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Extract from the Register of European Patents

EP About this file: EP2518074

EP2518074 - Phosphoinositide 3-kinase inhibitor compounds and methods of use [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.05.2016
Database last updated on 20.07.2024
Most recent event   Tooltip06.10.2017Lapse of the patent in a contracting state
New state(s): BG, CY, HU, MT, NL		published on 08.11.2017  [2017/45]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
For all designated states
Genentech, Inc.
1 DNA Way, MS49
South San Francisco, CA 94080-4990 / US
[N/P]
Former [2012/44]For all designated states
F.Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
For all designated states
Genentech, Inc.
1 DNA Way, MS49
South San Francisco, CA 94080-4990 / US
Inventor(s)01 / Bayliss, Tracy
Grenzacherstrasse 124
4070 Basel / CH
02 / Cchuckowree, Irina
Grenzacherstrasse 124
4070 Basel / CH
03 / Folkes, Adrian
Grenzacherstrasse 124
4070 Basel / CH
04 / Oxenford, Sally
Grenzacherstrasse 124
4070 Basel / CH
05 / Wan, Nan Chi
Grenzacherstrasse 124
4070 Basel / CH
06 / Castanedo, Georgette
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
07 / Goldsmith, Richard
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
08 / Gunzer, Janet
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
09 / Heffron, Tim
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
10 / Mathieu, Simon
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
11 / Olivero, Alan
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
12 / Staben, Steven
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
13 / Sutherlin, Daniel P
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
14 / Zhu, Bing-Yang
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
 [2013/08]
Former [2012/44]01 / Bayliss, Tracy
957 Buckingham Avenue
Slough, Berkshire SL1 4NL / GB
02 / Cchuckowree, Irina
957 Buckingham Avenue
Slough, Berkshire SL1 4NL / GB
03 / Folkes, Adrian
957 Buckingham Avenue
Slough, Berkshire SL1 4NL / GB
04 / Oxenford, Sally
957 Buckingham Avenue
Slough, Berkshire SL1 4NL / GB
05 / Wan, Nan Chi
957 Buckingham Avenue
Slough, Berkshire SL1 4NL / GB
06 / Castanedo, Georgette
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
07 / Goldsmith, Richard
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
08 / Gunzer, Janet
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
09 / Heffron, Tim
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
10 / Mathieu, Simon
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
11 / Olivero, Alan
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
12 / Staben, Steven
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
13 / Sutherlin, Daniel P
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
14 / Zhu, Bing-Yang
1 DNA Way, MS-49
South San Francisco, CA California 94080 / US
Representative(s)Keen, Celia Mary
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
[2012/44]
Application number, filing date12177885.605.12.2007
[2012/44]
Priority number, dateUS20060873448P07.12.2006         Original published format: US 873448 P
US20070977257P03.10.2007         Original published format: US 977257 P
[2012/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2518074
Date:31.10.2012
Language:EN
[2012/44]
Type: B1 Patent specification 
No.:EP2518074
Date:22.07.2015
Language:EN
[2015/30]
Search report(s)(Supplementary) European search report - dispatched on:EP10.09.2012
ClassificationIPC:C07D491/04, C07D495/04, A61K31/5377, A61K31/519, A61P35/00
[2012/44]
CPC:
A61K31/5377 (EP,US); C07D495/04 (EP,KR,US); A61K31/519 (EP,KR,US);
A61P1/16 (EP); A61P17/02 (EP); A61P17/06 (EP);
A61P19/00 (EP); A61P25/00 (EP); A61P25/06 (EP);
A61P25/28 (EP); A61P29/00 (EP); A61P3/10 (EP);
A61P31/04 (EP); A61P31/12 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P35/04 (EP); A61P37/02 (EP);
