EP2625195 - CANCER TARGETS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.02.2017 Database last updated on 02.11.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states University Of Dundee Nethergate Dundee DD1 4HN / GB | [2013/33] | Inventor(s) | 01 /
SOUTH, Andrew Centre of Molecular Medicine Division of Cancer Research CRC Level 7 Ninewells Hospital and Medical School Dundee DD1 9SY / GB | 02 /
POURREYRON, Celine Centre of Molecular Medicine Division of Cancer Research CRC Level 7 Ninewells Hospital and Medical School Dundee DD1 9SY / GB | 03 /
WATT, Stephen Centre of Molecular Medicine Division of Cancer Research CRC Level 7 Ninewells Hospital and Medical School Dundee DD1 9SY / GB | 04 /
FOERSTER, John Centre of Molecular Medicine Division of Education Mailbox 3 Ninewells Hospital and Medical School Dundee DD1 9SY / GB | [2013/33] | Representative(s) | Gibbs, Richard, et al Marks & Clerk LLP Atholl Exchange 6 Canning Street Edinburgh EH3 8EG / GB | [2013/42] |
Former [2013/33] | Gibbs, Richard Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS / GB | Application number, filing date | 11779194.7 | 07.10.2011 | [2016/14] | WO2011GB01455 | Priority number, date | GB20100016995 | 08.10.2010 Original published format: GB 201016995 | [2013/33] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2012046006 | Date: | 12.04.2012 | Language: | EN | [2012/15] | Type: | A2 Application without search report | No.: | EP2625195 | Date: | 14.08.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 12.04.2012 takes the place of the publication of the European patent application. | [2013/33] | Type: | B1 Patent specification | No.: | EP2625195 | Date: | 06.04.2016 | Language: | EN | [2016/14] | Search report(s) | International search report - published on: | EP | 24.05.2012 | Classification | IPC: | C07K14/47, G01N33/50, C12Q1/68, C12N15/113, A61K38/17, A61K39/395, A61K48/00 | [2013/33] | CPC: |
C12Q1/6886 (EP,US);
C07K14/47 (EP,US);
C12N15/113 (EP,US);
C12N2310/14 (EP,US);
C12N2320/12 (EP,US);
C12Q2600/158 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/33] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | KREBSZIELMOLEKÜLE | [2013/33] | English: | CANCER TARGETS | [2013/33] | French: | CIBLES POUR LE TRAITEMENT DE CANCERS | [2013/33] | Entry into regional phase | 30.04.2013 | National basic fee paid | 30.04.2013 | Designation fee(s) paid | 30.04.2013 | Examination fee paid | Examination procedure | 30.04.2013 | Amendment by applicant (claims and/or description) | 30.04.2013 | Examination requested [2013/33] | 08.04.2014 | Despatch of a communication from the examining division (Time limit: M04) | 18.08.2014 | Reply to a communication from the examining division | 13.11.2014 | Despatch of a communication from the examining division (Time limit: M04) | 23.03.2015 | Reply to a communication from the examining division | 29.09.2015 | Communication of intention to grant the patent | 04.02.2016 | Fee for grant paid | 04.02.2016 | Fee for publishing/printing paid | 04.02.