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Extract from the Register of European Patents

EP About this file: EP2668207

EP2668207 - PATHOGENIC MYCOBACTERIA-DERIVED MANNOSE-CAPPED LIPOARABINOMANNAN ANTIGEN BINDING PROTEINS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  22.02.2019
Database last updated on 07.10.2024
FormerGrant of patent is intended
Status updated on  23.05.2018
FormerExamination is in progress
Status updated on  23.12.2016
Most recent event   Tooltip22.02.2019Application deemed to be withdrawnpublished on 27.03.2019  [2019/13]
Applicant(s)For all designated states
National University of Singapore
21 Lower Kent Ridge Road
Singapore 119077 / SG
For all designated states
DSO National Laboratories
20 Science Park Drive
Singapore 118230 / SG
[2013/49]
Inventor(s)01 / MACARY, Paul Anthony
c/o National University of Singapore
Yong Loo Lin School of Medicine
Department of Microbiology
21 Lower Kent Ridge Road
Singapore 119077 / SG
02 / CHAN, Conrad En Zuo
c/o National University of Singapore
Yong Loo Lin School of Medicine
Department of Microbiology
21 Lower Kent Ridge Road
Singapore 119077 / SG
03 / HANSON, Brendon John
c/o DSO National Laboratories
20 Science Park Drive
Singapore 118230 / SG
04 / WENK, Markus R
c/o National University of Singapore
Yong Loo Lin School of Medicine
Department of Biochemistry
21 Lower Kent Ridge Road
Singapore 119077 / SG
 [2013/49]
Representative(s)Goodfellow, Hugh Robin
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2013/49]
Application number, filing date12739329.625.01.2012
WO2012SG00022
Priority number, dateUS201161435396P24.01.2011         Original published format: US 201161435396 P
[2013/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012102679
Date:02.08.2012
Language:EN
[2012/31]
Type: A1 Application with search report 
No.:EP2668207
Date:04.12.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 02.08.2012 takes the place of the publication of the European patent application.
[2013/49]
Search report(s)International search report - published on:AU02.08.2012
(Supplementary) European search report - dispatched on:EP11.05.2015
ClassificationIPC:C07K16/12, G01N33/569, A61K39/40, A61P31/06
[2013/49]
CPC:
C07K16/1289 (EP,US); A61P31/06 (EP); G01N33/5695 (EP,US);
C07K2317/21 (EP,US); C07K2317/24 (EP,US); C07K2317/33 (EP,US);
C07K2317/52 (EP,US); C07K2317/522 (EP,US); C07K2317/55 (EP,US);
C07K2317/92 (EP,US); G01N2400/00 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/49]
TitleGerman:AUS KRANKHEITSERREGENDEN MYKOBAKTERIEN GEWONNENE MANNOSE-GEKAPSELTE LIPOARABINOMANNAN-ANTIGEN-BINDENDE PROTEINE[2013/49]
English:PATHOGENIC MYCOBACTERIA-DERIVED MANNOSE-CAPPED LIPOARABINOMANNAN ANTIGEN BINDING PROTEINS[2013/49]
French:PROTÉINES DE LIAISON À L'ANTIGÈNE LIPOARABINOMANNANE COIFFÉ D'UN MANNOSE PROVENANT DE MYCOBACTÉRIES PATHOGÈNES[2013/49]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase23.08.2013National basic fee paid 
23.08.2013Search fee paid 
23.08.2013Designation fee(s) paid 
23.08.2013Examination fee paid 
Examination procedure23.08.2013Examination requested  [2013/49]
07.12.2015Amendment by applicant (claims and/or description)
04.05.2016Despatch of a communication from the examining division (Time limit: M04)
13.09.2016Reply to a communication from the examining division
13.12.2016Despatch of a communication from the examining division (Time limit: M06)
28.09.2017Reply to a communication from the examining division
24.05.2018Communication of intention to grant the patent
05.10.2018Application deemed to be withdrawn, date of legal effect  [2019/13]
09.11.2018Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2019/13]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.05.2016
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
28.09.2017Request for further processing filed
28.09.2017Full payment received (date of receipt of payment)
Request granted
09.10.2017Decision despatched
Fees paidRenewal fee
27.01.2014Renewal fee patent year 03
13.01.2015Renewal fee patent year 04
25.01.2016Renewal fee patent year 05
11.01.2017Renewal fee patent year 06
25.01.2018Renewal fee patent year 07
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Documents cited:Search[XI]WO2006078164  (SCHAPPELIJK ONDERZOEK EN PATIE [NL], et al) [X] 1,3,4,12,14 * page 9, line 27 - line 32 * * examples 1,2 * [I] 2,5-11,13,15;
 [I]  - B. HAMASUR ET AL, "A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab')2 fragment prolong survival of mice infected with Mycobacterium tuberculosis", CLINICAL & EXPERIMENTAL IMMUNOLOGY, (20041001), vol. 138, no. 1, doi:10.1111/j.1365-2249.2004.02593.x, ISSN 0009-9104, pages 30 - 38, XP055186233 [I] 5,11 * abstract * * page 31, column r, paragraph 4 - page 32, column l, paragraph 4 * * discussion;; figures 2-6 *