A61P37/06 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P5/00 (EP); A61P7/02 (EP); A61P9/00 (EP);
A61P9/10 (EP); C07D413/14 (EP,US); C07D491/04 (EP,KR,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/30]
Former [2012/44]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesAL30.04.2013
BA30.04.2013
HR30.04.2013
MK30.04.2013
RS30.04.2013
TitleGerman:Phosphoinositid-3-Kinase-Hemmer-Verbindungen und Verfahren zur Verwendung[2012/44]
English:Phosphoinositide 3-kinase inhibitor compounds and methods of use[2012/44]
French:Composés inhibiteurs de phosphoinositide 3-kinase et procédés d'utilisation[2012/44]
Examination procedure30.04.2013Amendment by applicant (claims and/or description)
30.04.2013Examination requested  [2013/24]
14.08.2013Despatch of a communication from the examining division (Time limit: M06)
21.03.2014Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
02.06.2014Reply to a communication from the examining division
27.06.2014Despatch of a communication from the examining division (Time limit: M06)
07.01.2015Reply to a communication from the examining division
04.02.2015Communication of intention to grant the patent
03.06.2015Fee for grant paid
03.06.2015Fee for publishing/printing paid
03.06.2015Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP07854962.3  / EP2114949
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20070854962) is  16.07.2010
Opposition(s)25.04.2016No opposition filed within time limit [2016/26]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
02.06.2014Request for further processing filed
02.06.2014Full payment received (date of receipt of payment)
Request granted
18.06.2014Decision despatched
Fees paidRenewal fee
25.07.2012Renewal fee patent year 03
25.07.2012Renewal fee patent year 04
25.07.2012Renewal fee patent year 05
11.12.2012Renewal fee patent year 06
06.12.2013Renewal fee patent year 07
05.12.2014Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.12.2007
AT22.07.2015
BE22.07.2015
BG22.07.2015
CY22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
MC22.07.2015
MT22.07.2015
NL22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SI22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
IE05.12.2015
LU05.12.2015
[2017/39]
Former [2017/03]AT22.07.2015
BE22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
MC22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SI22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
IE05.12.2015
LU05.12.2015
Former [2016/45]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
MC22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SI22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
IE05.12.2015
LU05.12.2015
BE31.12.2015
Former [2016/36]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
MC22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SI22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
LU05.12.2015
BE31.12.2015
Former [2016/34]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
MC22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
LU05.12.2015
BE31.12.2015
Former [2016/33]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
MC22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
BE31.12.2015
Former [2016/24]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
BE31.12.2015
Former [2016/23]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
PL22.07.2015
RO22.07.2015
SE22.07.2015
SK22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
Former [2016/22]AT22.07.2015
CZ22.07.2015
DK22.07.2015
EE22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
PL22.07.2015
SE22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
Former [2016/20]AT22.07.2015
DK22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
PL22.07.2015
SE22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
Former [2016/11]AT22.07.2015
FI22.07.2015
LT22.07.2015
LV22.07.2015
PL22.07.2015
SE22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
Former [2016/10]FI22.07.2015
LT22.07.2015
