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Extract from the Register of European Patents

EP About this file: EP2694964

EP2694964 - HIGH-THROUGHPUT SCREENING FOR COMPOUNDS MODULATING LEVELS OF CELLULAR MACROMOLECULES [Right-click to bookmark this link]
Former [2014/07]HIGH-THROUGHPUT SCREENING FOR COMPOUNDS MODULATING EXPRESSION OF CELLULAR MACROMOLECULES
[2019/25]
StatusNo opposition filed within time limit
Status updated on  10.07.2020
Database last updated on 06.11.2024
FormerThe patent has been granted
Status updated on  24.05.2019
FormerGrant of patent is intended
Status updated on  31.01.2019
FormerExamination is in progress
Status updated on  25.11.2016
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037 / US
[2014/07]
Inventor(s)01 / LASMEZAS, Corinne
1828 Flower Drive
Palm Beach Gardens, FL 33410 / US
02 / WEISSMANN, Charles
100 Sunrise Avenue
Palm Beach, FL 33480 / US
 [2019/26]
Former [2014/07]01 / LASMEZAS, Corinne
1828 Flower Drive
Palm Beach Gardens FL 33410 / US
02 / WEISSMANN, Charles
100 Sunrise Avenue
Palm Beach FL 33480 / US
Representative(s)Inspicos P/S
Agern Allé 24
2970 Hørsholm / DK
[N/P]
Former [2019/26]Inspicos P/S
Kogle Allé 2
2970 Hørsholm / DK
Former [2014/07]Inspicos A/S
Kogle Allé 2 P.O. Box 45
2970 Hørsholm / DK
Application number, filing date12768275.506.04.2012
[2019/26]
WO2012US32587
Priority number, dateUS201161472962P07.04.2011         Original published format: US 201161472962 P
[2014/07]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012139040
Date:11.10.2012
Language:EN
[2012/41]
Type: A1 Application with search report 
No.:EP2694964
Date:12.02.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 11.10.2012 takes the place of the publication of the European patent application.
[2014/07]
Type: B1 Patent specification 
No.:EP2694964
Date:26.06.2019
Language:EN
[2019/26]
Search report(s)International search report - published on:US11.10.2012
(Supplementary) European search report - dispatched on:EP26.09.2014
ClassificationIPC:G01N33/50, G01N33/542, G01N33/543
[2014/44]
CPC:
G01N33/542 (EP,US); G01N33/50 (RU); G01N33/5023 (US);
A61K31/14 (EP,US); A61K31/35 (EP,US); A61K31/351 (EP,US);
A61K31/436 (EP,US); A61K31/454 (EP,US); A61K31/4745 (EP,US);
G01N33/5041 (US); G01N33/5058 (US); G01N33/543 (US);
G01N2500/04 (US); G01N2500/10 (US); G01N33/52 (RU) (-)
Former IPC [2014/07]G01N33/50
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/07]
Extension statesBA07.11.2013
ME07.11.2013
TitleGerman:HOCHDURCHSATZ-SCREENING NACH VERBINDUNGEN ZUR MODULATION DER LEVEL ZELLULÄRER MAKROMOLEKÜLE[2019/25]
English:HIGH-THROUGHPUT SCREENING FOR COMPOUNDS MODULATING LEVELS OF CELLULAR MACROMOLECULES[2019/25]
French:CRIBLAGE À HAUT DÉBIT POUR DES COMPOSÉS MODULANT LE NIVEAU DE MACROMOLÉCULES CELLULAIRES[2019/25]
Former [2014/07]HOCHDURCHSATZ-SCREENING NACH VERBINDUNGEN ZUR MODULATION DER EXPRESSION ZELLULÄRER MAKROMOLEKÜLE
Former [2014/07]HIGH-THROUGHPUT SCREENING FOR COMPOUNDS MODULATING EXPRESSION OF CELLULAR MACROMOLECULES
Former [2014/07]CRIBLAGE À HAUT DÉBIT POUR DES COMPOSÉS MODULANT L'EXPRESSION DE MACROMOLÉCULES CELLULAIRES
Entry into regional phase07.11.2013National basic fee paid 
07.11.2013Search fee paid 
07.11.2013Designation fee(s) paid 
07.11.2013Examination fee paid 
Examination procedure07.11.2013Examination requested  [2014/07]
22.04.2015Amendment by applicant (claims and/or description)
24.11.2016Despatch of a communication from the examining division (Time limit: M04)
31.03.2017Reply to a communication from the examining division
12.07.2017Despatch of a communication from the examining division (Time limit: M04)
06.11.2017Reply to a communication from the examining division
19.02.2018Despatch of a communication from the examining division (Time limit: M06)
03.09.2018Reply to a communication from the examining division
01.02.2019Communication of intention to grant the patent
15.05.2019Fee for grant paid
15.05.2019Fee for publishing/printing paid
15.05.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.11.2016
Opposition(s)03.06.2020No opposition filed within time limit [2020/33]
Fees paidRenewal fee
17.02.2014Renewal fee patent year 03
30.04.2015Renewal fee patent year 04
31.03.2016Renewal fee patent year 05
02.05.2017Renewal fee patent year 06
11.04.2018Renewal fee patent year 07
15.04.2019Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.04.2012
AL26.06.2019
CY26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
MK26.06.2019
MT26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU06.04.2020
[2022/32]
Former [2022/27]HU06.04.2012
AL26.06.2019
CY26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
MT26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU06.04.2020
Former [2021/08]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU06.04.2020
Former [2020/52]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/37]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/36]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/24]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
PL26.06.2019
RO26.06.2019
RS26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
PT28.10.2019
IS24.02.2020
Former [2020/17]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/14]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SK26.06.2019
SM26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/12]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SK26.06.2019
BG26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/11]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SK26.06.2019
BG26.09.2019
GR27.09.2019
PT28.10.2019
Former [2020/10]AL26.06.2019
CZ26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
BG26.09.2019
GR27.09.2019
PT28.10.2019
Former [2020/09]AL26.06.2019
CZ26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RS26.06.2019
BG26.09.2019
GR27.09.2019
Former [2019/51]AL26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RS26.06.2019
BG26.09.2019
GR27.09.2019
Former [2019/50]AL26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RS26.06.2019
GR27.09.2019
Former [2019/47]FI26.06.2019
LT26.06.2019
Documents cited:Search[X]  - Megan Simmer, "FLOW CYTOMETRY: A TECHNOLOGY TO COUNT AND SORT CELLS", (20061006), URL: http://www.scq.ubc.ca/flow-cytometry-a-technology-to-count-and-sort-cells/, (20140910), XP055139351 [X] 1,5,6,8-10,12,13,16,17 * figure 5 *
 [X]  - E. ZAHAVY ET AL, "Detection of Frequency Resonance Energy Transfer Pair on Double-Labeled Microsphere and Bacillus anthracis Spores by Flow Cytometry", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (20030401), vol. 69, no. 4, doi:10.1128/AEM.69.4.2330-2339.2003, ISSN 0099-2240, pages 2330 - 2339, XP055139359 [X] 1,3,5-10,12-17 * figure 1 *

