EP2584037 - METHOD FOR CONSTRUCTING RECOMBINANT BACTERIUM FOR PRODUCING NON-NATIVE PROTEIN, AND UTILIZATION OF SAME [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 16.06.2017 Database last updated on 09.09.2024 | Most recent event Tooltip | 06.03.2020 | Lapse of the patent in a contracting state New state(s): TR | published on 08.04.2020 [2020/15] | Applicant(s) | For all designated states Riken 2-1 Hirosawa Wako-shi, Saitama 351-0198 / JP | [2016/32] |
Former [2013/17] | For all designated states Riken 2-1, Hirosawa Wako-shi Saitama 351-0198 / JP | Inventor(s) | 01 /
YOKOYAMA, Shigeyuki RIKEN Yokohama Institute 1-7-22, Suehiro-cho Tsurumi-ku Yokohama-shi Kanagawa 230-0045 / JP | 02 /
MUKAI, Takahito RIKEN Yokohama Institute 1-7-22, Suehiro-cho Tsurumi-ku Yokohama-shi Kanagawa 230-0045 / JP | 03 /
SAKAMOTO, Kensaku RIKEN Yokohama Institute 1-7-22, Suehiro-cho Tsurumi-ku Yokohama-shi Kanagawa 230-0045 / JP | 04 /
MATSUMOTO, Akiko RIKEN Yokohama Institute 1-7-22, Suehiro-cho Tsurumi-ku Yokohama-shi Kanagawa 230-0045 / JP | [2013/17] | Representative(s) | Plasseraud IP 104 Rue de Richelieu CS92104 75080 Paris Cedex 02 / FR | [N/P] |
Former [2016/32] | Cabinet Plasseraud 66, rue de la Chaussée d'Antin 75440 Paris Cedex 09 / FR | ||
Former [2013/17] | Cabinet Plasseraud 52, rue de la Victoire 75440 Paris Cedex 09 / FR | Application number, filing date | 11795797.7 | 16.06.2011 | [2016/32] | WO2011JP63778 | Priority number, date | JP20110047663 | 04.03.2011 Original published format: JP 2011047663 | JP20100137635 | 16.06.2010 Original published format: JP 2010137635 | [2013/17] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011158895 | Date: | 22.12.2011 | Language: | JA | [2011/51] | Type: | A1 Application with search report | No.: | EP2584037 | Date: | 24.04.2013 | Language: | EN | [2013/17] | Type: | B1 Patent specification | No.: | EP2584037 | Date: | 10.08.2016 | Language: | EN | [2016/32] | Search report(s) | International search report - published on: | JP | 22.12.2011 | (Supplementary) European search report - dispatched on: | EP | 07.10.2013 | Classification | IPC: | C12N15/09, C12N1/21, C12P21/02, C12N9/10 | [2013/17] | CPC: |
C07K14/245 (EP,US);
C12N15/11 (EP,US);
C12N15/67 (EP,US);
C12N15/70 (EP,US);
C12N9/93 (EP,US);
C12P21/02 (EP,US);
Y02P20/52 (US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/17] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | VERFAHREN ZUR KONSTRUKTION EINES REKOMBINANTEN BAKTERIUMS ZUR HERSTELLUNG EINES NICHT-NATIVEN PROTEINS UND ANWENDUNG DIESES VERFAHRENS | [2013/17] | English: | METHOD FOR CONSTRUCTING RECOMBINANT BACTERIUM FOR PRODUCING NON-NATIVE PROTEIN, AND UTILIZATION OF SAME | [2013/17] | French: | PROCÉDÉ DE CONSTRUCTION D'UNE BACTÉRIE RECOMBINANTE POUR LA PRODUCTION D'UNE PROTÉINE NON NATIVE, ET SON UTILISATION | [2013/17] | Entry into regional phase | 20.12.2012 | Translation filed | 20.12.2012 | National basic fee paid | 20.12.2012 | Search fee paid | 20.12.2012 | Designation fee(s) paid | 20.12.2012 | Examination fee paid | Examination procedure | 20.12.2012 | Examination requested [2013/17] | 24.04.2014 | Amendment by applicant (claims and/or description) | 22.05.2014 | Despatch of a communication from the examining division (Time limit: M06) | 03.11.2014 | Reply to a communication from the examining division | 25.08.2015 | Despatch of a communication from the examining division (Time limit: M04) | 01.12.2015 | Reply to a communication from the examining division | 29.01.2016 | Communication of intention to grant the patent | 13.05.2016 | Fee for grant paid | 13.05.2016 | Fee for publishing/printing paid | 13.05.