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Extract from the Register of European Patents

EP About this file: EP2686449

EP2686449 - MULTIPLEXED DIGITAL ASSAYS WITH COMBINATORIAL USE OF SIGNALS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.09.2021
Database last updated on 16.09.2024
FormerThe patent has been granted
Status updated on  16.10.2020
FormerGrant of patent is intended
Status updated on  28.05.2020
FormerExamination is in progress
Status updated on  16.12.2016
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT
published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
Bio-Rad Laboratories, Inc.
1000 Alfred Nobel Drive
Hercules, CA 94547 / US
[2021/15]
Former [2014/04]For all designated states
Bio-Rad Laboratories, Inc.
1000 Alfred Nobel Drive
Hercules, CA 94547 / US
Inventor(s)01 / SAXONOV, Serge
5799 Balmoral Dr.
Oakland, CA 94619 / US
02 / DUBE, Simant
4301 Lake Washington Boulevard NE
Kirkland, WA 98033 / US
03 / HINDSON, Benjamin, J.
1039 Bannock Street
Livermore, CA 94551 / US
04 / MCCOY, Adam, M.
1707 Van Damme Drive
Davis, CA 95616 / US
 [2020/26]
Former [2014/10]01 / SAXONOV, Serge
5799 Balmoral Drive
Oakland, CA 94619-2439 / US
02 / DUBE, Simant
4301 Lake Washington Boulevard NE
Kirkland, WA 98033 / US
03 / HINDSON, Benjamin, J.
1039 Bannock Street
Livermore, CA 94551 / US
04 / MCCOY, Adam, M.
1707 Van Damme Drive
Davis, CA 95616 / US
Former [2014/09]01 / SAXONOV, Serge
5799 Balmoral Drive
Oakland, CA 94619-2439 / US
02 / DUBE, Simant
4301 Lake Washington Boulevard NE
Kirkland Washington 98033 / US
03 / HINDSON, Benjamin, J.
1039 Bannock Street
Livermore, CA 94551 / US
04 / MCCOY, Adam, M.
1707 Van Damme Drive
Davis, CA 95616 / US
Former [2014/04]01 / SAXONOV, Serge
6676 Heartwood Drive
Oakland, CA 94611 / US
02 / DUBE, Simant
5386 Case Avenue, Apt. 1621
Pleasanton, CA 94566 / US
03 / HINDSON, Benjamin, J.
1039 Bannock Street
Livermore, CA 94551 / US
04 / MCCOY, Adam, M.
1707 Van Damme Drive
Davis, CA 95616 / US
Representative(s)dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
Deichmannhaus am Dom
Bahnhofsvorplatz 1
50667 Köln / DE
[2020/47]
Former [2014/04]von Kreisler Selting Werner
Deichmannhaus am Dom
Bahnhofsvorplatz 1
50667 Köln / DE
Application number, filing date12760944.419.03.2012
[2020/47]
WO2012US29712
Priority number, dateUS201161454373P18.03.2011         Original published format: US 201161454373 P
[2014/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012129187
Date:27.09.2012
Language:EN
[2012/39]
Type: A1 Application with search report 
No.:EP2686449
Date:22.01.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 27.09.2012 takes the place of the publication of the European patent application.
[2014/04]
Type: B1 Patent specification 
No.:EP2686449
Date:18.11.2020
Language:EN
[2020/47]
Search report(s)International search report - published on:US27.09.2012
(Supplementary) European search report - dispatched on:EP12.01.2015
ClassificationIPC:C12Q1/6851, G16B5/00, G16B20/00, G16B25/00
[2020/24]
CPC:
C12Q1/6851 (EP,CN,US); C12Q1/686 (US); G16B20/00 (EP,US);
G16B20/20 (EP,CN,US); G16B25/00 (EP,US); G16B25/20 (EP,CN,US);
G16B5/00 (EP,US); G06F17/10 (US); G06F17/11 (US);
G06F17/12 (US) (-)
C-Set:
C12Q1/6851, C12Q2537/143, C12Q2537/165, C12Q2563/159 (CN,EP,US)
Former IPC [2014/04]C12Q1/68, G01N21/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/04]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MULTIPLEXIERTE DIGITALASSAYS MIT KOMBINATORISCHER NUTZUNG VON SIGNALEN[2014/04]
English:MULTIPLEXED DIGITAL ASSAYS WITH COMBINATORIAL USE OF SIGNALS[2014/04]
French:ESSAIS NUMÉRIQUES MULTIPLEXÉS AVEC UTILISATION COMBINÉE DE SIGNAUX[2014/04]
Entry into regional phase16.09.2013National basic fee paid 
16.09.2013Search fee paid 
16.09.2013Designation fee(s) paid 
16.09.2013Examination fee paid 
Examination procedure16.09.2013Examination requested  [2014/04]
06.08.2015Amendment by applicant (claims and/or description)
14.12.2016Despatch of a communication from the examining division (Time limit: M04)
24.04.2017Reply to a communication from the examining division
28.02.2018Despatch of a communication from the examining division (Time limit: M04)
04.07.2018Reply to a communication from the examining division
21.12.2018Despatch of a communication from the examining division (Time limit: M06)
25.06.2019Reply to a communication from the examining division
22.10.2019Despatch of a communication from the examining division (Time limit: M06)
30.04.2020Reply to a communication from the examining division
29.05.2020Communication of intention to grant the patent
08.10.2020Fee for grant paid
08.10.2020Fee for publishing/printing paid
08.10.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.12.2016
Opposition(s)19.08.2021No opposition filed within time limit [2021/43]
Fees paidRenewal fee
07.04.2014Renewal fee patent year 03
27.03.2015Renewal fee patent year 04
31.03.2016Renewal fee patent year 05
27.03.2017Renewal fee patent year 06
29.03.2018Renewal fee patent year 07
29.03.2019Renewal fee patent year 08
27.03.2020Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
31.03.201403   M06   Fee paid on   07.04.2014
Opt-out from the exclusive  Tooltip
