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EP2744777
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EP About this file: EP2744777
| EP2744777 - TRANS-CLOMIPHENE METABOLITES AND USES THEREOF [Right-click to bookmark this link] | Status | The application has been withdrawn Status updated on 23.03.2018 Database last updated on 16.11.2024 | Most recent event Tooltip | 23.03.2018 | Withdrawal of application | published on 25.04.2018 [2018/17] | 23.03.2018 | New entry: Date of cancellation oral proceedings | Applicant(s) | For all designated states Repros Therapeutics Inc. 2408 Timberloch Place, B-7 The Woodlands, TX 77380 / US | [2014/26] | Inventor(s) | 01 /
PODOLSKI, Joseph, S. 3 Pebble Hollow Court The Woodlands, TX 77381 / US | 02 /
WIEHLE, Ronald, D. 13903 Viewfield Court Houston, TX 77059 / US | [2014/26] | Representative(s) | Nederlandsch Octrooibureau P.O. Box 29720 2502 LS The Hague / NL | [2014/26] | Application number, filing date | 12750508.9 | 03.08.2012 | WO2012US49451 | Priority number, date | US201161515278P | 04.08.2011 Original published format: US 201161515278 P | [2014/26] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013020017 | Date: | 07.02.2013 | Language: | EN | [2013/06] | Type: | A1 Application with search report | No.: | EP2744777 | Date: | 25.06.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 07.02.2013 takes the place of the publication of the European patent application. | [2014/26] | Search report(s) | International search report - published on: | EP | 07.02.2013 | Classification | IPC: | C07C217/18, A61K31/138, A61P3/06 | [2014/26] | CPC: |
C07C217/18 (EP,US);
A61P15/00 (EP);
A61P15/08 (EP);
A61P15/10 (EP);
A61P19/00 (EP);
A61P19/10 (EP);
A61P21/00 (EP);
A61P3/06 (EP);
A61P3/10 (EP);
A61P35/00 (EP)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/26] | Extension states | ME | 30.01.2014 | Title | German: | TRANSCLOMIPHEN-METABOLITEN UND IHRE VERWENDUNG | [2014/26] | English: | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | [2014/26] | French: | MÉTABOLITES DU TRANS-CLOMINOPHÈNE ET LEURS UTILISATIONS | [2014/26] | Entry into regional phase | 30.01.2014 | National basic fee paid | 30.01.2014 | Designation fee(s) paid | 30.01.2014 | Examination fee paid | Examination procedure | 30.01.2014 | Examination requested [2014/26] | 22.09.2014 | Amendment by applicant (claims and/or description) | 17.02.2016 | Despatch of a communication from the examining division (Time limit: M04) | 20.06.2016 | Reply to a communication from the examining division | 16.03.2018 | Application withdrawn by applicant [2018/17] | 16.03.2018 | Cancellation of oral proceeding that was planned for 18.04.2018 | 18.04.2018 | Date of oral proceedings (cancelled) | Divisional application(s) | EP18161551.9 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 17.02.2016 | Fees paid | Renewal fee | 27.08.2014 | Renewal fee patent year 03 | 27.08.2015 | Renewal fee patent year 04 | 29.08.2016 | Renewal fee patent year 05 | 28.08.2017 | Renewal fee patent year 06 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [AD]US2009099265 (VAN AS ANDRE [US]) [AD] 1-22 * the whole document *; | [AD]US2009215906 (PODOLSKI JOSEPH S [US]) [AD] 1-22* the whole document *; | [X] - BOIAN GANCHEV ET AL, "Quantification of clomiphene metabolite isomers in human plasma by rapid-resolution liquid chromatographyâ electrospray ionizationâ tandem mass spectrometry", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER, BERLIN, DE, (20110501), vol. 400, no. 10, doi:10.1007/S00216-011-5045-9, ISSN 1618-2650, pages 3429 - 3441, XP019924908 [X] 1-22 * the whole document * DOI: http://dx.doi.org/10.1007/s00216-011-5045-9 | [X] - R.JEFFREY BAUMANN ET AL, "Clomiphene Analogs with Activity In Vitro and In Vivo against Human Breast Cancer Cells", BIOCHEMICAL PHARMACOLOGY, (19980301), vol. 55, no. 6, doi:10.1016/S0006-2952(97)00574-1, ISSN 0006-2952, pages 841 - 851, XP055039842 [X] 1-3,17,18,21 * the whole document * DOI: http://dx.doi.org/10.1016/S0006-2952(97)00574-1 | [X] - PETER C. RUENITZ ET AL, "Phenolic metabolites of clomiphene. [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects in MCF 7 breast cancer cells", JOURNAL OF MEDICINAL CHEMISTRY, (19890101), vol. 32, no. 1, doi:10.1021/jm00121a035, ISSN 0022-2623, pages 192 - 197, XP055039844 [X] 1-3,17,18 * the whole document * DOI: http://dx.doi.org/10.1021/jm00121a035 | Examination | WO2007019165 | - Thomas E. Mürdter ET AL, "Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites", Human Molecular Genetics, (20111122), vol. 21, no. 5, pages 1145 - 1154, XP055349370 | by applicant | JPH04312522 | WO9535093 | US6096338 | US6126969 | US6129933 | US6143353 | US6190591 | US6221399 | US6248363 | US7368480 | US2008242726 | US2009099265 | US2009215906 | US7759360 | - TENOVER ET AL., J. CLIN. ENDOCRINOL. METAB., vol. 64, page 1103 | - TENOVER ET AL., J. CLIN. ENDOCRINOL. METAB., (1987), vol. 64, page 1118 | - ERNST ET AL., J. PHARMACEUT. SCI., (1976), vol. 65, page 148 | - MESHALI ET AL., INT. J. PHAR., (1993), vol. 89, pages L77 - L81 | - KHARENKO, INTERN. SYMP. CONTROL REL. BIOACT. MATER., (1995), vol. 22, pages 232 - 233 | - DANGPRASIT ET AL., DRUG. DEVEL. AND INCL. PHARM., (1995), vol. 21, no. 20, pages 2323 - 2337 |