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Extract from the Register of European Patents

EP About this file: EP2651445

EP2651445 - PHARMACEUTICAL COMPOSITION CONSISTING OF RNA HAVING ALKALI METAL AS COUNTER ION AND FORMULATED WITH DICATIONS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  02.10.2020
Database last updated on 06.11.2024
FormerExamination is in progress
Status updated on  11.12.2019
FormerGrant of patent is intended
Status updated on  19.09.2019
FormerExamination is in progress
Status updated on  27.12.2016
Most recent event   Tooltip02.10.2020Application deemed to be withdrawnpublished on 04.11.2020  [2020/45]
Applicant(s)For all designated states
SPRNA GmbH
Kanzleistrasse 23
8004 Zürich / CH
[2013/43]
Inventor(s)01 / PASCOLO, Steve
Kanzleistrasse 231
8004 Zürich / CH
 [2013/43]
Representative(s)Habermann, Hruschka & Schnabel
Patentanwälte
Montgelasstraße 2
81679 München / DE
[2013/43]
Application number, filing date11794809.116.12.2011
WO2011EP73151
Priority number, dateEP2010019549316.12.2010         Original published format: EP 10195493
[2013/43]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2012103985
Date:09.08.2012
Language:EN
[2012/32]
Type: A2 Application without search report 
No.:EP2651445
Date:23.10.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 09.08.2012 takes the place of the publication of the European patent application.
[2013/43]
Search report(s)International search report - published on:EP27.09.2012
ClassificationIPC:A61K47/00, C12N15/88, A61K9/00
[2013/43]
CPC:
A61K9/0019 (EP,US); C12N15/117 (EP,US); A61K47/02 (EP,US);
C12N15/11 (US); C12N15/111 (EP,US); C12N15/113 (EP,US);
C12N15/88 (EP,US); C12N2310/11 (EP,US); C12N2310/14 (EP,US);
C12N2320/32 (EP,US); Y02A50/30 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/43]
TitleGerman:PHARMAZEUTISCHE ZUSAMMENSETZUNG AUS RNA MIT ALKALIMETALL ALS GEGENION UND FORMULIERT MIT DIKATIONEN[2013/43]
English:PHARMACEUTICAL COMPOSITION CONSISTING OF RNA HAVING ALKALI METAL AS COUNTER ION AND FORMULATED WITH DICATIONS[2013/43]
French:COMPOSITION PHARMACEUTIQUE À BASE D'ARN QUI COMPREND UN MÉTAL ALCALIN EN TANT QUE CONTRE-ION ET FORMULÉ AVEC DES DICATIONS[2013/43]
Entry into regional phase15.07.2013National basic fee paid 
15.07.2013Designation fee(s) paid 
15.07.2013Examination fee paid 
Examination proceduredeletedCommunication of intention to grant the patent
15.07.2013Amendment by applicant (claims and/or description)
15.07.2013Examination requested  [2013/43]
24.10.2014Despatch of a communication from the examining division (Time limit: M06)
24.04.2015Reply to a communication from the examining division
16.12.2016Despatch of a communication from the examining division (Time limit: M06)
26.06.2017Reply to a communication from the examining division
31.10.2017Despatch of a communication from the examining division (Time limit: M06)
25.04.2018Reply to a communication from the examining division
20.09.2019Communication of intention to grant the patent
01.10.2019Observations by third parties
11.12.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
16.12.2019Despatch of a communication from the examining division (Time limit: M04)
03.06.2020Application deemed to be withdrawn, date of legal effect  [2020/45]
29.06.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2020/45]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.10.2014
Fees paidRenewal fee
17.10.2013Renewal fee patent year 03
08.10.2014Renewal fee patent year 04
07.10.2015Renewal fee patent year 05
21.11.2016Renewal fee patent year 06
06.11.2017Renewal fee patent year 07
17.12.2018Renewal fee patent year 08
14.10.2019Renewal fee patent year 09
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Cited inInternational search[Y]EP1083232  (JUNG GUENTHER PROF DR [DE], et al) [Y] 18-23 * paragraph [0049] *;
 [XYI]US2008267873  (HOERR INGMAR [DE], et al) [X] 1-15,17 * paragraph [0033] - paragraph [0080] * * page 2 - page 8; examples 1-2 * [Y] 18-23 [I] 16;
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DOI:   http://dx.doi.org/10.1038/SJ.GT.3302964
ExaminationWO2006008154
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DOI:   http://dx.doi.org/10.1002/1521-4141(200001)30:1<1::AID-IMMU1>3.3.CO;2-R
    - DIEBOLD SS; KAISHO T; HEMMI H; AKIRA S; REIS E SOUSA C., "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA", SCIENCE, (20040305), vol. 303, no. 5663, doi:doi:10.1126/science.1093616, pages 1529 - 31, XP002675306