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 22.05.2014 | Opposition(s) | 11.05.2017 | No opposition filed within time limit [2017/29] | Fees paid | Renewal fee | 10.06.2013 | Renewal fee patent year 03 | 31.03.2014 | Renewal fee patent year 04 | 10.06.2015 | Renewal fee patent year 05 | 27.06.2016 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 16.06.2011 | AL | 10.08.2016 | AT | 10.08.2016 | BE | 10.08.2016 | CY | 10.08.2016 | CZ | 10.08.2016 | DK | 10.08.2016 | EE | 10.08.2016 | ES | 10.08.2016 | FI | 10.08.2016 | HR | 10.08.2016 | IT | 10.08.2016 | LT | 10.08.2016 | LV | 10.08.2016 | MC | 10.08.2016 | MK | 10.08.2016 | NL | 10.08.2016 | PL | 10.08.2016 | RO | 10.08.2016 | RS | 10.08.2016 | SE | 10.08.2016 | SI | 10.08.2016 | SK | 10.08.2016 | SM | 10.08.2016 | TR | 10.08.2016 | BG | 10.11.2016 | NO | 10.11.2016 | GR | 11.11.2016 | IS | 10.12.2016 | PT | 12.12.2016 | [2020/15] |
Former [2019/51] | HU | 16.06.2011 | |
AL | 10.08.2016 | ||
AT | 10.08.2016 | ||
BE | 10.08.2016 | ||
CY | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
MC | 10.08.2016 | ||
MK | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SI | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2019/46] | HU | 16.06.2011 | |
AL | 10.08.2016 | ||
AT | 10.08.2016 | ||
BE | 10.08.2016 | ||
CY | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
MC | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SI | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2019/31] | HU | 16.06.2011 | |
AL | 10.08.2016 | ||
AT | 10.08.2016 | ||
BE | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
MC | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SI | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2018/46] | AL | 10.08.2016 | |
AT | 10.08.2016 | ||
BE | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
MC | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SI | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2018/11] | AT | 10.08.2016 | |
BE | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
MC | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SI | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2017/37] | AT | 10.08.2016 | |
BE | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SI | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2017/32] | AT | 10.08.2016 | |
BE | 10.08.2016 | ||
CZ | 10.08.2016 | ||
DK | 10.08.2016 | ||
EE | 10.08.2016 | ||
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RO | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
SK | 10.08.2016 | ||
SM | 10.08.2016 | ||
BG | 10.11.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2017/13] | AT | 10.08.2016 | |
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
LV | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2017/11] | AT | 10.08.2016 | |
ES | 10.08.2016 | ||
