EP2556058 - RADIOPROTECTOR COMPOUNDS AND METHODS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 20.04.2018 Database last updated on 02.11.2024 | |
Former | The patent has been granted Status updated on 12.05.2017 | ||
Former | Grant of patent is intended Status updated on 03.01.2017 | Most recent event Tooltip | 10.07.2020 | Lapse of the patent in a contracting state New state(s): AL | published on 12.08.2020 [2020/33] | Applicant(s) | For all designated states Peter MacCallum Cancer Institute Smorgon Family Building St Andrew's Place East Melbourne, VIC 3002 / AU | [2013/07] | Inventor(s) | 01 /
MARTIN, Roger, Francis 10/165 Ford Street Ivanhoe, Victoria 3079 / AU | 02 /
WHITE, Jonathan 11 Freeman Street Wheelers Hill, Victoria 3150 / AU | 03 /
LOBACHEVSKY, Pavel 3 Reichelt Avenue Montmorency, Victoria 3094 / AU | 04 /
WINKLER, David 5/158-160 Wattletree Road Malvern, Victoria 3144 / AU | 05 /
SKENE, Colin 1/10 Shirley Avenue Glen Waverley, Victoria 3150 / AU | 06 /
MARCUCCIO, Sebastian 5 Sporing Court Endeavour Hills, Victoria 3802 / AU | [2013/07] | Representative(s) | Goodall, Scott, et al Sagittarius IP Marlow International Parkway Marlow SL7 1YL / GB | [N/P] |
Former [2013/19] | Goodall, Scott, et al Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB | ||
Former [2013/07] | Sagittarius IP Three Globeside Fieldhouse Lane Marlow Buckinghamshire SL7 1HZ / GB | Application number, filing date | 11764947.5 | 06.04.2011 | [2017/24] | WO2011AU00392 | Priority number, date | US20100321288P | 06.04.2010 Original published format: US 321288 P | [2013/07] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011123890 | Date: | 13.10.2011 | Language: | EN | [2011/41] | Type: | A1 Application with search report | No.: | EP2556058 | Date: | 13.02.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 13.10.2011 takes the place of the publication of the European patent application. | [2013/07] | Type: | B1 Patent specification | No.: | EP2556058 | Date: | 14.06.2017 | Language: | EN | [2017/24] | Search report(s) | International search report - published on: | AU | 13.10.2011 | (Supplementary) European search report - dispatched on: | EP | 27.08.2013 | Classification | IPC: | C07D235/18, A61P39/00, A61K31/4184, A61P43/00 | [2013/07] | CPC: |
C07D401/14 (EP,US);
C07D405/14 (EP,KR,US);
A61K31/496 (KR);
A61P39/00 (EP);
A61P43/00 (EP);
C07D235/18 (EP,KR,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/07] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | RADIOPROTEKTORVERBINDUNGEN UND -VERFAHREN | [2013/07] | English: | RADIOPROTECTOR COMPOUNDS AND METHODS | [2013/07] | French: | COMPOSÉS RADIOPROTECTEURS ET PROCÉDÉS CORRESPONDANTS | [2013/07] | Entry into regional phase | 05.11.2012 | National basic fee paid | 05.11.2012 | Search fee paid | 05.11.2012 | Designation fee(s) paid | 05.11.2012 | Examination fee paid | Examination procedure | 05.11.2012 | Examination requested [2013/07] | 31.03.2014 | Amendment by applicant (claims and/or description) | 19.02.2015 | Despatch of a communication from the examining division (Time limit: M06) | 30.07.2015 | Reply to a communication from the examining division | 20.11.2015 | Despatch of a communication from the examining division (Time limit: M06) | 06.05.2016 | Reply to a communication from the examining division | 04.01.2017 | Communication of intention to grant the patent | 04.05.2017 | Fee for grant paid | 04.05.2017 | Fee for publishing/printing paid | 04.05.