| Cited in | International search | Type: | Patent literature | Publication No.: | WO2006030220
[XDPI] (DOMANTIS LTD et al.) [XDP] 35 * Examples 10, 17-19, especially page 384, lines 29-31;page 385, lines 3-7 *[I] 1-34 | Type: | Patent literature | Publication No.: | WO2008142164
[XI] (ABLYNX NV et al.) [I] 1-34 | Type: | Patent literature | Publication No.: | WO2010125187
[XDI] (ABLYNX NV et al.) [XD] 35 * Example 11, especially page 248, lines 5-9 *[I] 1-34 | Type: | Non-patent literature | Publication information: | [XDPI] RAHBARIZADEH F ET AL: "Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 43, no. 5, 1 February 2006 (2006-02-01), pages 426 - 435, XP025037145, ISSN: 0161-5890, [retrieved on 20060201], DOI: 10.1016/J.MOLIMM.2005.03.003 [I] 1-34 | DOI: | http://dx.doi.org/10.1016/j.molimm.2005.03.003 | Type: | Non-patent literature | Publication information: | [XDI] RAHBARIZADEH F ET AL: "High expression and purification of the recombinant camelid anti-MUC1 single domain antibodies in Escherichia coli", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 44, no. 1, 1 November 2005 (2005-11-01), pages 32 - 38, XP027390195, ISSN: 1046-5928, [retrieved on 20050930], DOI: 10.1016/J.PEP.2005.04.008 [I] 1-34 | DOI: | http://dx.doi.org/10.1016/j.pep.2005.04.008 | Type: | Non-patent literature | Publication information: | [XI] ANONYMOUS: "EasySelect (TM) Pichia Expression Kit", 18 June 2010 (2010-06-18), pages I-VIII - 1-87, XP055015858, Retrieved from the Internet | Type: | Non-patent literature | Publication information: | [XDPI] ANONYMOUS: "Pichia Fermentation Process Guidelines", 30 May 2002 (2002-05-30), pages 1 - 11, XP055015860, Retrieved from the Internet | Cited in | Opposition | Type: | Patent literature | Publication No.: | WO2006030220
| Type: | Patent literature | Publication No.: | WO2008142164
| Type: | Patent literature | Publication No.: | WO2010125187
| Type: | Patent literature | Publication No.: | WO2010056550
| Type: | Patent literature | Publication No.: | US2008274101
| Type: | Patent literature | Publication No.: | US7459425
| Type: | Patent literature | Publication No.: | EP2011068982
| Type: | Patent literature | Publication No.: | US201313824481
| Type: | Non-patent literature | Publication information: | RAHBARIZADEH ET AL.: "Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris", MOLECULAR IMMUNOLOGY, vol. 43, no. 5, 1 February 2006 (2006-02-01), pages 426 - 435, XP025037145 | DOI: | http://dx.doi.org/10.1016/j.molimm.2005.03.003 | Type: | Non-patent literature | Publication information: | RAHBARIZADEH ET AL.: "High expression and purification of the recombinant camelid anti-MUC1 single domain antibodies in Escherichia coli", PROTEIN EXPRESSION AND PURIFICATION, 1 November 2005 (2005-11-01), pages 32 - 38, XP027390195 | DOI: | http://dx.doi.org/10.1016/j.pep.2005.04.008 | Type: | Non-patent literature | Publication information: | ANONYMOUS: "EasySelect (TM) Pichia Expression Kit", INVITROGEN - LIFE TECHNOLOGIES, 2010, pages I-VIII,1 - 87, XP055015858, Retrieved from the Internet | Type: | Non-patent literature | Publication information: | ANONYMOUS: "Pichia Fermentation Process Guidelines", INVITROGEN - LIFE TECHNOLOGIES, 2002, pages 1 - 11, XP055015860, Retrieved from the Internet | Type: | Non-patent literature | Publication information: | LIN ET AL.: "Ion chromatographic quantification of cyanate in urea solutions: estimation of the efficiency of cyanate scavengers for use in recombinant protein manufacturing", JOURNAL OF CHROMATOGRAPHY, vol. 803, no. 2, 25 April 2004 (2004-04-25), pages 353 - 362, XP004500042 | DOI: | http://dx.doi.org/10.1016/j.jchromb.2004.01.017 | Type: | Non-patent literature | Publication information: | STARK G. R. ET AL.: "Reactions of the cyanate present in aqueous urea with amino acids and proteins", J. BIOL. CHEM., vol. 235, no. 11, November 1960 (1960-11-01), pages 3177 - 3181, XP055519480 | Type: | Non-patent literature | Publication information: | STARK ET