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EP About this file: EP2714921

EP2714921 - EPIGENETIC CO-REPRESSORS OF THE GAMMA-GLOBIN GENE AND METHODS OF USING SAME [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 04.05.2018 Database last updated on 05.10.2024
Former	Examination is in progress Status updated on 01.09.2017
Most recent event Tooltip	04.05.2018	Application deemed to be withdrawn	published on 06.06.2018 [2018/23]
Applicant(s)	For all designated states Regents of the University of Michigan 3003 South State Street Room 1070 Ann Arbor, Michigan 48109-1280 / US
	[2014/15]
Inventor(s)	01 / ENGEL, James Douglas 3695 Delhi Overlook Ann Arbor, Michigan 48103 / US
	02 / TANABE, Osamu 2285 Boulder Ridge Blvd. Ann Arbor, Michigan 48103 / US
	03 / SHI, Lihong 2010 Medford Apt. D132 Ann Arbor, Michigan 48104 / US
	[2014/15]
Representative(s)	Conroy, John, et al Fish & Richardson P.C. Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München / DE
	[N/P]
Former [2014/15]	Coehn, Markus Fish & Richardson P.C. High Light Business Towers Mies-van-der-Rohe-Strasse 8 80807 München / DE
Application number, filing date	12789967.2	24.05.2012
	WO2012US39368
Priority number, date	US201161490175P	26.05.2011 Original published format: US 201161490175 P
	US201261588245P	19.01.2012 Original published format: US 201261588245 P
	[2014/15]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2012162514
	Date:	29.11.2012
	Language:	EN
	[2012/48]
	Type:	A2 Application without search report
	No.:	EP2714921
	Date:	09.04.2014
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 29.11.2012 takes the place of the publication of the European patent application.
	[2014/15]
Search report(s)	International search report - published on:	KR	04.04.2013
	(Supplementary) European search report - dispatched on:	EP	15.04.2015
Classification	IPC:	C12Q1/02, C12N15/63, C12N15/52, G01N33/68, C12Q1/48, C12Q1/26, A61K31/00	[2015/01]
	CPC:	G01N33/6854 (EP,US); A61K31/135 (EP,US); A61K31/145 (EP,US); A61K31/7068 (EP,US); A61K31/708 (EP,US); A61P7/00 (EP); (+) G01N33/80 (EP,US); G01N2333/91017 (EP,US); G01N2500/10 (EP,US) (-)
	Former IPC [2014/15]	C12Q1/02, C12N15/63, C12N15/52, G01N33/68
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/15]
Title	German:	EPIGENETISCHE COREPRESSOREN DES GAMMA-GLOBIN-GENS UND VERWENDUNGSVERFAHREN DAFÜR	[2014/15]
	English:	EPIGENETIC CO-REPRESSORS OF THE GAMMA-GLOBIN GENE AND METHODS OF USING SAME	[2014/15]
	French:	CORÉPRESSEURS ÉPIGÉNÉTIQUES DU GÈNE DE LA GAMMAGLOBULINE ET LEURS PROCÉDÉS D'UTILISATION	[2014/15]
Entry into regional phase	28.11.2013	National basic fee paid
	28.11.2013	Search fee paid
	28.11.2013	Designation fee(s) paid
	28.11.2013	Examination fee paid
Examination procedure	28.11.2013	Amendment by applicant (claims and/or description)
	28.11.2013	Examination requested [2014/15]
	21.08.2015	Despatch of a communication from the examining division (Time limit: M06)
	15.02.2016	Reply to a communication from the examining division
	23.08.2017	Despatch of a communication from the examining division (Time limit: M04)
	03.01.2018	Application deemed to be withdrawn, date of legal effect [2018/23]
	30.01.2018	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2018/23]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 21.08.2015
Fees paid	Renewal fee
	27.05.2014	Renewal fee patent year 03
	27.05.2015	Renewal fee patent year 04
	27.05.2016	Renewal fee patent year 05
	30.05.2017	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[A] - TANABE OSAMU ET AL, "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, (20020701), vol. 21, no. 13, doi:10.1093/EMBOJ/CDF340, ISSN 0261-4189, pages 3434 - 3442, XP002459822 [A] 1-5,9-11 * the whole document * DOI: http://dx.doi.org/10.1093/emboj/cdf340
