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EP Citations: EP2632946

Cited inInternational search
Type:Patent literature
Publication No.:WO2006030220  [XDPI]
 (DOMANTIS LTD et al.) [XDP] 35 * Examples 10, 17-19, especially page 384, lines 29-31;page 385, lines 3-7 *[I] 1-34
Type:Patent literature
Publication No.:WO2008142164  [XI]
 (ABLYNX NV et al.) [I] 1-34
Type:Patent literature
Publication No.:WO2010125187  [XDI]
 (ABLYNX NV et al.) [XD] 35 * Example 11, especially page 248, lines 5-9 *[I] 1-34
Type:Non-patent literature
Publication information:[XDPI]   RAHBARIZADEH F ET AL: "Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 43, no. 5, 1 February 2006 (2006-02-01), pages 426 - 435, XP025037145, ISSN: 0161-5890, [retrieved on 20060201], DOI: 10.1016/J.MOLIMM.2005.03.003 [I] 1-34
DOI: http://dx.doi.org/10.1016/j.molimm.2005.03.003
Type:Non-patent literature
Publication information:[XDI]   RAHBARIZADEH F ET AL: "High expression and purification of the recombinant camelid anti-MUC1 single domain antibodies in Escherichia coli", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 44, no. 1, 1 November 2005 (2005-11-01), pages 32 - 38, XP027390195, ISSN: 1046-5928, [retrieved on 20050930], DOI: 10.1016/J.PEP.2005.04.008 [I] 1-34
DOI: http://dx.doi.org/10.1016/j.pep.2005.04.008
Type:Non-patent literature
Publication information:[XI]   ANONYMOUS: "EasySelect (TM) Pichia Expression Kit", 18 June 2010 (2010-06-18), pages I-VIII - 1-87, XP055015858, Retrieved from the Internet [retrieved on 20120106] [X] 35 * whole document, especially the Abstract * [I] 1-34
Type:Non-patent literature
Publication information:[XDPI]   ANONYMOUS: "Pichia Fermentation Process Guidelines", 30 May 2002 (2002-05-30), pages 1 - 11, XP055015860, Retrieved from the Internet [retrieved on 20120106] [I] 1-34
Cited inOpposition
Type:Patent literature
Publication No.:WO2006030220  
Type:Patent literature
Publication No.:WO2008142164  
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Type:Non-patent literature
Publication information:  RAHBARIZADEH ET AL.: "Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris", MOLECULAR IMMUNOLOGY, vol. 43, no. 5, 1 February 2006 (2006-02-01), pages 426 - 435, XP025037145
DOI: http://dx.doi.org/10.1016/j.molimm.2005.03.003
Type:Non-patent literature
Publication information:  RAHBARIZADEH ET AL.: "High expression and purification of the recombinant camelid anti-MUC1 single domain antibodies in Escherichia coli", PROTEIN EXPRESSION AND PURIFICATION, 1 November 2005 (2005-11-01), pages 32 - 38, XP027390195
DOI: http://dx.doi.org/10.1016/j.pep.2005.04.008
Type:Non-patent literature
Publication information:  ANONYMOUS: "EasySelect (TM) Pichia Expression Kit", INVITROGEN - LIFE TECHNOLOGIES, 2010, pages I-VIII,1 - 87, XP055015858, Retrieved from the Internet
Type:Non-patent literature
Publication information:  ANONYMOUS: "Pichia Fermentation Process Guidelines", INVITROGEN - LIFE TECHNOLOGIES, 2002, pages 1 - 11, XP055015860, Retrieved from the Internet
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Publication information:  LIN ET AL.: "Ion chromatographic quantification of cyanate in urea solutions: estimation of the efficiency of cyanate scavengers for use in recombinant protein manufacturing", JOURNAL OF CHROMATOGRAPHY, vol. 803, no. 2, 25 April 2004 (2004-04-25), pages 353 - 362, XP004500042
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Publication information:  STARK G. R. ET AL.: "Reactions of the cyanate present in aqueous urea with amino acids and proteins", J. BIOL. CHEM., vol. 235, no. 11, November 1960 (1960-11-01), pages 3177 - 3181, XP055519480
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Publication information:  STARK ET AL.: "The use of cyanate for the determination of NH2-terminal residues in proteins", J. BIOL. CHEM., vol. 238, no. 1, 1963, pages 214 - 226, XP055519482
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Publication information:  GNTER JAGSCHIES ET AL.: "Handbook of Process Chromatography: Development, Manufacturing, Validation and Economics", 2008, ELSEVIER, article "Chapter 5", pages: 127 - 135, XP055519484
