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Extract from the Register of European Patents

EP About this file: EP2565184

EP2565184 - THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.11.2016
Database last updated on 12.11.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Toray Industries, Inc.
1-1, Nihonbashi-Muromachi 2-chome Chuo-ku
Tokyo 103-8666 / JP
[2013/10]
Inventor(s)01 / NAKAO, Kaoru
c/o Basic Research Center
Toray Industries Inc.
10-1 Tebiro 6-chome
Kamakura-shi Kanagawa 248-8555 / JP
02 / MIYAMOTO, Yohei
c/o Basic Research Center
Toray Industries Inc.
10-1 Tebiro 6-chome
Kamakura-shi Kanagawa 248-8555 / JP
03 / YAMADA, Naohiro
c/o Tokyo Head Office
Toray Industries Inc.
Toray Bldg.
8-1 Mihama 1-chome
Urayasu-shi Chiba 279-8555 / JP
 [2013/10]
Representative(s)Kador & Partner Part mbB
Corneliusstraße 15
80469 München / DE
[N/P]
Former [2016/01]Kador & Partner
Corneliusstraße 15
80469 München / DE
Former [2013/10]Kador & Partner
Corneliusstrasse 15
80469 München / DE
Application number, filing date11775099.228.04.2011
[2016/01]
WO2011JP60355
Priority number, dateJP2010010324628.04.2010         Original published format: JP 2010103246
[2013/10]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011136318
Date:03.11.2011
Language:JA
[2011/44]
Type: A1 Application with search report 
No.:EP2565184
Date:06.03.2013
Language:EN
[2013/10]
Type: B1 Patent specification 
No.:EP2565184
Date:30.12.2015
Language:EN
[2015/53]
Type: B8 Corrected title page of specification 
No.:EP2565184
Date:09.03.2016
[2016/10]
Search report(s)International search report - published on:JP03.11.2011
(Supplementary) European search report - dispatched on:EP08.08.2013
ClassificationIPC:A61K31/415, A61K31/421, A61K31/426, A61P25/28
[2015/23]
CPC:
C07D231/12 (EP,KR,US); A61K31/415 (EP,KR,US); A61K31/015 (EP,KR,US);
A61K31/4155 (EP,KR,US); A61K31/421 (EP,KR,US); A61K31/426 (EP,KR,US);
A61K31/427 (EP,KR,US); A61K31/4439 (EP,KR,US); A61P25/28 (EP);
C07D263/32 (EP,KR,US); C07D277/24 (EP,KR,US); C07D401/04 (EP,KR,US) (-)
Former IPC [2013/10]C07D231/12, A61K31/415, A61K31/421, A61K31/426, A61P25/28, C07D263/32, C07D277/24, C07D401/04
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/10]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MITTEL ZUR BEHANDLUNG ODER PRÄVENTION VON MORBUS ALZHEIMER[2016/07]
English:THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE[2013/10]
French:AGENT THÉRAPEUTIQUE ET AGENT PRÉVENTIV CONTRE LA MALADIE D'ALZHEIMER[2016/07]
Former [2013/10]THERAPEUTIKUM UND PROPHYLAKTIKUM FÜR MORBUS ALZHEIMER
Former [2013/10]AGENT THÉRAPEUTIQUE ET AGENT CONSERVATEUR CONTRE LA MALADIE D'ALZHEIMER
Entry into regional phase23.10.2012Translation filed 
23.10.2012National basic fee paid 
23.10.2012Search fee paid 
23.10.2012Designation fee(s) paid 
23.10.2012Examination fee paid 
Examination procedure23.10.2012Examination requested  [2013/10]
05.11.2013Amendment by applicant (claims and/or description)
10.07.2014Despatch of a communication from the examining division (Time limit: M04)
05.11.2014Reply to a communication from the examining division
05.06.2015Communication of intention to grant the patent
09.09.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
09.09.2015Fee for grant paid
09.09.2015Fee for publishing/printing paid
08.10.2015Communication of intention to grant the patent
29.10.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.07.2014
Opposition(s)03.10.2016No opposition filed within time limit [2016/49]
Fees paidRenewal fee
29.04.2013Renewal fee patent year 03
27.03.2014Renewal fee patent year 04
28.04.2015Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.04.2011
AL30.12.2015
AT30.12.2015
BG30.12.2015
CY30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
MC30.12.2015
MK30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
TR30.12.2015
NO30.03.2016
GR31.03.2016
IE28.04.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
MT30.04.2016
PT02.05.2016
[2018/46]
Former [2018/38]HU28.04.2011
AT30.12.2015
BG30.12.2015
CY30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
MC30.12.2015
MK30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
TR30.12.2015
NO30.03.2016
GR31.03.2016
IE28.04.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
MT30.04.2016
PT02.05.2016
Former [2018/31]HU28.04.2011
AT30.12.2015
CY30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
MC30.12.2015
MK30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
TR30.12.2015
NO30.03.2016
GR31.03.2016
IE28.04.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
MT30.04.2016
PT02.05.2016
Former [2018/29]HU28.04.2011
AT30.12.2015
CY30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
MC30.12.2015
MK30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
TR30.12.2015
NO30.03.2016
GR31.03.2016
IE28.04.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
PT02.05.2016
Former [2018/28]HU28.04.2011
AT30.12.2015
CY30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
MC30.12.2015
MK30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
IE28.04.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
PT02.05.2016
Former [2017/38]AT30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
IE28.04.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
PT02.05.2016
Former [2017/16]AT30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SI30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
PT02.05.2016
Former [2017/07]AT30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
LU28.04.2016
CH30.04.2016
IS30.04.2016
LI30.04.2016
PT02.05.2016
Former [2017/04]AT30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
LU28.04.2016
IS30.04.2016
PT02.05.2016
Former [2016/46]AT30.12.2015
CZ30.12.2015
DK30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
IS30.04.2016
PT02.05.2016
Former [2016/38]AT30.12.2015
CZ30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SK30.12.2015
SM30.12.2015
NO30.03.2016
GR31.03.2016
IS30.04.2016
PT02.05.2016
Former [2016/36]AT30.12.2015
CZ30.12.2015
EE30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RO30.12.2015
RS30.12.2015
SE30.12.2015
SK30.12.2015
NO30.03.2016
GR31.03.2016
Former [2016/34]CZ30.12.2015
FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RS30.12.2015
SE30.12.2015
NO30.03.2016
GR31.03.2016
Former [2016/30]FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
NL30.12.2015
RS30.12.2015
SE30.12.2015
NO30.03.2016
GR31.03.2016
Former [2016/25]FI30.12.2015
HR30.12.2015
LT30.12.2015
LV30.12.2015
RS30.12.2015
SE30.12.2015
NO30.03.2016
GR31.03.2016
Former [2016/24]FI30.12.2015
HR30.12.2015
LT30.12.2015
RS30.12.2015
SE30.12.2015
NO30.03.2016
GR31.03.2016
Former [2016/23]HR30.12.2015
LT30.12.2015
RS30.12.2015
SE30.12.2015
NO30.03.2016
Former [2016/21]LT30.12.2015
NO30.03.2016
Former [2016/20]LT30.12.2015
Documents cited:Search[YP]WO2010050577  (TORAY INDUSTRIES [JP], et al) [YP] 1-5 * the whole document *;
 EP2341047  [ ] (TORAY INDUSTRIES [JP]) [ ] * See compounds of the claims and of the examples, and the pharmaceutical compositions comprising them *;
 [YD]WO0066562  (REDDY RESEARCH FOUNDATION [IN], et al) [YD] 1-5 * See cyclohexan-pyrazole derivative of example 70 (page 85) as agent for treating Alzheimer's disease (see claims 18, 22, 24, 25, 29) *;
 [YD]WO02051442  (TAKEDA CHEMICAL INDUSTRIES LTD [JP], et al) [YD] 1-5 * See cyclohexan-thiazole derivatives of examples 13-30 (page 140) as agent for treating Alzheimer's disease (see claims 7, 9, 11) *;
 [Y]WO0101986  (LIPTON STUART A [US]) [Y] 1-5 * See compounds of formula 1 in claim for treatment of Alzheimer (see claim 19) an dsee specific compounds haveing RN: 152121-30 7 and 152121-47-6 *;
 [Y]WO2004014367  (PHARMACIA CORP [US], et al) [Y] 1-5 * See compounds from B79 to B86 and their use for the treatment of Alzheimer (pages 62-65 and claims) *
 [Y]  - RUBÉN MARTÍN ET AL, "Sequential Copper-Catalyzed Vinylation/Cyclization: An Efficient Synthesis of Functionalized Oxazoles", ORGANIC LETTERS, (20071201), vol. 9, no. 26, doi:10.1021/ol7024718, ISSN 1523-7060, pages 5521 - 5524, XP055073887 [Y] 1-5 * See compound of formula 5 in table 1 *

