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EP About this file: EP2686314

EP2686314 - 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 16.12.2016 Database last updated on 02.11.2024
Most recent event Tooltip	16.12.2016	Application deemed to be withdrawn	published on 18.01.2017 [2017/03]
Applicant(s)	For all designated states F. Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel / CH
	[N/P]
Former [2014/04]	For all designated states F.Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel / CH
Inventor(s)	01 / FENG, Jianwen c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 / US
	02 / LOKE, Pui Leng 114 Milton Park Abingdon, Oxfordshire OX14 4SA / GB
	03 / MONTALBETTI, Christian A.G.N. 114 Milton Park Abingdon, Oxfordshire OX14 4SA / GB
	04 / STABEN, Steven c/o Genentech, Inc. 1 DNA Way South San Francisco, California 94080 / US
	[N/P]
Former [2014/04]	01 / FENG, Jianwen c/o Genentech Inc. 1 DNA Way South San Francisco, California 94080 / US
	02 / LOKE, Pui Leng 114 Milton Park Abingdon, Oxfordshire OX14 4SA / GB
	03 / MONTALBETTI, Christian A.G.N. 114 Milton Park Abingdon, Oxfordshire OX14 4SA / GB
	04 / STABEN, Steven c/o Genentech Inc. 1 DNA Way South San Francisco, California 94080 / US
Representative(s)	Schirlin, Julien F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel / CH
	[2014/04]
Application number, filing date	12710902.3	15.03.2012
	WO2012EP54518
Priority number, date	US201161453494P	16.03.2011 Original published format: US 201161453494 P
	[2014/04]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2012123522
	Date:	20.09.2012
	Language:	EN
	[2012/38]
	Type:	A1 Application with search report
	No.:	EP2686314
	Date:	22.01.2014
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 20.09.2012 takes the place of the publication of the European patent application.
	[2014/04]
Search report(s)	International search report - published on:	EP	20.09.2012
Classification	IPC:	C07D491/08, C07F7/08	[2016/14]
	CPC:	C07D401/14 (EP,US); C07D417/14 (EP,KR,US); C07F7/0805 (US); A61K31/506 (KR); A61P1/00 (EP); A61P1/04 (EP); (+) A61P11/00 (EP); A61P11/02 (EP); A61P11/06 (EP); A61P15/00 (EP); A61P15/08 (EP); A61P17/00 (EP); A61P17/06 (EP); A61P19/02 (EP); A61P19/08 (EP); A61P25/00 (EP); A61P29/00 (EP); A61P29/02 (EP); A61P35/00 (EP); A61P35/02 (EP); A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP); C07D403/04 (EP,US); C07D403/14 (EP,US); C07D405/14 (EP,US); C07D413/14 (EP,US); C07D487/04 (EP,US); C07D491/08 (EP,US); C07D491/10 (EP,US); C07D491/107 (EP,US) (-)
	Former IPC [2014/04]	C07D401/14, C07D403/04, C07D403/14, C07D405/14, C07D413/14, C07D417/14, C07D487/04, C07D491/10, A61K31/506, A61K31/53, A61P29/00, A61P35/00
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/04]
Title	German:	6,5-HETEROCYCLISCHE PROPARGYLALKOHOLVERBINDUNGEN UND DEREN VERWENDUNG	[2016/14]
	English:	6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR	[2014/04]
	French:	COMPOSÉS D'ALCOOL PROPARGYLIQUE 6,5-HÉTÉROCYCLIQUES ET LEUR UTILISATION	[2016/14]
	Former [2014/04]	6,5-HETEROCYCLISCHE PROPARGYLALKOHOLVERBINDUNGEN UND IHRE VERWENDUNGEN
	Former [2014/04]	COMPOSÉS D'ALCOOL PROPARGYLIQUE 6,5-HÉTÉROCYCLIQUES ET UTILISATIONS DE CEUX-CI
Entry into regional phase	16.10.2013	National basic fee paid
	16.10.2013	Designation fee(s) paid
	16.10.2013	Examination fee paid
Examination procedure	16.10.2013	Examination requested [2014/04]
	12.05.2014	Amendment by applicant (claims and/or description)
	16.09.2014	Despatch of a communication from the examining division (Time limit: M06)