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 19.02.2015 | Opposition(s) | 15.03.2018 | No opposition filed within time limit [2018/21] | Fees paid | Renewal fee | 12.06.2013 | Renewal fee patent year 03 | 25.03.2014 | Renewal fee patent year 04 | 10.04.2015 | Renewal fee patent year 05 | 11.04.2016 | Renewal fee patent year 06 | 10.04.2017 | Renewal fee patent year 07 | Penalty fee | Additional fee for renewal fee | 30.04.2013 | 03   M06   Fee paid on   12.06.2013 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 06.04.2011 | AL | 14.06.2017 | AT | 14.06.2017 | CY | 14.06.2017 | CZ | 14.06.2017 | DK | 14.06.2017 | EE | 14.06.2017 | ES | 14.06.2017 | FI | 14.06.2017 | HR | 14.06.2017 | IT | 14.06.2017 | LT | 14.06.2017 | LV | 14.06.2017 | MC | 14.06.2017 | MK | 14.06.2017 | NL | 14.06.2017 | PL | 14.06.2017 | PT | 14.06.2017 | RO | 14.06.2017 | RS | 14.06.2017 | SE | 14.06.2017 | SI | 14.06.2017 | SK | 14.06.2017 | SM | 14.06.2017 | TR | 14.06.2017 | BG | 14.09.2017 | NO | 14.09.2017 | GR | 15.09.2017 | IS | 14.10.2017 | [2020/33] |
Former [2020/31] | HU | 06.04.2011 | |
AT | 14.06.2017 | ||
CY | 14.06.2017 | ||
CZ | 14.06.2017 | ||
DK | 14.06.2017 | ||
EE | 14.06.2017 | ||
ES | 14.06.2017 | ||
FI | 14.06.2017 | ||
HR | 14.06.2017 | ||
IT | 14.06.2017 | ||
LT | 14.06.2017 | ||
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MK | 14.06.2017 | ||
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PT | 14.06.2017 | ||
RO | 14.06.2017 | ||
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SM | 14.06.2017 | ||
TR | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
IS | 14.10.2017 | ||
Former [2020/27] | HU | 06.04.2011 | |
AT | 14.06.2017 | ||
CZ | 14.06.2017 | ||
DK | 14.06.2017 | ||
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MC | 14.06.2017 | ||
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PT | 14.06.2017 | ||
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RS | 14.06.2017 | ||
SE | 14.06.2017 | ||
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SM | 14.06.2017 | ||
TR | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
IS | 14.10.2017 | ||
Former [2020/15] | AT | 14.06.2017 | |
CZ | 14.06.2017 | ||
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EE | 14.06.2017 | ||
ES | 14.06.2017 | ||
FI | 14.06.2017 | ||
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MC | 14.06.2017 | ||
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SM | 14.06.2017 | ||
TR | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
IS | 14.10.2017 | ||
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CZ | 14.06.2017 | ||
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EE | 14.06.2017 | ||
ES | 14.06.2017 | ||
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SM | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
IS | 14.10.2017 | ||
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CZ | 14.06.2017 | ||
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SM | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
IS | 14.10.2017 | ||
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EE | 14.06.2017 | ||
ES | 14.06.2017 | ||
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SM | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
IS | 14.10.2017 | ||
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CZ | 14.06.2017 | ||
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ES | 14.06.2017 | ||
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SM | 14.06.2017 | ||
BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
GR | 15.09.2017 | ||
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BG | 14.09.2017 | ||
NO | 14.09.2017 | ||
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Former [2017/49] | ES | 14.06.2017 | |
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NO | 14.09.2017 | ||