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.03.2012
AL18.11.2020
AT18.11.2020
CY18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
MK18.11.2020
MT18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
TR18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
[2024/41]
Former [2024/29]HU19.03.2012
AL18.11.2020
AT18.11.2020
CY18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
MK18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
TR18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2024/22]HU19.03.2012
AL18.11.2020
AT18.11.2020
CY18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
MK18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2023/27]HU19.03.2012
AL18.11.2020
AT18.11.2020
CY18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2023/24]AL18.11.2020
AT18.11.2020
CY18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/34]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/23]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/10]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/09]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
LU19.03.2021
Former [2022/07]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
IE19.03.2021
Former [2021/51]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
ES18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/49]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/48]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
FI18.11.2020
HR18.11.2020
IT18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/46]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
NL18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/45]AL18.11.2020
AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
MC18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/37]AT18.11.2020
CZ18.11.2020
DK18.11.2020
EE18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/36]AT18.11.2020
CZ18.11.2020
EE18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/35]AT18.11.2020
CZ18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
PL18.11.2020
RO18.11.2020
RS18.11.2020
SE18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/34]AT18.11.2020
CZ18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
PL18.11.2020
RS18.11.2020
SE18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/33]AT18.11.2020
FI18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
PL18.11.2020
RS18.11.2020
SE18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/32]AT18.11.2020
FI18.11.2020
HR18.11.2020
LV18.11.2020
PL18.11.2020
RS18.11.2020
SE18.11.2020
SM18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/28]AT18.11.2020
FI18.11.2020
HR18.11.2020
LV18.11.2020
PL18.11.2020
RS18.11.2020
SE18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/25]AT18.11.2020
FI18.11.2020
LV18.11.2020
PL18.11.2020
RS18.11.2020
SE18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/24]AT18.11.2020
FI18.11.2020
LV18.11.2020
RS18.11.2020
SE18.11.2020
BG18.02.2021
NO18.02.2021
GR19.02.2021
PT18.03.2021
Former [2021/23]FI18.11.2020
LV18.11.2020
RS18.11.2020
SE18.11.2020
NO18.02.2021
GR19.02.2021
PT18.03.2021
Former [2021/22]FI18.11.2020
RS18.11.2020
NO18.02.2021
PT18.03.2021
Former [2021/21]FI18.11.2020
PT18.03.2021
Former [2021/20]FI18.11.2020
Documents cited:Search[Y]WO03064691  (GLOBAL GENOMICS AB [SE], et al) [Y] 7-10 * abstract * * page 24, line 14 - line 30 *;
 [XY]WO2010036352  (QUANTALIFE INC, et al) [X] 1-4,6 * abstract * * page 24, line 14 - line 30 * * page 75, line 22 - line 28 * * page 77, line 23 - line 31 * * page 219, line 27 - line 30 * * page 220, line 1 - line 14 * * page 231, line 20 - line 28 * * page 252, line 16 - line 19 * * page 257, line 23 - line 32 * [Y] 5,7-10;
 [A]US2010233686  (HIGUCHI RUSSELL [US], et al) [A] 1-15 * abstract * * page 24, line 14 - line 30 *;
 [Y]US2010248385  (TAN WEIHONG [US], et al) [Y] 5 * abstract * * paragraph [0006] - paragraph [0007] * * paragraph [0119] *;
 [A]  - ZHISHAN HUA ET AL, "Multiplexed Real-Time Polymerase Chain Reaction on a Digital Microfluidic Platform", ANALYTICAL CHEMISTRY, (20100315), vol. 82, no. 6, doi:10.1021/ac902510u, ISSN 0003-2700, pages 2310 - 2316, XP055138297 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1021/ac902510u
 [A]  - STAVROS THERIANOS ET AL, "Single-Channel Quantitative Multiplex Reverse Transcriptase-Polymerase Chain Reaction for Large Numbers of Gene Products Differentiates Nondemented from Neuropathological Alzheimer's Disease", AMERICAN JOURNAL OF PATHOLOGY., US, (20040301), vol. 164, no. 3, ISSN 0002-9440, pages 795 - 806, XP055159822 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0002-9440(10)63168-9
 [A]  - MARKEY A L ET AL, "High-throughput droplet PCR", METHODS, ACADEMIC PRESS, vol. 50, no. 4, ISSN 1046-2023, (20100401), pages 277 - 281, (20100202), XP026966681 [A] 1-15 * abstract * * Concluding remarks *
 [A]  - BEER N R ET AL, "On-chip, real-time, single-copy polymerase chain reaction in picoliter droplets", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 22, doi:10.1021/AC701809W, ISSN 0003-2700, (20071115), pages 8471 - 8475, (20071011), XP002575962 [A] 1-15 * abstract * * Conclusions *

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