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EP2649099
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EP About this file: EP2649099
| EP2649099 - SMALL-MOLECULE HYDROPHOBIC TAGGING OF FUSION PROTEINS AND INDUCED DEGRADATION OF SAME [Right-click to bookmark this link] | Status | The application has been refused Status updated on 28.06.2019 Database last updated on 31.08.2024 | |
| Former | Examination is in progress Status updated on 30.03.2018 | Most recent event Tooltip | 28.06.2019 | Refusal of application | published on 31.07.2019 [2019/31] | Applicant(s) | For all designated states Yale University Two Whitney Avenue New Haven, CT 06510 / US | [N/P] |
| Former [2013/42] | For all designated states Yale University Two Whitney Avenue New Haven, CT 06511 / US | Inventor(s) | 01 /
CREWS, Craig, M. 286 Livingston St. New Haven, CT 06511 / US | 02 /
TAE, Hyun, Seop 589A Prospect Street Hew Haven, CT 06511-2150 / US | 03 /
SCHNEEKLOTH, Ashley, R. 6120 Samuel Rd. New Market, MD 21774 / US | 04 /
NEKLESA, Taavi 614 East Slope Dr. Orange, CT 06577 / US | 05 /
SUNDBERG, Thomas 108 Edwards St. Apt 1 New Haven, CT 06511 / US | [2013/42] | Representative(s) | Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstraße 4 80802 München / DE | [N/P] |
| Former [2013/42] | Grünecker, Kinkeldey, Stockmair & Schwanhäusser Leopoldstrasse 4 80802 München / DE | Application number, filing date | 11846166.4 | 06.12.2011 | WO2011US63401 | Priority number, date | US20100420584P | 07.12.2010 Original published format: US 420584 P | US201161530014P | 01.09.2011 Original published format: US 201161530014 P | [2013/42] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2012078559 | Date: | 14.06.2012 | Language: | EN | [2012/24] | Type: | A2 Application without search report | No.: | EP2649099 | Date: | 16.10.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 14.06.2012 takes the place of the publication of the European patent application. | [2013/42] | Search report(s) | International search report - published on: | KR | 06.12.2012 | (Supplementary) European search report - dispatched on: | EP | 16.09.2016 | Classification | IPC: | C07K17/02, A61K31/708, A61K31/7076, A61K31/66, A61P31/00 | [2013/42] | CPC: |
C12N9/14 (EP,US);
G01N33/573 (US);
A61K47/52 (EP,US);
A61P31/00 (EP);
C07K1/13 (EP,US);
G01N33/5008 (EP,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/42] | Extension states | BA | 08.07.2013 | ME | 08.07.2013 | Title | German: | KLEINMOLEKÜLIGE HYDROPHOBE MARKIERUNG VON FUSIONSPROTEINEN UND INDUZIERTER ABBAU DAVON | [2013/42] | English: | SMALL-MOLECULE HYDROPHOBIC TAGGING OF FUSION PROTEINS AND INDUCED DEGRADATION OF SAME | [2013/42] | French: | MARQUAGE HYDROPHOBE DE PETITES MOLÉCULES DE PROTÉINES DE FUSION ET DÉGRADATION INDUITE DE CELLES-CI | [2013/42] | Entry into regional phase | 08.07.2013 | National basic fee paid | 08.07.2013 | Search fee paid | 08.07.2013 | Designation fee(s) paid | 08.07.2013 | Examination fee paid | Examination procedure | 08.07.2013 | Examination requested [2013/42] | 06.04.2017 | Amendment by applicant (claims and/or description) | 29.03.2018 | Despatch of a communication from the examining division (Time limit: M06) | 04.09.2018 | Reply to a communication from the examining division | 06.03.2019 | Cancellation of oral proceeding that was planned for 12.03.2019 | 12.03.2019 | Date of oral proceedings (cancelled) | 18.03.2019 | Despatch of communication that the application is refused, reason: substantive