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Extract from the Register of European Patents

EP About this file: EP2728003

EP2728003 - METHOD FOR DIAGNOSING TYPE OF PANCREATIC TUMOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  02.11.2018
Database last updated on 03.01.2025
FormerThe patent has been granted
Status updated on  24.11.2017
FormerGrant of patent is intended
Status updated on  19.07.2017
FormerExamination is in progress
Status updated on  24.02.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Kagoshima University
21-24, Korimoto 1-chome
Kagoshima-shi, Kagoshima 890-8580 / JP
[2014/19]
Inventor(s)01 / YOKOYAMA, Seiya
c/o Kagoshima University
21-24 Korimoto 1-chome
Kagoshima-shi Kagoshima 890-8580 / JP
02 / YONEZAWA, Suguru
c/o Kagoshima University
21-24 Korimoto 1-chome
Kagoshima-shi Kagoshima 890-8580 / JP
03 / KITAMOTO, Sho
c/o Kagoshima University
21-24 Korimoto 1-chome
Kagoshima-shi Kagoshima 890-8580 / JP
 [2014/19]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2017/52]
Former [2014/19]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date12805134.929.06.2012
[2017/52]
WO2012JP67262
Priority number, dateJP2011014484729.06.2011         Original published format: JP 2011144847
[2014/19]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013002422
Date:03.01.2013
Language:JA
[2013/01]
Type: A1 Application with search report 
No.:EP2728003
Date:07.05.2014
Language:EN
[2014/19]
Type: B1 Patent specification 
No.:EP2728003
Date:27.12.2017
Language:EN
[2017/52]
Search report(s)International search report - published on:JP03.01.2013
(Supplementary) European search report - dispatched on:EP27.02.2015
ClassificationIPC:C12N15/09, C12Q1/04, C12Q1/68, G01N33/50
[2014/19]
CPC:
C12Q1/6886 (EP,US); G01N33/57438 (EP,US); C12Q2600/112 (EP,US);
C12Q2600/154 (EP,US); C12Q2600/156 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/19]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR DIAGNOSE VON PANKREASTUMOREN[2014/19]
English:METHOD FOR DIAGNOSING TYPE OF PANCREATIC TUMOR[2014/19]
French:MÉTHODE DE DIAGNOSTIC DU TYPE DE TUMEUR PANCRÉATIQUE[2014/19]
Entry into regional phase29.01.2014Translation filed 
29.01.2014National basic fee paid 
29.01.2014Search fee paid 
29.01.2014Designation fee(s) paid 
29.01.2014Examination fee paid 
Examination procedure30.11.2012Request for preliminary examination filed
International Preliminary Examining Authority: JP
29.01.2014Examination requested  [2014/19]
25.09.2015Amendment by applicant (claims and/or description)
17.10.2016Despatch of a communication from the examining division (Time limit: M04)
21.02.2017Reply to a communication from the examining division
20.07.2017Communication of intention to grant the patent
16.11.2017Fee for grant paid
16.11.2017Fee for publishing/printing paid
17.11.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.10.2016
Opposition(s)28.09.2018No opposition filed within time limit [2018/49]
Fees paidRenewal fee
31.03.2014Renewal fee patent year 03
24.06.2015Renewal fee patent year 04
31.03.2016Renewal fee patent year 05
26.06.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU29.06.2012
AL27.12.2017
AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
MK27.12.2017
NL27.12.2017
PL27.12.2017
PT27.12.2017
RO27.12.2017
RS27.12.2017
SE27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
IE29.06.2018
LU29.06.2018
MT29.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
[2020/34]
Former [2020/31]HU29.06.2012
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DK27.12.2017
EE27.12.2017
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TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
IE29.06.2018
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MT29.06.2018
BE30.06.2018
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Former [2020/29]HU29.06.2012
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PL27.12.2017
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TR27.12.2017
BG27.03.2018
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GR28.03.2018
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IE29.06.2018
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BG27.03.2018
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GR28.03.2018
IS27.04.2018
IE29.06.2018
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MT29.06.2018
BE30.06.2018
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Former [2020/16]AT27.12.2017
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MC27.12.2017
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PL27.12.2017
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SM27.12.2017
TR27.12.2017
BG27.03.2018
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GR28.03.2018
IS27.04.2018
IE29.06.2018
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MT29.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/08]AT27.12.2017
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LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
IE29.06.2018
LU29.06.2018
MT29.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/24]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
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IT27.12.2017
LT27.12.2017
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MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
IE29.06.2018
LU29.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/21]AT27.12.2017
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EE27.12.2017
ES27.12.2017
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IT27.12.2017
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LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
IE29.06.2018
LU29.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/19]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
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RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
IE29.06.2018
LU29.06.2018
Former [2019/17]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
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MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU29.06.2018
Former [2019/15]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
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LV27.12.2017
MC27.12.2017
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PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2019/13]AT27.12.2017
CY27.12.2017
CZ27.12.2017
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ES27.12.2017
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SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/51]AT27.12.2017
CY27.12.2017
CZ27.12.2017
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EE27.12.2017
ES27.12.2017
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PL27.12.2017
RO27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/40]AT27.12.2017
CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/39]AT27.12.2017
CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/38]AT27.12.2017
CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/37]CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
LT27.12.2017
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NL27.12.2017
PL27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
Former [2018/34]FI27.12.2017
HR27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
RS27.12.2017
BG27.03.2018
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GR28.03.2018
Former [2018/25]FI27.12.2017
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LT27.12.2017
LV27.12.2017
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BG27.03.2018
NO27.03.2018
GR28.03.2018
Former [2018/23]FI27.12.2017
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Documents cited:Search[I]  - SUGURU YONEZAWA ET AL, "Significance of mucin expression in pancreatobiliary neoplasms", JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES ; (FORMERLY: JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY), SPRINGER JAPAN, JAPAN, (20090929), vol. 17, no. 2, ISSN 1868-6982, pages 108 - 124, XP019804353 [I] 1-9 * abstract * * page 121 - page 121 *
 [T]  - SEIYA YOKOYAMA ET AL, "Diagnosis of Pancreatic Neoplasms Using a Novel Method of DNA Methylation Analysis of Mucin Expression in Pancreatic Juice", PLOS ONE, (20140408), vol. 9, no. 4, doi:10.1371/journal.pone.0093760, page e93760, XP055169149 [T] * page 6; figure 3 *