DOI:   http://dx.doi.org/10.1111/j.1365-2249.2004.02593.x
 [A]  - MCKAY BROWN ET AL, "Tolerance to single, but not multiple, amino acid replacements in antibody V-H CDR2: A means of minimizing B cell wastage from somatic hypermutation?", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19960101), vol. 156, no. 9, ISSN 0022-1767, pages 3285 - 3291, XP002649029 [A] 2-15 * abstract *
 [A]  - WARK K L ET AL, "Latest technologies for the enhancement of antibody affinity", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 58, no. 5-6, doi:10.1016/J.ADDR.2006.01.025, ISSN 0169-409X, (20060807), pages 657 - 670, (20060807), XP024892147 [A] 1-4 * page 659, column l, paragraph 3 *

DOI:   http://dx.doi.org/10.1016/j.addr.2006.01.025
International search[X]WO2005010151  (ABGENIX INC [US], et al);
 [X]WO2009094551  (AMGEN INC [US], et al);
 [X]  - DRIESSEN N.N. ET AL, "Role of Phosphatidylinositol Mannosides in the interaction between Mycobacteria and DC-SIGN", INFECTION AND IMMUNITY, (2009), vol. 77, no. 10, pages 4538 - 4547, XP055114219

DOI:   http://dx.doi.org/10.1128/IAI.01256-08
 [X]  - APPELMELK B.J. ET AL, "The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction", CELLULAR MICROBIOLOGY, (2008), vol. 10, no. 4, pages 930 - 944, XP055114220