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 08.04.2014 | Opposition(s) | 10.01.2017 | No opposition filed within time limit [2017/11] | Fees paid | Renewal fee | 14.10.2013 | Renewal fee patent year 03 | 30.03.2015 | Renewal fee patent year 04 | 12.10.2015 | Renewal fee patent year 05 | Penalty fee | Additional fee for renewal fee | 31.10.2014 | 04   M06   Fee paid on   30.03.2015 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 07.10.2011 | AL | 06.04.2016 | AT | 06.04.2016 | BE | 06.04.2016 | BG | 06.04.2016 | CY | 06.04.2016 | CZ | 06.04.2016 | DK | 06.04.2016 | EE | 06.04.2016 | ES | 06.04.2016 | FI | 06.04.2016 | HR | 06.04.2016 | IT | 06.04.2016 | LT | 06.04.2016 | LV | 06.04.2016 | MC | 06.04.2016 | MK | 06.04.2016 | NL | 06.04.2016 | PL | 06.04.2016 | RO | 06.04.2016 | RS | 06.04.2016 | SE | 06.04.2016 | SI | 06.04.2016 | SK | 06.04.2016 | SM | 06.04.2016 | TR | 06.04.2016 | NO | 06.07.2016 | GR | 07.07.2016 | IS | 06.08.2016 | PT | 08.08.2016 | IE | 07.10.2016 | LU | 07.10.2016 | CH | 31.10.2016 | LI | 31.10.2016 | MT | 31.10.2016 | FR | 02.11.2016 | [2018/46] |
Former [2018/45] | HU | 07.10.2011 | |
AT | 06.04.2016 | ||
BE | 06.04.2016 | ||
BG | 06.04.2016 | ||
CY | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
MC | 06.04.2016 | ||
MK | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
TR | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
IE | 07.10.2016 | ||
LU | 07.10.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
MT | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2018/38] | HU | 07.10.2011 | |
AT | 06.04.2016 | ||
BE | 06.04.2016 | ||
BG | 06.04.2016 | ||
CY | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
MC | 06.04.2016 | ||
MK | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
IE | 07.10.2016 | ||
LU | 07.10.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
MT | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2018/31] | HU | 07.10.2011 | |
AT | 06.04.2016 | ||
BE | 06.04.2016 | ||
CY | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
MC | 06.04.2016 | ||
MK | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
IE | 07.10.2016 | ||
LU | 07.10.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
MT | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2018/28] | HU | 07.10.2011 | |
AT | 06.04.2016 | ||
BE | 06.04.2016 | ||
CY | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
MC | 06.04.2016 | ||
MK | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
IE | 07.10.2016 | ||
LU | 07.10.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2017/51] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
IE | 07.10.2016 | ||
LU | 07.10.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2017/42] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
LU | 07.10.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2017/37] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SI | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
CH | 31.10.2016 | ||
LI | 31.10.2016 | ||
FR | 02.11.2016 | ||
Former [2017/11] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SK | 06.04.2016 | ||
SM | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2017/10] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
SK | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2017/09] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
CZ | 06.04.2016 | ||
DK | 06.04.2016 | ||
EE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RO | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2017/07] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
DK | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2017/03] | AT | 06.04.2016 | |
BE | 06.04.2016 | ||
