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Extract from the Register of European Patents

EP About this file: EP2702172

EP2702172 - METHOD FOR DETERMINING CLINICALLY RELEVANT HYPOXIA IN CANCER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.11.2020
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  05.12.2019
FormerGrant of patent is intended
Status updated on  16.07.2019
FormerExamination is in progress
Status updated on  27.01.2017
Most recent event   Tooltip29.07.2022Lapse of the patent in a contracting state
New state(s): FR		published on 31.08.2022  [2022/35]
Applicant(s)For all designated states
Aarhus Universitet
Nordre Ringgade 1
8000 Aarhus C / DK
[2015/01]
Former [2014/10]For all designated states
Overgaard, Jens
Strandvejen 134
8000 Aarhus C / DK
For all designated states
Sørensen, Brita Singers
Højager 1
8530 Hjortshøj / DK
For all designated states
Alsner, Jan
Hjulbjergvej 48C
8270 Højbjerg / DK
For all designated states
Wiuf, Carsten
Serridslevvej 16 3.4
2100 København Ø / DK
For all designated states
Nordsmark, Marianne
Fortebakken 9
8240 Risskov / DK
For all designated states
Toustrup, Kasper
P.S. Krøyers Vej 30
8270 Højbjerg / DK
Inventor(s)01 / Overgaard, Jens
Strandvejen 134
8000 Århus C / DK
02 / Sørensen, Brita Singers
Højager 1
8530 Hjortshøj / DK
03 / Toustrup, Kasper
P.S. Krøyers Vej 30
8270 Højbjerg / DK
04 / Alsner, Jan
Hjulbjergvej 48C
8270 Højbjeg / DK
05 / Wiuf, Carsten
Serridslevvej 16, 3.4
2100 København Ø / DK
06 / Nordsmark, Marianne
Fortebakken 9
8240 Risskov / DK
 [2020/01]
Former [2015/01]01 / Overgaard, Jens
Strandvejen 134
8000 Århus C / DK
02 / Sørensen, Brita Singers
Højager 1
8530 Hjortshøj / DK
03 / Toustrup, Kasper
P.S. Krøyers Vej 30
8270 Højbjerg / DK
04 / Alsner, Jan
Hjulbjergvej 48C
8270 Højbjeg / DK
05 / Wiuf, Carsten
Serridslevvej 16 3.4
2100 København Ø / DK
06 / Nordsmark, Marianne
Fortebakken 9
8240 Risskov / DK
Former [2014/10]01 / see applicant
...
Representative(s)Høiberg P/S
Adelgade 12
1304 Copenhagen K / DK
[2020/01]
Former [2014/10]Høiberg A/S
St. Kongensgade 59 A
1264 Copenhagen K / DK
Application number, filing date12724283.230.04.2012
[2020/01]
WO2012DK50144
Priority number, dateDK2011007021229.04.2011         Original published format: DK 201170212
[2014/10]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012146259
Date:01.11.2012
Language:EN
[2012/44]
Type: A1 Application with search report 
No.:EP2702172
Date:05.03.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 01.11.2012 takes the place of the publication of the European patent application.
[2014/10]
Type: B1 Patent specification 
No.:EP2702172
Date:01.01.2020
Language:EN
[2020/01]
Search report(s)International search report - published on:EP01.11.2012
ClassificationIPC:C12Q1/6886
[2019/27]
CPC:
C12Q1/6886 (EP,US); A61K31/5377 (EP,US); A61K45/06 (US);
A61N5/10 (US); A61P35/00 (EP); A61P43/00 (EP);
G01N33/4925 (US); A61N2005/1098 (US); C12Q2600/106 (EP,US);
C12Q2600/112 (EP,US); C12Q2600/118 (US); C12Q2600/158 (US) (-)
Former IPC [2014/10]C12Q1/68, A61K31/415, A61K31/4164
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/10]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR BESTIMMUNG VON KLINISCH RELEVANTER HYPOXIE BEI KREBS[2014/10]
English:METHOD FOR DETERMINING CLINICALLY RELEVANT HYPOXIA IN CANCER[2014/10]
French:MÉTHODE DE DÉTERMINATION DE LA PRÉSENCE D'UNE HYPOXIE CLINIQUEMENT PERTINENTE EN CAS DE CANCER[2014/10]
Entry into regional phase29.11.2013National basic fee paid 
29.11.2013Designation fee(s) paid 
29.11.2013Examination fee paid 
Examination procedure29.11.2013Examination requested  [2014/10]
20.06.2014Amendment by applicant (claims and/or description)
30.01.2017Despatch of a communication from the examining division (Time limit: M06)
09.08.2017Reply to a communication from the examining division
17.07.2019Communication of intention to grant the patent
22.11.2019Fee for grant paid
22.11.2019Fee for publishing/printing paid
22.11.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.01.2017
Opposition(s)02.10.2020No opposition filed within time limit [2020/50]
Fees paidRenewal fee
28.04.2014Renewal fee patent year 03
08.04.2015Renewal fee patent year 04
18.04.2016Renewal fee patent year 05
20.04.2017Renewal fee patent year 06
24.10.2018Renewal fee patent year 07
26.04.2019Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
30.04.201807   M06   Fee paid on   24.10.2018
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.04.2012
AL01.01.2020
AT01.01.2020
CY01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
MK01.01.2020
MT01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
TR01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
FR30.04.2020
GB30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
[2022/35]
Former [2022/31]HU30.04.2012
AL01.01.2020
AT01.01.2020
CY01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
MK01.01.2020
MT01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
TR01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
GB30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2022/30]HU30.04.2012
AL01.01.2020
AT01.01.2020
CY01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
MT01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
TR01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
GB30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2022/27]HU30.04.2012
AT01.01.2020
CY01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
MT01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
TR01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
GB30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2022/26]AT01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
TR01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
GB30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2021/22]AT01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
GB30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2021/20]AT01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
IE30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2021/10]AT01.01.2020
CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
IT01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
NL01.01.2020
PL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SI01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
BE30.04.2020
CH30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2021/08]CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
NL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
CH30.04.2020
LI30.04.2020
LU30.04.2020
IS01.05.2020
PT27.05.2020
Former [2020/52]CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
MC01.01.2020
NL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
IS01.05.2020
PT27.05.2020
Former [2020/50]CZ01.01.2020
EE01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
IS01.05.2020
PT27.05.2020
Former [2020/49]CZ01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SK01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
IS01.05.2020
PT27.05.2020
Former [2020/48]CZ01.01.2020
ES01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RO01.01.2020
RS01.01.2020
SE01.01.2020
SM01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
IS01.05.2020
PT27.05.2020
Former [2020/40]CZ01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RS01.01.2020
SE01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
IS01.05.2020
PT27.05.2020
Former [2020/39]CZ01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RS01.01.2020
SE01.01.2020
BG01.04.2020
NO01.04.2020
GR02.04.2020
PT27.05.2020
Former [2020/38]CZ01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RS01.01.2020
SE01.01.2020
NO01.04.2020
GR02.04.2020
PT27.05.2020
Former [2020/37]CZ01.01.2020
FI01.01.2020
HR01.01.2020
LT01.01.2020
LV01.01.2020
NL01.01.2020
RS01.01.2020
SE01.01.2020
NO01.04.2020
PT27.05.2020
Former [2020/36]CZ01.01.2020
FI01.01.2020
LT01.01.2020
NL01.01.2020
RS01.01.2020
NO01.04.2020
PT27.05.2020
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FI01.01.2020
LT01.01.2020
NL01.01.2020
NO01.04.2020
Former [2020/33]NL01.01.2020
Cited inInternational search[A] WO2008154927  (GENMAB AS et al.)
 [IY]   BRITA SINGERS SRENSEN ET AL: "Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro", ACTA ONCOLOGICA, vol. 49, no. 7, 1 October 2010 (2010-10-01), pages 895 - 905, XP055011557, ISSN: 0284-186X, DOI: 10.3109/02841861003614343