DOI:   http://dx.doi.org/10.1111/j.1462-5822.2007.01097.x
by applicantUS3773919
 US4179337
 EP0036676
 US4301144
 EP0058481
 US4399216
 EP0088046
 US4496689
 EP0133988
 EP0143949
 US4640835
 US4670417
 WO8801649
 US4740461
 US4791192
 US4912040
 US4946778
 US4959455
 US5006309
 US5089424
 WO9203918
 WO9222645
 WO9222647
 WO9222670
 EP0546073
 WO9312227
 US5260203
 WO9400569
 WO9402602
 WO9425585
 WO9614436
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 US5545807
 US5545806
 WO9634096
 US5591669
 US5612205
 WO9713852
 US5625825
 US5625126
 EP0773288
 US5633425
 US5643763
 US5661016
 EP0546073
 US5721367
 EP0843961
 WO9824893
 WO9824884
 US5770429
 US5789650
 US5789215
 US5814318
 US5874299
 US5877397
 US5885793
 WO9925044
 US5939598
 US5981175
 US6023010
 US6075181
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 JP3068506B
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 US2012009196
    - APPELMELK et al., Cellular Microbiology, (20080000), vol. 10, pages 930 - 944
    - DRIESSEN et al., Infection and Immunity, (20090000), vol. 77, pages 4538 - 4547
    - HAMASUR et al., Clin Exp Immunol, (20040000), vol. 138, pages 30 - 38
    - NIGOU, J.; M. GILLERON; G. PUZO, "Lipoarabinomannans: from structure to biosynthesis", Biochimie, (20030000), vol. 85, no. 1-2, pages 153 - 66
    - GRAHAM et al., Virology, (19730000), vol. 52, page 456
    - CHU et al., Gene, (19810000), vol. 13, page 197
    - Griffin, A. M., and Griffin, H. G., Computer Analysis of Sequence Data, Humana Press, (19940000), 1
    - CARILLO et al., SIAM J. Applied Math., (19880000), vol. 48, page 1073
    - DEVEREUX et al., Nucl. Acid Res., (19840000), vol. 12, page 387
    - Genetics Computer Group, University of Wisconsin
    - DAYHOFF et al., Atlas of Protein Sequence and Structure, (19780000), vol. 5, pages 345 - 352
    - HENIKOFF et al., Proc. Natl. Acad. Sci. U.S.A., (19920000), vol. 89, pages 10915 - 10919
    - NEEDLEMAN et al., J. Mol. Biol., (19700000), vol. 48, pages 443 - 453
    - KYTE et al., J. Mol. Biol., (19820000), vol. 157, pages 105 - 131
    - FAUCHERE, J., Adv. Drug Res., (19860000), vol. 15, page 29
    - VEBER; FREIDINGER, TINS, (19850000), page 392
    - EVANS et al., J. Med. Chem., (19870000), vol. 30, page 1229
    - RIZO; GIERASCH, Ann. Rev. Biochem., (19920000), vol. 61, page 387
    - SONGSIVILAI; LACHMANN, Clin. Exp. Immunol., (19900000), vol. 79, pages 315 - 321
    - KOSTELNY et al., J. Immunol., (19920000), vol. 148, pages 1547 - 1553
    - CHOTHIA; LESK, J. Mol. Biol., (19870000), vol. 196, pages 901 - 917
    - CHOTHIA et al., Nature, (19890000), vol. 342, pages 878 - 883
    - JOHNSON; WU, Nucleic Acids Res., (20000000), vol. 28, pages 214 - 8
    - CHOTHIA et al., J. Mol. Biol., (19860000), vol. 196, pages 901 - 17
    - CHOTHIA et al., Nature, (19890000), vol. 342, pages 877 - 83
    - MARTIN et al., Proc Natl Acad Sci (USA, (19890000), vol. 86, pages 9268 - 9272
    - AbMTM, A Computer Program for Modeling Variable Regions of Antibodies, Oxford Molecular, Ltd.
    - SAMUDRALA et al., "Ab Initio Protein Structure Prediction Using a Combined Hierarchical Approach", PROTEINS, Structure, Function and Genetics, (19990000), vol. 3, pages 194 - 198, XP001146416
    - MACCALLUM et al., J. Mol. Biol., (19960000), vol. 5, pages 732 - 45
    - SONGSIVILAI et al., Clin. Exp. Immunol., (19900000), vol. 79, pages 315 - 321
    - STAHLI et al., Methods in Enzymology, (19830000), vol. 9, pages 242 - 253
    - KIRKLAND et al., J. Immunol., (19860000), vol. 137, pages 3614 - 3619
    - MOREL et al., Molec. Immunol., (19880000), vol. 25, pages 7 - 15
    - CHEUNG et al., Virology, (19900000), vol. 176, pages 546 - 552
    - MOLDENHAUER et al., Scand. J. Immunol., (19900000), vol. 32, pages 77 - 82