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
IT | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2016/52] | AT | 06.04.2016 | |
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RS | 06.04.2016 | ||
SE | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2016/51] | AT | 06.04.2016 | |
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RS | 06.04.2016 | ||
NO | 06.07.2016 | ||
GR | 07.07.2016 | ||
IS | 06.08.2016 | ||
PT | 08.08.2016 | ||
Former [2016/50] | AT | 06.04.2016 | |
ES | 06.04.2016 | ||
FI | 06.04.2016 | ||
HR | 06.04.2016 | ||
LT | 06.04.2016 | ||
LV | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
RS | 06.04.2016 | ||
NO | 06.07.2016 | ||
IS | 06.08.2016 | ||
Former [2016/49] | FI | 06.04.2016 | |
LT | 06.04.2016 | ||
NL | 06.04.2016 | ||
PL | 06.04.2016 | ||
NO | 06.07.2016 | ||
IS | 06.08.2016 | ||
Former [2016/48] | LT | 06.04.2016 | |
NL | 06.04.2016 | ||
NO | 06.07.2016 | ||
IS | 06.08.2016 | ||
Former [2016/46] | LT | 06.04.2016 | |
NL | 06.04.2016 | ||
NO | 06.07.2016 | ||
Former [2016/44] | NL | 06.04.2016 | Cited in | International search | [A]US2006147930 (SLAMON DENNIS J [US], et al) [A] 1-14 * the whole document *; | [AD] - NINDL INGO ET AL, "Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, (20060808), vol. 5, no. 1, doi:10.1186/1476-4598-5-30, ISSN 1476-4598, page 30, XP021018292 [AD] 1-14 * abstract * DOI: http://dx.doi.org/10.1186/1476-4598-5-30 | [A] - DANG CHANTIP ET AL, "Identification of dysregulated genes in cutaneous squamous cell carcinoma.", ONCOLOGY REPORTS SEP 2006 LNKD- PUBMED:16865251, (200609), vol. 16, no. 3, ISSN 1021-335X, pages 513 - 519, XP002667334 [A] 1-14 * abstract * DOI: http://dx.doi.org/10.3892/or.16.3.513 | [AD] - HAIDER ASIFA S ET AL, "Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia.", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY APR 2006 LNKD- PUBMED:16470182, (200604), vol. 126, no. 4, ISSN 0022-202X, pages 869 - 881, XP002667335 [AD] 1-14 * abstract * DOI: http://dx.doi.org/10.1038/SJ.JID.5700157 | [A] - ONDO ET AL, "Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, (20061114), vol. 55, no. 6, doi:10.1016/J.JAAD.2006.06.031, ISSN 0190-9622, pages 1092 - 1094, XP005725747 [A] 1-14 * abstract * DOI: http://dx.doi.org/10.1016/j.jaad.2006.06.031 | [AD] - K YAMAGUCHI ET AL, "C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer", BRITISH JOURNAL OF CANCER, (20100119), vol. 102, no. 2, doi:10.1038/sj.bjc.6605500, ISSN 0007-0920, pages 325 - 331, XP055016595 [AD] 1-14 * the whole document * DOI: http://dx.doi.org/10.1038/sj.bjc.6605500 | [AD] - CAI YONG ET AL, "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 31 OCT 2003 LNKD- PUBMED:12963728, (20031031), vol. 278, no. 44, ISSN 0021-9258, pages 42733 - 42736, XP002667336 [AD] 1-14 * the whole document * DOI: http://dx.doi.org/10.1074/JBC.C300389200 | [A] - "Sequence 1062030 from Patent EP2213738.", EMBL, (20100826), Database accession no. HH185315, URL: EBI, XP002667337 [A] 7 * sequence . * | [XP] - S A WATT ET AL, "Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma", ONCOGENE, (20110523), vol. 30, no. 46, doi:10.1038/onc.2011.180, ISSN 0950-9232, pages 4666 - 4677, XP055016610 [XP] 1-14 * the whole document * DOI: http://dx.doi.org/10.1038/onc.2011.180 | by applicant | GB2185187 | US3249109 | US3598122 | US4144317 | US4262003 | US4307717 | - PCR