AL.: "The use of cyanate for the determination of NH2-terminal residues in proteins", J. BIOL. CHEM., vol. 238, no. 1, 1963, pages 214 - 226, XP055519482 | Type: | Non-patent literature | Publication information: | GNTER JAGSCHIES ET AL.: "Handbook of Process Chromatography: Development, Manufacturing, Validation and Economics", 2008, ELSEVIER, article "Chapter 5", pages: 127 - 135, XP055519484 | Type: | Non-patent literature | Publication information: | VINCENT LEE: "Peptide and Protein Drug Discovery", 1990, CRC PRESS, article "Carbamylation", pages: 189, XP055519505 | Type: | Non-patent literature | Publication information: | CREGG ET AL.: "Methods in Molecular Biology. Pichia protocols, 2nd ed.", 2007, HUMANA PRESS, article "chapter 6", pages: 77-79,94 - 95, XP055519500 | Type: | Non-patent literature | Publication information: | HARMSEN ET AL.: "Properties, production, and applications of camelid single-domain antibody fragments", APPL MICROBIOL BIOTECHNOL, vol. 77, no. 1, November 2007 (2007-11-01), pages 13 - 22, XP055519503 | DOI: | http://dx.doi.org/10.1007/s00253-007-1142-2 | Type: | Non-patent literature | Publication information: | "The Gold Sheet", PHARMACEUTICAL & BIOTECHNOLOGY QUALITY CONTROL, vol. 38, no. 9, September 2004 (2004-09-01), pages 1 - 32, XP055731017 | Type: | Non-patent literature | Publication information: | BOERNER, KATHLEEN CLOUSE: "Defining Your Product Profile and Maintaining Control Over It Part 3", BIOPROCESS TECHNICAL, October 2005 (2005-10-01), pages 51 - 56, XP055731022 | Type: | Non-patent literature | Publication information: | PAUL RAINVILLE, KEFEI ZHENG, CLAUDE MALLET, REB RUSSELL II, DETECTING CARBAMYLATION OF INTACT PROTEINS AND PEPTIDES BY LC/MS(/MS, 2002, pages 1, XP055731108 | Type: | Non-patent literature | Publication information: | AHN ET AL.: "BiopharmaLynx: A new bioinformatics tool for automated LC/MS peptide mapping assignment", WATERS - THE SCIENCE OF WHAT IS POSSIBLE, September 2008 (2008-09-01), pages 1 - 6, XP055731028 | Type: | Non-patent literature | Publication information: | MIDDELHOVEN: "The pathway of arginine breakdown in Saccharomyces cerevisiae", BIOCHIM. BIOPHYS. ACTA, vol. 93, 1964, pages 650 - 652, XP025792842, DOI: 10.1016/0304-4165(64)90349-6 | DOI: | http://dx.doi.org/10.1016/0304-4165(64)90349-6 | Type: | Non-patent literature | Publication information: | K KITAMOTO, K ODA, K GOMI, K TAKAHASHI: "Genetic Engineering of a Sake Yeast Producing No Urea by Successive Disruption of Arginase Gene", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 57, 1991, pages 301 - 306, XP055731032 | DOI: | http://dx.doi.org/10.1128/AEM.57.1.301-306.1991 | Type: | Non-patent literature | Publication information: | J. RICHARD DICKINSON, MICHAEL SCHWEIZER: "THE METABOLISM AND MOLECULAR PHYSIOLOGY OF SACCHAROMYCES CEREVISIAE", 2004, CRC PRESS, article J. RICHARD DICKINSON, MICHAEL SCHWEIZER, pages: 1 - 476 | Type: | Non-patent literature | Publication information: | "Biology of Microorganisms on Grapes in Must and in Wine", 2009, SPRINGER, article KNIG HELMUT, UNDEN GOTTFRIED, FRHLICH JRGEN, pages: 1 - 521 | Type: | Non-patent literature | Publication information: | MARC CARNICER, KRISTIN BAUMANN, ISABELLE TPLITZ, FRANCESC SNCHEZ-FERRANDO, DIETHARD MATTANOVICH, PAU FERRER & JOAN ALBIOL: "Macromolecular and Elemental Composition Analysis and Extracellular Metabolite Balances of Pichia pastoris growing at different oxygen levels", MICROBIAL CELL FACTORIES, December 2009 (2009-12-01), pages - 14, XP021067674 | Type: | Non-patent literature | Publication information: | ZOLODZ M D; HERBERG J T; NAREPEKHA H E; RALEIGH E; FARBER M R; DUFIELD R L; BOYLE D M: "Separation by hydrophobic interaction chromatography and structural determination by mass spectrometry of mannosylated glycoforms of a recombinant transferrin-extendin-4 fusion protein from yeast", JOURNAL OF CHROMATOGRAPHY A, October 2009 (2009-10-01), pages 225 - 234, XP026817105 | Type: | Non-patent literature | Publication information: | O. BOU, O. FARNS, A. GONZLEZ, R. FERNNDEZ, J.A. ACOSTA, R. VALDS, L.J. GONZLEZ, Y. GUANCHE, G. IZQUIERDO, M. SUREZ, I. DOM: "Production and biochemical characterization of the recombinant Boophilus microplus Bm95 antigen from Pichia pastoris", EXPERIMENTAL AND APPLIED ACAROLOGY, vol. 32, 2004, pages 119 - 128, XP055731099 | Cited in | by applicant | Type: | Patent literature | Publication No.: | WO9425591