    - MOULT J., Curr. Op. in Biotech., (19960000), vol. 7, no. 4, pages 422 - 427
    - CHOU et al., Biochemistry, (19740000), vol. 13, no. 2, pages 222 - 245
    - CHOU et al., Biochemistry, (19740000), vol. 113, no. 2, pages 211 - 222
    - CHOU et al., Adv. Enzymol. Relat. Areas Mol. Biol., (19780000), vol. 47, pages 45 - 148
    - CHOU et al., Ann. Rev. Biochem., vol. 47, pages 251 - 276
    - CHOU et al., Biophys. J., (19790000), vol. 26, pages 367 - 384
    - HOLM et al., Nucl. Acid. Res., (19990000), vol. 27, no. 1, pages 244 - 247
    - BRENNER et al., Curr. Op. Struct. Biol., (19970000), vol. 7, no. 3, pages 369 - 376
    - JONES, D., Curr. Opin. Struct. Biol., (19970000), vol. 7, no. 3, pages 377 - 87
    - SIPPL et al., Structure, (19960000), vol. 4, no. 1, pages 15 - 19
    - BOWIE et al., Science, (19910000), vol. 253, pages 164 - 170
    - GRIBSKOV et al., Meth. Enzym., (19900000), vol. 183, pages 146 - 159
    - GRIBSKOV et al., Proc. Nat. Acad. Sci. USA, (19870000), vol. 84, no. 13, pages 4355 - 4358
    - THORNTON et al., Nature, (19910000), vol. 354, page 105
    - DAYHOFF, M. O., Atlas of Protein Sequence and Structure, National Biomedical Research Foundation, (19720000), vol. 5, pages 101 - 110
    - HUDSON, Curr. Opin. Biotech., (19990000), vol. 9, pages 395 - 402
    - CHOWDHURY; PASTAN, Nature Biotech., (19990000), vol. 17, pages 568 - 572
    - HOOGENBOOM et al., J. Mol. Biol., (19910000), vol. 227, page 381
    - MARKS et al., J Mol Biol, (19910000), vol. 222, page 581
    - MULLINAX et al., Proc Natl Acad Sci, (19900000), vol. 87, pages 8095 - 8099
    - MENDEZ et al., Nature Genetics, (19970000), vol. 15, pages 146 - 156
    - BRAMS et al., J. Immunol., (19980000), vol. 160, pages 2051 - 2058
    - CARBALLIDO et al., Nat. Med., (20000000), vol. 6, pages 103 - 106
    - MCCUNE et al., Science, (19880000), vol. 241, pages 1532 - 1639
    - LFVERSEN et al., Sem. Immunol., (19960000), vol. 8, pages 243 - 248
    - MARTENSSON et al., Immunol., (19940000), vol. 83, pages 1271 - 179
    - MOSIER et al., Nature, (19880000), vol. 335, pages 256 - 259
    - MARTENSSON et al., Immunol., (19950000), vol. 84, pages 224 - 230
    - MURPHY et al., Blood, (19950000), vol. 86, pages 1946 - 1953
    - ISHIDA et al., Cloning Stem Cells, (20020000), vol. 4, pages 91 - 102
    - SMITH et al., J. Virol., (19830000), vol. 46, page 584
    - ENGELHARD et al., Proc. Nat. Acad. Sci., (19940000), vol. 91, pages 3224 - 7
    - CAPALDI et al., Biochem. Biophys. Res. Comm., (19770000), vol. 76, page 425
    - SIDMAN et al., Biopolymers, (19830000), vol. 22, pages 547 - 556
    - LANGER et al., J. Biomed. Mater. Res., (19810000), vol. 15, pages 167 - 277
    - LANGER, Chem. Tech., (19820000), vol. 12, pages 98 - 105
    - EPPSTEIN et al., Proc. Natl. Acad. Sci. USA, (19850000), vol. 82, pages 3688 - 3692
    - OELLERICH, M., J. Clin. Chem. Clin. BioChem, (19840000), vol. 22, page 895 904
    - A.L. LEHNINGER, Biochemistry, Worth Publishers, Inc.
    - S. Colowick and N. Kaplan, Methods In Enzymology, Academic Press, Inc.
    - CAREY; SUNDBERG, Advanced Organic Chemistry, 3rd ed., Plenum Press, (19920000), vol. A and B
    - DE HAARD, H.J.W, "Construction of large naive Fab libraries", Methods Mol Biol, (20010000), vol. 178, pages 87 - 100
    - ADAMS, E. W.; RATNER, D. M.; BOKESCH, H. R.; MCMAHON, J. B.; O'KEEFE, B. R.; SEEBERGER, P. H., "Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions", Chem Biol, (20040000), vol. 11, pages 875 - 881
    - RATNER, D. M.; PLANTE, O. J.; SEEBERGER, P. H., "A linear synthesis of branched high-mannose oligosaccharides from the HIV-1 viral surface envelope glycoprotein gp120", European Journal of Organic Chemistry, (20020000), doi:doi:10.1002/1099-0690(200203)2002:5<826::AID-EJOC826>3.0.CO;2-2, pages 826 - 833, XP055041433