		[A] - TANABE OSAMU ET AL, "Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, (20070502), vol. 26, no. 9, doi:10.1038/SJ.EMBOJ.7601676, ISSN 0261-4189, pages 2295 - 2306, XP002459821 [A] 1-5,9-11 * the whole document * DOI: http://dx.doi.org/10.1038/sj.emboj.7601676
		[X] - KOLODZIEJ ET AL, "Characterization of nuclear orphan receptor TR2/TR4 complexes in erythroid cells", BLOOD CELLS, MOLECULES AND DISEASES, LAJOLLA, US, (20070202), vol. 38, no. 2, doi:10.1016/J.BCMD.2006.10.071, ISSN 1079-9796, page 149, XP005862023 [X] 1-5,9-11 * abstract * DOI: http://dx.doi.org/10.1016/j.bcmd.2006.10.071
		[A] - PERRINE SUSAN P, "Fetal Globin Induction--Can It Cure {beta} Thalassemia?", HEMATOLOGY, AMERICAN SOCIETY OF HEMATOLOGY, WASHINGTON, DC, US, (20050101), doi:10.1182/ASHEDUCATION-2005.1.38, ISSN 1520-4391, pages 38 - 44, XP002457643 [A] 1-5,9-11 * the whole document * DOI: http://dx.doi.org/10.1182/asheducation-2005.1.38
		[A] - STEINBERG M H ET AL, "Pharmacologic modulation of fetal hemoglobin", MEDICINE, WILLIAMS AND WILKINS, BALTIMORE, US, (20010101), vol. 80, no. 5, doi:10.1097/00005792-200109000-00007, ISSN 0025-7974, pages 328 - 344, XP008086149 [A] 1-5,9-11 * the whole document * DOI: http://dx.doi.org/10.1097/00005792-200109000-00007
		[A] - K. GHOSHAL ET AL, "5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal", MOLECULAR AND CELLULAR BIOLOGY, (20050601), vol. 25, no. 11, doi:10.1128/MCB.25.11.4727-4741.2005, ISSN 0270-7306, pages 4727 - 4741, XP055153499 [A] 1-5,9-11 * the whole document * DOI: http://dx.doi.org/10.1128/MCB.25.11.4727-4741.2005
		[X] - BOHACEK REGINE ET AL, "Identification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and PSEUDO receptor models", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL PUBLISHING TD., OXFORD, GB, (20060101), vol. 67, no. 5, doi:10.1111/J.1747-0285.2006.00386.X, ISSN 1747-0277, pages 318 - 328, XP002457646 [X] 1-5 * abstract * * (p. 320, co. 1, par. 4 * DOI: http://dx.doi.org/10.1111/j.1747-0285.2006.00386.x
		[X] - M. S. BOOSALIS ET AL, "Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation", BLOOD, (20010515), vol. 97, no. 10, doi:10.1182/blood.V97.10.3259, ISSN 0006-4971, pages 3259 - 3267, XP055152816 [X] 1-5 * p. 3260, co. 2, "Reporter gene assays" * DOI: http://dx.doi.org/10.1182/blood.V97.10.3259
		[X] - SZULAWSKA ET AL, "Accumulation of gamma-globin mRNA and induction of irreversible erythroid differentiation after treatment of CML cell line K562 with new doxorubicin derivatives", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, (20061208), vol. 73, no. 2, doi:10.1016/J.BCP.2006.09.028, ISSN 0006-2952, pages 175 - 184, XP022342408 [X] 9-11 * abstract and p. 183, co. 1 * DOI: http://dx.doi.org/10.1016/j.bcp.2006.09.028
		[A] - T. YOKOCHI, "Doxorubicin Inhibits DNMT1, Resulting in Conditional Apoptosis", MOLECULAR PHARMACOLOGY, (20040831), vol. 66, no. 6, doi:10.1124/mol.104.002634, ISSN 0026-895X, pages 1415 - 1420, XP055152914 [A] 9-11 * the whole document * DOI: http://dx.doi.org/10.1124/mol.104.002634
	International search	[X]US5700640 (VOSS JEFFREY W [US], et al);
		[X] - CAO, H. ET AL., "Induction of human gamma globin gene expression by histone deacetylase inhibitors", BLOOD, (20040115), vol. 103, no. 2, pages 701 - 709, XP008102231 DOI: http://dx.doi.org/10.1182/blood-2003-02-0478
		[X] - LANDON, S. ET AL., "Gamma-globin gene promoter elements required for interaction with globin enhancers", BLOOD, (19980101), vol. 91, no. 1, pages 309 - 318, XP002174751
		[A] - TANABE, 0. ET AL., "Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4", EMBO JOURNAL, (20070412), vol. 26, pages 2295 - 2306, XP002459821 DOI: http://dx.doi.org/10.1038/sj.emboj.7601676

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