DOI:   http://dx.doi.org/10.3109/02841861003614343
 [XY]   JENS OVERGAARD: "Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck - A systematic review and meta-analysis", RADIOTHERAPY AND ONCOLOGY, vol. 100, no. 1, 19 April 2011 (2011-04-19), pages 22 - 32, XP055011177, ISSN: 0167-8140, DOI: 10.1016/j.radonc.2011.03.004

DOI:   http://dx.doi.org/10.1016/j.radonc.2011.03.004
 [XY]   L. B. HARRISON: "Impact of Tumor Hypoxia and Anemia on Radiation Therapy Outcomes", THE ONCOLOGIST, vol. 7, no. 6, 1 December 2002 (2002-12-01), pages 492 - 508, XP055011170, ISSN: 1083-7159, DOI: 10.1634/theoncologist.7-6-492

DOI:   http://dx.doi.org/10.1634/theoncologist.7-6-492
 [I]   KELEG SHEREEN ET AL: "Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, US, vol. 121, 1 January 2007 (2007-01-01), pages 21 - 32, XP002496945, ISSN: 0020-7136, [retrieved on 20070208], DOI: 10.1002/IJC.22596

DOI:   http://dx.doi.org/10.1002/ijc.22596
 [A]   ROBERT G. BRISTOW ET AL: "Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability", NATURE REVIEWS CANCER, vol. 8, no. 3, 1 March 2008 (2008-03-01), pages 180 - 192, XP055011090, ISSN: 1474-175X, DOI: 10.1038/nrc2344

DOI:   http://dx.doi.org/10.1038/nrc2344
Examination  K. TOUSTRUP ET AL: "Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer", CANCER RESEARCH, vol. 71, no. 17, 1 September 2011 (2011-09-01), pages 5923 - 5931, XP055011554, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-1182 [P]

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-11-1182
by applicant  MOON ET AL.: "The potential role of intrinsic hypoxia markers as prognostic variables in cancer", ANTIOXID REDOX SIGNAL, vol. 9, 2007, pages 1237 - 1294
   CHI ET AL.: "Gene expression programs in response to hypoxia: Cell type specificity and prognostic significance in human cancers", PLOS MED, vol. 3, 2006, pages E47
   WINTER ET AL.: "Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers", CANCER RES, vol. 67, 2007, pages 3441 - 3449
   BUFFA ET AL.: "Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene", BR J CANCER, vol. 102, 2010, pages 428 - 435
   SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
   NEEDLEMAN; WUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
   PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. (U.S.A., vol. 85, 1988, pages 2444
   M. KANEHISA, NUCLEIC ACIDS RES., vol. 12, 1984, pages 203
   SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", vol. 1-3, 1989, COLD SPRING HARBOR LABORATORY
   "Current Protocols in Molecular Biology", 1987, GREENE PUBLISHING AND WILEY-INTERSCIENCE
   "Remington: The Science and Practice of Pharmacy", 2000, LIPPINCOTT WILLIAMS & WILKINS
   REMINGTON'S PHARMACEUTICAL SCIENCES, 1980
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.