DOI:   http://dx.doi.org/10.1002/1099-0690(200203)2002:5<826::AID-EJOC826>3.0.CO;2-2
    - HOLEMANN, A.; STOCKER, B. L.; SEEBERGER, P. H., "Synthesis of a core arabinomannan oligosaccharide of Mycobacterium tuberculosis", J Org Chern, (20060000), vol. 71, pages 8071 - 8088
    - BOEHME, C. et al., "Detection of mycobacterial lipoarabinomannan with an antigen-capture ELISA in unprocessed urine of Tanzanian patients with suspected tuberculosis", Trans R Soc Trop Med Hyg, (20050000), vol. 99, no. 12, doi:doi:10.1016/j.trstmh.2005.04.014, pages 893 - 900, XP025362112

DOI:   http://dx.doi.org/10.1016/j.trstmh.2005.04.014
    - TESSEMA, T.A. et al., "Diagnostic evaluation of urinary lipoarabinomannan at an Ethiopian tuberculosis centre", Scand J Infect Dis, (20010000), vol. 33, no. 4, doi:doi:10.1080/003655401300077306, pages 279 - 84, XP002987576

DOI:   http://dx.doi.org/10.1080/003655401300077306
    - KAMBASHI, B. et al., "Utility of nucleic acid amplification techniques for the diagnosis of pulmonary tuberculosis in sub-Saharan Africa", Int J Tuberc Lung Dis, (20010000), vol. 5, no. 4, pages 364 - 9
    - PAI, M. et al., "Nucleic acid amplification tests in the diagnosis of tuberculous pleuritis: a systematic review and meta-analysis", BMC Infect Dis, (20040000), vol. 4, doi:doi:10.1186/1471-2334-4-6, page 6, XP021004039

DOI:   http://dx.doi.org/10.1186/1471-2334-4-6
    - STEINGART, K.R. et al., "Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review", Lancet Infect Dis, (20060000), vol. 6, no. 10, doi:doi:10.1016/S1473-3099(06)70602-8, pages 664 - 74, XP024968691

DOI:   http://dx.doi.org/10.1016/S1473-3099(06)70602-8
    - ELLIOTT, A.M. et al., "egative sputum smear results in HIV-positive patients with pulmonary tuberculosis in Lusaka, Zambia", Tuber Lung Dis, (19930000), vol. 74, no. 3, pages 191 - 4
    - STEINGART, K.R. et al., "Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review", PLoS Med, (20070000), vol. 4, no. 6, doi:doi:10.1371/journal.pmed.0040202, page e202, XP002637795

DOI:   http://dx.doi.org/10.1371/journal.pmed.0040202
    - PAI, M.; A. ZWERLING; D. MENZIES, "Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update", Ann Intern Med, (20080000), vol. 149, no. 3, pages 177 - 84
    - CHO, S.N. et al., "Production of monoclonal antibodies to lipoarabinomannan-B and use in the detection of mycobacterial antigens in sputum", Yonsei Med J, (19900000), vol. 31, no. 4, pages 333 - 8, XP002035610
    - PEREIRA ARIAS-BOUDA, L.M. et al., "Development of antigen detection assay for diagnosis of tuberculosis using sputum samples", J Clin Microbiol, (20000000), vol. 38, no. 6, pages 2278 - 83, XP002535045
    - ARAJ, G.F. et al., "Improved detection of mycobacterial antigens in clinical specimens by combined enzyme-linked immunosorbent assay", Diagn Microbiol Infect Dis, (19930000), vol. 17, no. 2, doi:doi:10.1016/0732-8893(93)90022-Y, pages 119 - 27, XP023915457

DOI:   http://dx.doi.org/10.1016/0732-8893(93)90022-Y
    - PUROHIT, M.R. et al., "mmunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64", Diagn Pathol, (20070000), vol. 2, page 36, XP021039236
    - BABA, K. et al., "Rapid and specific diagnosis of tuberculous pleuritis with immunohistochemistry by detecting Mycobacterium tuberculosis complex specific antigen MPT64 in patients from a HIV endemic area", Appl Immunohistochem Mol Morphol, (20080000), vol. 16, no. 6, pages 554 - 61
    - HAMASUR, B. et al., "Rapid diagnosis of tuberculosis by detection of mycobacterial lipoarabinomannan in urine", J Microbiol Methods, (20010000), vol. 45, no. 1, doi:doi:10.1016/S0167-7012(01)00239-1, pages 41 - 52, XP002369551

DOI:   http://dx.doi.org/10.1016/S0167-7012(01)00239-1
    - BEN-SELMA, W. et al., "Rapid detection of Mycobacterium tuberculosis in sputum by Patho-TB kit in comparison with direct microscopy and culture", Diagn Microbiol Infect Dis, (20090000), vol. 65, no. 3, doi:doi:10.1016/j.diagmicrobio.2009.07.021, pages 232 - 5, XP026682686

DOI:   http://dx.doi.org/10.1016/j.diagmicrobio.2009.07.021
    - CHAKRABORTY, N. et al., "A rapid immunochromatographic assay for the detection of Mycobacterium tuberculosis antigens in pulmonary samples from HIV seropositive patients and its comparison with conventional methods", J Microbiol Methods, (20090000), vol. 76, no. 1, doi:doi:10.1016/j.mimet.2008.09.005, pages 12 - 7, XP025780010

