.", STEM CELLS AND DEVELOPMENT, (2007), vol. 16, pages 869 - 882
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