Primer: A Laboratory Manual, COLD SPRING HARBOUR LABORATORY PRESS | - JOSEPH SAMBROOK, DAVID RUSSELL, Molecular Cloning: A Laboratory Manual, COLD SPRING HARBOUR LABORATORY PRESS | - OLENA MOROZOVAA, MARCO A. MARRA, "Applications of next-generation sequencing technologies in functional genomics", GENOMICS, (200811), vol. 92, no. 5, doi:doi:10.1016/j.ygeno.2008.07.001, pages 255 - 264, XP025535324 DOI: http://dx.doi.org/10.1016/j.ygeno.2008.07.001 | - RONAGHI, "Pyrosequencing sheds light on DNA sequencing", GENOME RESEARCH, (2001), vol. 11, doi:doi:10.1101/gr.11.1.3, pages 3 - 11, XP000980886 DOI: http://dx.doi.org/10.1101/gr.11.1.3 | - MOSMANN T, "Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays", JOURNAL OF IMMUNOLOGICAL METHODS, (1983), vol. 65, no. 1-2, doi:doi:10.1016/0022-1759(83)90303-4, pages 55 - 63, XP023973702 DOI: http://dx.doi.org/10.1016/0022-1759(83)90303-4 | - BARRETT ET AL., GDS2546, (2009), URL: http://www.ncbi.nlm.nih.gov/geo | - EDGAR ET AL., NCBI GEO DATABASE, (2002), URL: http://www.ncbi.nlm.nih.gov/geo | - BOURDON, J. C., FERNANDES, K., MURRAY-ZMIJEWSKI, F., LIU, G., DIOT, A., XIRODIMAS, D. P., SAVILLE, M. K., LANE, D. P., "p53 isoforms can regulate p53 transcriptional activity", GENES DEV, (2005), vol. 19, doi:doi:10.1101/GAD.1339905, pages 2122 - 2137, XP002671568 DOI: http://dx.doi.org/10.1101/GAD.1339905 | - BRAAKHUIS, B. J., BRAKENHOFF, R. H., LEEMANS, C. R., "Gene expression profiling in head and neck squamous cell carcinoma", CURR OPIN OTOLARYNGOL HEAD NECK SURG, (2010), vol. 18, pages 67 - 71 | - CARVALHO, B., POSTMA, C., MONGERA, S., HOPMANS, E., DISKIN, S., VAN DE WIEL, M. A., VAN CRIEKINGE, W., THAS, O., MATTHAI, A., CUES, "Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression", GUT, (2009), vol. 58, doi:doi:10.1136/gut.2007.143065, pages 79 - 89, XP009113614 DOI: http://dx.doi.org/10.1136/gut.2007.143065 | - CHENG, H., FORCE, T., "Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics", CIRC RES, (2010), vol. 106, pages 21 - 34 | - CLARK, L. J., EDINGTON, K., SWAN, 1. R., MCLAY, K. A., NEWLANDS, W. J., WILLS, L. C., YOUNG, H. A., JOHNSTON, P. W., MITCHELL, R.,, "The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck", BR J CANCER, (1993), vol. 68, pages 617 - 620 | - CREIGHTON, C., KUICK, R., MISEK, D. E., RICKMAN, D. S., BRICHORY, F. M., ROUILLARD, J. M., OMENN, G. S., HANASH, S., "Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice", GENOME BIOL, (2003), vol. 4, doi:doi:10.1186/gb-2003-4-7-r46, page R46, XP021021213 DOI: http://dx.doi.org/10.1186/gb-2003-4-7-r46 | - CUNNINGHAM, J., SALES, M., PEARCE, A., HOWARD, J., STALLINGS, R., TELFORD, N., WILKIE, R., HUNTLY, B., THOMAS, A., O'MARCAIGH, A., "Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?", BR J HAEMATOL, (2002), vol. 119, pages 1062 - 1069 | - DAIRKEE, S. H., JI, Y., BEN, Y., MOORE, D. H., MENG, Z., JEFFREY, S. S., "A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue", BMC GENOMICS, (2004), vol. 5, doi:doi:10.1186/1471-2164-5-47, page 47, XP021002129 DOI: http://dx.doi.org/10.1186/1471-2164-5-47 | - DEGENHARDT, Y., LAMPKIN, T., "Targeting Polo-like Kinase in Cancer Therapy", CLIN CANCER RES, (2010), vol. 16, pages 384 - 9 | - DRUKER, B. J., TALPAZ, M., RESTA, D. J., PENG, B., BUCHDUNGER, E., FORD, J. M., LYDON, N. B., KANTARJIAN, H., CAPDEVILLE, R., OHNO, "Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia", N