GR | 15.09.2017 | Documents cited: | Search | [XA]WO2007045096 (UNIV SASKATCHEWAN [CA], et al) [X] 1,5,12,16 * 1-methyl-5-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-1H-Pyrrol-3-amine with Registry Number RN 934993-01-8 1-methyl-4-[[(1-methyl-1H-imidazol-2-yl)carbonyl]amino]-N-[1-methyl-5-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-1H-pyrrol-3-yl]-1H-Imidazole-2-carboxamide with Registry number 934992-57-1 1-methyl-N-[1-methyl-5-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-1H-pyrrol-3-yl]-1H-Imidazole-2-carboxamide with Registry number 934992-56-0 * * figure 4 * * the whole document * [A] 2-4,6-11,13-15; | [XI] - SINGH M P ET AL, "synthetic utility of catalytic Fe(III)/Fe(II) redox cycling towards fused heterocycles : A FACILE ACCESS TO SUBSTITUTED BENZIMIDAZOLE, BISBENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, (20000101), no. 10, doi:10.1055/S-2000-7111, ISSN 0039-7881, pages 1380 - 1390, XP002340033 [X] 1,5,12 * compounds 12, 14, 15 * * the whole document * [I] 2-4,6-11,13-16 DOI: http://dx.doi.org/10.1055/s-2000-7111 | [A] - KELLY D P ET AL, "DNA BINDING COMPOUNDS. VI SYNTHESIS AND CHARACTERIZATION OF 2,5'-DISUBSTITUTED BIBENZIMIDAZOLES RELATED TO THE DNA MINOR GROOVEBINDER HOECHST 33258", AUSTRALIAN JOURNAL OF CHEMISTRY, CSIRO - COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION, AUSTRALIA, (19940101), vol. 47, no. 9, ISSN 0004-9425, pages 1751 - 1769, XP000826532 [A] 1-16 * the whole document * | International search | [A]WO9704776 (PETER MACCALLUM CANCER INST [AU], et al); | [A]WO2004063170 (UNIV DELHI [IN], et al); | [A]WO2008074091 (PETER MACCALLUM CANCER INST [AU], et al); | [A] - TAWAR, U. ET AL., "Influence of Phenyl Ring Disubstitution on Bisbenzimidazole and Terbenzimidazole Cytotoxicity: Synthesis and Biological Evaluation as Radioprotectors", JOURNAL OF MEDICINAL CHEMISTRY, (2003), vol. 46, no. 18, pages 3785 - 3792, XP002288100 DOI: http://dx.doi.org/10.1021/jm030114w | by applicant | WO9704776 | WO0220500 | WO2005070906 | WO2008074091 | - METZ ET AL., CLIN CANCER RES., (2004), vol. 10, pages 6411 - 17 | - BURDELYA ET AL., SCIENCE, (2008), vol. 320, pages 226 - 30 | - Remington's Pharmaceutical Sciences, MACK PUBLISHING CO | - KELLY ET AL., AUST. J. CHEM., (1994), vol. 47, pages 247 - 262 | - WHITTAKER, J. CHEM. SOC., (1951), page 1565 | - J. MED. CHEM., (2007), vol. 50, no. 15, pages 3561 - 3572 | - WASELENKO, J. K.; MACVITTIE, T. J.; BLAKELY, W. F.; PESIK, N.; WILEY, A. L.; DICKERSON, W. E.; TSU, H.; CONFER, D. L.; COLEMAN, C., "Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group", ANN INTERN MED, (2004), vol. 140, doi:doi:10.7326/0003-4819-140-12-200406150-00015, pages 1037 - 1051, XP002683131 DOI: http://dx.doi.org/10.7326/0003-4819-140-12-200406150-00015 | - SMITH, P.J.; ANDERSON, C.O., INT. J. RADIAT. BIOL., (1984), vol. 46, page 331 | - YOUNG, S.D.; HILL, R.P., BRIT. J. CANCER, (1989), vol. 60, pages 715 - 721 | - MARTIN RF; BROADHURST S; REUM ME; SQUIRE CJ; CLARK GR; LOBACHEVSKY PN; WHITE JM; CLARK C; SY D; SPOTHEIM-MAURIZOT M, "In vitro studies with methylproamine: a potent new radioprotector", CANCER RES., (2004), vol. 64, no. 3, doi:doi:10.1158/0008-5472.CAN-03-2423, pages 1067 - 70, XP002517081 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-03-2423 | - KELLY, D. P.; BATEMAN, S. A.; HOOK, R. J.; MARTIN, R. F.; REUM, M. E.; ROSE, M.; WHITTAKER, A. R. D, AUST. J. CHEM., (1994), vol. 47, pages 1751 - 1769 | - SMITH PP; BRYANT EM; KAUR P; MCDOUGALL JK, "Cytogenetic analysis of eight human papillomavirus immortalized human keratinocyte cell lines", INT. J. CANCER, (19891215), vol. 44, no. 6, pages 1124 - 31 | - KELLY, D. P.; BATEMAN, S. A.; MARTIN, R. F.; ROSE, M.; WHITTAKER, A. R. D., AUST. J. CHEM., (1994), vol. 47, pages 247 - 262 | - KUZNETSOV ET AL., ZH. ORG. KHIM., (1986), vol. 22, pages 455 - 6 | - RENHOWE ET AL., J. MED. CHEM., (2009), vol. 52, pages 278 - 292 | - OKUMURA ET AL., BULL. CHEM. SOC. JAP., (1960), vol. 33, pages 1471 - 1472 | - RAM ET AL., J. HETEROCYCLIC CHEM., (1989), vol. 26, pages 1053 - 1059 |