	18.03.2015	Reply to a communication from the examining division
	31.03.2015	Despatch of a communication from the examining division (Time limit: M06)
	06.10.2015	Reply to a communication from the examining division
	16.03.2016	Communication of intention to grant the patent
	26.07.2016	Fee for grant paid
	26.07.2016	Fee for publishing/printing paid
	27.07.2016	Application deemed to be withdrawn, date of legal effect [2017/03]
	01.09.2016	Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time [2017/03]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 16.09.2014
Fees paid	Renewal fee
	10.03.2014	Renewal fee patent year 03
	06.03.2015	Renewal fee patent year 04
	08.03.2016	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[X]WO2005054230 (CYTOPIA RES PTY LTD [AU], et al) [X] 1-3,5-7,22,29 * claims 1,3-12 *;
		[A]WO2007058850 (SMITHKLINE BEECHAM CORP [US], et al) [A] 1,2,4,17-32* examples 1-10; claims 1-42 *;
		[XI]WO2008043019 (PHARMACOPEIA INC [US], et al) [X] 1-3,5,6,8-11,14,15,22-32 * table, compounds 93-96, 105, 107-110; paragraphs [00132] , [00164] , [00173]; claims 1,7-14,22-24,26 * [I] 21;
		[AD]WO2009158011 (AMGEN INC [US], et al) [AD] 1,2,4,17-32 * examples1-11,16-31,34-36,39-58,61-82,93-96,98-103, 107,108,111-116,119-140,180-236;; claims 1-27 *;
		[A]WO2010071837 (VERTEX PHARMA [US], et al) [A] 1-3,10,22,28 * claim 167, compound I-111; page 2; claims 115,167,168,169,177 *;
		[XP]WO2012012478 (MERCK SHARP & DOHME [US], et al) [XP] 1-3,5-10,15,16,22 * examples 75,80-82,92,93,99,140,150,152,319,397,401; claims 1-3,9,10,13,18 *;
		[XI] - CHEN ET AL, "Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, (20061101), vol. 16, no. 21, doi:10.1016/J.BMCL.2006.08.022, ISSN 0960-894X, pages 5633 - 5638, XP005663508 [X] 1-3,5-8,22-32 * table 1, compound 17; page 5633 - page 5635 * [I] 21 DOI: http://dx.doi.org/10.1016/j.bmcl.2006.08.022
		[X] - ALTMEYER M A ET AL, "Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 20, no. 14, ISSN 0960-894X, (20100715), pages 4038 - 4044, (20100527), XP027103980 [X] 1,3,5,22,28 * table 1, compound 30; page 4038 *
	by applicant	US3773919
		WO2009158011
		- MALININ, NL ET AL., NATURE, (1997), vol. 385, pages 540 - 4
		- BERGE, S. M. ET AL., "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, (1977), vol. 66, doi:doi:10.1002/jps.2600660104, pages 1 - 19, XP002675560 DOI: http://dx.doi.org/10.1002/jps.2600660104
		- FLEISHER, D. ET AL., "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", ADVANCED DRUG DELIVERY REVIEWS, (1996), vol. 19, doi:doi:10.1016/0169-409X(95)00103-E, page 115, XP002478093 DOI: http://dx.doi.org/10.1016/0169-409X(95)00103-E
		- J. MED. CHEM., (1996), vol. 39, page 10
		- Methods in Enzymology, ACADEMIC PRESS, (1985), vol. 42, pages 309 - 396
		- "Design and Application of Prodrugs", H. BUNDGAARD, A Textbook of Drug Design and Development, (1991), pages 113 - 191
		- BUNDGAARD, ADVANCED DRUG DELIVERY REVIEWS, (1992), vol. 8, pages 1 - 38
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		- CHINCILLA, C.; NDJERA, C., CHEM. REV., (2007), vol. 107, pages 874 - 922
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		- ORGANIC SYNTHESES, (1988), vol. 6, page 601
		- CHINCHILLA, R.; NAJERA, C., "The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry", CHEM. REV., (2007), vol. 107, doi:doi:10.1021/cr050992x, pages 874 - 922, XP055083001 DOI: http://dx.doi.org/10.1021/cr050992x

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