DOI:   http://dx.doi.org/10.1016/j.mimet.2008.09.005
    - SHAH, M. et al., "Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting", J Acquir Immune Defic Syndr, (20090000), vol. 52, no. 2, pages 145 - 51
    - REITHER, K. et al., "Low sensitivity of a urine LAM-ELISA in the diagnosis ofpulmonary tuberculosis", BMC Infect Dis, (20090000), vol. 9, page 141
    - LAWN, S.D. et al., "Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease", Aids, (20090000), vol. 23, no. 14, pages 1875 - 80
    - DHEDA, K. et al., "Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples", PLoS One, (20100000), vol. 5, no. 3, page e9848
    - CHATTERJEE, D., "The mycobacterial cell wall: structure, biosynthesis and sites of drug action", Curr Opin Chem Biol, (19970000), vol. 1, no. 4, pages 579 - 88
    - SCHLESINGER, L.S.; S.R. HULL; T.M. KAUFMAN, "Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages", J Immunol, (19940000), vol. 152, no. 8, pages 4070 - 9
    - KANG, P.B. et al., "The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis", J Exp Med, (20050000), vol. 202, no. 7, doi:doi:10.1084/jem.20051239, pages 987 - 99, XP055065055

DOI:   http://dx.doi.org/10.1084/jem.20051239
    - TORRELLES, J.B. et al., "Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan", J Biol Chem, (20080000), vol. 283, no. 46, pages 31417 - 28
    - MALIK, Z.A. et al., "Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase", J Immunol, (20030000), vol. 170, no. 6, pages 2811 - 5
    - THOMPSON, C.R. et al., "Sphingosine kinase 1 (SKI) is recruited to nascent phagosomes in human macrophages: inhibition of SKI translocation by Mycobacterium tuberculosis", J Immunol, (20050000), vol. 174, no. 6, pages 3551 - 61
    - VERGNE, I.; J. CHUA; V. DERETIC, "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade", J Exp Med, (20030000), vol. 198, no. 4, pages 653 - 9
    - WELIN, A. et al., "Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block", Infect Immun, (20080000), vol. 76, no. 7, pages 2882 - 7
    - GEIJTENBEEK, T.B. et al., "Mycobacteria target DC-SIGN to suppress dendritic cell function", J Exp Med, (20030000), vol. 197, no. 1, pages 7 - 17
    - PATHAK, S.K. et al., "Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages", J Biol Chem, (20050000), vol. 280, no. 52, pages 42794 - 800
    - FUJIWARA, N. et al., "Production and partial characterization of anti-cordfactor (trehalose-6,6'-dimycolate) IgG antibody in rabbits recognizing mycolic acid subclasses of Mycobacterium tuberculosis or Mycobacterium avium", FEMS Immunol Med Microbiol, (19990000), vol. 24, no. 2, pages 141 - 9
    - HAMASUR, B. et al., "A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab') fragment prolong survival of mice infected with Mycobacterium tuberculosis", Clin Exp Immunol, (20040000), vol. 138, no. 1, doi:doi:10.1111/j.1365-2249.2004.02593.x, pages 30 - 8, XP055186233

DOI:   http://dx.doi.org/10.1111/j.1365-2249.2004.02593.x
    - MEHTA, P.K.; G.K. KHULLER, "Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria", Med Microbiol Immunol, (19880000), vol. 177, no. 5, pages 265 - 84
    - HAMASUR, B. et al., "Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis", Vaccine, (20030000), vol. 21, no. 25-26, doi:doi:10.1016/S0264-410X(03)00274-3, pages 4081 - 93, XP004446186

DOI:   http://dx.doi.org/10.1016/S0264-410X(03)00274-3
    - HOOGENBOOM, H.R., "Selecting and screening recombinant antibody libraries", Nat Biotechnol, (20050000), vol. 23, no. 9, doi:doi:10.1038/nbt1126, pages 1105 - 16, XP002348401

DOI:   http://dx.doi.org/10.1038/nbt1126
 US20120051590
 US19950464584
 US19950462837
 US19950486853
 US19950486859
 US19900466008
 US19900574748
 US19900575962
 US19910810279
 US19920853408
 US19920904068
 US19920919297
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 US19930031801
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