LV22.07.2015
PL22.07.2015
SE22.07.2015
GR23.10.2015
IS22.11.2015
PT23.11.2015
Former [2016/09]FI22.07.2015
LT22.07.2015
LV22.07.2015
GR23.10.2015
Former [2016/07]LT22.07.2015
Documents cited:Search[ID]WO2006046040  (PIRAMED LTD [GB], et al) [ID] 1-15 * page 2, line 9 - page 4, line 14; example 6; compound 178 *;
 [AD]WO2006046031  (PIRAMED LTD [GB], et al) [AD] 1-15 * page 2, line 8 - page 3, line 22 *;
 [AD]WO2006046035  (PIRAMED LTD [GB], et al) [AD] 1-15 * page 2, line 8 - page 3, line 23 *;
 [IP]WO2007127175  (PIRAMED LTD [GB], et al) [IP] 1-15 * page 14, line 20 - page 17, line 6; compounds 5,25,39,77,78,81-84,87,88 *
by applicantUS5824492
 US5846824
 US6274327
 US7173029
 US7037915
 US6608056
 US6608053
 US6838457
 US6770641
 US6653320
 US6403588
 US6703414
 WO9715658
 WO2006046031
 WO2006046035
 WO2006046040
 WO2007042806
 WO2007042810
 WO2004017950
 US2004092561
 WO2004007491
 WO2004006916
 WO03037886
 US2003149074
 WO03035618
 WO03034997
 US2003158212
 EP1417976
 US2004053946
 JP2001247477
 JPH08175990
 JPH08176070
 WO2007122410
 WO2007127183
 WO2007127175
 US6492383
 US6232320
 US6187777
 US3763156
 US3661908
 US3475429
 US5075305
 US2003220365
 GB1393161
 WO9313664
 US6448433
 WO9615111
 US5583024
 US5674713
 US5700670
 US6602677
 US3773919
 WO2007084786
    - RAMEH ET AL., J. BIOL CHEM, (1999), vol. 274, pages 8347 - 8350
    - PANAYOTOU ET AL., TRENDS CELL BIOL, (1992), vol. 2, pages 358 - 60
    - WHITMAN ET AL., NATURE, (1988), vol. 332, page 664
    - VIVANCO ET AL., NATURE REV. CANCER, (2002), vol. 2, page 489
    - PHILLIPS ET AL., CANCER, (1998), vol. 83, page 41
    - WORKMAN P, BIOCHEM SOC TRANS, (2004), vol. 32, pages 393 - 396
    - YAGUCHI ET AL., JOUR. OF THE NAT. CANCER INST, (2006), vol. 98, no. 8, pages 545 - 556
    - The Chemistry of Heterocyclic Compounds, A series of Monographs, JOHN WILEY & SONS, (1950), vol. 13, 14,
    - J. AM. CHEM. SOC., (1960), vol. 82, page 5566
    - ANGEW CHEM. INTL. ED. ENGL., (1994), vol. 33, pages 183 - 186
    - WILMAN, "Prodrugs in Cancer Chemotherapy", BIOCHEMICAL SOCIETY TRANSACTIONS, (1986), vol. 14, pages 375 - 382
    - "Prodrugs: A Chemical Approach to Targeted Drug Delivery", STELLA ET AL., Directed Drug Delivery, HUMANA PRESS, (1985), pages 247 - 267
    - MIYAURA ET AL., CHEM. REV., (1995), vol. 95, pages 2457 - 2483
    - SUZUKI, A., J. ORGANOMET. CHEM., (1999), vol. 576, pages 147 - 168
    - SUZUKI, A., Metal-Catalyzed Cross-Coupling Reactions, Diederich, VCH, (1998), pages 49 - 97
    - OWENS ET AL., BIOORGANIC & MED. CHEM. LETTERS, (2003), vol. 13, pages 4143 - 4145
    - MOLANDER ET AL., ORGANIC LETTERS, (2002), vol. 4, no. 11, pages 1867 - 1870
    - LOCHMULLER, C. H., J. CHROMATOGR., (1975), vol. 113, no. 3, pages 283 - 302
    - E.; WILEN, S., Stereochemistry of Organic Compounds, JOHN WILEY & SONS, INC., (1994), page 322
    - JACOB III., J. ORG. CHEM., (1982), vol. 47, page 4165
    - OKAMOTO, J. CHROMATOGR., (1990), vol. 513, pages 375 - 378
    - J. IMMUNOL. METH., (1993), vol. 160, pages 81 - 88
    - CREE ET AL., ANTICANCER DRUGS, (1995), vol. 6, pages 398 - 404
    - Remington's Pharmaceutical Sciences, MACK PUBLISHING CO.
    - J. MED. CHEM., (1996), vol. 39, page 10
    - K. WIDDER, ET AL., Methods in Enzymology, ACADEMIC PRESS, (1985), vol. 42, pages 309 - 396
    - "Design and Application of Prodrugs", H. BUNDGAARD, A Textbook of Drug Design and Development, (1991), pages 113 - 191
    - H. BUNDGAARD, ADVANCED DRUG DELIVERY REVIEWS, (1992), vol. 8, pages 1 - 38
    - H. BUNDGAARD ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, (1988), vol. 77, page 285
    - N. KAKEYA ET AL., CHEM. PHARM. BULL., (1984), vol. 32, page 692
    - KUMAR ET AL., J. LABEL COMPD. RADIOPHARM., (2003), vol. 46, pages 1055 - 1065
    - MENDOZA ET AL., CANCER RES., (2002), vol. 62, pages 5485 - 5488
 US20070789423
 US20060873422
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.