ENGL J MED, (2001), vol. 344, doi:doi:10.1056/NEJM200104053441401, pages 1031 - 1037, XP008058364 DOI: http://dx.doi.org/10.1056/NEJM200104053441401 | - EDGAR, R., DOMRACHEV, M., LASH, A. E., "Gene Expression Omnibus: NCBI gene expression and hybridization array data repository", NUCLEIC ACIDS RES, (2002), vol. 30, pages 207 - 210 | - FINE, J. D., JOHNSON, L. B., WEINER, M., LI, K. P., SUCHINDRAN, C., "Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986-2006", J AM ACAD DERMATOL, (2009), vol. 60, doi:doi:10.1016/j.jaad.2008.09.035, pages 203 - 211, XP025892245 DOI: http://dx.doi.org/10.1016/j.jaad.2008.09.035 | - FONG, P. C., BOSS, D. S., YAP, T. A., TUTT, A., WU, P., MERGUI-ROELVINK, M., MORTIMER, P., SWAISLAND, H., LAU, A., O'CONNOR, M. J., "Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers", N ENGL J MED, (2009), vol. 361, doi:doi:10.1056/NEJMoa0900212, pages 123 - 134, XP003030947 DOI: http://dx.doi.org/10.1056/NEJMoa0900212 | - GALLEGOS RUIZ, M. 1., FLOOR, K., ROEPMAN, P., RODRIGUEZ, J. A., MEIJER, G. A., MOOI, W. J., JASSEM, E., NIKLINSKI, J., MULEY, T.,, "Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target", PLOS ONE, (2008), vol. 3, page E0001722 | - GIGLIA-MARI, G., SARASIN, A., "TP53 mutations in human skin cancers", HUM MUTAT, (2003), vol. 21, pages 217 - 228 | - GREEN, J., IKRAM, M., VYAS, J., PATEL, N., PROBY, C. M., GHALI, L., LEIGH, 1. M., O'TOOLE, E. A., STOREY, A., "Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumors", BR J CANCER, (2006), vol. 94, no. 144, pages 6 - 1451 | - GUAN, R., TAPANG, P., LEVERSON, J. D., ALBERT, D., GIRANDA, V. L., LUO, Y., "Small interfering RNA-mediated Polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals", CANCER RES, (2005), vol. 65, pages 2698 - 2704 | - HAIDER, A. S., PETERS, S. B., KAPORIS, H., CARDINALE, 1., FEI, J., OTT, J., BLUMENBERG, M., BOWCOCK, A. M., KRUEGER, J. G., CARUCC, "Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia", J INVEST DERMATOL, (2006), vol. 126, doi:doi:10.1038/SJ.JID.5700157, pages 869 - 881, XP002667335 DOI: http://dx.doi.org/10.1038/SJ.JID.5700157 | - HANAHAN, D., WEINBERG, R. A., "The hallmarks of cancer", CELL, (2000), vol. 100, pages 57 - 70 | - HAYAKAWA, T., OHTANI, Y., HAYAKAWA, N., SHINMYOZU, K., SAITO, M., ISHIKAWA, F., NAKAYAMA, J., "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation", GENES CELLS, (2007), vol. 12, pages 811 - 826 | - LIU, X., LEI, M., ERIKSON, R. L., "Normal cells, but not cancer cells, survive severe Plkl depletion", MOL CELL BIOL, (2006), vol. 26, doi:doi:10.1128/MCB.26.6.2093-2108.2006, pages 2093 - 2108, XP002482341 DOI: http://dx.doi.org/10.1128/MCB.26.6.2093-2108.2006 | - LIVAK, K. J., SCHMITTGEN, T. D., "Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method", METHODS, (2001), vol. 25, pages 402 - 408 | - MASTERS, J. R., "Human cancer cell lines: fact and fantasy", NAT REV MOL CELL BIOL, (2000), vol. 1, pages 233 - 236 | - MERLO, L. M., PEPPER, J. W., REID, B. J., MALEY, C. C., "Cancer as an evolutionary and ecological process", NAT REV CANCER, (2006), vol. 6, pages 924 - 935 | - MICHIELS, S., KOSCIELNY, S., HILL, C., "Interpretation of microarray data in cancer", BR J CANCER, (2007), vol. 96, pages 1155 - 1158 | - NINDL, 1., DANG, C., FORSCHNER, T., KUBAN, R. J., MEYER, T., STERRY, W., STOCKFLETH, E., "Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microan'ay