| Type: | Patent literature | Publication No.: | EP0368684
| Type: | Patent literature | Publication No.: | WO2004068820
| Type: | Patent literature | Publication No.: | WO2006030220
| Type: | Patent literature | Publication No.: | WO2006003388
| Type: | Patent literature | Publication No.: | WO2005018629
| Type: | Patent literature | Publication No.: | WO9404678
| Type: | Patent literature | Publication No.: | WO9504079
| Type: | Patent literature | Publication No.: | WO9634103
| Type: | Patent literature | Publication No.: | WO9937681
| Type: | Patent literature | Publication No.: | WO0040968
| Type: | Patent literature | Publication No.: | WO0043507
| Type: | Patent literature | Publication No.: | WO0065057
| Type: | Patent literature | Publication No.: | WO0140310
| Type: | Patent literature | Publication No.: | WO0144301
| Type: | Patent literature | Publication No.: | EP1134231
| Type: | Patent literature | Publication No.: | WO0248193
| Type: | Patent literature | Publication No.: | WO9749805
| Type: | Patent literature | Publication No.: | WO0121817
| Type: | Patent literature | Publication No.: | WO03035694
| Type: | Patent literature | Publication No.: | WO03054016
| Type: | Patent literature | Publication No.: | WO03055527
| Type: | Patent literature | Publication No.: | WO03050531
| Type: | Patent literature | Publication No.: | WO0190190
| Type: | Patent literature | Publication No.: | WO03025020
| Type: | Patent literature | Publication No.: | EP1433793
| Type: | Patent literature | Publication No.: | WO2004041867
| Type: | Patent literature | Publication No.: | WO2004041862
| Type: | Patent literature | Publication No.: | WO2004041865
| Type: | Patent literature | Publication No.: | WO2004041863
| Type: | Patent literature | Publication No.: | WO2004062551
| Type: | Patent literature | Publication No.: | WO2005044858
| Type: | Patent literature | Publication No.: | WO2006040153
| Type: | Patent literature | Publication No.: | WO2006079372
| Type: | Patent literature | Publication No.: | WO2006122786
| Type: | Patent literature | Publication No.: | WO2006122787
| Type: | Patent literature | Publication No.: | WO2006122825
| Type: | Patent literature | Publication No.: | WO2008101985
| Type: | Patent literature | Publication No.: | WO2008142164
| Type: | Patent literature | Publication No.: | WO9923221
| Type: | Patent literature | Publication No.: | WO2009068625
| Type: | Patent literature | Publication No.: | WO2010125187
| Type: | Patent literature | Publication No.: | WO2010115998
| Type: | Patent literature | Publication No.: | EP2011060738
| Type: | Patent literature | Publication No.: | WO2010139808
| Type: | Patent literature | Publication No.: | WO2011073180
| Type: | Non-patent literature | Publication information: | CLELAND ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 10, 1993, pages 307 - 377 | Type: | Non-patent literature | Publication information: | RYABOVA ET AL., NATURE BIOTECHNOLOGY, vol. 15, 1997, pages 79 | Type: | Non-patent literature | Publication information: | HUMPHREYS ET AL., FEES LETTERS, vol. 380, 1996, pages 194 | Type: | Non-patent literature | Publication information: | SHUSTA ET AL., NATURE BIOTECH., vol. 16, 1998, pages 773 | Type: | Non-patent literature | Publication information: | HSU ET AL., PROTEIN EXPR.