FI | 10.08.2016 | ||
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
NO | 10.11.2016 | ||
GR | 11.11.2016 | ||
IS | 10.12.2016 | ||
PT | 12.12.2016 | ||
Former [2017/10] | FI | 10.08.2016 | |
HR | 10.08.2016 | ||
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
NL | 10.08.2016 | ||
PL | 10.08.2016 | ||
RS | 10.08.2016 | ||
SE | 10.08.2016 | ||
NO | 10.11.2016 | ||
IS | 10.12.2016 | ||
Former [2017/09] | FI | 10.08.2016 | |
IT | 10.08.2016 | ||
LT | 10.08.2016 | ||
NL | 10.08.2016 | ||
NO | 10.11.2016 | ||
Former [2017/07] | LT | 10.08.2016 | Documents cited: | Search | [Y]WO02085923 (SCRIPPS RESEARCH INST [US], et al) [Y] 1-21 * the whole document *; | [Y]WO2008065398 (MEDICAL RES COUNCIL [GB], et al) [Y] 1-21 * the whole document *; | [Y] - J.-I. KATO ET AL, "Hda, a novel DnaA-related protein, regulates the replication cycle in Escherichia coli", THE EMBO JOURNAL, (20010801), vol. 20, no. 15, doi:10.1093/emboj/20.15.4253, ISSN 0261-4189, pages 4253 - 4262, XP055080838 [Y] 1-21 * the whole document * DOI: http://dx.doi.org/10.1093/emboj/20.15.4253 | [A] - NEUMANN HEINZ ET AL, "A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histories Defines the Effects of H3 K56 Acetylation", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 36, no. 1, doi:10.1016/J.MOLCEL.2009.07.027, ISSN 1097-2765, (20091009), pages 153 - 163, (20091008), XP002618196 [A] 1-21 * the whole document * DOI: http://dx.doi.org/10.1016/j.molcel.2009.07.027 | [Y] - TAIRA H ET AL, "Comprehensive screening of amber suppressor tRNAs suitable for incorporation of non-natural amino acids in a cell-free translation system", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 374, no. 2, doi:10.1016/J.BBRC.2008.07.020, ISSN 0006-291X, (20080919), pages 304 - 308, (20080715), XP023521474 [Y] 1-21 * the whole document * DOI: http://dx.doi.org/10.1016/j.bbrc.2008.07.020 | [XP] - T. MUKAI ET AL, "Codon reassignment in the Escherichia coli genetic code", NUCLEIC ACIDS RESEARCH, on-line, (20100811), vol. 38, no. 22, doi:10.1093/nar/gkq707, ISSN 0305-1048, pages 8188 - 8195, XP055081209 [XP] 1-21 * the whole document * DOI: http://dx.doi.org/10.1093/nar/gkq707 | International search | [Y]JP2005502322 (THE SCRIPPS RESEARCH INSTITUTE); | [Y]JP2010510798 (MEDICAL RESEARCH COUNCIL); | [A]JP2007501007 (RINA NETZWERK RNA- TECHNOLOGIEN GMBH); | [A]JP2007082543 (UNIV KYOTO) | [X] - KATO, JUN-ICHI ET AL., "Hda, a novel DnaA-related protein, regulates the replication cycle in Escherichia coli.", EMBO J., (2001), vol. 20, no. 15, pages 4253 - 4262 | [Y] - KATO, JUN-ICHI ET AL., "Construction of consecutive deletions of the Escherichia coli chromosome.", MOL. SYST. BIOL., (2007), vol. 3, no. 132, pages 1 - 7 | [XP] - MUKAI, TAKAHITO ET AL., "Codon reassignment in the Escherichia coli genetic code.", NUCLEIC ACIDS RES., (20100811), vol. 38, no. 22, pages 8188 - 8195 | [A] - FORSTER, ANTHONY C. ET AL., "Synthetic biology projects in vitro.", (2007), vol. 17, no. 1, pages 1 - 6 | [A] - IRAHA, FUMIE ET AL., "Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion.", NUCLEIC ACIDS RES., (2010), vol. 38, no. 11, pages 3682 - 3691 | [A] - RYDEN, S. M. ET AL., "A temperature- sensitive mutant of Escherichia coli that