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Extract from the Register of European Patents

EP About this file: EP2585171

EP2585171 - FORMATION OF NEUROMUSCULAR JUNCTIONS IN A DEFINED SYSTEM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.11.2019
Database last updated on 12.11.2024
FormerThe patent has been granted
Status updated on  23.11.2018
FormerGrant of patent is intended
Status updated on  18.07.2018
FormerExamination is in progress
Status updated on  03.02.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
University Of Central Florida Research Foundation, Inc.
12201 Research Parkway, Suite 501
Orlando FL 32826-3246 / US
[2018/52]
Former [2013/18]For all designated states
University Of Central Florida Research Foundation, Inc.
12201 Research Parkway, Suite 501
Orlando FL 32826-3246 / US
Inventor(s)01 / HICKMAN, James
4004 Lake Mira Dr.
Orlando, FL 32817 / US
02 / GUO, Xiufang
530 Veracliff Ct.
Oviedo, FL 32765 / US
 [2013/18]
Representative(s)Wibbelmann, Jobst, et al
Wuesthoff & Wuesthoff
Patentanwälte und Rechtsanwalt PartG mbB
Schweigerstrasse 2
81541 München / DE
[N/P]
Former [2018/52]Wibbelmann, Jobst, et al
Wuesthoff & Wuesthoff
Patentanwälte PartG mbB
Schweigerstrasse 2
81541 München / DE
Former [2013/18]Gardner, Rebecca Katherine
Dehns St Bride's House 10 Salisbury Square
GB-London EC4Y 8JD / GB
Application number, filing date11772857.606.05.2011
[2018/52]
WO2011US35585
Priority number, dateUS20100332003P06.05.2010         Original published format: US 332003 P
[2013/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011133985
Date:27.10.2011
Language:EN
[2011/43]
Type: A1 Application with search report 
No.:EP2585171
Date:01.05.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 27.10.2011 takes the place of the publication of the European patent application.
[2013/18]
Type: B1 Patent specification 
No.:EP2585171
Date:26.12.2018
Language:EN
[2018/52]
Search report(s)International search report - published on:US27.10.2011
(Supplementary) European search report - dispatched on:EP18.10.2013
ClassificationIPC:A61P21/00, C12N5/079, C12N5/077
[2013/18]
CPC:
C12N5/0697 (EP,US); G01N33/5058 (US); A61P21/00 (EP);
G01N33/48728 (US); G01N33/6872 (US); G01N33/6887 (US);
C12N2500/90 (EP,US); C12N2501/01 (EP,US); C12N2501/105 (EP,US);
C12N2501/13 (EP,US); C12N2501/385 (EP,US); C12N2501/41 (EP,US);
C12N2501/58 (EP,US); C12N2502/081 (EP,US); C12N2502/1335 (EP,US);
C12N2533/20 (EP,US); C12N2535/10 (EP,US); G01N2500/10 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/18]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:FORMIERUNG NEUROMUSKULÄRER VERBINDUNGEN IN EINEM DEFINIERTEN SYSTEM[2013/18]
English:FORMATION OF NEUROMUSCULAR JUNCTIONS IN A DEFINED SYSTEM[2013/18]
French:FORMATION DE JONCTIONS NEUROMUSCULAIRES DANS UN SYSTÈME DÉFINI[2013/18]
Entry into regional phase19.11.2012National basic fee paid 
19.11.2012Search fee paid 
19.11.2012Designation fee(s) paid 
19.11.2012Examination fee paid 
Examination procedure19.11.2012Examination requested  [2013/18]
16.05.2014Amendment by applicant (claims and/or description)
23.02.2016Despatch of a communication from the examining division (Time limit: M04)
10.05.2016Reply to a communication from the examining division
24.01.2017Despatch of a communication from the examining division (Time limit: M04)
23.05.2017Reply to a communication from the examining division
16.01.2018Despatch of a communication from the examining division (Time limit: M04)
05.02.2018Reply to a communication from the examining division
19.07.2018Communication of intention to grant the patent
19.11.2018Fee for grant paid
19.11.2018Fee for publishing/printing paid
19.11.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.02.2016
Opposition(s)27.09.2019No opposition filed within time limit [2019/49]
Fees paidRenewal fee
05.04.2013Renewal fee patent year 03
27.06.2014Renewal fee patent year 04
20.05.2015Renewal fee patent year 05
18.05.2016Renewal fee patent year 06
23.05.2017Renewal fee patent year 07
22.05.2018Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
31.05.201404   M06   Fee paid on   27.06.2014
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.05.2011
AL26.12.2018
AT26.12.2018
CY26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
MK26.12.2018
MT26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE06.05.2019
LU06.05.2019
[2022/31]
Former [2021/34]HU06.05.2011
AL26.12.2018
AT26.12.2018
CY26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
MT26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE06.05.2019
LU06.05.2019
Former [2021/32]HU06.05.2011
AL26.12.2018
AT26.12.2018
CY26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
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FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE06.05.2019
LU06.05.2019
Former [2021/26]AL26.12.2018
AT26.12.2018
CY26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE06.05.2019
LU06.05.2019
Former [2020/21]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE06.05.2019
LU06.05.2019
Former [2020/17]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
LU06.05.2019
Former [2020/13]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
LU06.05.2019
Former [2020/07]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/48]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/46]AL26.12.2018
AT26.12.2018
CZ26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/39]AL26.12.2018
CZ26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/37]AL26.12.2018
CZ26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/35]AL26.12.2018
CZ26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
PL26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/34]AL26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/33]AL26.12.2018
FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/26]AL26.12.2018
FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/25]FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/24]FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/23]FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
BG26.03.2019
NO26.03.2019
Former [2019/22]FI26.12.2018
LT26.12.2018
BG26.03.2019
NO26.03.2019
Former [2019/21]FI26.12.2018
LT26.12.2018
NO26.03.2019
Former [2019/20]LT26.12.2018
NO26.03.2019
Documents cited:Search[XY]  - Rumsey J.W., "TISSUE ENGINEERED MYELINATION AND THE STRETCH REFLEX ARC SENSORYCIRCUIT: DEFINED MEDIUM FORMULATION, INTERFACE DESIGN ANDMICROFABRICATION", Doctoral Dissertation University of central Florida, Orlando, FL, USA, Orlando, FL, USA, (2009), URL: http://etd.fcla.edu/CF/CFE0002904/Rumsey_John_W_200912_PhD.pdf, (20131001), XP055081906 [X] 1-8,10-15 * Chapter 8;; tables 8-2,9-1 * [Y] 9
 [XY]  - GUO XIUFANG ET AL, "Neuromuscular Junction Formation Between Human Stem-Cell-Derived Motoneurons and Rat Skeletal Muscle in a Defined System", TISSUE ENGINEERING PART C-METHODS, vol. 16, no. 6, (20100325), pages 1347 - 1355, URL: http://online.liebertpub.com/doi/abs/10.1089/ten.tec.2010.0040, (20130930), XP002713997 [X] 1-8,10-15 * the whole document * [Y] 9