expression profiling", MOL CANCER, (2006), vol. 5, no. 30 | - PEROU, C. M., JEFFREY, S. S., VAN DE RIJN, M., REES, C. A., EISEN, M. B., ROSS, D. T., PERGAMENSCHIKOV, A., WILLIAMS, C. F., ZHU,, "Distinctive gene expression patterns in human mammary epithelial cells and breast cancers", PROC NATL ACAD SCI U S A, (1999), vol. 96, doi:doi:10.1073/pnas.96.16.9212, pages 9212 - 9217, XP002204448 DOI: http://dx.doi.org/10.1073/pnas.96.16.9212 | - PICCART-GEBHART, M. J., PROCTER, M., LEYLAND-JONES, B., GOLDHIRSCH, A., UNTCH, M., SMITH, 1., GIANNI, L., BASELGA, J., BELL, R., J, "Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer", N ENGL J MED, (2005), vol. 353, pages 1659 - 1672 | - POURREYRON, C., COX, G., MAO, X., VOLZ, A., BAKSH, N., WONG, T., FASSIHI, H., ARITA, K., O'TOOLE, E. A., OCAMPO-CANDIANI, J. ET AL, "Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression", J INVEST DERMATOL, (2007), vol. 127, pages 2438 - 2444 | - PURDIE, K. J., LAMBERT, S. R., TEH, M. T., CHAPLIN, T., MOLLOY, G., RAGHAVAN, M., KELSELL, D. P., LEIGH, I. M., HARWOOD, C. A., PR, "Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis", GENES CHROMOSOMES CANCER, (2007), vol. 46, pages 661 - 669 | - RHEINWALD, J. G., BECKETT, M. A., "Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas", CANCER RES, (1981), vol. 41, pages 1657 - 1663 | - RIKER, A. I., ENKEMANN, S. A., FODSTAD, O., LIU, S., REN, S., MORRIS, C., XI, Y., HOWELL, P., METGE, B., SAMANT, R. S., "The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis", BMC MED GENOMICS, (2008), vol. 1, no. 13 | - ROMANOWSKA, M., REILLY, L., PALMER, C. N., GUSTAFSSON, M. C., FOERSTER, J., "Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo", PLOS ONE, (2010), vol. 5, page E9701 | - ROSS, D. T., SCHERF, U., EISEN, M. B., PEROU, C. M., REES, C., SPELLMAN, P., IYER, V., JEFFREY, S. S., VAN DE RIJN, M., WALTHAM, M, "Systematic variation in gene expression patterns in human cancer cell lines", NAT GENET, (2000), vol. 24, doi:doi:10.1038/73432, pages 227 - 235, XP002933374 DOI: http://dx.doi.org/10.1038/73432 | - SCHMIT, T. L., AHMAD, N., "Regulation of mitosis via mitotic kinases: new opportunities for cancer management", MOL CANCER THER, (2007), vol. 6, pages 1920 - 1931 | - SCHMIT, T. L., ZHONG, W., NIHAL, M., AHMAD, N., "Polo-like kinase 1 (Plkl) in non-melanoma skin cancers", CELL CYCLE, (2009), vol. 8, pages 2697 - 2702 | - SCHOFFSKI, P., "Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology", ONCOLOGIST, (2009), vol. 14, doi:doi:10.1634/theoncologist.2009-0010, pages 559 - 570, XP009161141 DOI: http://dx.doi.org/10.1634/theoncologist.2009-0010 | - SCOTTO, L., NARAYAN, G., NANDULA, S. V., ARIAS-PULIDO, H., SUBRAMANIYAM, S., SCHNEIDER, A., KAUFMANN, A. M., WRIGHT, J. D., POTHUR, "Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression", GENES CHROMOSOMES CANCER, (2008), vol. 47, pages 755 - 765 | - SHARMA, S. V., HABER, D. A., SETTLEMAN, J., "Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents", NAT REV CANCER, (2010), vol. 10, pages 241 - 253 | - SHI, L., JONES, W. D., JENSEN, R. V., HARRIS, S. C., PERKINS, R. G., GOODSAID, F. M., GUO, L., CRONER, L. J., BOYSEN, C., FANG, H., "The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies", BMC BIOINFORMATICS, (2008), vol. 9, no. 9, page 