DOI:   http://dx.doi.org/10.1371/journal.pone.0093760
International search[AP]WO2011099566  (UNIV KAGOSHIMA [JP], et al);
 [AP]WO2011132798  (UNIV KAGOSHIMA [JP], et al);
 [Y]  - SUGURU YONEZAWA, "Mucin gene expression mechanism related to a new classification of pancreatobiliary neoplasms", (20110527), URL: http://ir.kagoshima-u.ac.jp/bitstream/10232/11993/1/20590345seika.pdf, (20120904), XP055141997
 [Y]  - FURUKAWA TORU ET AL., "Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study.", VIRCHOWS ARCHIV., (2005), vol. 447, no. 5, pages 794 - 799, XP035106194

DOI:   http://dx.doi.org/10.1007/s00428-012-1260-9
 [Y]  - YONEZAWA SUGURU ET AL., "Precursor lesions of pancreatic cancer.", GUT AND LIVER, (2008), vol. 2, no. 3, pages 137 - 154, XP055142115

DOI:   http://dx.doi.org/10.5009/gnl.2008.2.3.137
 [Y]  - YOSHIHISA NAITO ET AL., "Histopathological and Immunohistochemical Study of Intraductal Papillar y Mucinous Neoplasm of the Pancreas with Special Reference to Its Histologic Subtypes", JOURNAL OF SAITAMA MEDICAL UNIVERSITY, (200812), vol. 35, no. L, pages T9 - T22, XP008172324
 [Y]  - ABRAMS, EZRA S. ET AL., "Comprehensive detection of single base changes in human genomic DNA using denaturing gradient gel electrophoresis and a GC clamp.", GENOMICS, (1990), vol. 7, no. 4, pages 463 - 475, XP024864895

DOI:   http://dx.doi.org/10.1016/0888-7543(90)90188-Z
 [A]  - SUGURU YONEZAWA, "Mucin: Hito Gan ni Okeru Rinsho Byorigakuteki Igi, Idenshi Hatsugen Kiko, Soki Shindan System eno Oyo", JOURNAL OF THE JAPANESE SOCIETY OF CLINICAL CYTOLOGY, (20100922), vol. 49, no. 2, page 431, XP008172836
 [A]  - YASUHIRO HIBI ET AL., "Pancreatic juice cytology and subclassification of intraductal papillary mucinous neoplasms of the pancreas", THE JOURNAL OF JAPAN PANCREAS SOCIETY, (2007), vol. 22, no. 4, pages 519 - 520, XP008172345