DOI:   http://dx.doi.org/10.1126/science.1093616
    - HEIL F; HEMMI H; HOCHREIN H; AMPENBERGER F; KIRSCHNING C; AKIRA S ET AL., "Species- specific recognition of single-stranded RNA via toll-like receptor 7 and 8", SCIENCE, (20040305), vol. 303, no. 5663, pages 1526 - 9
    - OZPOLAT B; SOOD AK; LOPEZ-BERESTEIN G., "Nanomedicine based approaches for the delivery of siRNA in cancer", J INTERN MED, vol. 267, no. 1, doi:doi:10.1111/j.1365-2796.2009.02191.x, pages 44 - 53, XP055242950

DOI:   http://dx.doi.org/10.1111/j.1365-2796.2009.02191.x
    - JARROSSAY D; NAPOLITANI G; COLONNA M; SALLUSTO F; LANZAVECCHIA A., "Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells", EUR J IMMUNOL, (200111), vol. 31, no. 11, pages 3388 - 93, XP055027927
    - PANTER G; KUZNIK A; JERALA R., "Therapeutic applications of nucleic acids as ligands for Toll-like receptors", CURR OPIN MOL THER, (200904), vol. 11, no. 2, pages 133 - 45
    - SCHEEL B; BRAEDEL S; PROBST J; CARRALOT JP; WAGNER H; SCHILD H ET AL., "Immunostimulating capacities of stabilized RNA molecules", EUR J IMMUNOL, (200402), vol. 34, no. 2, doi:doi:10.1002/eji.200324198, pages 537 - 47, XP002422103

DOI:   http://dx.doi.org/10.1002/eji.200324198
    - BOURQUIN C; SCHMIDT L; HORNUNG V; WURZENBERGER C; ANZ D; SANDHOLZER N ET AL., "Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response", BLOOD, (20070401), vol. 109, no. 7, pages 2953 - 60
    - DIEBOLD SS; MASSACRIER C; AKIRA S; PATUREL C; MOREL Y; REIS; SOUSA C., "Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides", EUR J IMMUNOL, (200612), vol. 36, no. 12, doi:doi:10.1002/eji.200636617, pages 3256 - 67, XP008101287

DOI:   http://dx.doi.org/10.1002/eji.200636617
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    - PROBST J; WEIDE B; SCHEEL B; PICHLER BJ; HOERR I; RAMMENSEE HG ET AL., "Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent", GENE THER, (200708), vol. 14, no. 15, doi:doi:10.1038/SJ.GT.3302964, pages 1175 - 80, XP002679377

DOI:   http://dx.doi.org/10.1038/SJ.GT.3302964
    - JING N; DE CLERCQ E; RANDO RF; PALLANSCH L; LACKMAN-SMITH C; LEE S ET AL., "Stability-activity relationships of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors. A basis for anti-HIV drug design", J BIOL CHEM, (20000204), vol. 275, no. 5, doi:doi:10.1074/jbc.275.5.3421, pages 3421 - 30, XP002952224

DOI:   http://dx.doi.org/10.1074/jbc.275.5.3421
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DOI:   http://dx.doi.org/10.1074/jbc.M410868200
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otherWO2006008154
 EP2651445
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