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Publication information:  VINCENT LEE: "Peptide and Protein Drug Discovery", 1990, CRC PRESS, article "Carbamylation", pages: 189, XP055519505
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Publication information:  CREGG ET AL.: "Methods in Molecular Biology. Pichia protocols, 2nd ed.", 2007, HUMANA PRESS, article "chapter 6", pages: 77-79,94 - 95, XP055519500
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Publication information:  HARMSEN ET AL.: "Properties, production, and applications of camelid single-domain antibody fragments", APPL MICROBIOL BIOTECHNOL, vol. 77, no. 1, November 2007 (2007-11-01), pages 13 - 22, XP055519503
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Publication information:  "The Gold Sheet", PHARMACEUTICAL & BIOTECHNOLOGY QUALITY CONTROL, vol. 38, no. 9, September 2004 (2004-09-01), pages 1 - 32, XP055731017
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Publication information:  BOERNER, KATHLEEN CLOUSE: "Defining Your Product Profile and Maintaining Control Over It Part 3", BIOPROCESS TECHNICAL, October 2005 (2005-10-01), pages 51 - 56, XP055731022
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Publication information:  PAUL RAINVILLE, KEFEI ZHENG, CLAUDE MALLET, REB RUSSELL II, DETECTING CARBAMYLATION OF INTACT PROTEINS AND PEPTIDES BY LC/MS(/MS, 2002, pages 1, XP055731108
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Publication information:  AHN ET AL.: "BiopharmaLynx: A new bioinformatics tool for automated LC/MS peptide mapping assignment", WATERS - THE SCIENCE OF WHAT IS POSSIBLE, September 2008 (2008-09-01), pages 1 - 6, XP055731028
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Publication information:  MIDDELHOVEN: "The pathway of arginine breakdown in Saccharomyces cerevisiae", BIOCHIM. BIOPHYS. ACTA, vol. 93, 1964, pages 650 - 652, XP025792842, DOI: 10.1016/0304-4165(64)90349-6
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Publication information:  K KITAMOTO, K ODA, K GOMI, K TAKAHASHI: "Genetic Engineering of a Sake Yeast Producing No Urea by Successive Disruption of Arginase Gene", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 57, 1991, pages 301 - 306, XP055731032
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Publication information:  J. RICHARD DICKINSON, MICHAEL SCHWEIZER: "THE METABOLISM AND MOLECULAR PHYSIOLOGY OF SACCHAROMYCES CEREVISIAE", 2004, CRC PRESS, article J. RICHARD DICKINSON, MICHAEL SCHWEIZER, pages: 1 - 476
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Publication information:  "Biology of Microorganisms on Grapes in Must and in Wine", 2009, SPRINGER, article KNIG HELMUT, UNDEN GOTTFRIED, FRHLICH JRGEN, pages: 1 - 521
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Publication information:  MARC CARNICER, KRISTIN BAUMANN, ISABELLE TPLITZ, FRANCESC SNCHEZ-FERRANDO, DIETHARD MATTANOVICH, PAU FERRER & JOAN ALBIOL: "Macromolecular and Elemental Composition Analysis and Extracellular Metabolite Balances of Pichia pastoris growing at different oxygen levels", MICROBIAL CELL FACTORIES, December 2009 (2009-12-01), pages - 14, XP021067674
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Publication information:  ZOLODZ M D; HERBERG J T; NAREPEKHA H E; RALEIGH E; FARBER M R; DUFIELD R L; BOYLE D M: "Separation by hydrophobic interaction chromatography and structural determination by mass spectrometry of mannosylated glycoforms of a recombinant transferrin-extendin-4 fusion protein from yeast", JOURNAL OF CHROMATOGRAPHY A, October 2009 (2009-10-01), pages 225 - 234, XP026817105
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Publication information:  O. BOU, O. FARNS, A. GONZLEZ, R. FERNNDEZ, J.A. ACOSTA, R. VALDS, L.J. GONZLEZ, Y. GUANCHE, G. IZQUIERDO, M. SUREZ, I. DOM: "Production and biochemical characterization of the recombinant Boophilus microplus Bm95 antigen from Pichia pastoris", EXPERIMENTAL AND APPLIED ACAROLOGY, vol. 32, 2004, pages 119 - 128, XP055731099
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