DOI:   http://dx.doi.org/10.2958/suizo.22.519
 [A]  - SUGURU YONEZAWA, "Mucin: Hito Gan ni Okeru Rinsho Byorigakuteki Igi to Idenshi Hatsugen Kiko no Kaimei kara Shuyo Akuseido Soki Shindan System no Kochiku made", NIPPON BYORI GAKKAI KAISHI, (20100326), vol. 99, pages 121 - 122, XP008172838
 [A]  - SUGURU YONEZAWA ET AL., "Mucin kara Mita Shuyo Shinten Process", KANTANSUI, (20090628), vol. 58, no. 6, pages 755 - 767, XP008172839
 [A]  - SUGURU YONEZAWA ET AL., "IPMN no Soshiki Agata to Bunka Hatsuiku", KANTANSUI, (20100928), vol. 61, no. 3, pages 343 - 358, XP008172840
 [A]  - MAKER, AJAY V. ET AL., "Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas.", ANNALS OF SURGICAL ONCOLOGY., (201101), vol. 18, no. 1, pages 199 - 206, XP019872263

DOI:   http://dx.doi.org/10.1245/s10434-010-1225-7
by applicantJP2004135661
 JP2005087050
 JP2005087049
 JP2005087048
 JP2005087047
 JP2005087046
 JP2005087045
 JP2005110645
 JP2007524393
 JP2007524369
 JP2008504018
 JP2010097922
 JP2011144847
 JP2011184427
 WO2011132798
    - NORISHIGE YAMADA; YUKARI NISHIDA; HIDEAKI TSUTSUMIDA; TOMOFUMI HAMADA; MASAMICHI GOTO; MICHIYO HIGASHI; MITSUHARU NOMOTO; SUGURU Y, "MUC expression is regulated by DNA methylation and histone H3-K9 modification in cancer cells", CANCER RES., (2008), vol. 68, no. 8, pages 2708 - 16
    - NORISHIGE YAMADA; TOMOFUMI HAMADA; MASAMICHI GOTO; HIDEAKI TSUTSUMIDA; MICHIYO HIGASHI; MITSUHARU NOMOTO; SUGURU YONEZAWA, "MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer", INT. J. CANCER, (2006), vol. 119, no. 8, pages 1850 - 7
    - NORISHIGE YAMADA; YUKARI NISHIDA; HIDEAKI TSUTSUMIDA; MASAMICHI GOTO; MICHIYO HIGASHI; MITSUHARU NOMOTO; SUGURU YONEZAWA, "Promoter CpG methylation in cancer cells contributes to regulation of MUC4", BR. J. CANCER, (2009), vol. 100, no. 2, pages 344 - 51
    - YAMADA N; NISHIDA Y; YOKOYAMA S; TSUTSUMIDA H; HOUJOU I; KITAMOTO S; GOTO M; HIGASHI M; YONEZAWA S., "Expression of MUCSAC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells", J. HEPATOBILIARY PANCREAT. SCI, (2010), vol. 17, no. 6, pages 844 - 854, XP019851335
    - GULDBERG, P.; GRONBAK, K.; AGGERHOLM, A.; PLATZ, A.; THOR STRATEN, P.; AHRENKIEL, V.; HOKLAND, P.; ZEUTHEN, J., "Detection of mutations in GC-rich DNA by bisulphite denaturing gradient gel electrophoresis", NUCLEIC ACIDS RES., (1998), vol. 26, no. 6, doi:doi:10.1093/nar/26.6.1548, pages 1548 - 1549, XP002929508

DOI:   http://dx.doi.org/10.1093/nar/26.6.1548
    - ABRAMS, E. S.; STANTON, V. P. JR., "Use of denaturing gradient gel electrophoresis to study conformational transitions in nucleic acids", METHODS ENZYMOL., (1992), vol. 212, doi:doi:10.1016/0076-6879(92)12006-C, pages 71 - 104, XP001156797

DOI:   http://dx.doi.org/10.1016/0076-6879(92)12006-C
    - NORISHIGE YAMADA; YUKARI NISHIDA; HIDEAKI TSUTSUMIDA; TOMOFUMI HAMADA; MASAMICHI GOTO; MICHIYO HIGASHI; MITSUHARU NOMOTO; SUGURU Y, "MUC1 expression is regulated by DNA methylation and histone H3-K9 modification in cancer cells", CANCER RES., (2008), vol. 68, no. 8, pages 2708 - 16
    - YAMADA N; NISHIDA Y; YOKOYAMA S; TSUTSUMIDA H; HOUJOU I; KITAMOTO S; GOTO M; HIGASHI M; YONEZAWA S., "Expression of MUCSAC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells", J. HEPATOBILIARY PANCREAT. SCI., (2010), vol. 17, no. 6, pages 844 - 854, XP019851335
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