DOI:   http://dx.doi.org/10.1128/AEM.69.4.2330-2339.2003
 [X]  - YANN GAMBIN ET AL, "Multicolor single-molecule FRET to explore protein folding and binding", MOLECULAR BIOSYSTEMS, (20100101), vol. 6, no. 9, doi:10.1039/c003024d, ISSN 1742-206X, page 1540, XP055139423 [X] 1,3,5-17 * the whole document *

DOI:   http://dx.doi.org/10.1039/c003024d
 [X]  - NOINAJ NICHOLAS ET AL, "Conformational changes in neuropeptidases", FASEB JOURNAL, & EXPERIMENTAL BIOLOGY 2005 MEETING/35TH INTERNATIONAL CONGRESS OF PHYSIOLOGICAL SCIENCES; SAN DIEGO, CA, USA; MARCH 31 -APRIL 06, 2005, (20050304), vol. 19, no. 4, Suppl. S, Part 1, ISSN 0892-6638, page A306, XP008172002 [X] 1-17 * abstract *
 [X]  - C. S. LEBAKKEN ET AL, "Development and Applications of a Broad-Coverage, TR-FRET-Based Kinase Binding Assay Platform", JOURNAL OF BIOMOLECULAR SCREENING, (20090629), vol. 14, no. 8, doi:10.1177/1087057109339207, ISSN 1087-0571, pages 924 - 935, XP055139546 [X] 1 * figure 1 *

DOI:   http://dx.doi.org/10.1177/1087057109339207
 [I]  - S. LU ET AL, "Fluorescence Resonance Energy Transfer Biosensors for Cancer Detection and Evaluation of Drug Efficacy", CLINICAL CANCER RESEARCH, (20100728), vol. 16, no. 15, doi:10.1158/1078-0432.CCR-10-1333, ISSN 1078-0432, pages 3822 - 3824, XP055139532 [I] 1-17 * figure 1 *

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-10-1333
 [T]  - Y. E. KARAPETYAN ET AL, "Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20130401), vol. 110, no. 17, doi:10.1073/pnas.1303510110, ISSN 0027-8424, pages 7044 - 7049, XP055139240

DOI:   http://dx.doi.org/10.1073/pnas.1303510110
International search[X]US2008108096  (RALPH PETER [US]);
 [Y]US2010070191  (GOLD LARRY [US], et al);
 [Y]  - DEGORCE ET AL., "HTRF: A Technology Tailored for Drug Discovery. A Review of Theoretical Aspects and Recent Applications Current Chemical Genomics", CURR CHEM GENOMICS, (2009), vol. 3, pages 22 - 32, XP055128395

DOI:   http://dx.doi.org/10.2174/1875397300903010022
Examination   - ISAAC T LI ET AL, "Protein biosensors based on the principle of fluorescence resonance energy transfer for monitoring cellular dynamics", BIOTECHNOLOGY LETTERS, SPRINGER NETHERLANDS, DORDRECHT, (20061005), vol. 28, no. 24, doi:10.1007/S10529-006-9193-5, ISSN 1573-6776, pages 1971 - 1982, XP019447288

DOI:   http://dx.doi.org/10.1007/s10529-006-9193-5
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.