shows enhanced misreading of UAG/A and increased efficiency for some tRNA nonsense suppressors.", MOL. GEN. GENET., (1984), vol. 193, no. 1, pages 38 - 45 | [A] - SHORT, GLENN F. III ET AL., "Effects of release factor 1 on in vitro protein translation and the elaboration of proteins containing unnatural amino acids.", BIOCHEMISTRY, (1999), vol. 38, no. 27, pages 8808 - 8819 | [A] - SHIMIZU, YOSHIHIRO ET AL., "Cell-free translation reconstituted with purified components.", NAT. BIOTECHNOL., (2001), vol. 19, no. 8, pages 751 - 755 | [A] - JEONG, HAEYOUNG ET AL., "Genome sequences of Escherichia coli B strains REL606 and BL21 (DE3).", J. MOL. BIOL., (2009), vol. 394, pages 644 - 652 | by applicant | US2009317910 | - RYDEN, S.M.; ISAKSSON, L.A., MOLECULAR AND GENERAL GENETICS, (1984), vol. 193, pages 38 - 45 | - KLEINA, L.G. ET AL., JOURNAL OF MOLECULAR BIOLOGY, (1990), vol. 213, pages 705 - 717 | - SHORT III, G.F. ET AL., BIOCHEMISTRY, (1999), vol. 38, pages 8808 - 8819 | - FORSTER, A.C. ET AL., GENOME RESEARCH, (2007), vol. 17, pages 1 - 6 | - WANG, H.H. ET AL., NATURE, (2009), vol. 460, pages 894 - 898 | - CHIN ET AL., MOL CELL, (20091009), vol. 36, no. 1, pages 153 - 63 | - YANAGISAWA T. ET AL., CHEM. BIOL., (2008), vol. 15, pages 1187 - 1197 | - SAKAMOTO K; MURAYAMA K; OKI K; IRAHA F; KATO-MURAYAMA M; TAKAHASHI M; OHTAKE K; KOBAYASHI T; KURAMITSU S; SHIROUZU M, "Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography", STRUCTURE, (20090311), vol. 17, no. 3, pages 335 - 44 | - GUO J; WANG J; ANDERSON JC; SCHULTZ PG., "Addition of an alpha-hydroxy acid to the genetic code of bacteria", ANGEW CHEM INT ED ENGL., (2008), vol. 47, no. 4, pages 722 - 5 | - WANG L; ZHANG Z; BROCK A; SCHULTZ PG., "Addition of the keto functional group to the genetic code of Escherichia coli.", PROC NATL ACAD SCI U S A., (20030107), vol. 100, no. 1, pages 56 - 61 | - PROC NATL ACAD SCI U S A., (20020820), vol. 99, no. 17, pages 11020 - 4 | - J AM CHEM SOC., (20020807), vol. 124, no. 31, pages 9026 - 7 | - ZUBAY ET AL., ANN. REV. GENET., (1973), vol. 7, pages 267 - 287 | - PRATT,J.M. ET AL., Transcription and Translation - A practical approach, IRL PRESS, (1984), pages 179 - 209 | - KIGAWA, T. ET AL., J. STRUCT. FUNCT. GENOMICS, (2004), vol. 5, pages 63 - 68 | - MOTOHASHI, T. ET AL., BIOCHEM BIOPHYS RES COMMUN, (2005), vol. 326, pages 564 - 569 | - SAKAMOTO, K. ET AL., STRUCTURE, (2009), vol. 17, pages 335 - 344 | - WANG L; SCHULTZ PG., "A general approach for the generation of orthogonal tRNAs", CHEM BIOL., (200109), vol. 8, no. 9, pages 883 - 90 | - CHIN JW; SANTORO SW; MARTIN AB; KING DS; WANG L; SCHULTZ PG, "Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli", J AM CHEM SOC., (20020807), vol. 124, no. 31, pages 9026 - 7 | - BABA ET AL., MOL. SYST. BIOL., (2006), vol. 2, page 0008 | - LIU, C.C.; SCHULTZ, P.G., NAT. BIOTECHNOL., (2006), vol. 24, pages 1436 - 1440 | - KOBAYASHI, K. ET AL., PROC. NATL. ACAD. SCI. USA, (2003), vol. 100, pages 4678 - 4683 | - GUO ET AL., ANGEW. CHEM. INT. ED. ENGL., (2009), vol. 48, pages 9148 - 9151 | - YANAGISAWA T. ET AL., CHEM, BIOL, (2008), vol. 15, pages 1187 - 1197 | - LIU, C.C.; SCHULTZ, P.G., ANNU. REV. BIOCHEM., (2010), vol. 79, pages 413 - 444 |