10 | - SHI, L., REID, L. H., JONES, W. D., SHIPPY, R., WARRINGTON, J. A., BAKER, S. C., COLLINS, P. J., DE LONGUEVILLE, F., KAWASAKI, E., "The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements", NAT BIOTECHNOL, (2006), vol. 24, doi:doi:10.1038/nbt1239, pages 1151 - 1161, XP055023548 DOI: http://dx.doi.org/10.1038/nbt1239 | - SOUTH, A. P., WAN, H., STONE, M. G., DOPPING-HEPENSTAL, P. J., PURKIS, P. E., MARSHALL, J. F., LEIGH, I. M., EADY, R. A., HART, I., "Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability", J CELL SCI, (2003), vol. 116, pages 3303 - 3314 | - STEEGMAIER, M., HOFFMANN, M., BAUM, A., LENART, P., PETRONCZKI, M., KRSSAK, M., GURTLER, U., GARIN-CHESA, P., LIEB, S., QUANT, J., "BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo", CURR BIOL, (2007), vol. 17, doi:doi:10.1016/j.cub.2006.12.037, pages 316 - 322, XP005890944 DOI: http://dx.doi.org/10.1016/j.cub.2006.12.037 | - TAKAI, N., HAMANAKA, R., YOSHIMATSU, J., MIYAKAWA, I., "Polo-like kinases (Plks) and cancer", ONCOGENE, (2005), vol. 24, doi:doi:10.1038/sj.onc.1208272, pages 287 - 291, XP002389831 DOI: http://dx.doi.org/10.1038/sj.onc.1208272 | - VAN DE VIJVER, M. J., HE, Y. D., VAN'T VEER, L. J., DAI, H., HART, A. A., VOSKUIL, D. W., SCHREIBER, G. J., PETERSE, J. L., ROBERT, "A gene- expression signature as a predictor of survival in breast cancer", N ENGL J MED, (2002), vol. 347, doi:doi:10.1056/NEJMoa021967, pages 1999 - 2009, XP008032093 DOI: http://dx.doi.org/10.1056/NEJMoa021967 | - VAN HAREN, R., FELDMAN, D., SINHA, A. A., "Systematic comparison of nonmelanoma skin cancer microarray datasets reveals lack of consensus genes", BR J DERMATOL, (2009), vol. 161, pages 1278 - 1287 | - WALLIS, S., LLOYD, S., WISE, I., IRELAND, G., FLEMING, T. P., GARROD, D., "he alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells", MOL BIOL CELL, (2000), vol. 11, pages 1077 - 1092, XP002520097 | - WEAVER, V. M., PETERSEN, O. W., WANG, F., LARABELL, C. A., BRIAND, P., DAMSKY, C., BISSEII, M. J., "Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies", J CELL BIOL, (1997), vol. 137, pages 231 - 245, XP002997413 | - WELSH, J. B., SAPINOSO, L. M., SU, A. I., KERN, S. G., WANG-RODRIGUEZ, J., MOSKALUK, C. A., FRIERSON, H. F., JR., HAMPTON, G. M., "Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer", CANCER RES, (2001), vol. 61, pages 5974 - 5978 | - WU, K., BONAVIDA, B., "he activated NF-kappaB-Snail-RKIP circuitry in cancer regulates both the metastatic cascade and resistance to apoptosis by cytotoxic drugs", CRIT REV IMMUNOL, (2009), vol. 29, pages 241 - 254 | - YAMAGUCHI, K., SAKAI, M., SHIMOKAWA, T., YAMADA, Y., NAKAMURA, Y., FURUKAWA, Y., "C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer", BR J CANCER, (2010), vol. 102, doi:doi:10.1038/sj.bjc.6605500, pages 325 - 331, XP055016595 DOI: http://dx.doi.org/10.1038/sj.bjc.6605500 | - NYSTROM, M. L., THOMAS, G. J., STONE, M., MACKENZIE, 1. C., HART, I. R., MARSHALL, J. F., "Development of a quantitative method to analyse tumour cell invasion in organotypic culture", J PATHOL, (2005), vol. 205, pages 468 - 475 | - BARRETT, T., TROUP, D. B., WILHITE, S. E., LEDOUX, P., RUDNEV, D., EVANGELISTA, C., KIM, I. F., SOBOLEVA, A., TOMASHEVSKY, M., MAR, "NCBI GEO: archive for high-throughput functional genomic data", NUCLEIC ACIDS RES, (2009), vol. 37, pages D885 - 890 |