DOI:   http://dx.doi.org/10.1021/ol7024718
International search[A]WO0066562  (REDDY RESEARCH FOUNDATION [IN], et al);
 [A]WO02051442  (TAKEDA CHEMICAL INDUSTRIES LTD [JP], et al);
 [A]WO2008105383  (TORAY INDUSTRIES [JP], et al)
ExaminationWO2004021988
by applicantWO0066562
 WO0007996
 WO2008105383
 WO2007111323
    - SCHATZBERG ET AL., Seishin Shinkei Yakurigagu Daijiten, NISHIMURA SHOTEN, (2009), page 785
    - SCHATZBERG ET AL., Seishin Shinkei Yakurigagu Daijiten, NISHIMURA SHOTEN, (2009), page 669
    - MILLER, GERIATR NURS, (2004), vol. 25, page 56
    - CLAYTON ET AL., ANESTHESIOLOGY, (2007), vol. 106, page 1019
    - CHEN ET AL., NEUROPHARMACOLOGY, (2009), vol. 57, page 121
    - SINIS ET AL., CLIN J PAIN, (2007), vol. 23, page 273
    - PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, WILEY-INTERSCIENCE
    - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (1989), vol. 39, pages 393 - 395
    - TETRAHEDRON, (1989), vol. 45, pages 5703 - 5742
    - TETRAHEDRON LETTERS, (2006), vol. 47, pages 1729 - 1731
    - lyakuhin no Kaihatsu, HIROKAWA SHOTEN, (1990), vol. 7, pages 163 - 198
    - PROG. MED., (1985), vol. 5, pages 2157 - 2161
    - SHINODA, BEHAV. BRAIN RES., (1999), vol. 99, page 17
    - OGURA, Japanese Pharmacology & Therapeutics, LIFE SCIENCE PUBLISHING, (1998), vol. 26, page S-1313
    - BLENNOW, LANCET, (2006), vol. 368, page 387
    - BULLOCK, INT. J. CLIN. PRAC., (2005), vol. 59, page 817
    - MALMBERG, PAIN, (1998), vol. 76, pages 215 - 222
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.