& PURIF., vol. 7, 1996, pages 281 | Type: | Non-patent literature | Publication information: | MOHAN ET AL., BIOTECHNOL. & BIOENG., vol. 98, 2007, pages 611 | Type: | Non-patent literature | Publication information: | XU ET AL., METABOL. ENGINEER., vol. 7, 2005, pages 269 | Type: | Non-patent literature | Publication information: | MERK ET AL., J. BIOCHEM., vol. 125, 1999, pages 328 | Type: | Non-patent literature | Publication information: | WHITELEY ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 22556 | Type: | Non-patent literature | Publication information: | GASSER ET AL., BIOTECHNOL. BIOENG., vol. 94, 2006, pages 353 | Type: | Non-patent literature | Publication information: | DEMAREST, GLASER, CURR. OPIN. DRUG DISCOV. DEVEL., vol. 11, no. 5, 2008, pages 675 - 87 | Type: | Non-patent literature | Publication information: | HONEGGER, HANDB. EXP. PHARMACOL., vol. 181, 2008, pages 47 - 68 | Type: | Non-patent literature | Publication information: | WANG ET AL., J. PHARM. SCI., vol. 96, no. 1, 2007, pages 1 - 26 | Type: | Non-patent literature | Publication information: | SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", vol. 1-3, 1989, COLD SPRING HARBOR LABORATORY PRESS | Type: | Non-patent literature | Publication information: | "Current protocols in molecular biology", 1987, GREEN PUBLISHING AND WILEY INTERSCIENCE | Type: | Non-patent literature | Publication information: | LEWIN: "Genes II", 1985, JOHN WILEY & SONS | Type: | Non-patent literature | Publication information: | OLD ET AL.: "Principles of Gene Manipulation: An Introduction to Genetic Engineering", 1981, UNIVERSITY OF CALIFORNIA PRESS | Type: | Non-patent literature | Publication information: | ROITT ET AL.: "Immunology", 2001, MOSBY/ELSEVIER | Type: | Non-patent literature | Publication information: | ROITT ET AL.: "Roitt's s Essential Immunology", 2001, BLACKWELL PUBLISHING | Type: | Non-patent literature | Publication information: | JANEWAY ET AL.: "Immunobiology", 2005, GARLAND SCIENCE PUBLISHING/CHURCHILL LIVINGSTONE | Type: | Non-patent literature | Publication information: | WARD ET AL., NATURE, vol. 341, no. 6242, 12 October 1989 (1989-10-12), pages 544 - 6 | Type: | Non-patent literature | Publication information: | HOLT ET AL., TRENDS BIOTECHNOL., vol. 21, no. 11, 2003, pages 484 - 490 | Type: | Non-patent literature | Publication information: | MUYLDERMANS, REVIEWS IN MOLECULAR BIOTECHNOLOGY, vol. 74, 2001, pages 277 - 302 | Type: | Non-patent literature | Publication information: | CONRATH ET AL., J. BIOL. CHEM., vol. 276, no. 10, 2001, pages 7346 - 7350 | Type: | Non-patent literature | Publication information: | GHAHROUDI ET AL., FEBS LETTERS, vol. 414, 1997, pages 521 - 526 | Type: | Non-patent literature | Publication information: | MUYLDERMANS, FEBS LETTERS, vol. 74, 2001, pages 277 - 302 | Type: | Non-patent literature | Publication information: | VRANKEN ET AL., BIOCHEMISTRY, vol. 41, 2002, pages 8570 - 8579 | Type: | Non-patent literature | Publication information: | GASSER ET AL., BIOTECHNOL. BIOENG., vol. 94, 2006, pages 535 | Type: | Non-patent literature | Publication information: | GASSER ET AL., APPL. ENVIRON. MICROBIOL., vol. 73, 2007, pages 6499 | Type: | Non-patent literature | Publication information: | DAMASCENO ET AL., MICROBIOL. BIOTECHNOL., vol. 74, 2007, pages 381 | Type: | Non-patent literature | Publication information: | "Methods in Molecular Biology, Pichia protocols", HUMANA PRESS | Type: | Non-patent literature | Publication information: | STARK ET AL., J. BIOL. CHEM., vol. 235, 1960, pages 3177 - 3181 | Type: | Non-patent literature | Publication information: | PRESTA, ADV. DRUG DELIV. REV., vol. 58, no. 5-6, 2006, pages 640 - 56 | Type: | Non-patent literature | Publication information: | LEVIN, WEISS, MOL. BIOSYST., vol. 2, no. 1, 2006, pages 49 - 57 | Type: | Non-patent literature | Publication information: | IRVING ET AL., J. IMMUNOL. METHODS, vol. 248, no. 1-2, 2001, pages 31 - 45 | Type: | Non-patent literature | Publication information: | SCHMITZ ET AL., PLACENTA, vol. 21, no. A, 2000, pages 106 - 12 | Type: | Non-patent literature | Publication information: | GONZALES ET AL., TUMOUR BIOL., vol. 26, no. 1, 2005, pages 31 - 43 |