DOI:   http://dx.doi.org/10.1089/ten.tec.2010.0040
 [X]  - RUMSEY J W ET AL, "Node of Ranvier formation on motoneurons in vitro", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 30, no. 21, doi:10.1016/J.BIOMATERIALS.2009.03.023, ISSN 0142-9612, (20090701), pages 3567 - 3572, (20090410), XP026128022 [X] 1-4,6-8,10-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2009.03.023
 [X]  - DAS M ET AL, "A defined long-term in vitro tissue engineered model of neuromuscular junctions", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 18, ISSN 0142-9612, (20100325), pages 4880 - 4888, (20100416), XP027013407 [X] 1-8,10-15 * the whole document *
 [A]  - DAS MAINAK ET AL, "Adult rat spinal cord culture on an organosilane surface in a novel serum-free medium", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY ANIMAL, (200511), vol. 41, no. 10, ISSN 1071-2690, pages 343 - 348, XP002713998 [A] 1-15
 [T]  - XIUFANG GUO ET AL, "Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 32, no. 36, doi:10.1016/J.BIOMATERIALS.2011.09.014, ISSN 0142-9612, (20110906), pages 9602 - 9611, (20110908), XP028316413

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2011.09.014
 [A]  - M. A. Ruegg ET AL, "Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction", Trends Neurosci., (19980101), pages 22 - 27, URL: http://ac.els-cdn.com/S0166223697011545/1-s2.0-S0166223697011545-main.pdf?_tid=5ad0fb32-2a79-11e3-a2b8-00000aab0f01&acdnat=1380618825_874b4369939a503e54fb328231c75271, (20131001), XP055081862 [A] 1-15

DOI:   http://dx.doi.org/10.1016/S0166-2236(97)01154-5
 [A]  - CAMPAGNA JASON A ET AL, "Evidence that agrin directly influences presynaptic differentiation at neuromuscular junctions in vitro", EUROPEAN JOURNAL OF NEUROSCIENCE, (199711), vol. 9, no. 11, ISSN 0953-816X, pages 2269 - 2283, XP002713999 [A] 1-15

DOI:   http://dx.doi.org/10.1111/j.1460-9568.1997.tb01645.x
International search[Y]US2008227137  (ZHANG SU-CHUN [US], et al);
 [Y]  - DAS ET AL., "Embryonic motoneuron-skeletal muscle co-culture in a defined system", NEUROSCIENCE, (200705), vol. 146, no. 2, pages 481 - 488, XP026865609
 [Y]  - YAN ET AL., "Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord. art. e39", PLOS MED., (200702), vol. 4, no. 2, pages 0318 - 0332
 [Y]  - BANDI ET AL., "Neural agrin controls maturation of the excitation-contraction coupling mechanism in human myotubes developing in vitro", AM J PHYSIOL CELL PHYSIOL, (200801), vol. 294, no. 1, pages C66 - C73
 [Y]  - BREWER ET AL., "NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multi electrode arrays", J NEUROSCI METHODS, (20080530), vol. 170, no. 2, pages 181 - 187, XP022612017

DOI:   http://dx.doi.org/10.1016/j.jneumeth.2008.01.009
by applicant   - RUMSEY J. W., "Tissue engineered myelination and the stretch reflex ARC sensory circuit: Defined medium formulation, interface design and microfabrication", DOCTORAL DISSERTATION
    - GUO XIUFANG ET AL., "Neuromuscular junction formation between human stem-cell-derived motoneurons and rat skeletal muscle in a defined system", TISSUE ENGINEERING PART C-METHODS, (20100325), vol. 16, no. 6, pages 1347 - 1355
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.