examination [2019/31] | 28.03.2019 | Application refused, date of legal effect [2019/31] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 29.03.2018 | Fees paid | Renewal fee | 27.12.2013 | Renewal fee patent year 03 | 29.12.2014 | Renewal fee patent year 04 | 28.12.2015 | Renewal fee patent year 05 | 27.12.2016 | Renewal fee patent year 06 | 27.12.2017 | Renewal fee patent year 07 | 31.12.2018 | Renewal fee patent year 08 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [L]US6303618 (GRIFFIN ROGER J [GB], et al) [L] 1-15 * column 43, line l *; | [X]US2004214258 (WOOD KEITH V [US], et al) [X] 1-9 * paragraphs [0162] , [0165] *; | [X]US2006149073 (TANAKA SHINJI [JP], et al) [X] 1-9 * paragraph [0021] *; | [X] - GEORGYI V. LOS ET AL, "HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis", ACS CHEMICAL BIOLOGY, (2008), vol. 3, no. 6, pages 373 - 382, XP055027634 [X] 1-9,11-13 * figure 1 * DOI: http://dx.doi.org/10.1021/cb800025k | [XP] - TAAVI K NEKLESA ET AL, "Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins", NATURE CHEMICAL BIOLOGY, GB, (20110703), vol. 7, no. 8, pages 538 - 543, XP055271644 [XP] 1-13,15 * figure 2 * DOI: http://dx.doi.org/10.1038/nchembio.597 | [A] - STEFAN BECK ET AL, "Fluorophore-assisted light inactivation: A high-throughput tool for direct target validation of proteins", PROTEOMICS, (2002), vol. 2, pages 247 - 255, XP055272458 [A] 14 * the whole document * DOI: http://dx.doi.org/10.1002/1615-9861(200203)2:3<247::AID-PROT247>3.0.CO;2-K | [L] - Marco Engeler, "Anthracene", (20160511), URL: http://www.chemexper.com/searchResult.shtml?format=ccd2013%2Cccd&target=structure&options=brandqtyoffercrm&searchValue=120127&searchTemplate=rn.value%3D%22%3F%22&Search=Search, (20160511), XP055272008 [L] * the whole document * | [L] - Anonymous, "Fluorescein sodium - 518-47-8 - Catalog of Chemical Suppliers", (20160512), URL: https://www.chemexper.com/chemicals/supplier/cas/518-47-8+Fluorescein+sodium.html, (20160512), XP055272421 [L] * the whole document * | [X] - SO M K ET AL, "HaloTag protein-mediated specific labeling of living cells with quantum dots", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2008), vol. 374, no. 3, pages 419 - 423, XP023783831 [X] 1-9 * Scheme 2 * DOI: http://dx.doi.org/10.1016/j.bbrc.2008.07.004 | [T] - HYUN SEOP TAE ET AL, "Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins", CHEMBIOCHEM, (20120305), vol. 13, no. 4, pages 538 - 541, XP055119230 [T] 1-15 * the whole document * DOI: http://dx.doi.org/10.1002/cbic.201100793 | International search | [A]US2004163138 (REED JOHN C [US], et al); | [X] - LOS, G. V. ET AL., "HaloTag: A novel protein labeling technology for cell imaging and protein analysis", ACS CHEMICAL BIOLOGY, (20080606), vol. 3, no. 6, pages 373 - 382, XP055027634 DOI: http://dx.doi.org/10.1021/cb800025k | [Y] - "HT2 [Expression vector pHT2]", GENBANK, (20041201), Database accession no. AAV70825.1, XP003030213 | [Y] - "HaloTag protein [HaloTag control vector]", GENBANK, (20100921), Database accession no. ADN27525.1, XP003030214 | [XP] - NEKLESA, T. K. ET AL., "Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins", NAT CHEM BIOL., (20110703), vol. 7, no. 8, pages 538 - 543, XP055118191 DOI: http://dx.doi.org/10.1038/nchembio.597 | [A] - KUBOTA, H. ET AL., "Quality control against misfolded proteins in the cytosol: a network for cell survival", J. BIOCHEM., (20090907), vol. 146, no. 5, pages 609 - 616, XP055118193 DOI: http://dx.doi.org/10.1093/jb/mvp139 |